Objective:To observe the clinical efficacy of 30%supramolecular salicylic acid combined with Yufa spray dressing in the treatment of moderate to severe seborrheic dermatitis(seborrheic dermatitis of the scalp,SDS).Met...Objective:To observe the clinical efficacy of 30%supramolecular salicylic acid combined with Yufa spray dressing in the treatment of moderate to severe seborrheic dermatitis(seborrheic dermatitis of the scalp,SDS).Methods:From January 2020 to December 2021,150 patients with SDS,who were treated in the Dermatology Clinic of the First Affiliated Hospital of Xi’an Medical University,were randomly divided into two groups,a treatment group and a control group,with 75 cases in each group.The treatment group was given 30%supramolecular salicylic acid combined with Yufa spray dressing on the basis of external medicine given to the control group,while the control group was given oral medicine combined with external medicine.Results:The difference in scores of erythema,scales,pruritus,and folliculitis of the treatment group before and after treatment was significant(P<0.01),indicating that supramolecular salicylic acid combined with Yufa spray dressing can relieve the symptoms of SDS.The difference in scores of erythema of the control group before and after treatment was significant as well(P<0.05),indicating that traditional antibiotics are also effective in treating SDS;however,there was no significant difference(P>0.05)in the scores of other signs and symptoms,such as scales,pruritus,and folliculitis,before and after treatment,indicating that traditional antibiotics have no obvious curative effect on SDS.After 12 weeks of treatment,the improvement in erythema,scaling,and folliculitis was significantly greater in the treatment group compared with the control group(P<0.05).Curative effect comparison showed that the total effective rate of the treatment group was 80.00%,compared with 25.67%of the control group,and the difference was statistically significant(P<0.05).Conclusion:30%supramolecular salicylic acid combined with Yufa spray dressing can significantly improve the therapeutic effect in moderate to severe SDS;the recurrence rate is lower,the course of treatment is shorted,and patients generally feel better;thus,it is a new option for the treatment of dermatitis.展开更多
<div style="text-align:justify;"> In view of the small transmission capacity and single signal modulation format of the existing optical transmission system, this paper proposes an ultra-high-speed opt...<div style="text-align:justify;"> In view of the small transmission capacity and single signal modulation format of the existing optical transmission system, this paper proposes an ultra-high-speed optical signal access scheme based on NEL0670, which can realize the transmission of 100 G DP-QPSK, 200 G DP-16QAM and 400 G DP-16QAM signals, and realize flexible and intelligent reception of multi-system optical signals. </div>展开更多
The Context: Aims: To evaluate the biocompatibility and in vitro genotoxicity of a non-copper nano silica polymer modified composite for filtering-type intra-vas devices. Settings and Design: Academic research laborat...The Context: Aims: To evaluate the biocompatibility and in vitro genotoxicity of a non-copper nano silica polymer modified composite for filtering-type intra-vas devices. Settings and Design: Academic research laboratory, Huazhong University of Science and Technology. Prospective experimental study. Methods and Material: Non-copper nano silica polymer modified composite rods were implanted into the back muscle of rabbits for biocompatibility evaluation. Comet assay was applied to the determination of DNA damage, while, Mutagenic activity was tested by means of Ames test using Salmonella typhimurium TA98 and TA 100 tester strains with and without metabolic activation. Statistical analysis used: qualitative and quantitative data were tested using the Chi-square test and Student’s test. Results: Only mild inflammatory reaction was observed in the surrounding tissues of the implanted nano-silica modified polymer composite in the early implantation stage, which was similar to that of the sham-operated group. The inflammatory reaction was completely disappeared after 12 weeks. No significant DNA damage (P > 0.05) were tested on the nano-silica modified polymer composite in Comet assay. In Ames test, the extracts from non-copper composite did not exert mutagenic effect on the bacterial. Conclusions: The non-copper nano silica modified composite did not exhibit in vitro genotoxicity and obvious inflammation in tissue, it would be a safe biomaterial for further clinical trial.展开更多
