Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the pr...Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.展开更多
BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected benefit.Understanding the risk factors for NVG occurrence ...BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected benefit.Understanding the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical research.AIM To develop a visual risk profile model to explore factors influencing DR after surgery.METHODS We retrospectively selected 151 patients with DR undergoing PPV.The patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after surgery.Independent risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction curve.RESULTS After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram model.The area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,respectively.The AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,respectively.CONCLUSION A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction accuracy.This study can help formulate relevant preventive and treatment measures.展开更多
Purpose–During the construction process of the China Railway Track System(CRTS)I type filling layer,the nonwoven fabric bags have been used as grouting templates for cement asphalt(CA)emulsified mortar.The porous str...Purpose–During the construction process of the China Railway Track System(CRTS)I type filling layer,the nonwoven fabric bags have been used as grouting templates for cement asphalt(CA)emulsified mortar.The porous structure of nonwoven fabrics endowed the templates with breathability and water permeability.The standard requires that the volume expansion rate of CA mortar must be controlled within 1%–3%,which can generate expansion pressure to ensure that the cavities under track slabs are filled fully.However,the expansion pressure caused some of the water to seep out from the periphery of the filling bag,and it would affect the actual mix proportion of CA mortar.The differences in physical and mechanical properties between the CA mortar under track slabs and the CA mortar formed in the laboratory were studied in this paper.The relevant results could provide important methods for the research of filling layer materials for CRTS I type and other types of ballastless tracks in China.Design/methodology/approach–During the inspection of filling layer,the samples of CA mortar from different working conditions and raw materials were taken by uncovering the track slabs and drilling cores.The physical and mechanical properties of CA mortar under the filling layer of the slab were systematically analyzed by testing the electrical flux,compressive strength and density of mortar in different parts of the filling layer.Findings–In this paper,the electric flux,the physical properties and mechanical properties of different parts of CA mortar under the track slab were investigated.The results showed that the density,electric flux and compressive strength of CA mortar were affected by the composition of raw materials for dry powders and different parts of the filling layer.In addition,the electrical flux of CA mortar gradually decreased within 90 days’age.The electrical flux of samples with the thickness of 54 mm was lower than 500 C.Therefore,the impermeability and durability of CA mortar could be improved by increasing the thickness of filling layer.Besides,the results showed that the compressive strength of CA mortar increased,while the density and electric flux decreased gradually,with the prolongation of hardening time.Originality/value–During 90 days’age,the electrical flux of the CA mortar gradually decreased with the increase of specimen thickness and the electrical flux of the specimens with the thickness of 54 mm was lower than 500 C.The impermeability and durability of the CA mortar could be improved by increasing the thickness of filling layer.The proposed method can provide reference for the further development and improvement of CRTS I and CRTS II type ballastless track in China.展开更多
To enhance the safety of road traffic operations,this paper proposed a model based on stacking integrated learning utilizing American road traffic accident statistics.Initially,the process involved data cleaning,trans...To enhance the safety of road traffic operations,this paper proposed a model based on stacking integrated learning utilizing American road traffic accident statistics.Initially,the process involved data cleaning,transformation,and normalization.Subsequently,various classification models were constructed,including logistic regression,k-nearest neighbors,gradient boosting,decision trees,AdaBoost,and extra trees models.Evaluation metrics such as accuracy,precision,recall,F1 score,and Hamming loss were employed.Upon analysis,the passive-aggressive classifier model exhibited superior comprehensive indices compared to other models.Based on the model’s output results,an in-depth examination of the factors influencing traffic accidents was conducted.Additionally,measures and suggestions aimed at reducing the incidence of severe traffic accidents were presented.These findings served as a valuable reference for mitigating the occurrence of traffic accidents.展开更多
In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on t...In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation.展开更多
