BACKGROUND Intra-abdominal infections(IAIs)is the most common type of surgical infection,with high associated morbidity and mortality rates.In recent years,due to the use of antibiotics,various drug-resistant bacteria...BACKGROUND Intra-abdominal infections(IAIs)is the most common type of surgical infection,with high associated morbidity and mortality rates.In recent years,due to the use of antibiotics,various drug-resistant bacteria have emerged,making the treatment of abdominal infections more challenging.Early surgical exploration can reduce the mortality of patients with abdominal infection and the occurrence of complications.However,available evidence regarding the optimal timing of IAI surgery is still weak.In study,we compared the effects of operation time on patients with abdominal cavity infection and tried to confirm the best timing of surgery.AIM To assess the efficacy of early vs delayed surgical exploration in the treatment of IAI,in terms of overall mortality.METHODS A systematic literature search was performed using PubMed,EMBASE,Cochrane Central Register of Controlled Trials,Ovid,and ScienceDirect.The systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method.Based on the timing of the surgical operation,we divided the literature into two groups:Early surgery and delayed surgery.For the early and delayed surgery groups,the intervention was performed with and after 12 h of the initial surgical intervention,respectively.The main outcome measure was the mortality rate.The literature search was performed from May 5 to 20,2021.We also searched the World Health Organization International Clinical Trials Registry Platform search portal and ClinicalTrials.gov on May 20,2021,for ongoing trials.This study was registered with the International Prospective Register of Systematic Reviews.RESULTS We identified nine eligible trial comparisons.Early surgical exploration of patients with IAIs(performed within 12 h)has significantly reduced the mortality and complications of patients,improved the survival rate,and shortened the hospital stay.CONCLUSION Early surgical exploration within 12 h may be more effective for the treatment of IAIs relative to a delayed operation.展开更多
Phytochemical investigation on the roots of Asparagus cochinchinensis led to the isolation of one new furostanol saponin,named 26-O-β-d-glucopyranosyl-22α-hydroxyl-(25R)-Δ5(6)-furost-3β,26-diol-3-O-α-l-rhamnopyra...Phytochemical investigation on the roots of Asparagus cochinchinensis led to the isolation of one new furostanol saponin,named 26-O-β-d-glucopyranosyl-22α-hydroxyl-(25R)-Δ5(6)-furost-3β,26-diol-3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside(1),along with three known congeners(2‒4).The structure of new saponin was elucidated via comprehensive inspection of its HRMS and NMR spectral data as well as chemical technology,whereas those of known ones were identified by comparison of their NMR and MS spectral data with those reported in literatures.All isolated saponins were evaluated for their cytotoxic effects on two human liver(MHCC97H)and lung adenocarcinoma(H1299)cancer cells in vitro.Among them,both 1 and 2 showed significant cytotoxicity against above mentioned cell lines.Further studies revealed that these two saponins could significantly inhibit their proliferation of MHCC97H and H1299 cells.展开更多
Schwann cells play an important role in the peripheral nervous system, especially in nerve repair following injury, so artificial nerve regeneration requires an effective technique for obtaining purified Schwann cells...Schwann cells play an important role in the peripheral nervous system, especially in nerve repair following injury, so artificial nerve regeneration requires an effective technique for obtaining purified Schwann cells. In vivo and in vitro pre-degeneration of peripheral nerves have been shown to obtain high-purity Schwann cells. We believed that in vitro pre-degeneration was simple and controllable, and available for the clinic. Thus, we co-cultured the crushed sciatic nerves with bone marrow-derived cells in vitro. Results demonstrated that, 3 hours after injury, a large number of mononuclear cells moved to the crushed nerves and a large number of bone marrow-derived cells infiltrated the nerve segments. These changes promoted the degradation of the nerve segments, and the dedifferentiation and proliferation of Schwann cells. Neural cell adhesion molecule and glial fibrillary acidic protein expression were detected in the crushed nerves. Schwann cell yield was 9.08 ± 2.01 × 104/mg. The purity of primary cultured Schwann cells was 88.4 ± 5.79%. These indicate a successful new method for obtaining Schwann cells of high purity and yield from adult crushed sciatic nerve using bone marrow-derived cells.展开更多
