Design of a robust catalyst with high activity but the low cost for the hydrodeoxygenation(HDO) of biooils is of great importance to bring the biorefinery concept into reality.In this study,density functional theory(D...Design of a robust catalyst with high activity but the low cost for the hydrodeoxygenation(HDO) of biooils is of great importance to bring the biorefinery concept into reality.In this study,density functional theory(DFT) calculation was adopted to analyze the optimal location of Ni on MoO_(3-x) containing oxygen vacancy,and the corresponding result demonstrated that metallic Ni cluster located at the neighborhood of oxygen vacancies would significantly evoke HDO activity.Enlightened by DFT results,NiMoO_(4) was first hydrothermally synthesized and then employed to fabricate Ni-MoO_(3-x) catalyst via a low-temperature reduction,where Ni escaped from NiMoO_(4) and was reduced to its metallic state.Such an evolution of Ni species also induced the formation of oxygen vacancies around metallic Ni cluster.In the HDO of p-cresol,Ni-MoO_(3-x) exhibited high activity with a complete conversion and a methylcyclohexane selectivity of 99.4% at 150℃.Moreover,the catalyst showed good versatility in catalyzing HDO of diverse lignin-derived oxygenates and lignin oil.2D HSQC NMR,gas chromatograph and elemental analysis of the lignin oil demonstrated the high deoxygenation efficiency and saturation of the benzene ring over Ni-MoO_(3-x).In the upgrading of crude lignin oil,the deoxygenation degree was up to 99%,and the overall carbon yield of the naphthenes was as high as 69.4%.Importantly,the structures and carbon numbers of the naphthene products are similar to jet fuel-range cycloalka nes,which are expected to have a high density that can be blended into jet fuel to raise the range(or payload) of airplanes.This work demonstrates the feasibility for improving the targeted catalytic reactivity by rational tailoring the catalyst structure under the guidance of theoretical analysis,and provides an energy-efficient route for the upgrading of lignin crude oil into valuable naphthenes.展开更多
Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate o...Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate of UC in China has increased year by year,but there is no effective cure method in Western medicine.Traditional Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity,convenience,effectiveness,and low cost.Therefore,integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment,and has made significant progress in UC.On the basis of learning from a number of consensuses at home and abroad,combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine,the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western medicine.In this consensus,the pathogenesis,etiology and pathogenesis,diagnosis,integrated traditional Chinese and Western medicine treatment,and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by experts.This article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.展开更多
To enhance the hydrogen release during hydrogen storage,several Pt-Ir supported on Mg-Al mixed oxide catalysts were prepared and then applied into the dehydrogenation of methylcyclohexane(MCH)in this study.The effects...To enhance the hydrogen release during hydrogen storage,several Pt-Ir supported on Mg-Al mixed oxide catalysts were prepared and then applied into the dehydrogenation of methylcyclohexane(MCH)in this study.The effects of iridium content,reduction temperature on the activity and stability of the catalysts were studied in detail.In the presence of Ir,metal particle size was decrea sed and electron transfer between Ir and Pt was observed.High reduction temperature increased the metallic Ir content but enlarged the particle size of active site s.During the dehydrogenation reaction on Pt-Ir bimetallic catalyst,MCH was efficiently converted into toluene and PtIr-5/Mg-Al-275 exhibited the highe st activity.After prolonging the residence time and raising the reaction temperature to 350℃the conversion and hydrogen evolution rate were increased to 99.9%and 578.7 mmol·(g Pt)^-1·min^-1,respectively.Moreover,no carbon deposition was observed in the spent catalyst,presenting a high anti-coking ability and good potential for industrial application.展开更多
Multiple phase transitions are detected in sodium amide(NaNH2), an important hydrogen storage material, upon compression in diamond anvil cells(DAC) by using Raman spectroscopy and x-ray diffraction(XRD) measurements....Multiple phase transitions are detected in sodium amide(NaNH2), an important hydrogen storage material, upon compression in diamond anvil cells(DAC) by using Raman spectroscopy and x-ray diffraction(XRD) measurements.Additional Bragg reflections appear on lower and higher angle sides of the original ones at ~1.07 GPa and 1.84 GPa,accompanied by obvious changes in Raman spectroscopy, respectively.It reveals that NaNH2 undergoes the high-pressure phase sequence(α-β-γ) up to 20 GPa at room temperature.Spectral analysis indicates an orthorhombic structure with PBAN space group for the γ phase.We also experimentally observe high pressure induced recrystallization in alkaline amide compounds for the first time.展开更多