How to effectively transform the pro-oncogenic tumor microenvironments(TME)surrounding a tumor into an anti-tumoral never fails to attract people to study.Small interfering RNA(siRNA)is considered one of the most note...How to effectively transform the pro-oncogenic tumor microenvironments(TME)surrounding a tumor into an anti-tumoral never fails to attract people to study.Small interfering RNA(siRNA)is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference(RNAi).The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent years.Using siRNA drugs to silence critical proteins in TME was one of the most efficient solutions.However,the manufacture of a siRNA delivery system faces three major obstacles,i.e.,appropriate cargo protection,accurately targeted delivery,and site-specific cargo release.In the following review,we summarized the pharmacological actions of siRNA drugs in remolding TME.In addition,the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly discussed.In the meanwhile,the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also presented.Ultimately,we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene therapy.This summary offers a thorough analysis and roadmap for general readers working in the field.展开更多
Two-dimensional(2D)semiconductors have attracted considerable interest for their unique physical properties.Here,we report the intrinsic cryogenic electronic transport properties in few-layer MoSe_(2)field-effect tran...Two-dimensional(2D)semiconductors have attracted considerable interest for their unique physical properties.Here,we report the intrinsic cryogenic electronic transport properties in few-layer MoSe_(2)field-effect transistors(FETs)that are fully encapsulated in ultraclean hexagonal boron nitride dielectrics and are simultaneously van der Waals contacted with gold electrodes.The FETs exhibit electronically favorable channel/dielectric interfaces with low densities of interfacial traps(<1010cm^(-2)),which lead to outstanding device characteristics at room temperature,including near-Boltzmann-limit subthreshold swings(65 mV/dec),high carrier mobilities(53–68 cm^(2)·V-1·s^(-1)),and negligible scanning hystereses(<15 mV).The dependence of various contact-related parameters with temperature and carrier density is also systematically characterized to understand the van der Waals contacts between gold and MoSe_(2).The results provide insightful information about the device physics in van der Waals contacted and encapsulated 2D FETs.展开更多
Self-oscillation is an intriguing and omnipresent phenomenon that governs a broad range of growth dynamics and formation of nanoscale periodic and delicate heterostructures.A self-oscillating growth phenomenon of cata...Self-oscillation is an intriguing and omnipresent phenomenon that governs a broad range of growth dynamics and formation of nanoscale periodic and delicate heterostructures.A self-oscillating growth phenomenon of catalyst droplets,consuming surface-coating a-Si/a-Ge bilayer,is exploited to accomplish a high-frequency alternating growth of ultrathin crystalline Si and Ge(c-Si/c-Ge)nano-slates,with Ge-rich layer thickness of 14–19 nm,embedded within a superlattice nanowire structure,with pre-known position and uniform channel diameter.A subsequent selective etching of the Ge-rich segments leaves a chain of ultrafine standing c-Si nanosheets down to~6 nm thick,without the use of any expensive high-resolution lithography and growth modulation control.A ternary-phase-competition model has been established to explain the underlying formation mechanism of this nanoscale self-oscillating growth dynamics.It is also suggested that these ultrathin nanosheets could help to produce ultrathin fin-channels for advanced electronics,or provide size-specified trapping sites to capture and position hetero nanoparticle for high-precision labelling or light emission.展开更多
Two-dimensional(2D)van der Waals semiconductors are appealing for low-power transistors.Here,we show the feasibility in enhancing carrier mobility in 2D semiconductors through engineering the vertical distribution of ...Two-dimensional(2D)van der Waals semiconductors are appealing for low-power transistors.Here,we show the feasibility in enhancing carrier mobility in 2D semiconductors through engineering the vertical distribution of carriers confined inside ultrathin channels via symmetrizing gate configuration or increasing channel thickness.Through self-consistently solving the Schr¨odinger–Poisson equations,the shapes of electron envelope functions are extensively investigated by clarifying their relationship with gate configuration,channel thickness,dielectric permittivity,and electron density.The impacts of electron distribution variation on various carrier scattering matrix elements and overall carrier mobility are insightfully clarified.It is found that the carrier mobility can be generally enhanced in the dual-gated configuration due to the centralization of carrier redistribution in the nanometer-thick semiconductor channels and the rate of increase reaches up to 23%in Hf O2 dual-gated 10-layer MoS_(2) channels.This finding represents a viable strategy for performance optimization in transistors consisting of 2D semiconductors.展开更多