We propose and demonstrate an alternative method for spectral filtering and frequency stabilization of both 780-nm and 960-nm lasers using a high-finesse length-tunable cavity(HFLTC).Firstly,the length of HFLTC is sta...We propose and demonstrate an alternative method for spectral filtering and frequency stabilization of both 780-nm and 960-nm lasers using a high-finesse length-tunable cavity(HFLTC).Firstly,the length of HFLTC is stabilized to a commercial frequency reference.Then,the two lasers are locked to this HFLTC using the Pound–Drever–Hall(PDH)method which can narrow the linewidths and stabilize the frequencies of both lasers simultaneously.Finally,the transmitted lasers of HFLTC with each power up to about 100μW,which act as seed lasers,are amplified using the injection locking method for single-atom Rydberg excitation.The linewidths of obtained lasers are narrowed to be less than 1 k Hz,meanwhile the obtained lasers'phase noise around 750 k Hz are suppressed about 30 d B.With the spectrally filtered lasers,we demonstrate a Rabi oscillation between the ground state and Rydberg state of single-atoms in an optical trap tweezer with a decay time of(67±37)μs,which is almost not affected by laser phase noise.We found that the maximum short-term laser frequency fluctuation of a single excitation lasers is at~3.3 k Hz and the maximum long-term laser frequency drift of a single laser is~46 k Hz during one month.Our work develops a stable and repeatable method to provide multiple laser sources of ultra-low phase noise,narrow linewidth,and excellent frequency stability,which is essential for high precision atomic experiments,such as neutral atom quantum computing,quantum simulation,quantum metrology,and so on.展开更多
The(Fe_(82)Al_(13.5)Ga_(4.5))_(99.9)(NbC)_(0.1) sheets with strong Goss texture and large magnetostriction were prepared by rolling and isothermal annealing processes.Single Goss grain growth was observed in sheets un...The(Fe_(82)Al_(13.5)Ga_(4.5))_(99.9)(NbC)_(0.1) sheets with strong Goss texture and large magnetostriction were prepared by rolling and isothermal annealing processes.Single Goss grain growth was observed in sheets undergoing isothermal annealing at 1050 ℃ for 1 h using Ar as protecting gas.With annealing time increasing to 8 h at1050℃,a largest magnetostriction of 154×10^(-6) is obtained in sheet and a large λ_(//)(the maximum magnetostriction with magnetic field parallel to rolling direction)of 160×10^(-6) along the rolling direction is also observed.The fact that a λ_(//) of 160×10^(-6) along RD can be achieved with only 4.5 at% Ga in the Fe-18 at%(Al,Ga) sheet is of practical importance.Compared with previous studies in Fe-Al and Fe-Ga sheets,this paper provides a more efficient approach to prepare strong Goss textured sheets.In this way,a slow continuous heating process,sulfur-induced surface energy control and high-temperature annealing above 1200 ℃ are no more necessary.It shows a good prospect for industrial production of high-performance magnetostrictive alloy sheets.展开更多
Agarwood is an important non-timber forest product widely used in religious and cultural activities as perfume and fragrance and as traditional medicine in Asia. The high value of agarwood and the inflated consuming m...Agarwood is an important non-timber forest product widely used in religious and cultural activities as perfume and fragrance and as traditional medicine in Asia. The high value of agarwood and the inflated consuming market have led to constant rising of the prices. In general, the price of the agarwood is determined according to its quality, which can be divided into different grades. But up to now, there is not any standard quality grading system which could be used overwhelmingly throughout the agarwood producing, commerce and consumption. Therefore, we reviewed agarwood in diversified grading indexes, systems and methods.展开更多
The effects of heat treatments on the phase transformation behavior of Ti49 Ni49.5 Fe1 V0.5 and Ti48 Ni48.5 Fe1 V2.5 alloys were investigated. The results indicate that the alloys subjected to different heat treatment...The effects of heat treatments on the phase transformation behavior of Ti49 Ni49.5 Fe1 V0.5 and Ti48 Ni48.5 Fe1 V2.5 alloys were investigated. The results indicate that the alloys subjected to different heat treatments have B2 structure at room temperature. All the specimens exhibit a twostage B2→R→B190martensitic transformation on cooling, but a B190→B2 one-stage reverse martensitic transformation on heating except aged A1 alloy, which undergoes an abnormal two-stage transformation upon heating. The phase transformation temperatures are affected by heat treatments and V content, which can be attributed to the variation of the second-phase particles content in the matrix.展开更多
Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international community.Previous studies have been focusing on rapid analgesia of acupuncture thr...Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international community.Previous studies have been focusing on rapid analgesia of acupuncture through the regulation of nervous system,but few studies on the inflammation regulatory mechanisms in which acupuncture inhibits the peripheral sensitization-induced pain.Based on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems,we put forward the scientific hypothesis that acupuncture regulates neuroendocrine-immune(NEI)network and key response media therein,so as to achieve anti-inflammatory and analgesic effects in target organs.We have established a platform for acupuncture at ST36 to alleviate inflammatory pain in adjuvant induced arthritic rats.Based on the complex network analysis of multi-dimensional data from multi-time point and multi-site detection of NEI common signaling molecules,we have clarified the regulatory effects of acupuncture on NEI network and corresponding downstream immune network.Results indicated that monocytes/macrophages are the key targeting cells of acupuncture regulation,and acupuncture may display the anti-inflammatory and analgesic effects by regulating polarization of T cells in lymph nodes and polarization of M1/M2 macrophages in inflamed joints/paws.In addition,we have spotted a key molecule for acupuncture analgesia,CXCL1,as well as clarified the novel central analgesic mechanism of acupuncture mediated by CXCL1/CXCR2 desensitization.Thereby,we have provided novel evidence of the anti-inflammatory and analgesic actions of acupuncture through regulating NEI network and several key substances,highlighting a systemic research paradigm for investigating mechanisms of acupuncture actions.展开更多
The isoscaling parameters aevai in the fissioning systems,i.e.,those extracted from the Evaluated Nuclear Data Library(ENDF/B-VIII.O)and the Joint Evaluated Fission and Fusion File(JEFF-3.3),show an obvious difference...The isoscaling parameters aevai in the fissioning systems,i.e.,those extracted from the Evaluated Nuclear Data Library(ENDF/B-VIII.O)and the Joint Evaluated Fission and Fusion File(JEFF-3.3),show an obvious difference from simple statistic model prediction where only the symmetry energy plays the dominant role.To explain the aeVai as a function of the charge number of the fission fragment,a statistic scission point model is adopted.Our analysis shows that the effects of the shell correction,nuclear shape deformation,and intrinsic temperature of fission fragments are indispensable as well as the symmetry energy.Furthermore,an alternative method for extracting the intrinsic temperatures of fission fragments is proposed based on the isoscaling relationship in fission fragments.The intrinsic temperatures of the light fragments are higher than those of the heavy fragments.展开更多
基金Taishan Scholar Foundation of Shandong Province,No.2018092901.
文摘BACKGROUND Intra-abdominal infections(IAIs)is the most common type of surgical infection,with high associated morbidity and mortality rates.In recent years,due to the use of antibiotics,various drug-resistant bacteria have emerged,making the treatment of abdominal infections more challenging.Early surgical exploration can reduce the mortality of patients with abdominal infection and the occurrence of complications.However,available evidence regarding the optimal timing of IAI surgery is still weak.In study,we compared the effects of operation time on patients with abdominal cavity infection and tried to confirm the best timing of surgery.AIM To assess the efficacy of early vs delayed surgical exploration in the treatment of IAI,in terms of overall mortality.METHODS A systematic literature search was performed using PubMed,EMBASE,Cochrane Central Register of Controlled Trials,Ovid,and ScienceDirect.The systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method.Based on the timing of the surgical operation,we divided the literature into two groups:Early surgery and delayed surgery.For the early and delayed surgery groups,the intervention was performed with and after 12 h of the initial surgical intervention,respectively.The main outcome measure was the mortality rate.The literature search was performed from May 5 to 20,2021.We also searched the World Health Organization International Clinical Trials Registry Platform search portal and ClinicalTrials.gov on May 20,2021,for ongoing trials.This study was registered with the International Prospective Register of Systematic Reviews.RESULTS We identified nine eligible trial comparisons.Early surgical exploration of patients with IAIs(performed within 12 h)has significantly reduced the mortality and complications of patients,improved the survival rate,and shortened the hospital stay.CONCLUSION Early surgical exploration within 12 h may be more effective for the treatment of IAIs relative to a delayed operation.
基金the National Natural Science Foundation of China(Grant Nos.31770388 and U1802281)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(Grant No.2019QZKK0502).