In situ Raman spectroscopy and x-ray diffraction measurements are used to explore the structural stability of CaB6 at high pressures and room temperature. The results show no evidence of structural phase transitions u...In situ Raman spectroscopy and x-ray diffraction measurements are used to explore the structural stability of CaB6 at high pressures and room temperature. The results show no evidence of structural phase transitions up to at least 40 GPa.The obtained equation of state with smooth pressure dependencies yields a zero-pressure isothermal bulk modulus B0=170(5) GPa, which agrees well with the previous measurements. The frequency shifts for A1g, Eg, and T2g vibrational modes of polycrystalline CaB6 are obtained with pressure uploading. As the pressure increases, all the vibration modes have smooth monotonic pressure dependence. The Gr¨uneisen parameter of Eg modes is the largest, indicating its largest dependence on the volume of a crystal lattice.展开更多
We conduct extensive research into the structures of Be_(x)Zn_(1-x)OO ternary alloys in a pressure range of 0-60GPa,using the ab initio total energy evolutionary algorithm and total energy calculations,finding several...We conduct extensive research into the structures of Be_(x)Zn_(1-x)OO ternary alloys in a pressure range of 0-60GPa,using the ab initio total energy evolutionary algorithm and total energy calculations,finding several metastable structures.Our pressure-composition phase diagram is constructed using the enthalpy results.In addition,we calculate the electronic structures of the Be_(x)Zn_(1-x)OO structures and investigate the bandgap values at varying pressures and Be content.The calculated results show that the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with an increase in Be content at the same pressure.Moreover,the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with the increasing pressure with fixed Be content.At the same Be content,the formation enthalpy of the Be_(x)Zn_(1-x)OO ternary alloys first decreases,then increases with the increasing pressure.展开更多
Ammonium iodine(NH4I)as an important member of hydrogen-rich compounds has attracted a great deal of attention owing to its interesting structural changes triggered by the relative orientations of adjacent ammonium io...Ammonium iodine(NH4I)as an important member of hydrogen-rich compounds has attracted a great deal of attention owing to its interesting structural changes triggered by the relative orientations of adjacent ammonium ions.Previous studies of ammonium iodide have remained in the low pressure range experimentally,which we first extended to so high pressure(250 GPa).We have investigated the structures of ammonium iodine under high pressure through ab initio evolutionary algorithm and total energy calculations based on density functional theory.The static enthalpy calculations show that phase V is stable until 85 GPa where a new phase Ibam is identified.Calculations of phonon spectra show that the Ibam phase is stable between 85 GPa and 101 GPa and the Cm phase is stable up to 130 GPa.In addition,ammonium iodine dissociates into NH3,H2,and I2 at 74 GPa.Subsequently,we analyzed phonon spectra and electronic band structures,finding that phonon softening is not the reason of dissociation and NH4I is always a semiconductor within the pressure range.展开更多
Silane(SiH4)is a promising hydrogen-rich compound for pursing high temperature superconducting.Previous high pressure measurements of Raman,x-ray diffraction and theoretical studies on SiH4 mainly focused on its polym...Silane(SiH4)is a promising hydrogen-rich compound for pursing high temperature superconducting.Previous high pressure measurements of Raman,x-ray diffraction and theoretical studies on SiH4 mainly focused on its polymorphic structures above 50 GPa,while the structure and the stability under lower pressure range are still unclear.Here we report an investigation of condensed SiH4 by Brillouin scattering measurements at high temperature up to 407 K and high pressure up to 18 GPa.Brillouin scattering frequencies of fluid SiH4 under compression are obtained under isothermal conditions of 300 K,359 K and 407 K.The SiH4 becomes unstable with increasing temperature and subsequently decomposes into silicon and H2.We find that compression at room temperature induces two velocity anomalies corresponding to a fluid-solid state transition and a phaseⅣto phase V transition,respectively.Brillouin scattering spectra has been a powerful tool to investigate the fruitful phases and structure transitions in the hydrogen-rich compound under extreme conditions.展开更多
In this paper, diversity-multiplexing tradeoff (DMT) curve for 2×2 Dual-Polarized uncorrelated Rice MIMO channels is studied. Exact expressions for statistic information of mutual information exponent are derived...In this paper, diversity-multiplexing tradeoff (DMT) curve for 2×2 Dual-Polarized uncorrelated Rice MIMO channels is studied. Exact expressions for statistic information of mutual information exponent are derived. Impacts of channel parameters such as signal to noise ratio (SNR), k-factor and cross polarization discrimination (XPD) on mutual information exponent are analyzed. Compared to conventional single-polarized (SP) Rice MIMO systems, a qualitatively different behavior is observed for DP Rice systems. The work in this paper, allows identifying quantitatively for which channels (k-factor) and SNR levels the use of dual polarization becomes beneficial. Gamma or lognormal distribution are used to describe mutual information component, and a theoretical formulation for finite-SNR DMT curve in 2×2 DP uncorrelated Rice channels is presented for the first time, which is valid in low and medium SNRs when multiplexing gain is larger than 0.75.展开更多