In smart environments,more and more teaching data sources are uploaded to remote cloud centers which promote the development of the smart campus.The outsourcing of massive teaching data can reduce storage burden and c...In smart environments,more and more teaching data sources are uploaded to remote cloud centers which promote the development of the smart campus.The outsourcing of massive teaching data can reduce storage burden and computational cost,but causes some privacy concerns because those teaching data(especially personal image data)may contain personal private information.In this paper,a privacy-preserving image feature extraction algorithm is proposed by using mean value features.Clients use block scrambling and chaotic map to encrypt original images before uploading to the remote servers.Cloud servers can directly extract image mean value features from encrypted images.Experiments show the effectiveness and security of our algorithm.It can achieve information search over the encrypted images on the smart campus.展开更多
The prediction system EpiSIX was used to study the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,based on reported data from December 9,2022,to January 30,2023,released by The Chines...The prediction system EpiSIX was used to study the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,based on reported data from December 9,2022,to January 30,2023,released by The Chinese Center for Disease Control and Prevention on February 1,2023.Three kinds of reported data were used for model fitting:the daily numbers of positive nucleic acid tests and deaths,and the daily number of hospital beds taken by COVID-19 patients.It was estimated that the overall infection rate was 87.54%and the overall case fatality rate was 0.078%–0.116%(median 0.100%).Assuming that a new COVID-19 epidemic outbreak would start in March or April of 2023,induced by a slightly more infectious mutant strain,we predicted a possible large rebound between September and October 2023,with a peak demand of between 800,000 and 900,000 inpatient beds.If no such new outbreak was induced by other variants,then the current COVID-19 epidemic course in China's Mainland would remain under control until the end of 2023.However,it is suggested that the necessary medical resources be prepared to manage possible COVID-19 epidemic emergencies in the near future,especially for the period between September and October 2023.展开更多
Background:A COVID-19 outbreak in the rural areas of Shijiazhuang City was attributed to the complex interactions among vaccination,host,and non-pharmaceutical interventions(NPIs).Herein,we investigated the epidemiolo...Background:A COVID-19 outbreak in the rural areas of Shijiazhuang City was attributed to the complex interactions among vaccination,host,and non-pharmaceutical interventions(NPIs).Herein,we investigated the epidemiological characteristics of all reported symptomatic cases by picking Shijiazhuang City,Hebei Province in Northern China as research objective.In addition,we established an age-group mathematical model to perform the optimal fitting and to investigate the dynamical profiles under three scenarios.Methods:All reported symptomatic cases of Shijiazhuang epidemic(January 2-February 3,2021)were investigated in our study.The cases were classified by gender,age group and location,the distributions were analyzed by epidemiological characteristics.Furthermore,the reported data from Health Commission of Hebei Province was also analyzed by using an age-group mathematical model by two phases and three scenarios.Results:Shijiazhuang epidemic caused by SARS-CoV-2 wild strain was recorded with the peak 84 cases out of 868 reported symptomatic cases on January 11,2021,which was implemented with strong NPIs by local government and referred as baseline situation in this study.The research results showed that R0 under baseline situation ranged from 4.47 to 7.72,and Rt of Gaocheng Distinct took 3.72 with 95%confidence interval from 3.23 to 4.35 on January 9,the declining tendencies of Rt under baseline situation were kept till February 3,the value of Rt reached below 1 on January 19 and remained low value up to February 3 for Gaocheng District and Shijiazhuang City during Shijiazhuang epidemic.This indicated Shijiazhuang epidemic was