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Seeing Is Believing:Directly Imaging Contractions of Artificial Molecular Muscles with Platinum Atom Markers
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作者 Dan-Yang Zhang Yonghui Zheng +5 位作者 yefei jiang Wei-Jian Li Xu-Qing Wang Lianrui Hu Wei Wang Hai-Bo Yang 《CCS Chemistry》 CSCD 2024年第9期2162-2174,共13页
Artificial molecular muscles undergo well-controlled contractile and extensile motions upon external stimulation,leading to remarkable length changes.Evaluating such length changes at the molecular level is essential ... Artificial molecular muscles undergo well-controlled contractile and extensile motions upon external stimulation,leading to remarkable length changes.Evaluating such length changes at the molecular level is essential to the design of integrated artificial molecular muscles that mimic biological muscles.Taking advantage of the strong contrast of platinum(Pt)atoms in high-angle annular dark-field scanning transmission electron microscopy images,we imaged Pt-containing molecular[c2]daisy chains directly by employing metal atom markers.The length changes and associated conformational transformations of these newly developed artificial molecular muscles have been measured experimentally in combination with theoretical calculations.The contraction ratios of these two molecular muscles with the TEMPO or pyrene anchoring group were calculated to be 21.0%or 15.7%respectively,suggesting a substantial anchoring effect.This study demonstrates the experimental measurement of the length changes of artificial molecular muscles and provides a new avenue for investigating the motion of artificial molecular machines. 展开更多
关键词 mechanically interlocked molecules molecular[c2]daisy chain artificial molecular machines high-angle annular dark-field scanning transmission electron microscopy stimuli responsiveness
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Treatment of Alzheimer's disease with small-molecule photosensitizers
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作者 yefei jiang Zhiyong Zeng +4 位作者 Jianhua Yao Ying Guan Peipei Jia Xiaoli Zhao Lin Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第5期132-142,共11页
Alzheimer's disease is a neurodegenerative disease that signals for excessβ-amyloid(Aβ)aggregation.Although people have made great attempts to control the aggregation of Aβ,no effective medications have been pr... Alzheimer's disease is a neurodegenerative disease that signals for excessβ-amyloid(Aβ)aggregation.Although people have made great attempts to control the aggregation of Aβ,no effective medications have been produced yet.Due to its excellent temporal and spatial selectivity,photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ,with some achievement.To enhance the research and application of photodynamic therapy in Alzheimer's disease,this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles. 展开更多
关键词 Alzheimer’s disease PHOTOSENSITIZER Aβaggregation PDT
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Structure regulation for ultra-high luminescence quantum yield lanthanide complex and simultaneous detection of cancer marker and ferrous ion 被引量:6
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作者 Min Liu Zhifeng Li +6 位作者 Jianhui Xiong yefei jiang Ting Tang Jinkai Qiu Junwei Yao Seik Weng Ng Chenghui Zeng 《Journal of Rare Earths》 SCIE EI CAS CSCD 2021年第10期1194-1203,I0002,共11页
The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is design... The exploitation of a highly selective and sensitive probe to detect both cancer marker and metal ion is of great importance.In this work,the "one stone two bird" agent of 1,10-phenanthroline(phen) is designed to disrupt the polymeric lanthanide MOFs(LnMOFs,[Ln(CHO_(2))_(3)]n,Ln=Tb,la;Eu,1 b,CHO_(2)=formic acid) {[Ln(CHO_(2))_(4)·(C_(2) H_(8) N)]n,Ln=Y,2 a;Gd,2 b;Dy,2 c,C_(2)H_(8) N=dimethylamine}) into a soluble mononuclear species [Ln(phen)_(2)(NO_(3))_(3),Ln=Tb,3 a;Eu,3 b] as well as to provide an antenna for efficient photons absorption,resulting in an ultra-high luminescence quantum yield(QY,90%) europium complex.The luminescence QY is among the highest record of monomeric(zero-dimensional) lanthanide complexes.Furthermore,mononuclear Tb3+complex(3 a) functions as a multiplex sensor towards both Fe^(2+)and cancer marker of 5-hydroxyindole-3-acetic acid(5-HIAA).Importantly,the limit of detection(LOD)for sensing 5-HIAA is an ultra-sensitive value of 1 × 10 s mol/L,which is even lower than that necessary for the early diagnosis of carcinoid tumors.More interestingly,sensing results in simulated urine reveals that 3 a has potential application for early diagnosis in the clinic. 展开更多
关键词 Ultra-high luminescence quantum yield Lanthanide complex Simultaneous detection Cancer marker Ferrous ion Rare earths
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