Ebian spotted cattle has the ability to adapt to the local natural ecological environment,and is one of the excellent local cattle breeds in Sichuan.Ebian spotted cattle is a breed of cattle for both service and meat ...Ebian spotted cattle has the ability to adapt to the local natural ecological environment,and is one of the excellent local cattle breeds in Sichuan.Ebian spotted cattle is a breed of cattle for both service and meat use and formed through long-term natural selection and artificial selection.Because of the weak development and utilization of this breed,the economic benefits of excellent breeds have not been fully brought into play,and farmers'enthusiasm in breeding is poor,so that the number of Ebian spotted cattle has reduced year by year.In order to strengthen the protection,development and utilization of Ebian spotted cattle as a local excellent breed,combined with the third national survey of livestock and poultry genetic resources in 2021,Ebian spotted cattle was investigated,and a comprehensive,scientific and objective analysis of its population numbers was conducted.Besides,reasonable suggestions were put forward.展开更多
Background:Social support is related to depression,but the gender differences and related factors that contribute to low social support among adolescents with subthreshold depression remain to be elucidated.This study...Background:Social support is related to depression,but the gender differences and related factors that contribute to low social support among adolescents with subthreshold depression remain to be elucidated.This study explores the relationship between social support and depression,in addition to the gender difference in the incidence of low social support among adolescents with subthreshold depression and its related factors.Methods:A total of 371 Chinese adolescents with subthreshold depression were recruited.All subjects were rated on the Social Support Scale for Adolescents,the Response Style Scale,the Self-Perception Profile for Children,the Individualism-collectivism scale.Results:Binary logistic regression indicated that the stability dimension of cognitive style,the generality dimension of the Cognitive Style Questionnaire,and the social acceptance dimension of the Self-Perception Profile for Children scale were significantly correlated with social support level in male adolescents with subthreshold depression.In contrast,the total score of the Self-Perception Profile for Children scale,the social acceptance of the Self-Perception Profile for Children scale,total individualism,and total collectivism were significantly correlated with social support level in female adolescents with subthreshold depression.Limitations:This study is a cross-sectional study,and its effectiveness in explaining factors that influence levels of social support is limited.Conclusions:The gender difference between low social support among adolescents with subthreshold depression is related to cognitive style,self-perception,and collectivism–individualism.展开更多
Purpose–The construction of cement asphalt(CA)emulsified mortar can obviously disturb the slab status after the fine adjustment.To decrease or eliminate the influence of CA mortar grouting on track slab geometry stat...Purpose–The construction of cement asphalt(CA)emulsified mortar can obviously disturb the slab status after the fine adjustment.To decrease or eliminate the influence of CA mortar grouting on track slab geometry status,the effects of grouting funnel,slab pressing method,mortar expansion ratio,seepage ratio and grouting area on China Railway Track System Type(CRTS I)track slab geometry status were discussed in this paper.Design/methodology/approach–Combined with engineering practice,this paper studied the expansion law of filling layer mortar,the liquid level height of the filling funnel,the pressure plate device and the amount of exudation water and systematically analyzed the influence of filling layer mortar construction on the state of track slab.Relevant precautions and countermeasures were put forward.Findings–The results showed that the track slab floating values of four corners were different with the CA mortar grouting and the track slab corner near CA mortar grouting hole had the maximum floating values.The anti-floating effect of“7”shaped slab pressing device was more efficient than fixed-joint angle iron,and the slab floating value could be further decreased by increasing the amount of“7”shaped slab pressing devices.After CA mortar grouting,the track slab floating pattern had a close correlation with the expansion rate and water seepage rate of CA mortar over time and the expansion and water seepage rate of the mortar were faster when the temperature was high.Furthermore,the use of strip CA mortar filling under the rail bearing platform on bothsides could effectively reduce the float under the track slab,and it could also save mortar consumption and reduce costs.Originality/value–This study plays an important role in controlling the floating values,CA mortar dosage and the building cost of projects by grouting CA mortar at two flanks of filling space.The research results have guiding significance for the design and construction of China’s CRTS I,CRTS II and CRTS III track slab.展开更多
基金supported by the STI 2030-Major Projects 2022ZD0208500(to DY)the National Natural Science Foundation of China,Nos.82072011(to YX),82121003(to DY),82271120(to YS)+2 种基金Sichuan Science and Technology Program,No.2022ZYD0066(to YS)a grant from Chinese Academy of Medical Science,No.2019-12M-5-032(to YS)the Fundamental Research Funds for the Central Universities,No.ZYGX2021YGLH219(to KC)。
文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.
