BACKGROUND A reliable test is essential for diagnosing Helicobacter pylori(H.pylori)infection,and crucial for managing H.pylori-related diseases.Serving as an excellent method for detecting H.pylori infection,histolog...BACKGROUND A reliable test is essential for diagnosing Helicobacter pylori(H.pylori)infection,and crucial for managing H.pylori-related diseases.Serving as an excellent method for detecting H.pylori infection,histologic examination is a test that clinicians heavily rely on,especially when complemented with immunohistochemistry(IHC).Additionally,other diagnostic tests for H.pylori,such as the rapid urease test(CLO test)and stool antigen test(SA),are also highly sensitive and specific.Typically,the results of histology and other tests align with each other.However,on rare occasions,discrepancy between histopathology and other H.pylori diagnostic tests occurs.AIM To investigate the discordance between histology and other H.pylori tests,the underlying causes,and the impact on clinical management.METHODS Pathology reports of gastric biopsies were retrieved spanning August 2013 and July 2018.Reports were included in the study only if there were other H.pylori tests within seven days of the biopsy.These additional tests include CLO test,SA,and H.pylori culture.Concordance between histopathology and other tests was determined based on the consistency of results.In instances where histology results were negative while other tests were positive,the slides were retrieved for re-assessment,and the clinical chart was reviewed.RESULTS Of 1396 pathology reports were identified,each accompanied by one additional H.pylori test.The concordance rates in detecting H.pylori infection between biopsy and other tests did not exhibit significant differences based on the number of biopsy fragments.117 discrepant cases were identified.Only 20 cases(9 with CLO test and 11 with SA)had negative biopsy but positive results in other tests.Four cases initially stained with Warthin-Starry turned out to be positive for H.pylori with subsequent IHC staining.Among the remaining 16 true discrepant cases,10 patients were on proton pump inhibitors before the biopsy and/or other tests.Most patients underwent treatment,except for two who were untreated,and two patients who were lost to follow-up.CONCLUSION There are rare discrepant cases with negative biopsy but positive in SA or CLO test.Various factors may contribute to this inconsistency.Most patients in such cases had undergone treatment.展开更多
In this paper,a fast element-free Galerkin(FEFG)method for three-dimensional(3D)elasticity problems is established.The FEFG method is a combination of the improved element-free Galerkin(IEFG)method and the dimension s...In this paper,a fast element-free Galerkin(FEFG)method for three-dimensional(3D)elasticity problems is established.The FEFG method is a combination of the improved element-free Galerkin(IEFG)method and the dimension splitting method(DSM).By using the DSM,a 3D problem is converted to a series of 2D ones,and the IEFG method with a weighted orthogonal function as the basis function and the cubic spline function as the weight function is applied to simulate these 2D problems.The essential boundary conditions are treated by the penalty method.The splitting direction uses the finite difference method(FDM),which can combine these 2D problems into a discrete system.Finally,the system equation of the 3D elasticity problem is obtained.Some specific numerical problems are provided to illustrate the effectiveness and advantages of the FEFG method for 3D elasticity by comparing the results of the FEFG method with those of the IEFG method.The convergence and relative error norm of the FEFG method for elasticity are also studied.展开更多
多孔碳材料由于具有优异的导电性,高的孔隙率以及可有效地吸附多硫化物等优点被广泛应用于锂硫电池.本文以植酸(PA)和三聚氰胺作为磷源和氮源,通过高温裂解法成功制备了N,P共掺杂的三维多孔碳纳米复合材料(FeNi/FeNiP@NP-C)作为载硫基质...多孔碳材料由于具有优异的导电性,高的孔隙率以及可有效地吸附多硫化物等优点被广泛应用于锂硫电池.本文以植酸(PA)和三聚氰胺作为磷源和氮源,通过高温裂解法成功制备了N,P共掺杂的三维多孔碳纳米复合材料(FeNi/FeNiP@NP-C)作为载硫基质.FeNi/FeNiP@NP-C三维多孔碳骨架具有良好的导电性能,它不仅能够有效地吸附可溶性多硫化物,同时能够促进电子转移从而提高反应动力学.实验结果表明S@FeNi/FeNiP@NP-C正极有较好的电化学性能和循环稳定性,在硫负载量为1.0 mg cm^(-2)以及0.1C的电流密度下,S@FeNi/FeNiP@NPC电极可达到1035.8 mAh g^(-1)的初始放电比容量,在0.1 C电流密度及较高硫负载量(4.3 mg cm^(-2))下循环100圈后仍能保持435.5 mAh g-1的放电比容量.展开更多