under control on January 19.However,if the strong NPIs were kept,but remote isolation operated on January 11 was not implemented as of February 9,then the scale of Shijiazhuang epidemic reached 9,482 cases from age group who were 60 years old and over out of 31,017 symptomatic cases.The investigation also revealed that Shijiazhuang epidemic reached 132,648 symptomatic cases for age group who were 60 years old and over(short for G2)under risk-based strategies(Scenario A),58,048 symptomatic cases for G2 under late quarantine strategies(Scenario B)and 207,124 symptomatic cases for G2 under late quarantine double risk strategies(Scenario C),and that the corresponding transmission tendencies of Rt for three scenarios were consistently controlled on Jan 29,2021.Compared with baseline situation,the dates for controlling Rt below 1 under three scenarios were delayed 10 days.Conclusions:Shijiazhuang epidemic was the first COVID-19 outbreak in the rural areas in Hebei Province of Northern China.The targeted interventions adopted in early 2021 were effective to halt the transmission due to the implementation of a strict and village-wide closure.However we found that age group profile and NPIs played critical rules to successfully contain Shijiazhuang epidemic,which should be considered by public health policies in rural areas of China's Mainland during the dynamic zero-COVID policy.展开更多
Oxygen(O_(2))profoundly influences the physiological processes of aerobic organisms through a range of mechanisms.Recently,increasing evidence has revealed the relationship between viral infection and oxygen levels.Ho...Oxygen(O_(2))profoundly influences the physiological processes of aerobic organisms through a range of mechanisms.Recently,increasing evidence has revealed the relationship between viral infection and oxygen levels.However,due to a lack of feasible methods and in vivo models,how oxygen directly affects antiviral capability remains largely unknown.In contrast to terrestrial animals,fish live in water for life,where oxygen levels change more frequently than on land in areas with similar altitude.Therefore,fish appear to be ideal organisms for elucidating the effect of oxygen levels on antiviral responses.In this study,we report that zebrafish under low oxygen conditions are more susceptible to SVCV infection.Further assays indicate that low oxygen tension not only suppresses SVCV-induced IFN activation but also promotes SVCV replication in both zebrafish cell lines and zebrafish.This study provides novel insights into the effect of oxygen on antiviral responses and virus replication.展开更多
The World Health Organization(WHO)declared monkeypox as a public health emergency of international concern(PHEIC)on July 23,2022,their highest level of alert.This raised concerns about the management of the global mon...The World Health Organization(WHO)declared monkeypox as a public health emergency of international concern(PHEIC)on July 23,2022,their highest level of alert.This raised concerns about the management of the global monkeypox outbreak,as well as the scientific analysis and accurate prediction of the future course of the epidemic.This study used EpiSIX(an analysis and prediction system for epidemics based on a general SEIR model)to analyze the monkeypox epidemic and to forecast the major tendencies based on data from the USA CDC(https://www.cdc.gov)and the WHO(https://www.who.int/health-topics/monkeypox).The global outbreak of monkeypox started in the UK on May 2,2022,which marked the beginning of an epidemic wave.As of October 28,2022,the cumulative number of reported cases worldwide was 77,115,with 36 deaths.EpiSIX simulations predict that the global monkeypox epidemic will enter a low epidemic status on March 1,2023 with the cumulative number of confirmed cases ranging from 85,000 to 124,000,and the total number of deaths ranging from 60 to 87.Our analysis revealed that the basic reproduction number(R0)of monkeypox virus(MPXV)is near to 3.1 and the percentage of asymptomatic individuals is 13.1%–14.5%,both of which are similar to the data for SARS.The vaccination efficiency against susceptibility(VEs)of individuals who have had monkeypox is~79%,and the vaccination efficiency against infectiousness(VEi)of individuals who have had monkeypox is~76%–82%.The mean incubation period for monkeypox is 8 days.In total,94.7%of infected individuals develop symptoms within 20 days and recover within 2 weeks after the confirmation of symptoms.Simulation results using EpiSIX showed that ring vaccination was remarkably effective against monkeypox.Our findings confirmed that a 20-day isolation for close contacts is necessary.展开更多