Zinc-based aqueous rechargeable batteries have attracted extensive attention due to their low cost,safety,and environmental friendliness.However,dendrite growth and hydrogen evolution of Zn anodes limit their large-sc...Zinc-based aqueous rechargeable batteries have attracted extensive attention due to their low cost,safety,and environmental friendliness.However,dendrite growth and hydrogen evolution of Zn anodes limit their large-scale application.A new strategy to produce a polyacrylamide/reduced graphene oxide(PAM@rGO)molecular nanobrush coating and control Zn electrolyte interface engineering is proposed for use in highly reversible Zn plating/stripping.Hydrogen evolution is inhibited,and Zn deposition is consolidated using the rich zincophilic functional groups of the branched polyacrylamide chain and the high conductivity of rGO.Due to the synergistic effects of corrosion resistance and dendrite-free growth,PAM@rGO/Zn provides prolonged and reversible Zn plating/stripping.Density functional theory(DFT)calculations expand on homogenized nucleation.The PAM@rGO/Zn||activated carbon(AC)capacitor exhibits long cyclic stability,fast ion transfer,and minimal interfacial impedance.This study provides experimental and theoretical bases for the structural design of Zn anode.展开更多
Liver cirrhosis is a leading cause of death from liver‐related diseases accompanied by a variety of complications;however,hepatic fibrosis,an inevitable stage of cirrhosis,is possible to be reversed and cured.Hepatic...Liver cirrhosis is a leading cause of death from liver‐related diseases accompanied by a variety of complications;however,hepatic fibrosis,an inevitable stage of cirrhosis,is possible to be reversed and cured.Hepatic stellate cells(HSCs)are the primary cells that secrete extracellular matrix in the liver and play a dominant role in the pathogenesis of hepatic fibrosis.Effective therapeutic approaches for reversing hepatic fibrosis aim at inhibiting the activation of HSCs and inducing their inactivation or death.This review highlights the mechanism by which traditional Chinese medicine(TCM)regulates the activity of HSCs and exerts antifibrotic effects,providing insights and prospects for the treatment of hepatic fibrosis with TCM.展开更多
Aqueous rechargeable zinc-ion hybrid supercapacitors are considered to be a promising candidate for large-scale energy storage devices owing to their high safety,long life,and low price.In this paper,a nitrogen doped ...Aqueous rechargeable zinc-ion hybrid supercapacitors are considered to be a promising candidate for large-scale energy storage devices owing to their high safety,long life,and low price.In this paper,a nitrogen doped hierarchical porous carbon is evaluated as the cathode for aqueous rechargeable zinc-ion hybrid supercapacitors.Benefiting from the synergistic merits of excellent structural features of N-HPC and tiny zinc dendrite of Zn anode in ZnSO4 electrolyte,the zinc-ion hybrid supercapacitor exhibits excellent energy storage performance including high capacity of 136.8 mAh·g^−1 at 0.1·Ag^−1,high energy density of 191 Wh·kg^−1,large power density of 3,633.4 W·kg^−1,and satisfactory cycling stability of up to 5,000 cycles with a capacity retention of 90.9%.This work presents a new prospect of developing high-performance aqueous rechargeable zinc ion energy storage devices.展开更多
Lipid-based formulations(LBFs)have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs.However,construction of in vitro and in vivo correlations(IVIVCs)for LBFs is quite chall...Lipid-based formulations(LBFs)have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs.However,construction of in vitro and in vivo correlations(IVIVCs)for LBFs is quite challenging,owing to a complex in vivo processing of these formulations.In this paper,we start with a brief introduction on the gastrointestinal digestion of lipid/LBFs and its relation to enhanced oral drug absorption;based on the concept of IVIVCs,the current status of in vitro models to establish IVIVCs for LBFs is reviewed,while future perspectives in this field are discussed.In vitro tests,which facilitate the understanding and prediction of the in vivo performance of solid dosage forms,frequently fail to mimic the in vivo processing of LBFs,leading to inconsistent results.In vitro digestion models,which more closely simulate gastrointestinal physiology,are a more promising option.Despite some successes in IVIVC modeling,the accuracy and consistency of these models are yet to be validated,particularly for human data.A reliable IVIVC model can not only reduce the risk,time,and cost of formulation development but can also contribute to the formulation design and optimization,thus promoting the clinical translation of LBFs.展开更多
聚酞菁具有典型的化学交联结构和均匀分散的金属活性位点,但是较差的活性和导电性限制了其作为氧还原催化剂的应用.本文通过热解聚酞菁铁与多孔碳的混合物制备了三元氧还原催化剂,产物Fe_(3)O_(4)/Fe_(3)N/Fe-N-C@PC-2.5在碱性溶液中的...聚酞菁具有典型的化学交联结构和均匀分散的金属活性位点,但是较差的活性和导电性限制了其作为氧还原催化剂的应用.本文通过热解聚酞菁铁与多孔碳的混合物制备了三元氧还原催化剂,产物Fe_(3)O_(4)/Fe_(3)N/Fe-N-C@PC-2.5在碱性溶液中的半波电势为0.90 V,远高于市售20%Pt/C的半波电势.电化学测试和X射线吸收精细结构相结合,将Fe_(3)O_(4)/Fe_(3)N/Fe-N-C@PC-2.5的优异氧还原活性归因于Fe_(3)O_(4),Fe_(3)N和Fe-N4三种组分的共存.以Fe_(3)O_(4)/Fe_(3)N/FeN-C@PC-2.5作为空气阴极催化剂的锌空气电池具有较高的开路电压和峰值功率密度.在恒电流放电过程中,该电池的比容量可达到815.7 mA h g^(-1).展开更多
Maternal sodium butyrate(SB)intake has important effects on offspring growth and development.This study aimed to investigate the impacts of maternal SB supplementation during gestation and lactation on fatty acid comp...Maternal sodium butyrate(SB)intake has important effects on offspring growth and development.This study aimed to investigate the impacts of maternal SB supplementation during gestation and lactation on fatty acid composition and lipid metabolism in the offspring skeletal muscle of pigs.Twenty sows(Yorkshire,parity 2 to 3)were assigned to the control group(diets without SB,n=10)and SB group(diets with 0.1%SB,n=10).The results showed maternal SB supplementation throughout gestation and lactation increased(P<0.05)body weight of offspring piglets at weaning.The concentrations of triglyceride in plasma and milk were enhanced(P<0.05).Maternal SB induced(P<0.05)lipid accumulation with increased expression of peroxisome proliferator activated receptorγ(PPARγ)by enrichment of the acetylation of H3 acetylation K27(H3 K27)in offspring skeletal muscle.Meanwhile,the concentrations of C18:2 n-6,C18:3 n-3,total polyunsaturated fatty acid(PUFA),n-6 PUFA and n-3 PUFA decreased(P<0.05)in skeletal muscle of weaning piglets derived from SB sows.Together,these results showed that maternal SB supplementation could influence offspring growth performance,lipid metabolism and fatty acid composition of the skeletal muscle.展开更多