文摘BACKGROUND A reliable test is essential for diagnosing Helicobacter pylori(H.pylori)infection,and crucial for managing H.pylori-related diseases.Serving as an excellent method for detecting H.pylori infection,histologic examination is a test that clinicians heavily rely on,especially when complemented with immunohistochemistry(IHC).Additionally,other diagnostic tests for H.pylori,such as the rapid urease test(CLO test)and stool antigen test(SA),are also highly sensitive and specific.Typically,the results of histology and other tests align with each other.However,on rare occasions,discrepancy between histopathology and other H.pylori diagnostic tests occurs.AIM To investigate the discordance between histology and other H.pylori tests,the underlying causes,and the impact on clinical management.METHODS Pathology reports of gastric biopsies were retrieved spanning August 2013 and July 2018.Reports were included in the study only if there were other H.pylori tests within seven days of the biopsy.These additional tests include CLO test,SA,and H.pylori culture.Concordance between histopathology and other tests was determined based on the consistency of results.In instances where histology results were negative while other tests were positive,the slides were retrieved for re-assessment,and the clinical chart was reviewed.RESULTS Of 1396 pathology reports were identified,each accompanied by one additional H.pylori test.The concordance rates in detecting H.pylori infection between biopsy and other tests did not exhibit significant differences based on the number of biopsy fragments.117 discrepant cases were identified.Only 20 cases(9 with CLO test and 11 with SA)had negative biopsy but positive results in other tests.Four cases initially stained with Warthin-Starry turned out to be positive for H.pylori with subsequent IHC staining.Among the remaining 16 true discrepant cases,10 patients were on proton pump inhibitors before the biopsy and/or other tests.Most patients underwent treatment,except for two who were untreated,and two patients who were lost to follow-up.CONCLUSION There are rare discrepant cases with negative biopsy but positive in SA or CLO test.Various factors may contribute to this inconsistency.Most patients in such cases had undergone treatment.
基金supported by the National Natural Science Foundation of China(Grant Nos.52004169 and 11571223).
文摘In this paper,a fast element-free Galerkin(FEFG)method for three-dimensional(3D)elasticity problems is established.The FEFG method is a combination of the improved element-free Galerkin(IEFG)method and the dimension splitting method(DSM).By using the DSM,a 3D problem is converted to a series of 2D ones,and the IEFG method with a weighted orthogonal function as the basis function and the cubic spline function as the weight function is applied to simulate these 2D problems.The essential boundary conditions are treated by the penalty method.The splitting direction uses the finite difference method(FDM),which can combine these 2D problems into a discrete system.Finally,the system equation of the 3D elasticity problem is obtained.Some specific numerical problems are provided to illustrate the effectiveness and advantages of the FEFG method for 3D elasticity by comparing the results of the FEFG method with those of the IEFG method.The convergence and relative error norm of the FEFG method for elasticity are also studied.
文摘多孔碳材料由于具有优异的导电性,高的孔隙率以及可有效地吸附多硫化物等优点被广泛应用于锂硫电池.本文以植酸(PA)和三聚氰胺作为磷源和氮源,通过高温裂解法成功制备了N,P共掺杂的三维多孔碳纳米复合材料(FeNi/FeNiP@NP-C)作为载硫基质.FeNi/FeNiP@NP-C三维多孔碳骨架具有良好的导电性能,它不仅能够有效地吸附可溶性多硫化物,同时能够促进电子转移从而提高反应动力学.实验结果表明S@FeNi/FeNiP@NP-C正极有较好的电化学性能和循环稳定性,在硫负载量为1.0 mg cm^(-2)以及0.1C的电流密度下,S@FeNi/FeNiP@NPC电极可达到1035.8 mAh g^(-1)的初始放电比容量,在0.1 C电流密度及较高硫负载量(4.3 mg cm^(-2))下循环100圈后仍能保持435.5 mAh g-1的放电比容量.