The transmission and prevalence of Hand,Foot and Mouth Disease(HFMD)are affected by a variety of natural and socio-economic environmental factors.This study aims to quantitatively investigate the non-stationary and sp...The transmission and prevalence of Hand,Foot and Mouth Disease(HFMD)are affected by a variety of natural and socio-economic environmental factors.This study aims to quantitatively investigate the non-stationary and spatially varying associations between various environmental factors and HFMD risk.We collected HFMD surveillance cases and a series of relevant environmental data from 2013 to 2021 in Xi'an,Northwest China.By controlling the spatial and temporal mixture effects of HFMD,we constructed a Bayesian spatiotemporal mapping model and characterized the impacts of different driving factors into global linear,non-stationary and spatially varying effects.The results showed that the impact of meteorological conditions on HFMD risk varies in both type and magnitude above certain thresholds(temperature:30°C,precipitation:70 mm,solar radiation:13000 kJ/m^(2),pressure:945 hPa,humidity:69%).Air pollutants(PM_(2.5),PM_(10),NO_(2))showed an inverted U-shaped relationship with the risk of HFMD,while other air pollutants(O_(3),SO_(2))showed nonlinear fluctuations.Moreover,the driving effect of increasing temperature on HFMD was significant in the 3-year period,while the inhibitory effect of increasing precipitation appeared evident in the 5-year period.In addition,the proportion of urban/suburban/rural area had a strong influence on HFMD,indicating that the incidence of HFMD firstly increased and then decreased during the rapid urbanization process.The influence of population density on HFMD was not only limited by spatial location,but also varied between high and low intervals.Higher road density inhibited the risk of HFMD,but higher night light index promoted the occurrence of HFMD.Our findings further demonstrated that both ecological and socioeconomic environmental factors can pose multiple driving effects on increasing the spatiotemporal risk of HFMD,which is of great significance for effectively responding to the changes in HFMD epidemic outbreaks.展开更多
文摘Objective:To observe the clinical efficacy of 30%supramolecular salicylic acid combined with Yufa spray dressing in the treatment of moderate to severe seborrheic dermatitis(seborrheic dermatitis of the scalp,SDS).Methods:From January 2020 to December 2021,150 patients with SDS,who were treated in the Dermatology Clinic of the First Affiliated Hospital of Xi’an Medical University,were randomly divided into two groups,a treatment group and a control group,with 75 cases in each group.The treatment group was given 30%supramolecular salicylic acid combined with Yufa spray dressing on the basis of external medicine given to the control group,while the control group was given oral medicine combined with external medicine.Results:The difference in scores of erythema,scales,pruritus,and folliculitis of the treatment group before and after treatment was significant(P<0.01),indicating that supramolecular salicylic acid combined with Yufa spray dressing can relieve the symptoms of SDS.The difference in scores of erythema of the control group before and after treatment was significant as well(P<0.05),indicating that traditional antibiotics are also effective in treating SDS;however,there was no significant difference(P>0.05)in the scores of other signs and symptoms,such as scales,pruritus,and folliculitis,before and after treatment,indicating that traditional antibiotics have no obvious curative effect on SDS.After 12 weeks of treatment,the improvement in erythema,scaling,and folliculitis was significantly greater in the treatment group compared with the control group(P<0.05).Curative effect comparison showed that the total effective rate of the treatment group was 80.00%,compared with 25.67%of the control group,and the difference was statistically significant(P<0.05).Conclusion:30%supramolecular salicylic acid combined with Yufa spray dressing can significantly improve the therapeutic effect in moderate to severe SDS;the recurrence rate is lower,the course of treatment is shorted,and patients generally feel better;thus,it is a new option for the treatment of dermatitis.
