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阿托伐他汀对激素性股骨头坏死大鼠的作用及对Wnt/β-catenin信号通路的影响 被引量:2
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作者 朱磊 周正新 +8 位作者 顾一帆 李文华 李亮 刘涛 康金平 韩士鼎 徐寰 朱彩玉 王壮壮 《中国现代医学杂志》 CAS 北大核心 2022年第24期34-39,共6页
目的探究阿托伐他汀对激素性股骨头坏死大鼠的作用及对果蝇无翅基因/β-连环蛋白(Wnt/β-catenin)信号通路的影响。方法30只SD雄性大鼠随机分为对照组、模型组及阿托伐他汀组,每组10只。模型组和阿托伐他汀组复制激素性股骨头坏死模型... 目的探究阿托伐他汀对激素性股骨头坏死大鼠的作用及对果蝇无翅基因/β-连环蛋白(Wnt/β-catenin)信号通路的影响。方法30只SD雄性大鼠随机分为对照组、模型组及阿托伐他汀组,每组10只。模型组和阿托伐他汀组复制激素性股骨头坏死模型并对每只大鼠腹腔注射醋酸泼尼松龙(24.5 mg/kg)和青霉素钠(8万u),2次/周,连续给药6周,共18只大鼠模型复制成功。模型复制的同时,阿托伐他汀组腹腔注射阿托伐他汀1 mg/(kg·d),对照组与模型组给予等量的生理盐水,连续治疗6周后,检测各组大鼠血清钙(S-Ca)、血清磷(S-P)水平,以及血清碱性磷酸酶(ALP)、转化生长因子β_(1)(TGF-β_(1))水平;比较大鼠骨组织ALP、TGF-β_(1)mRNA相对表达量;比较大鼠骨组织Wnt1、β-catenin蛋白的表达。结果与对照组比较,模型组大鼠血清S-Ca、S-P及TGF⁃β_(1)水平降低(P<0.05),ALP水平升高(P<0.05),ALP mRNA相对表达量升高(P<0.05),TGF⁃β_(1)mRNA相对表达量降低(P<0.05),Wnt1水平和β-catenin蛋白相对表达量下降(P<0.05);与模型组比较,阿托伐他汀组大鼠血清S-Ca、S-P及TGF⁃β_(1)水平升高(P<0.05),ALP水平降低(P<0.05),ALP mRNA相对表达量下降(P<0.05),TGF-β_(1)mRNA相对表达量升高(P<0.05),Wnt1水平和β-catenin蛋白相对表达量升高(P<0.05)。结论阿托伐他汀能够改善激素性股骨头坏死大鼠骨代谢指标,其机制可能与Wnt/β-catenin信号通路有关。 展开更多
关键词 激素性股骨头坏死 阿托伐他汀 大鼠 果蝇无翅基因/β-连环蛋白信号通路
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角膜缘干细胞移植术治疗原发性翼状胬肉 被引量:6
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作者 王天宇 顾一帆 +2 位作者 杨敏 张谊 汪朝阳 《国际眼科杂志》 CAS 北大核心 2020年第9期1473-1476,共4页
目的:评价自体角膜缘干细胞移植治疗原发性翼状胬肉的安全性和有效性。方法:前瞻性观察性研究。采用自体角膜缘干细胞移植术治疗鼻侧原发性翼状胬肉264例(男性142例,女性122例)。患者平均年龄54.22±15.24岁。翼状胬肉术后1、3、7d... 目的:评价自体角膜缘干细胞移植治疗原发性翼状胬肉的安全性和有效性。方法:前瞻性观察性研究。采用自体角膜缘干细胞移植术治疗鼻侧原发性翼状胬肉264例(男性142例,女性122例)。患者平均年龄54.22±15.24岁。翼状胬肉术后1、3、7d及1、3、6、9、12、36mo进行定期随访。评估手术时间,角膜上皮愈合时间,术后复发率和手术并发症。结果:平均手术时间为25.7±2.6min。经过至少3a的术后随访,术后角膜上皮愈合时间为3.85±0.72d。14例患者出现眼科并发症。本研究未发现虹膜睫状体炎、睑球粘连、角膜溃疡等威胁视力的严重并发症。结膜移植片水肿5例,肉芽肿形成3例,结膜下血肿6例。随访3a,11例患者复发,复发率为4.17%,首次出现复发时间为3mo,平均8mo。结论:经长期随访,自体角膜缘干细胞移植术无严重并发症,复发率低,是治疗原发性翼状胬肉安全有效的方法。我们还建议对于原发性翼状胬肉手术,12mo的术后随访为最佳时间。 展开更多
关键词 复发率 并发症 翼状胬肉
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Effect of carrier mobility on performance of perovskite solar cells
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作者 顾一帆 杜会静 +2 位作者 李楠楠 杨蕾 周春宇 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第4期415-424,共10页
The high carrier mobility and long diffusion length of perovskite material have been regarded because of its excellent photovoltaic performance. However, many studies have shown that a diffusion length longer than 1 ... The high carrier mobility and long diffusion length of perovskite material have been regarded because of its excellent photovoltaic performance. However, many studies have shown that a diffusion length longer than 1 μm and higher carrier mobility have no positive effect on the cells' performance. Studies of organic solar cells