A search for the dimuon decay of the Standard Model Higgs boson is performed using Monte Carlo simulated events to mimic data corresponding to an integrated luminosity of 5.6 ab^(-1)collected with the Circular Electro...A search for the dimuon decay of the Standard Model Higgs boson is performed using Monte Carlo simulated events to mimic data corresponding to an integrated luminosity of 5.6 ab^(-1)collected with the Circular Electron-Positron Collider detector in e^(+)e^(-)collisions at√s=240 GeV.This study investigates the e^(+)e^(-)→ZH,Z→qq,H→μ^(+)μ^(-)process,and the expected significance considering only the statistical uncertainty in the data for a background-only hypothesis for a Higgs boson with a mass of 125 GeV is found to be 6.1σ,corresponding to a precision of 19%.The systematic impacts from the background Monte Carlo statistical fluctuations are estimated to be negligible.Moreover,the dependence of the measurement accuracy on the muon momentum resolution of the CEPC detector is investigated.It is found that the muon momentum resolution must be better than 204 MeV to discover the H→μμprocess at the nominal integrated luminosity,If the resolution is 100%worse than the designed parameter,the integrated luminosity must be greater than 7.2 ab^(-1)to reach 5σsignificance.展开更多
Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors.The recipe of Mongolian medicine Sendeng Decoction was recorded in“The Pleasure of the Viewer”compiled by Jigwood...Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors.The recipe of Mongolian medicine Sendeng Decoction was recorded in“The Pleasure of the Viewer”compiled by Jigwood Danjinzhamusu.Mongolian medicine clinical experience proved that Sendeng Decoction had good antipyretic,analgesic,anti-inflammatory and anti-rheumatism effect.However,the mechanism of this drug in psoriasis is still unclear.In this study,imiquimod cream(IMQ)was used to construct psoriasis model in 8-week-old male BALB/c mice,and Sendeng Decoction was used to treat the mice with psoriasis.The results showed that PASI score and spleen index decreased after Sendeng Decoction treatment.Meanwhile,HE staining showed that the pathological structure was improved,flow cytometry results showed that the proportion of Treg cells increased and Th17 cells decreased,and results of Western blot showed that the level of p38 MAPK,p-p38 MAPK,p-STAT3 and p-JAK1 decreased observably.More importantly,the above results were most significant in Sendeng's M group,which was similar to MTX group.Our results indicated that Mongolian medicine Sendeng Decoction can effectively relieve the symptoms of psoriasis mice induced by IMQ,mainly by regulating the ratio of Th17/Treg cells through the JAK/STAT and p38 MAPK pathways to reduce the inflammatory state in mice,thereby improving the symptoms of dermatitis.展开更多
基金supported by the National Key R&D Program of China (2022YFB3805401, 2019YFC1905300)the National Natural Science Foundation of China (22178297)+1 种基金the Hunan Provincial Natural Science Foundation (2022JJ40425, 2022JJ40432)the Process Intensification and Green Chemical Engineering Innovation Team of Hunan Province。
文摘Design of a robust catalyst with high activity but the low cost for the hydrodeoxygenation(HDO) of biooils is of great importance to bring the biorefinery concept into reality.In this study,density functional theory(DFT) calculation was adopted to analyze the optimal location of Ni on MoO_(3-x) containing oxygen vacancy,and the corresponding result demonstrated that metallic Ni cluster located at the neighborhood of oxygen vacancies would significantly evoke HDO activity.Enlightened by DFT results,NiMoO_(4) was first hydrothermally synthesized and then employed to fabricate Ni-MoO_(3-x) catalyst via a low-temperature reduction,where Ni escaped from NiMoO_(4) and was reduced to its metallic state.Such an evolution of Ni species also induced the formation of oxygen vacancies around metallic Ni cluster.In the HDO of p-cresol,Ni-MoO_(3-x) exhibited high activity with a complete conversion and a methylcyclohexane selectivity of 99.4% at 150℃.Moreover,the catalyst showed good versatility in catalyzing HDO of diverse lignin-derived oxygenates and lignin oil.2D HSQC NMR,gas chromatograph and elemental analysis of the lignin oil demonstrated the high deoxygenation efficiency and saturation of the benzene ring over Ni-MoO_(3-x).In the upgrading of crude lignin oil,the deoxygenation degree was up to 99%,and the overall carbon yield of the naphthenes was as high as 69.4%.Importantly,the structures and carbon numbers of the naphthene products are similar to jet fuel-range cycloalka nes,which are expected to have a high density that can be blended into jet fuel to raise the range(or payload) of airplanes.This work demonstrates the feasibility for improving the targeted catalytic reactivity by rational tailoring the catalyst structure under the guidance of theoretical analysis,and provides an energy-efficient route for the upgrading of lignin crude oil into valuable naphthenes.
