In this study, the environmental indicators （including temperature, light, air relative humidity and CO2 concentration） of facility watermelon in Beijing area were monitored with US350 environmental sensor during th...In this study, the environmental indicators （including temperature, light, air relative humidity and CO2 concentration） of facility watermelon in Beijing area were monitored with US350 environmental sensor during the whole growth period. The results showed that in the solar greenhouses in Beijing area, the average air temperature was in the range of 10.67-29.95 ℃ during the whole growth period of watermelon, the average soil temperature ranged from 16.92 to 35.10 ℃, the average light intensity changed from 268.37 to 13 842.60 Ix, the average air relative humidity ranged from 52.40% to 94.26%, and the average CO2 concentration was in the range of 455-631 ml/m3; and in the spring greenhouses in Beijing area, the variation range of average air temperature was 14.05-29.84 ℃ during the whole growth period of watermelon, the average soil temperature ranged from 17.47 to 28.12 ℃, the average light intensity was in the range of 55.80-12 858.64 Ix, the average soil moisture content ranged from 18.19%-34.56%, the variation range of average air relative humidity was 20.72%-96.26%, and the average CO2 concentra- tion was in the range of 351-544 ml/m3,展开更多
Rheumatoid arthritis is a chronic,systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate.Several drugs have been used for the treatment of rheumatoid arth...Rheumatoid arthritis is a chronic,systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate.Several drugs have been used for the treatment of rheumatoid arthritis,but their use is limited by suboptimal bioavailability,serious adverse effects,and nonnegligible first-pass effects.In contrast,transdermal drug delivery systems(TDDSs)can avoid these drawbacks and improve patient compliance,making them a promising option for the treatment of rheumatoid arthritis(RA).Of course,TDDSs also face unique challenges,as the physiological barrier of the skin makes drug delivery somewhat limited.To overcome this barrier and maximize drug delivery efficiency,TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology,and different generations of TDDSs have been derived,which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery.In this review,we summarize the different generations of transdermal drug delivery systems,the corresponding transdermal strategies,and their applications in the treatment of RA.展开更多
基金Supported by Industry Technology System of Watermelon and Melon in China(BAIC10-2017)
文摘In this study, the environmental indicators （including temperature, light, air relative humidity and CO2 concentration） of facility watermelon in Beijing area were monitored with US350 environmental sensor during the whole growth period. The results showed that in the solar greenhouses in Beijing area, the average air temperature was in the range of 10.67-29.95 ℃ during the whole growth period of watermelon, the average soil temperature ranged from 16.92 to 35.10 ℃, the average light intensity changed from 268.37 to 13 842.60 Ix, the average air relative humidity ranged from 52.40% to 94.26%, and the average CO2 concentration was in the range of 455-631 ml/m3; and in the spring greenhouses in Beijing area, the variation range of average air temperature was 14.05-29.84 ℃ during the whole growth period of watermelon, the average soil temperature ranged from 17.47 to 28.12 ℃, the average light intensity was in the range of 55.80-12 858.64 Ix, the average soil moisture content ranged from 18.19%-34.56%, the variation range of average air relative humidity was 20.72%-96.26%, and the average CO2 concentra- tion was in the range of 351-544 ml/m3,
基金supported by the Scientific Research Project of Liaoning Province Education Department (2020LJC16),China。
文摘Rheumatoid arthritis is a chronic,systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate.Several drugs have been used for the treatment of rheumatoid arthritis,but their use is limited by suboptimal bioavailability,serious adverse effects,and nonnegligible first-pass effects.In contrast,transdermal drug delivery systems(TDDSs)can avoid these drawbacks and improve patient compliance,making them a promising option for the treatment of rheumatoid arthritis(RA).Of course,TDDSs also face unique challenges,as the physiological barrier of the skin makes drug delivery somewhat limited.To overcome this barrier and maximize drug delivery efficiency,TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology,and different generations of TDDSs have been derived,which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery.In this review,we summarize the different generations of transdermal drug delivery systems,the corresponding transdermal strategies,and their applications in the treatment of RA.