文摘异源图像配准中,由于图像的成像机理差异,图像像素强度关联和旋转畸变是不可避免的两大问题,针对图像像素强度关联问题,提出了基于辐射不变特征变换(radiation-variation insensitive feature transform,RIFT)的图像配准算法,对图像间像素关联差异小的图像对配准有良好的精度,但对旋转畸变图像会产生较多错误匹配。对于旋转畸变问题,传统的ORB(oriented fast and rotated brief)算法,对旋转图像的配准有一定的稳定性,但对于强度变化不明显的图像对,特征点检测质量较低,配准精度不理想。因此本文将相位一致性(phase consistency,PC)融合进ORB算法,利用相位信息代替传统的图像强度信息,再构造旋转不变性BRIEF特征描述子,对图像像素强度变化和旋转畸变均具有鲁棒性。用图像像素强度关联不明显的红外图像和可见光图像进行配准实验,本文算法针对不同旋转幅度的图像的配准精度较高,RMSE稳定在1.7~2.1,优于RIFT算法,在特征点检测数量、配准精度和效率等性能上均有良好性能。
基金Supported by the Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-037A.
文摘BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected benefit.Understanding the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical research.AIM To develop a visual risk profile model to explore factors influencing DR after surgery.METHODS We retrospectively selected 151 patients with DR undergoing PPV.The patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after surgery.Independent risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction curve.RESULTS After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram model.The area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,respectively.The AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,respectively.CONCLUSION A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction accuracy.This study can help formulate relevant preventive and treatment measures.
基金This article was funded by the National Natural Science Foundation of China(No.51408610).
文摘Purpose–During the construction process of the China Railway Track System(CRTS)I type filling layer,the nonwoven fabric bags have been used as grouting templates for cement asphalt(CA)emulsified mortar.The porous structure of nonwoven fabrics endowed the templates with breathability and water permeability.The standard requires that the volume expansion rate of CA mortar must be controlled within 1%–3%,which can generate expansion pressure to ensure that the cavities under track slabs are filled fully.However,the expansion pressure caused some of the water to seep out from the periphery of the filling bag,and it would affect the actual mix proportion of CA mortar.The differences in physical and mechanical properties between the CA mortar under track slabs and the CA mortar formed in the laboratory were studied in this paper.The relevant results could provide important methods for the research of filling layer materials for CRTS I type and other types of ballastless tracks in China.Design/methodology/approach–During the inspection of filling layer,the samples of CA mortar from different working conditions and raw materials were taken by uncovering the track slabs and drilling cores.The physical and mechanical properties of CA mortar under the filling layer of the slab were systematically analyzed by testing the electrical flux,compressive strength and density of mortar in different parts of the filling layer.Findings–In this paper,the electric flux,the physical properties and mechanical properties of different parts of CA mortar under the track slab were investigated.The results showed that the density,electric flux and compressive strength of CA mortar were affected by the composition of raw materials for dry powders and different parts of the filling layer.In addition,the electrical flux of CA mortar gradually decreased within 90 days’age.The electrical flux of samples with the thickness of 54 mm was lower than 500 C.Therefore,the impermeability and durability of CA mortar could be improved by increasing the thickness of filling layer.Besides,the results showed that the compressive strength of CA mortar increased,while the density and electric flux decreased gradually,with the prolongation of hardening time.Originality/value–During 90 days’age,the electrical flux of the CA mortar gradually decreased with the increase of specimen thickness and the electrical flux of the specimens with the thickness of 54 mm was lower than 500 C.The impermeability and durability of the CA mortar could be improved by increasing the thickness of filling layer.The proposed method can provide reference for the further development and improvement of CRTS I and CRTS II type ballastless track in China.
文摘To enhance the safety of road traffic operations,this paper proposed a model based on stacking integrated learning utilizing American road traffic accident statistics.Initially,the process involved data cleaning,transformation,and normalization.Subsequently,various classification models were constructed,including logistic regression,k-nearest neighbors,gradient boosting,decision trees,AdaBoost,and extra trees models.Evaluation metrics such as accuracy,precision,recall,F1 score,and Hamming loss were employed.Upon analysis,the passive-aggressive classifier model exhibited superior comprehensive indices compared to other models.Based on the model’s output results,an in-depth examination of the factors influencing traffic accidents was conducted.Additionally,measures and suggestions aimed at reducing the incidence of severe traffic accidents were presented.These findings served as a valuable reference for mitigating the occurrence of traffic accidents.
基金support from the staff of the National Engineering Research Center for Functional Food,Jiangnan Universitysupported by the Postdoctoral Research Funding of Jiangsu Province (2021K269B)National Key Research & Developmental Program of China (2018YFA0900300)。
文摘In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation.