文摘<div style="text-align:justify;"> In view of the small transmission capacity and single signal modulation format of the existing optical transmission system, this paper proposes an ultra-high-speed optical signal access scheme based on NEL0670, which can realize the transmission of 100 G DP-QPSK, 200 G DP-16QAM and 400 G DP-16QAM signals, and realize flexible and intelligent reception of multi-system optical signals. </div>
文摘The Context: Aims: To evaluate the biocompatibility and in vitro genotoxicity of a non-copper nano silica polymer modified composite for filtering-type intra-vas devices. Settings and Design: Academic research laboratory, Huazhong University of Science and Technology. Prospective experimental study. Methods and Material: Non-copper nano silica polymer modified composite rods were implanted into the back muscle of rabbits for biocompatibility evaluation. Comet assay was applied to the determination of DNA damage, while, Mutagenic activity was tested by means of Ames test using Salmonella typhimurium TA98 and TA 100 tester strains with and without metabolic activation. Statistical analysis used: qualitative and quantitative data were tested using the Chi-square test and Student’s test. Results: Only mild inflammatory reaction was observed in the surrounding tissues of the implanted nano-silica modified polymer composite in the early implantation stage, which was similar to that of the sham-operated group. The inflammatory reaction was completely disappeared after 12 weeks. No significant DNA damage (P > 0.05) were tested on the nano-silica modified polymer composite in Comet assay. In Ames test, the extracts from non-copper composite did not exert mutagenic effect on the bacterial. Conclusions: The non-copper nano silica modified composite did not exhibit in vitro genotoxicity and obvious inflammation in tissue, it would be a safe biomaterial for further clinical trial.
基金A This work was supported in part by the National Natural Science Foundation of China(61872408)the Natural Science Foundation of Hunan Province(2020JJ4238)+2 种基金the Social Science Fund of Hunan Province(16YBA102)the Study and Innovative Experiment Project for College Students in HNFNU(YSXS1842)the Research Fund of Hunan Provincial Key Laboratory of Informationization Technology for Basic Education(2015TP1017).
文摘In smart environments,more and more teaching data sources are uploaded to remote cloud centers which promote the development of the smart campus.The outsourcing of massive teaching data can reduce storage burden and computational cost,but causes some privacy concerns because those teaching data(especially personal image data)may contain personal private information.In this paper,a privacy-preserving image feature extraction algorithm is proposed by using mean value features.Clients use block scrambling and chaotic map to encrypt original images before uploading to the remote servers.Cloud servers can directly extract image mean value features from encrypted images.Experiments show the effectiveness and security of our algorithm.It can achieve information search over the encrypted images on the smart campus.
基金This study was supported by grants from a Consultancy Project of the Chinese Academy of Engineering(CAE,2022-JB-06)Natural Science Foundation of Shaanxi Province,China(2023-JC-YB-676)+1 种基金Innovation Foundation of Medical Research Project of Xi’an City(2022YXYJ0040)Natural Science Foundation of Fujian Province of China(2021 J01621).
文摘The prediction system EpiSIX was used to study the COVID-19 epidemic in China's Mainland between November 2022 and January 2023,based on reported data from December 9,2022,to January 30,2023,released by The Chinese Center for Disease Control and Prevention on February 1,2023.Three kinds of reported data were used for model fitting:the daily numbers of positive nucleic acid tests and deaths,and the daily number of hospital beds taken by COVID-19 patients.It was estimated that the overall infection rate was 87.54%and the overall case fatality rate was 0.078%–0.116%(median 0.100%).Assuming that a new COVID-19 epidemic outbreak would start in March or April of 2023,induced by a slightly more infectious mutant strain,we predicted a possible large rebound between September and October 2023,with a peak demand of between 800,000 and 900,000 inpatient beds.If no such new outbreak was induced by other variants,then the current COVID-19 epidemic course in China's Mainland would remain under control until the end of 2023.However,it is suggested that the necessary medical resources be prepared to manage possible COVID-19 epidemic emergencies in the near future,especially for the period between September and October 2023.
基金supported by Special Projects of the Central Government Guiding Local Science and Technology Development (2021L3018)the Natural Science Foundation of Fujian Province of China (2021J01621)+2 种基金Consultancy Project by the Chinese Academy of Engineering (2022-JB-06)National Natural Science Foundation of China (12231012)Scientific Research Training Program in Fuzhou University (26040).
