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Mechanism of size effects in microcylindrical compression of pure copper considering grain orientation distribution 被引量:1
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作者 Chuan-Jie Wang Chun-Ju Wang +2 位作者 Bin Guo De-Bin Shan yan-yan chang 《Rare Metals》 SCIE EI CAS CSCD 2013年第1期18-24,共7页
In microscale deformation, the magnitudes of specimen and grain sizes are usually identical, and size- dependent phenomena of deformation behavior occur, namely, size effects. In this study, size effects in micro- cyl... In microscale deformation, the magnitudes of specimen and grain sizes are usually identical, and size- dependent phenomena of deformation behavior occur, namely, size effects. In this study, size effects in micro- cylindrical compression were investigated experimentally. It was found that, with the increase of grain size and decrease of specimen size, flow stress decreases and inhomogeneous material flow increases. These size effects tend to be more distinct with miniaturization. Thereafter, a modified model considering orientation distribution of surface grains and continuity between surface grains and inner grains is developed to model size effects in micro- forming. Through finite element simulation, the effects of specimen size, grain size, and orientation of surface grains on the flow stress and inhomogeneous deformation were analyzed. There is a good agreement between experimental and simulation results. 展开更多
关键词 MICROFORMING Cylindrical compression Sizeeffects Grain orientation Inhomogeneous deformation
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GABA_A Receptor Activity Suppresses the Transition from Interictal to Ictal Epileptiform Discharges in Juvenile Mouse Hippocampus 被引量:4
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作者 yan-yan chang Xin-Wei Gong +3 位作者 Hai-Qing Gong Pei-Ji Liang Pu-Ming Zhang Qin-Chi Lu 《Neuroscience Bulletin》 SCIE CAS CSCD 2018年第6期1007-1016,共10页
Exploring the transition from inter-ictal to ictal epileptiform discharges(IDs) and how GABAAreceptormediated action affects the onset of IDs will enrich our understanding of epileptogenesis and epilepsy treatment.We ... Exploring the transition from inter-ictal to ictal epileptiform discharges(IDs) and how GABAAreceptormediated action affects the onset of IDs will enrich our understanding of epileptogenesis and epilepsy treatment.We used Mg2+-free artificial cerebrospinal fluid(ACSF) to induce epileptiform discharges in juvenile mouse hippocampal slices and used a micro-electrode array to record the discharges. After the slices were exposed to Mg2+-free ACSF for 10 min–20 min, synchronous recurrent seizurelike events were recorded across the slices, and each event evolved from inter-ictal epileptiform discharges(IIDs) to pre-ictal epileptiform discharges(PIDs), and then to IDs.During the transition from IIDs to PIDs, the duration of discharges increased and the inter-discharge interval decreased. After adding 3 lmol/L of the GABAAreceptor agonist muscimol, PIDs and IDs disappeared, and IIDs remained. Further, the application of 10 lmol/L muscimol abolished all the epileptiform discharges. When the GABAAreceptor antagonist bicuculline was applied at 10 lmol/L, IIDs and PIDs disappeared, and IDs remained at decreased intervals. These results indicated that there are dynamic changes in the hippocampal network preceding the onset of IDs, and GABAAreceptor activity suppresses the transition from IIDs to IDs in juvenile mouse hippocampus. 展开更多
关键词 Epileptiform discharge Gamma-aminobutyric acid BICUCULLINE MUSCIMOL Micro-electrode array Hippocampal slice
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