文摘Phytochemical investigation on the roots of Asparagus cochinchinensis led to the isolation of one new furostanol saponin,named 26-O-β-d-glucopyranosyl-22α-hydroxyl-(25R)-Δ5(6)-furost-3β,26-diol-3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside(1),along with three known congeners(2‒4).The structure of new saponin was elucidated via comprehensive inspection of its HRMS and NMR spectral data as well as chemical technology,whereas those of known ones were identified by comparison of their NMR and MS spectral data with those reported in literatures.All isolated saponins were evaluated for their cytotoxic effects on two human liver(MHCC97H)and lung adenocarcinoma(H1299)cancer cells in vitro.Among them,both 1 and 2 showed significant cytotoxicity against above mentioned cell lines.Further studies revealed that these two saponins could significantly inhibit their proliferation of MHCC97H and H1299 cells.
基金supported by the Key University Natural Science Research Project of Anhui Province of China,No.KJ2016A870
文摘Schwann cells play an important role in the peripheral nervous system, especially in nerve repair following injury, so artificial nerve regeneration requires an effective technique for obtaining purified Schwann cells. In vivo and in vitro pre-degeneration of peripheral nerves have been shown to obtain high-purity Schwann cells. We believed that in vitro pre-degeneration was simple and controllable, and available for the clinic. Thus, we co-cultured the crushed sciatic nerves with bone marrow-derived cells in vitro. Results demonstrated that, 3 hours after injury, a large number of mononuclear cells moved to the crushed nerves and a large number of bone marrow-derived cells infiltrated the nerve segments. These changes promoted the degradation of the nerve segments, and the dedifferentiation and proliferation of Schwann cells. Neural cell adhesion molecule and glial fibrillary acidic protein expression were detected in the crushed nerves. Schwann cell yield was 9.08 ± 2.01 × 104/mg. The purity of primary cultured Schwann cells was 88.4 ± 5.79%. These indicate a successful new method for obtaining Schwann cells of high purity and yield from adult crushed sciatic nerve using bone marrow-derived cells.
基金National Key Research and Development Program of China(Grant No.2016YFA0302800)the National Natural Science Foundation of China(Grant Nos.U20A2074 and 12074391)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB 21010100)the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2017378)K.C.Wong Education Foundation(Grant No.GJTD-2019-15)。
文摘We propose and demonstrate an alternative method for spectral filtering and frequency stabilization of both 780-nm and 960-nm lasers using a high-finesse length-tunable cavity(HFLTC).Firstly,the length of HFLTC is stabilized to a commercial frequency reference.Then,the two lasers are locked to this HFLTC using the Pound–Drever–Hall(PDH)method which can narrow the linewidths and stabilize the frequencies of both lasers simultaneously.Finally,the transmitted lasers of HFLTC with each power up to about 100μW,which act as seed lasers,are amplified using the injection locking method for single-atom Rydberg excitation.The linewidths of obtained lasers are narrowed to be less than 1 k Hz,meanwhile the obtained lasers'phase noise around 750 k Hz are suppressed about 30 d B.With the spectrally filtered lasers,we demonstrate a Rabi oscillation between the ground state and Rydberg state of single-atoms in an optical trap tweezer with a decay time of(67±37)μs,which is almost not affected by laser phase noise.We found that the maximum short-term laser frequency fluctuation of a single excitation lasers is at~3.3 k Hz and the maximum long-term laser frequency drift of a single laser is~46 k Hz during one month.Our work develops a stable and repeatable method to provide multiple laser sources of ultra-low phase noise,narrow linewidth,and excellent frequency stability,which is essential for high precision atomic experiments,such as neutral atom quantum computing,quantum simulation,quantum metrology,and so on.
基金financially supported by the National Natural Science Foundation of China (Nos. 51271019 and 51501006)。
文摘The(Fe_(82)Al_(13.5)Ga_(4.5))_(99.9)(NbC)_(0.1) sheets with strong Goss texture and large magnetostriction were prepared by rolling and isothermal annealing processes.Single Goss grain growth was observed in sheets undergoing isothermal annealing at 1050 ℃ for 1 h using Ar as protecting gas.With annealing time increasing to 8 h at1050℃,a largest magnetostriction of 154×10^(-6) is obtained in sheet and a large λ_(//)(the maximum magnetostriction with magnetic field parallel to rolling direction)of 160×10^(-6) along the rolling direction is also observed.The fact that a λ_(//) of 160×10^(-6) along RD can be achieved with only 4.5 at% Ga in the Fe-18 at%(Al,Ga) sheet is of practical importance.Compared with previous studies in Fe-Al and Fe-Ga sheets,this paper provides a more efficient approach to prepare strong Goss textured sheets.In this way,a slow continuous heating process,sulfur-induced surface energy control and high-temperature annealing above 1200 ℃ are no more necessary.It shows a good prospect for industrial production of high-performance magnetostrictive alloy sheets.