文摘Background:A COVID-19 outbreak in the rural areas of Shijiazhuang City was attributed to the complex interactions among vaccination,host,and non-pharmaceutical interventions(NPIs).Herein,we investigated the epidemiological characteristics of all reported symptomatic cases by picking Shijiazhuang City,Hebei Province in Northern China as research objective.In addition,we established an age-group mathematical model to perform the optimal fitting and to investigate the dynamical profiles under three scenarios.Methods:All reported symptomatic cases of Shijiazhuang epidemic(January 2-February 3,2021)were investigated in our study.The cases were classified by gender,age group and location,the distributions were analyzed by epidemiological characteristics.Furthermore,the reported data from Health Commission of Hebei Province was also analyzed by using an age-group mathematical model by two phases and three scenarios.Results:Shijiazhuang epidemic caused by SARS-CoV-2 wild strain was recorded with the peak 84 cases out of 868 reported symptomatic cases on January 11,2021,which was implemented with strong NPIs by local government and referred as baseline situation in this study.The research results showed that R0 under baseline situation ranged from 4.47 to 7.72,and Rt of Gaocheng Distinct took 3.72 with 95%confidence interval from 3.23 to 4.35 on January 9,the declining tendencies of Rt under baseline situation were kept till February 3,the value of Rt reached below 1 on January 19 and remained low value up to February 3 for Gaocheng District and Shijiazhuang City during Shijiazhuang epidemic.This indicated Shijiazhuang epidemic was under control on January 19.However,if the strong NPIs were kept,but remote isolation operated on January 11 was not implemented as of February 9,then the scale of Shijiazhuang epidemic reached 9,482 cases from age group who were 60 years old and over out of 31,017 symptomatic cases.The investigation also revealed that Shijiazhuang epidemic reached 132,648 symptomatic cases for age group who were 60 years old and over(short for G2)under risk-based strategies(Scenario A),58,048 symptomatic cases for G2 under late quarantine strategies(Scenario B)and 207,124 symptomatic cases for G2 under late quarantine double risk strategies(Scenario C),and that the corresponding transmission tendencies of Rt for three scenarios were consistently controlled on Jan 29,2021.Compared with baseline situation,the dates for controlling Rt below 1 under three scenarios were delayed 10 days.Conclusions:Shijiazhuang epidemic was the first COVID-19 outbreak in the rural areas in Hebei Province of Northern China.The targeted interventions adopted in early 2021 were effective to halt the transmission due to the implementation of a strict and village-wide closure.However we found that age group profile and NPIs played critical rules to successfully contain Shijiazhuang epidemic,which should be considered by public health policies in rural areas of China's Mainland during the dynamic zero-COVID policy.
基金supported by the National Key Research and Development Program of China[2018YFD0900602 to W.X.,2022YFF1000302 to X.L.]NSFC[31830101 and 31721005 to W.X.,32273171 to X.L.]+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308 to W.X.]the Natural Science Foundation of Hubei Province of China[2022CFA110 to X.L.].
文摘Oxygen(O_(2))profoundly influences the physiological processes of aerobic organisms through a range of mechanisms.Recently,increasing evidence has revealed the relationship between viral infection and oxygen levels.However,due to a lack of feasible methods and in vivo models,how oxygen directly affects antiviral capability remains largely unknown.In contrast to terrestrial animals,fish live in water for life,where oxygen levels change more frequently than on land in areas with similar altitude.Therefore,fish appear to be ideal organisms for elucidating the effect of oxygen levels on antiviral responses.In this study,we report that zebrafish under low oxygen conditions are more susceptible to SVCV infection.Further assays indicate that low oxygen tension not only suppresses SVCV-induced IFN activation but also promotes SVCV replication in both zebrafish cell lines and zebrafish.This study provides novel insights into the effect of oxygen on antiviral responses and virus replication.