文摘Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate of UC in China has increased year by year,but there is no effective cure method in Western medicine.Traditional Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity,convenience,effectiveness,and low cost.Therefore,integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment,and has made significant progress in UC.On the basis of learning from a number of consensuses at home and abroad,combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine,the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western medicine.In this consensus,the pathogenesis,etiology and pathogenesis,diagnosis,integrated traditional Chinese and Western medicine treatment,and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by experts.This article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.
基金supported by the National Natural Science Foundation of China(Nos.21676225 and 21776236)Natural Science Foundation of Hunan Province(2018JJ2384)+2 种基金Fund of Hunan Provincial Education Department(19A478)Collaborative Innovation Centre of New Chemical Technologies for Environmental Benignity and Efficient Resource UtilizationEngineering Research Centre of Chemical Process Simulation and Optimization of Ministry of Education。
文摘To enhance the hydrogen release during hydrogen storage,several Pt-Ir supported on Mg-Al mixed oxide catalysts were prepared and then applied into the dehydrogenation of methylcyclohexane(MCH)in this study.The effects of iridium content,reduction temperature on the activity and stability of the catalysts were studied in detail.In the presence of Ir,metal particle size was decrea sed and electron transfer between Ir and Pt was observed.High reduction temperature increased the metallic Ir content but enlarged the particle size of active site s.During the dehydrogenation reaction on Pt-Ir bimetallic catalyst,MCH was efficiently converted into toluene and PtIr-5/Mg-Al-275 exhibited the highe st activity.After prolonging the residence time and raising the reaction temperature to 350℃the conversion and hydrogen evolution rate were increased to 99.9%and 578.7 mmol·(g Pt)^-1·min^-1,respectively.Moreover,no carbon deposition was observed in the spent catalyst,presenting a high anti-coking ability and good potential for industrial application.
基金Project supported by the National Key R&D Program of China(Grant Nos.2018YFA0305900 and 2016YFB0201204)the National Natural Science Foundation of China(Grant Nos.51632002,51572108,11504127,91745203,and 11634004)+1 种基金Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT 15R23)National Fund for Fostering Talents of Basic Science,China(Grant No.J1103202)
文摘Multiple phase transitions are detected in sodium amide(NaNH2), an important hydrogen storage material, upon compression in diamond anvil cells(DAC) by using Raman spectroscopy and x-ray diffraction(XRD) measurements.Additional Bragg reflections appear on lower and higher angle sides of the original ones at ~1.07 GPa and 1.84 GPa,accompanied by obvious changes in Raman spectroscopy, respectively.It reveals that NaNH2 undergoes the high-pressure phase sequence(α-β-γ) up to 20 GPa at room temperature.Spectral analysis indicates an orthorhombic structure with PBAN space group for the γ phase.We also experimentally observe high pressure induced recrystallization in alkaline amide compounds for the first time.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51572108,51632002,11504127,11674122,11574112,11474127,and11634004)the 111 Project,China(Grant No.B12011)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT 15R23)the National Found for Fostering Talents of Basic Science,China(Grant No.J1103202)
文摘In situ Raman spectroscopy and x-ray diffraction measurements are used to explore the structural stability of CaB6 at high pressures and room temperature. The results show no evidence of structural phase transitions up to at least 40 GPa.The obtained equation of state with smooth pressure dependencies yields a zero-pressure isothermal bulk modulus B0=170(5) GPa, which agrees well with the previous measurements. The frequency shifts for A1g, Eg, and T2g vibrational modes of polycrystalline CaB6 are obtained with pressure uploading. As the pressure increases, all the vibration modes have smooth monotonic pressure dependence. The Gr¨uneisen parameter of Eg modes is the largest, indicating its largest dependence on the volume of a crystal lattice.