基金supported by the Natural Science Foundation of China(U2230123,81870683,82121003 and 82201234)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-032)the Department of Science and Technology of Sichuan Province,China(22ZYZYTS0159,2022YFS0606,2023YFS0125,2023YFS0131,2023NSFSC0033,and 22ZYZYTS0151)
文摘How to effectively transform the pro-oncogenic tumor microenvironments(TME)surrounding a tumor into an anti-tumoral never fails to attract people to study.Small interfering RNA(siRNA)is considered one of the most noteworthy research directions that can regulate gene expression following a process known as RNA interference(RNAi).The research about siRNA delivery targeting tumor cells and TME has been on the rise in recent years.Using siRNA drugs to silence critical proteins in TME was one of the most efficient solutions.However,the manufacture of a siRNA delivery system faces three major obstacles,i.e.,appropriate cargo protection,accurately targeted delivery,and site-specific cargo release.In the following review,we summarized the pharmacological actions of siRNA drugs in remolding TME.In addition,the delivery strategies of siRNA drugs and combination therapy with siRNA drugs to remodel TME are thoroughly discussed.In the meanwhile,the most recent advancements in the development of all clinically investigated and commercialized siRNA delivery technologies are also presented.Ultimately,we propose that nanoparticle drug delivery siRNA may be the future research focus of oncogene therapy.This summary offers a thorough analysis and roadmap for general readers working in the field.
基金the National Key R&D Program of China(Grant Nos.2022YFA1203802 and 2021YFA1202903)the National Natural Science Foundation of China(Grant Nos.92264202,61974060,and 61674080)the Innovation and Entrepreneurship Program of Jiangsu Province。
文摘Two-dimensional(2D)semiconductors have attracted considerable interest for their unique physical properties.Here,we report the intrinsic cryogenic electronic transport properties in few-layer MoSe_(2)field-effect transistors(FETs)that are fully encapsulated in ultraclean hexagonal boron nitride dielectrics and are simultaneously van der Waals contacted with gold electrodes.The FETs exhibit electronically favorable channel/dielectric interfaces with low densities of interfacial traps(<1010cm^(-2)),which lead to outstanding device characteristics at room temperature,including near-Boltzmann-limit subthreshold swings(65 mV/dec),high carrier mobilities(53–68 cm^(2)·V-1·s^(-1)),and negligible scanning hystereses(<15 mV).The dependence of various contact-related parameters with temperature and carrier density is also systematically characterized to understand the van der Waals contacts between gold and MoSe_(2).The results provide insightful information about the device physics in van der Waals contacted and encapsulated 2D FETs.
基金the National Natural Science Foundation of China(Grant Nos.92164201,61921005,61974064,61934004,and 11874198)。
文摘Self-oscillation is an intriguing and omnipresent phenomenon that governs a broad range of growth dynamics and formation of nanoscale periodic and delicate heterostructures.A self-oscillating growth phenomenon of catalyst droplets,consuming surface-coating a-Si/a-Ge bilayer,is exploited to accomplish a high-frequency alternating growth of ultrathin crystalline Si and Ge(c-Si/c-Ge)nano-slates,with Ge-rich layer thickness of 14–19 nm,embedded within a superlattice nanowire structure,with pre-known position and uniform channel diameter.A subsequent selective etching of the Ge-rich segments leaves a chain of ultrafine standing c-Si nanosheets down to~6 nm thick,without the use of any expensive high-resolution lithography and growth modulation control.A ternary-phase-competition model has been established to explain the underlying formation mechanism of this nanoscale self-oscillating growth dynamics.It is also suggested that these ultrathin nanosheets could help to produce ultrathin fin-channels for advanced electronics,or provide size-specified trapping sites to capture and position hetero nanoparticle for high-precision labelling or light emission.
基金the National Key R&D Program of China(Grant Nos.2022YFA1203802 and 2021YFA1202903)the National Natural Science Foundation of China(Grant Nos.92264202,61974060,and 61674080)the Innovation and Entrepreneurship Program of Jiangsu Province。
文摘Two-dimensional(2D)van der Waals semiconductors are appealing for low-power transistors.Here,we show the feasibility in enhancing carrier mobility in 2D semiconductors through engineering the vertical distribution of carriers confined inside ultrathin channels via symmetrizing gate configuration or increasing channel thickness.Through self-consistently solving the Schr¨odinger–Poisson equations,the shapes of electron envelope functions are extensively investigated by clarifying their relationship with gate configuration,channel thickness,dielectric permittivity,and electron density.The impacts of electron distribution variation on various carrier scattering matrix elements and overall carrier mobility are insightfully clarified.It is found that the carrier mobility can be generally enhanced in the dual-gated configuration due to the centralization of carrier redistribution in the nanometer-thick semiconductor channels and the rate of increase reaches up to 23%in Hf O2 dual-gated 10-layer MoS_(2) channels.This finding represents a viable strategy for performance optimization in transistors consisting of 2D semiconductors.
