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用于眼后段持续给药的原位pH触发凝胶系统中三七总皂苷的研制与评价 被引量:1
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作者 卢鹏 王仁兴 +10 位作者 岳兴 高艳泉 张清清 邢斌 张颖 于昌祥 蔡新富 尚强 Dereje Kebebe 皮嘉欣 刘志东 《Acupuncture and Herbal Medicine》 2021年第2期107-121,共15页
目的:为三七总皂苷(PNS)在pH敏感型原位凝胶中的研究及相关制剂的开发和改进奠定基础。方法:我们使用Carbopol■940(一种常用的pH敏感聚合物)和增稠剂羟丙基甲基纤维素(HPMC E4M)作为眼用凝胶基质来制备PNS眼用原位凝胶。此外,通过评估... 目的:为三七总皂苷(PNS)在pH敏感型原位凝胶中的研究及相关制剂的开发和改进奠定基础。方法:我们使用Carbopol■940(一种常用的pH敏感聚合物)和增稠剂羟丙基甲基纤维素(HPMC E4M)作为眼用凝胶基质来制备PNS眼用原位凝胶。此外,通过评估凝胶能力和体外释放研究结果进行配方优化。还进行了体外(角膜渗透、流变学和稳定性)和体内(眼部刺激和玻璃体的初步药代动力学)研究。结果:研究表明,含有三七总皂苷的原位凝胶系统显示出药物的缓释性,使其成为改善眼后生物利用度的理想眼部给药系统。结论:本研究为原位pH触发凝胶中PNS的研究及相关制剂的开发和改进奠定了基础。同时,它将传统中药与现代原位凝胶技术相结合,为糖尿病视网膜病变等后眼病的治疗提供了新的方向。 展开更多
关键词 Carbopol■940 羟丙基甲基纤维素 三七皂苷 pH触发凝胶系统 缓释药物释放
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Research progress on chemical composition, pharmacological effects of Forsythia suspensa (Thunb.) Vahl and predictive analysis on Q-marker
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作者 Hui Peng Peng Lu +5 位作者 Yiting Liu Chuanxin Liu yanquan gao EbukaOlisaemeka Nwafor Yuelin Zhang Zhidong Liu 《TMR Modern Herbal Medicine》 2020年第2期86-112,共27页
Lianqiao(Forsythia suspensa(Thunb.)Vahl,Abbreviated as“F.suspensa”below)is traditional Chinese medicine in China,widely distributed all over the country and also highly rich in resources.The Northwest Territories is... Lianqiao(Forsythia suspensa(Thunb.)Vahl,Abbreviated as“F.suspensa”below)is traditional Chinese medicine in China,widely distributed all over the country and also highly rich in resources.The Northwest Territories is a genuine producing area.There are many chemical components in F.suspensa,including lignans,phenylethanolic glycosides,flavonoids,C6-C2 natural alcohols and their glycosides,phenolic acids,terpenes and volatile oils.Among them,lignans and phenylethanolic glycosides are the main active components.Based on the review of chemical components or constituents and main pharmacological activities,according to the definition of quality marker,the components of quality marker of F.suspensa were predicted and analyzed from the aspects of plant genetics and chemical composition,traditional efficacy,traditional medicine,new efficacy,blood entering composition,measurable composition,effective composition in different compatibility,and the influence of storage conditions of extract.Further research on its medicinal active ingredients will provide scientific basis for the evaluation of F.suspensa quality. 展开更多
关键词 F. suspensa Phenylethanol GLYCOSIDES Lignans QUALITY CONTROL Q-marker
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