基金Supported by the National Key Research and Development Program of China(Grant Nos.2016YFB0201204,2018YFA0703404,and 2017YFA0403704)the National Natural Science Foundation of China(Grant Nos.11574109 and 91745203)the Program for Changjiang Scholars and Innovative Research Team in Universities(Grant No.IRT_15R23).
文摘We conduct extensive research into the structures of Be_(x)Zn_(1-x)OO ternary alloys in a pressure range of 0-60GPa,using the ab initio total energy evolutionary algorithm and total energy calculations,finding several metastable structures.Our pressure-composition phase diagram is constructed using the enthalpy results.In addition,we calculate the electronic structures of the Be_(x)Zn_(1-x)OO structures and investigate the bandgap values at varying pressures and Be content.The calculated results show that the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with an increase in Be content at the same pressure.Moreover,the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with the increasing pressure with fixed Be content.At the same Be content,the formation enthalpy of the Be_(x)Zn_(1-x)OO ternary alloys first decreases,then increases with the increasing pressure.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11574109,51632002,51572108,91745203,and 11574112)the National Key Research and Development Program of China(Grant Nos.2016YFB0201204 and 2018YFA0305900)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT 15R23)the National Fund for Fostering Talents of Basic Science of China(Grant No.J1103202).
文摘Ammonium iodine(NH4I)as an important member of hydrogen-rich compounds has attracted a great deal of attention owing to its interesting structural changes triggered by the relative orientations of adjacent ammonium ions.Previous studies of ammonium iodide have remained in the low pressure range experimentally,which we first extended to so high pressure(250 GPa).We have investigated the structures of ammonium iodine under high pressure through ab initio evolutionary algorithm and total energy calculations based on density functional theory.The static enthalpy calculations show that phase V is stable until 85 GPa where a new phase Ibam is identified.Calculations of phonon spectra show that the Ibam phase is stable between 85 GPa and 101 GPa and the Cm phase is stable up to 130 GPa.In addition,ammonium iodine dissociates into NH3,H2,and I2 at 74 GPa.Subsequently,we analyzed phonon spectra and electronic band structures,finding that phonon softening is not the reason of dissociation and NH4I is always a semiconductor within the pressure range.
基金Supported by the National Key Research and Development Program(Grant No.2017YFA0403704)the National Natural Science Foundation of China(Grant Nos.11474127,11574112,11274137,and 11504127)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT1132)China Postdoctoral Science Foundation(Grant No.2015M570265)。
文摘Silane(SiH4)is a promising hydrogen-rich compound for pursing high temperature superconducting.Previous high pressure measurements of Raman,x-ray diffraction and theoretical studies on SiH4 mainly focused on its polymorphic structures above 50 GPa,while the structure and the stability under lower pressure range are still unclear.Here we report an investigation of condensed SiH4 by Brillouin scattering measurements at high temperature up to 407 K and high pressure up to 18 GPa.Brillouin scattering frequencies of fluid SiH4 under compression are obtained under isothermal conditions of 300 K,359 K and 407 K.The SiH4 becomes unstable with increasing temperature and subsequently decomposes into silicon and H2.We find that compression at room temperature induces two velocity anomalies corresponding to a fluid-solid state transition and a phaseⅣto phase V transition,respectively.Brillouin scattering spectra has been a powerful tool to investigate the fruitful phases and structure transitions in the hydrogen-rich compound under extreme conditions.
文摘In this paper, diversity-multiplexing tradeoff (DMT) curve for 2×2 Dual-Polarized uncorrelated Rice MIMO channels is studied. Exact expressions for statistic information of mutual information exponent are derived. Impacts of channel parameters such as signal to noise ratio (SNR), k-factor and cross polarization discrimination (XPD) on mutual information exponent are analyzed. Compared to conventional single-polarized (SP) Rice MIMO systems, a qualitatively different behavior is observed for DP Rice systems. The work in this paper, allows identifying quantitatively for which channels (k-factor) and SNR levels the use of dual polarization becomes beneficial. Gamma or lognormal distribution are used to describe mutual information component, and a theoretical formulation for finite-SNR DMT curve in 2×2 DP uncorrelated Rice channels is presented for the first time, which is valid in low and medium SNRs when multiplexing gain is larger than 0.75.
基金supported by the National Natural Science Foundation of China(Nos.22208273 and 22272204)Tianchi Talent Plan of Xinjiang Uygur Autonomous Region.
文摘Zinc-based aqueous rechargeable batteries have attracted extensive attention due to their low cost,safety,and environmental friendliness.However,dendrite growth and hydrogen evolution of Zn anodes limit their large-scale application.A new strategy to produce a polyacrylamide/reduced graphene oxide(PAM@rGO)molecular nanobrush coating and control Zn electrolyte interface engineering is proposed for use in highly reversible Zn plating/stripping.Hydrogen evolution is inhibited,and Zn deposition is consolidated using the rich zincophilic functional groups of the branched polyacrylamide chain and the high conductivity of rGO.Due to the synergistic effects of corrosion resistance and dendrite-free growth,PAM@rGO/Zn provides prolonged and reversible Zn plating/stripping.Density functional theory(DFT)calculations expand on homogenized nucleation.The PAM@rGO/Zn||activated carbon(AC)capacitor exhibits long cyclic stability,fast ion transfer,and minimal interfacial impedance.This study provides experimental and theoretical bases for the structural design of Zn anode.