基金National Natural Science Foundation of China(No.81403055,81303312)Science&Technology Programs from Hainan Province of China(No.ZDKJ2016004)CAMS Initiative for Innovative Medicine(CAMS-I2M-2-003)
文摘Agarwood is an important non-timber forest product widely used in religious and cultural activities as perfume and fragrance and as traditional medicine in Asia. The high value of agarwood and the inflated consuming market have led to constant rising of the prices. In general, the price of the agarwood is determined according to its quality, which can be divided into different grades. But up to now, there is not any standard quality grading system which could be used overwhelmingly throughout the agarwood producing, commerce and consumption. Therefore, we reviewed agarwood in diversified grading indexes, systems and methods.
基金financially supported by the Industry,Education and Research Projects of the China Aviation Industrial(No.cxy2012BH04)
文摘The effects of heat treatments on the phase transformation behavior of Ti49 Ni49.5 Fe1 V0.5 and Ti48 Ni48.5 Fe1 V2.5 alloys were investigated. The results indicate that the alloys subjected to different heat treatments have B2 structure at room temperature. All the specimens exhibit a twostage B2→R→B190martensitic transformation on cooling, but a B190→B2 one-stage reverse martensitic transformation on heating except aged A1 alloy, which undergoes an abnormal two-stage transformation upon heating. The phase transformation temperatures are affected by heat treatments and V content, which can be attributed to the variation of the second-phase particles content in the matrix.
基金Acknowledgments This study was financially supported by the National Natural Science Foundation of China （Grant No. 31272364） and the Important National Science ＆ Technology Specific Project of China （Grant No. 2012ZX 10004219）.
基金supported by the National Natural Science Foundation of China(NSFC)No.81330088,81873369,81873368,81973939,81973944,81804182Natural science foundation of Zhejiang province LY20H270008
文摘Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international community.Previous studies have been focusing on rapid analgesia of acupuncture through the regulation of nervous system,but few studies on the inflammation regulatory mechanisms in which acupuncture inhibits the peripheral sensitization-induced pain.Based on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems,we put forward the scientific hypothesis that acupuncture regulates neuroendocrine-immune(NEI)network and key response media therein,so as to achieve anti-inflammatory and analgesic effects in target organs.We have established a platform for acupuncture at ST36 to alleviate inflammatory pain in adjuvant induced arthritic rats.Based on the complex network analysis of multi-dimensional data from multi-time point and multi-site detection of NEI common signaling molecules,we have clarified the regulatory effects of acupuncture on NEI network and corresponding downstream immune network.Results indicated that monocytes/macrophages are the key targeting cells of acupuncture regulation,and acupuncture may display the anti-inflammatory and analgesic effects by regulating polarization of T cells in lymph nodes and polarization of M1/M2 macrophages in inflamed joints/paws.In addition,we have spotted a key molecule for acupuncture analgesia,CXCL1,as well as clarified the novel central analgesic mechanism of acupuncture mediated by CXCL1/CXCR2 desensitization.Thereby,we have provided novel evidence of the anti-inflammatory and analgesic actions of acupuncture through regulating NEI network and several key substances,highlighting a systemic research paradigm for investigating mechanisms of acupuncture actions.
基金Supported by the National Natural Science Foundation of China(11790325,11875323,11875125,11947410,11705163,11790320,11790323,11961141003)the National Key R&D Program of China(2018 YFA0404404)+1 种基金the Continuous Basic Scientific Research Project(WDJC-2019-09,WDJC-2019-13,BJ20002501)of the funding of China Institute of Atomic EnergyChinese-Polish Joint project by the National Science Foundation of China(11961131010)。
文摘The isoscaling parameters aevai in the fissioning systems,i.e.,those extracted from the Evaluated Nuclear Data Library(ENDF/B-VIII.O)and the Joint Evaluated Fission and Fusion File(JEFF-3.3),show an obvious difference from simple statistic model prediction where only the symmetry energy plays the dominant role.To explain the aeVai as a function of the charge number of the fission fragment,a statistic scission point model is adopted.Our analysis shows that the effects of the shell correction,nuclear shape deformation,and intrinsic temperature of fission fragments are indispensable as well as the symmetry energy.Furthermore,an alternative method for extracting the intrinsic temperatures of fission fragments is proposed based on the isoscaling relationship in fission fragments.The intrinsic temperatures of the light fragments are higher than those of the heavy fragments.