基金Science and Technology Plan of Sichuan Province,China(2021YFYZ0001)Sichuan Beef Cattle Innovation Team of National Modern Agricultural Industrial Technology System(SCCXTD-2023-13)Special Project for Financial Operation of Sichuan Province,China。
文摘Ebian spotted cattle has the ability to adapt to the local natural ecological environment,and is one of the excellent local cattle breeds in Sichuan.Ebian spotted cattle is a breed of cattle for both service and meat use and formed through long-term natural selection and artificial selection.Because of the weak development and utilization of this breed,the economic benefits of excellent breeds have not been fully brought into play,and farmers'enthusiasm in breeding is poor,so that the number of Ebian spotted cattle has reduced year by year.In order to strengthen the protection,development and utilization of Ebian spotted cattle as a local excellent breed,combined with the third national survey of livestock and poultry genetic resources in 2021,Ebian spotted cattle was investigated,and a comprehensive,scientific and objective analysis of its population numbers was conducted.Besides,reasonable suggestions were put forward.
文摘Background:Social support is related to depression,but the gender differences and related factors that contribute to low social support among adolescents with subthreshold depression remain to be elucidated.This study explores the relationship between social support and depression,in addition to the gender difference in the incidence of low social support among adolescents with subthreshold depression and its related factors.Methods:A total of 371 Chinese adolescents with subthreshold depression were recruited.All subjects were rated on the Social Support Scale for Adolescents,the Response Style Scale,the Self-Perception Profile for Children,the Individualism-collectivism scale.Results:Binary logistic regression indicated that the stability dimension of cognitive style,the generality dimension of the Cognitive Style Questionnaire,and the social acceptance dimension of the Self-Perception Profile for Children scale were significantly correlated with social support level in male adolescents with subthreshold depression.In contrast,the total score of the Self-Perception Profile for Children scale,the social acceptance of the Self-Perception Profile for Children scale,total individualism,and total collectivism were significantly correlated with social support level in female adolescents with subthreshold depression.Limitations:This study is a cross-sectional study,and its effectiveness in explaining factors that influence levels of social support is limited.Conclusions:The gender difference between low social support among adolescents with subthreshold depression is related to cognitive style,self-perception,and collectivism–individualism.
基金funded by the National Natural Science Foundation of China(No.51408610).
文摘Purpose–The construction of cement asphalt(CA)emulsified mortar can obviously disturb the slab status after the fine adjustment.To decrease or eliminate the influence of CA mortar grouting on track slab geometry status,the effects of grouting funnel,slab pressing method,mortar expansion ratio,seepage ratio and grouting area on China Railway Track System Type(CRTS I)track slab geometry status were discussed in this paper.Design/methodology/approach–Combined with engineering practice,this paper studied the expansion law of filling layer mortar,the liquid level height of the filling funnel,the pressure plate device and the amount of exudation water and systematically analyzed the influence of filling layer mortar construction on the state of track slab.Relevant precautions and countermeasures were put forward.Findings–The results showed that the track slab floating values of four corners were different with the CA mortar grouting and the track slab corner near CA mortar grouting hole had the maximum floating values.The anti-floating effect of“7”shaped slab pressing device was more efficient than fixed-joint angle iron,and the slab floating value could be further decreased by increasing the amount of“7”shaped slab pressing devices.After CA mortar grouting,the track slab floating pattern had a close correlation with the expansion rate and water seepage rate of CA mortar over time and the expansion and water seepage rate of the mortar were faster when the temperature was high.Furthermore,the use of strip CA mortar filling under the rail bearing platform on bothsides could effectively reduce the float under the track slab,and it could also save mortar consumption and reduce costs.Originality/value–This study plays an important role in controlling the floating values,CA mortar dosage and the building cost of projects by grouting CA mortar at two flanks of filling space.The research results have guiding significance for the design and construction of China’s CRTS I,CRTS II and CRTS III track slab.