基金Major Project of Shanghai Municipal S and T Commission,Grant/Award Number:19401972300Shandong Province Key R&D Program(Major Science and Technology Innovation Project),Grant/Award Number:2021CXGC010509+2 种基金Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Key Disciplines of Liver and Gall Bladder Diseases,Key Laboratory of Chronic Deficiency Liver Disease of the State Administration of Traditional Chinese Medicine of the People's Republic of China,Grant/Award Number:20DZ2272200Shanghai Key Specialty of Traditional Chinese Clinical Medicine,Grant/Award Number:shslczdzk01201Outstanding TCM reserve talents of Shanghai University of Traditional Chinese Medicine(2020)。
文摘Liver cirrhosis is a leading cause of death from liver‐related diseases accompanied by a variety of complications;however,hepatic fibrosis,an inevitable stage of cirrhosis,is possible to be reversed and cured.Hepatic stellate cells(HSCs)are the primary cells that secrete extracellular matrix in the liver and play a dominant role in the pathogenesis of hepatic fibrosis.Effective therapeutic approaches for reversing hepatic fibrosis aim at inhibiting the activation of HSCs and inducing their inactivation or death.This review highlights the mechanism by which traditional Chinese medicine(TCM)regulates the activity of HSCs and exerts antifibrotic effects,providing insights and prospects for the treatment of hepatic fibrosis with TCM.
基金This work was supported by the National Natural Science Foundation of China(No.21471162)the Hunan Provincial Science and Technology Plan Project(No.2017TP1001).
文摘Aqueous rechargeable zinc-ion hybrid supercapacitors are considered to be a promising candidate for large-scale energy storage devices owing to their high safety,long life,and low price.In this paper,a nitrogen doped hierarchical porous carbon is evaluated as the cathode for aqueous rechargeable zinc-ion hybrid supercapacitors.Benefiting from the synergistic merits of excellent structural features of N-HPC and tiny zinc dendrite of Zn anode in ZnSO4 electrolyte,the zinc-ion hybrid supercapacitor exhibits excellent energy storage performance including high capacity of 136.8 mAh·g^−1 at 0.1·Ag^−1,high energy density of 191 Wh·kg^−1,large power density of 3,633.4 W·kg^−1,and satisfactory cycling stability of up to 5,000 cycles with a capacity retention of 90.9%.This work presents a new prospect of developing high-performance aqueous rechargeable zinc ion energy storage devices.
基金supported by Science and Technology Commission of Shanghai Municipality(Nos.19430741400 and 19410761200,China)National Natural Science Foundation of China(Nos.81973247 and 81703434)
文摘Lipid-based formulations(LBFs)have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs.However,construction of in vitro and in vivo correlations(IVIVCs)for LBFs is quite challenging,owing to a complex in vivo processing of these formulations.In this paper,we start with a brief introduction on the gastrointestinal digestion of lipid/LBFs and its relation to enhanced oral drug absorption;based on the concept of IVIVCs,the current status of in vitro models to establish IVIVCs for LBFs is reviewed,while future perspectives in this field are discussed.In vitro tests,which facilitate the understanding and prediction of the in vivo performance of solid dosage forms,frequently fail to mimic the in vivo processing of LBFs,leading to inconsistent results.In vitro digestion models,which more closely simulate gastrointestinal physiology,are a more promising option.Despite some successes in IVIVC modeling,the accuracy and consistency of these models are yet to be validated,particularly for human data.A reliable IVIVC model can not only reduce the risk,time,and cost of formulation development but can also contribute to the formulation design and optimization,thus promoting the clinical translation of LBFs.
基金financially supported by the Basic Research Project of the Science and Technology Innovation Commission of Shenzhen (JCYJ20200109141640095 and JCYJ20190809115413414)the National Natural Science Foundation of China (21671096 and 21905180)+2 种基金the Natural Science Foundation of Guangdong Province (2018A030310225)Guangdong Provincial Key Laboratory of Energy Materials for Electric Power (2018B030322001)support from the Center for Computational Science and Engineering and Core Research Facilities of SUSTech。
文摘聚酞菁具有典型的化学交联结构和均匀分散的金属活性位点,但是较差的活性和导电性限制了其作为氧还原催化剂的应用.本文通过热解聚酞菁铁与多孔碳的混合物制备了三元氧还原催化剂,产物Fe_(3)O_(4)/Fe_(3)N/Fe-N-C@PC-2.5在碱性溶液中的半波电势为0.90 V,远高于市售20%Pt/C的半波电势.电化学测试和X射线吸收精细结构相结合,将Fe_(3)O_(4)/Fe_(3)N/Fe-N-C@PC-2.5的优异氧还原活性归因于Fe_(3)O_(4),Fe_(3)N和Fe-N4三种组分的共存.以Fe_(3)O_(4)/Fe_(3)N/FeN-C@PC-2.5作为空气阴极催化剂的锌空气电池具有较高的开路电压和峰值功率密度.在恒电流放电过程中,该电池的比容量可达到815.7 mA h g^(-1).