基金This study was supported by grants from the Consultancy Project by the Chinese Academy of Engineering(CAE,2022-JB-06)the Natural Science Foundation of Fujian Province(2021 J01621)+1 种基金the National Natural Science Foundation of China(No.61873154)the National Key R&D Program of China(2021ZD0114102).
文摘The World Health Organization(WHO)declared monkeypox as a public health emergency of international concern(PHEIC)on July 23,2022,their highest level of alert.This raised concerns about the management of the global monkeypox outbreak,as well as the scientific analysis and accurate prediction of the future course of the epidemic.This study used EpiSIX(an analysis and prediction system for epidemics based on a general SEIR model)to analyze the monkeypox epidemic and to forecast the major tendencies based on data from the USA CDC(https://www.cdc.gov)and the WHO(https://www.who.int/health-topics/monkeypox).The global outbreak of monkeypox started in the UK on May 2,2022,which marked the beginning of an epidemic wave.As of October 28,2022,the cumulative number of reported cases worldwide was 77,115,with 36 deaths.EpiSIX simulations predict that the global monkeypox epidemic will enter a low epidemic status on March 1,2023 with the cumulative number of confirmed cases ranging from 85,000 to 124,000,and the total number of deaths ranging from 60 to 87.Our analysis revealed that the basic reproduction number(R0)of monkeypox virus(MPXV)is near to 3.1 and the percentage of asymptomatic individuals is 13.1%–14.5%,both of which are similar to the data for SARS.The vaccination efficiency against susceptibility(VEs)of individuals who have had monkeypox is~79%,and the vaccination efficiency against infectiousness(VEi)of individuals who have had monkeypox is~76%–82%.The mean incubation period for monkeypox is 8 days.In total,94.7%of infected individuals develop symptoms within 20 days and recover within 2 weeks after the confirmation of symptoms.Simulation results using EpiSIX showed that ring vaccination was remarkably effective against monkeypox.Our findings confirmed that a 20-day isolation for close contacts is necessary.
基金This work was supported by grants from the National Natural Science Foundation of China(L.S.,grant number:42201448),(K.L.,grant number:82273689)Natural Science Foundation of Hubei Province(L.S.,grant number:2022CFB610).
文摘The transmission and prevalence of Hand,Foot and Mouth Disease(HFMD)are affected by a variety of natural and socio-economic environmental factors.This study aims to quantitatively investigate the non-stationary and spatially varying associations between various environmental factors and HFMD risk.We collected HFMD surveillance cases and a series of relevant environmental data from 2013 to 2021 in Xi'an,Northwest China.By controlling the spatial and temporal mixture effects of HFMD,we constructed a Bayesian spatiotemporal mapping model and characterized the impacts of different driving factors into global linear,non-stationary and spatially varying effects.The results showed that the impact of meteorological conditions on HFMD risk varies in both type and magnitude above certain thresholds(temperature:30°C,precipitation:70 mm,solar radiation:13000 kJ/m^(2),pressure:945 hPa,humidity:69%).Air pollutants(PM_(2.5),PM_(10),NO_(2))showed an inverted U-shaped relationship with the risk of HFMD,while other air pollutants(O_(3),SO_(2))showed nonlinear fluctuations.Moreover,the driving effect of increasing temperature on HFMD was significant in the 3-year period,while the inhibitory effect of increasing precipitation appeared evident in the 5-year period.In addition,the proportion of urban/suburban/rural area had a strong influence on HFMD,indicating that the incidence of HFMD firstly increased and then decreased during the rapid urbanization process.The influence of population density on HFMD was not only limited by spatial location,but also varied between high and low intervals.Higher road density inhibited the risk of HFMD,but higher night light index promoted the occurrence of HFMD.Our findings further demonstrated that both ecological and socioeconomic environmental factors can pose multiple driving effects on increasing the spatiotemporal risk of HFMD,which is of great significance for effectively responding to the changes in HFMD epidemic outbreaks.