have demonstrated the existence of an optimal mobility value, while systematic research of the carrier mobility in the PSCs is very rare. To make these questions clear, the effect of carrier mobility on perovskite solar cells' performance is studied in depth in this paper by simulation.Our study shows that the optimal mobility value of the charge transportation layer and absorption layer are influenced by both doping concentration and layer thickness. The appropriate carrier mobility can reduce the carrier recombination rate and enhance the carrier concentration, thus improving the cells' performance. A high efficiency of 27.39% is obtained in the simulated cell with the combination of the optimized parameters in the paper. 展开更多
关键词 PEROVSKITE solar cells device simulation CARRIER MOBILITY PHOTOVOLTAIC PERFORMANCE
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Pars plana vitrectomy relieves the depression in patients with symptomatic vitreous floaters
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作者 Rong-Han Wu Jun-Hong Jiang +2 位作者 yi-fan gu Nived Moonasar Zhong Lin 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第3期412-416,共5页
AIM:To investigate the depressive state among the patients with symptomatic vitreous floaters(SVF),as well as its change after SVF removal via vitrectomy surgery.METHODS:Twenty-eight eyes of 28 patients who underwent ... AIM:To investigate the depressive state among the patients with symptomatic vitreous floaters(SVF),as well as its change after SVF removal via vitrectomy surgery.METHODS:Twenty-eight eyes of 28 patients who underwent 27-gauge pars plana vitrectomy(PPV)for SVF were included.Thirty-nine eyes of 39 age-and gendermatched healthy volunteers without SVF were also recruited as a healthy control.Center for Epidemiologic Studies Depression(CES-D)was used to assess volunteers and patients’depression(before and 1 wk after PPV).RESULTS:The CES-D score was 18.3±8.6 for patients,and was 12.4±6.0 for healthy control(P=0.003).Patients were significantly more likely to be in a depressive state(53.6%,defined as CES-D score≥16)than the healthy control(20.5%,P=0.005).For patients with SVF,the CES-D score was negatively correlated with their age(rs=-0.42,P=0.025).After PPV,both the CES-D score(11.9±5.4 vs 18.3±8.6,P<0.001)and proportion of depressive state(18.5%vs 53.6%,P=0.005)were significantly decreased.CONCLUSION:This study suggests that symptoms of vitreous floaters have an apparently negative impact on patients’psychological state.The PPV can effectively relieve the depressive state for patients with SVF. 展开更多
关键词 DEPRESSION SYMPTOMATIC VITREOUS FLOATERS PARS plana vitrectomy CES-D
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