基金supported by the National Key Research and Development Program of China(2016YFD0500502)the National Natural Science Foundation of China(31772696)。
文摘Maternal sodium butyrate(SB)intake has important effects on offspring growth and development.This study aimed to investigate the impacts of maternal SB supplementation during gestation and lactation on fatty acid composition and lipid metabolism in the offspring skeletal muscle of pigs.Twenty sows(Yorkshire,parity 2 to 3)were assigned to the control group(diets without SB,n=10)and SB group(diets with 0.1%SB,n=10).The results showed maternal SB supplementation throughout gestation and lactation increased(P<0.05)body weight of offspring piglets at weaning.The concentrations of triglyceride in plasma and milk were enhanced(P<0.05).Maternal SB induced(P<0.05)lipid accumulation with increased expression of peroxisome proliferator activated receptorγ(PPARγ)by enrichment of the acetylation of H3 acetylation K27(H3 K27)in offspring skeletal muscle.Meanwhile,the concentrations of C18:2 n-6,C18:3 n-3,total polyunsaturated fatty acid(PUFA),n-6 PUFA and n-3 PUFA decreased(P<0.05)in skeletal muscle of weaning piglets derived from SB sows.Together,these results showed that maternal SB supplementation could influence offspring growth performance,lipid metabolism and fatty acid composition of the skeletal muscle.
基金the Innovative Research Program of IHEP(E2545AU210)CAS Center for Excellence in Particle Physics+11 种基金Yifang Wang’s Science Studio of the Ten Thousand Talents Projectthe CAS/SAFEA International Partnership Program for Creative Research Teams(H751S018S5)IHEP Innovation Grant(Y4545170Y2)Key Research Program of Frontier Sciences,CAS(XQYZDY-SSW-SLH002)Chinese Academy of Science Special Grant for Large Scientific Project(113111KYSB20170005)the National Natural Science Foundation of China(11675202)the National 1000 Talents Program of ChinaFermi Research Alliance,LLC(DE-AC02-07CH11359)the NSF(PHY1620074)the Maryland Center for Fundamental Physics(MCFP)Tsinghua University Initiative Scientific Research Programthe Beijing Municipal Science and Technology Commission project(Z181100004218003)。
文摘A search for the dimuon decay of the Standard Model Higgs boson is performed using Monte Carlo simulated events to mimic data corresponding to an integrated luminosity of 5.6 ab^(-1)collected with the Circular Electron-Positron Collider detector in e^(+)e^(-)collisions at√s=240 GeV.This study investigates the e^(+)e^(-)→ZH,Z→qq,H→μ^(+)μ^(-)process,and the expected significance considering only the statistical uncertainty in the data for a background-only hypothesis for a Higgs boson with a mass of 125 GeV is found to be 6.1σ,corresponding to a precision of 19%.The systematic impacts from the background Monte Carlo statistical fluctuations are estimated to be negligible.Moreover,the dependence of the measurement accuracy on the muon momentum resolution of the CEPC detector is investigated.It is found that the muon momentum resolution must be better than 204 MeV to discover the H→μμprocess at the nominal integrated luminosity,If the resolution is 100%worse than the designed parameter,the integrated luminosity must be greater than 7.2 ab^(-1)to reach 5σsignificance.
基金Research project of Mongolian medicine collaborative innovation cultivation center of Inner Mongolia Autonomous Region.
文摘Psoriasis is a chronic papulosquamous skin disease occurring worldwide caused by varieties of factors.The recipe of Mongolian medicine Sendeng Decoction was recorded in“The Pleasure of the Viewer”compiled by Jigwood Danjinzhamusu.Mongolian medicine clinical experience proved that Sendeng Decoction had good antipyretic,analgesic,anti-inflammatory and anti-rheumatism effect.However,the mechanism of this drug in psoriasis is still unclear.In this study,imiquimod cream(IMQ)was used to construct psoriasis model in 8-week-old male BALB/c mice,and Sendeng Decoction was used to treat the mice with psoriasis.The results showed that PASI score and spleen index decreased after Sendeng Decoction treatment.Meanwhile,HE staining showed that the pathological structure was improved,flow cytometry results showed that the proportion of Treg cells increased and Th17 cells decreased,and results of Western blot showed that the level of p38 MAPK,p-p38 MAPK,p-STAT3 and p-JAK1 decreased observably.More importantly,the above results were most significant in Sendeng's M group,which was similar to MTX group.Our results indicated that Mongolian medicine Sendeng Decoction can effectively relieve the symptoms of psoriasis mice induced by IMQ,mainly by regulating the ratio of Th17/Treg cells through the JAK/STAT and p38 MAPK pathways to reduce the inflammatory state in mice,thereby improving the symptoms of dermatitis.
