As one of the most famous large language models,ChatGPT has great potential for application in physical education.It can provide personalized exercise plans,a variety of exercise options,and interactive support.The in...As one of the most famous large language models,ChatGPT has great potential for application in physical education.It can provide personalized exercise plans,a variety of exercise options,and interactive support.The integration of ChatGPT into the teaching process can promote college students’participation in physical activities and improve their mental health while expanding the traditional teaching environment and promoting the reform of traditional teaching methods.However,the application of ChatGPT faces challenges and obstacles in physical education.To make full use of ChatGPT in physical education,it can be combined with wearable devices and sports equipment to enhance the efficiency of interactions with users.Relevant policies are urgently needed to avoid the improper use of users’data.展开更多
Pathological scarring and scleroderma,which are the most common conditions of skin fibrosis,pathologically manifest as fibroblast proliferation and extracellular matrix(ECM)hyperplasia.Fibroblast proliferation and ECM...Pathological scarring and scleroderma,which are the most common conditions of skin fibrosis,pathologically manifest as fibroblast proliferation and extracellular matrix(ECM)hyperplasia.Fibroblast proliferation and ECM hyperplasia lead to fibrotic tissue remodeling,causing an exaggerated and prolonged wound-healing response.The pathogenesis of these diseases has not been fully clarified and is unfortunately accompanied by exceptionally high medical needs and poor treatment effects.Currently,a promising and relatively low-cost treatment has emerged-adipose-derived stem cell(ASC)therapy as a branch of stem cell therapy,including ASCs and their derivatives-purified ASC,stromal vascular fraction,ASC-conditioned medium,ASC exosomes,etc.,which are rich in sources and easy to obtain.ASCs have been widely used in therapeutic settings for patients,primarily for the defection of soft tissues,such as breast enhancement and facial contouring.In the field of skin regeneration,ASC therapy has become a hot research topic because it is beneficial for reversing skin fibrosis.The ability of ASCs to control profibrotic factors as well as anti-inflammatory and immunomodulatory actions will be discussed in this review,as well as their new applications in the treatment of skin fibrosis.Although the long-term effect of ASC therapy is still unclear,ASCs have emerged as one of the most promising systemic antifibrotic therapies under development.展开更多
Objective:Histone modification has a significant effect on gene expression.Enhancer of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltra...Objective:Histone modification has a significant effect on gene expression.Enhancer of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltransferase enzyme.The development of anoikis resistance in tumor cells is considered to be a critical step in the metastatic process of primary malignant tumors.The purpose of this study was to investigate the effect and mechanism of anoikis resistance in ovarian adenocarcinoma peritoneal metastasis.Methods:In addition to examining EZH2 protein expression in ovarian cancer omental metastatic tissues,we established a model of ovarian cancer cell anoikis and a xenograft tumor model in nude mice.Anoikis resistance and ovarian cancer progression were tested after EZH2 and N6-methyladenosine(m6A)levels were modified.Results:EZH2 expression was significantly higher in ovarian cancer omental metastatic tissues than in normal ovarian tissues.Reducing the level of EZH2 decreased the level of m6A and ovarian cancer cell anoikis resistance in vitro and inhibited ovarian cancer progression in vivo.M6a regulation altered the effect of EZH2 on anoikis resistance.Conclusion:Our results indicate that EZH2 contributes to anoikis resistance and promotes ovarian adenocarcinoma abdominal metastasis by m6A modification.Our findings imply the potential of the clinical application of m6A and EZH2 for patients with ovarian cancer.展开更多
With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently necessary.Digital interventions offer advantages such as high accessibility,anonymity,an...With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently necessary.Digital interventions offer advantages such as high accessibility,anonymity,and accurate identification,which can promote the reconstruction of students’mental health through the provision of psychological support platforms,psychological assessment tools,and online mental health activities.However,we recognize that digital interventions must undergo many adjustments,and corresponding ethical norms require further clarification.It is crucial for different stakeholders to collaborate and work toward maximizing the effectiveness of digital interventions for the reconstruction of mental health after the COVID-19 pandemic.展开更多
Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI patients.Acupuncture has been used to improve neurological deficits in p...Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI patients.Acupuncture has been used to improve neurological deficits in patients with TBI.This meta-analysis aims to evaluate the effects and safety of acupuncture in improving consciousness in patients with TBI when compared with other therapies.Methods:A systematic search was conducted in electronic databases PubMed,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Allied and Complementary Medicine Database,WHO International Clinical Trials Registry Platform,ClinicalTrials.gov,and Google Scholar for randomized controlled trials that investigated the effect of acupuncture on patients with TBI.From the inception of databases to March 2023.Results:A total of 653 participants were included in nine trials.We found that acupuncture adjunct to routine treatment significantly improved the wakeup rate of patients in TBI when compared with routine treatment alone(relative risk=1.36,95%confidence interval:1.16 to 1.59,I2=4.78%,P=0).Additionally,we found that acupuncture is significantly associated with reduced impaired consciousness after TBI when adjunct to medicine therapy.As a safe intervention,acupuncture can also improve the activities of daily living for people with TBI(mean difference=15.71,95%confidence interval:9.19 to 22.22,I2=0%,P=0).Conclusion:Acupuncture can improve consciousness and braise wakeup of patients with TBI when adjunct to conventional treatment compared with routine treatment alone.Further high-quality studies are needed to confirm these findings and to determine the optimal acupuncture treatment parameter for TBI.展开更多
Background:Nonalcoholic fatty liver disease(NAFLD)is an independent risk factor for severe acute pancreatitis(AP).The underlying mechanism remains unclear.We sought to determine how bacterial translocation and cholest...Background:Nonalcoholic fatty liver disease(NAFLD)is an independent risk factor for severe acute pancreatitis(AP).The underlying mechanism remains unclear.We sought to determine how bacterial translocation and cholesterol metabolism in the liver and pancreas affect the severity of AP in NAFLD mice.Methods:C57BL/6N mice were fed on a high-fat diet(HFD)to generate the NAFLD model,and mice in the control group were provided with a normal diet(ND).After being anesthetized with ketamine/xylazine,mice got a retrograde infusion of taurocholic acid sodium into the pancreatic duct to induce AP,and sham operation(SO)was used as control.Serum amylase and Schmidt’s pathological score system were used to evaluate AP severity.Bacterial loads,total cholesterol level,and cholesterol metabolic-associated molecules[low-density lipoprotein receptor(LDLR)and ATP-binding cassette transporter A1(ABCA1)]were analyzed in the liver and pancreas.Results:Compared with the ND-AP group,mice in the HFD-AP group had severer pancreatitis,manifested with higher serum amylase levels and higher AP pathologic scores,especially the inflammation and hemorrhage scores.Compared with the HFD-SO group and ND-AP group,bacterial loads in the liver and pancreas were significantly higher in the HFD-AP group.Mice in the HFD-AP group showed a decreased LDLR expression and an increased ABCA1 expression in the pancreas,although there was no significant difference in pancreas total cholesterol between the HFD-AP group and the ND-AP group.Conclusions:NAFLD aggravates AP via increasing bacterial translocation in the liver and pancreas and affecting pancreas cholesterol metabolism in mice.展开更多
Computational psychiatry is an emerging field that not only explores the biological basis of mental illness but also considers the diagnoses and identifies the underlying mechanisms.One of the key strengths of computa...Computational psychiatry is an emerging field that not only explores the biological basis of mental illness but also considers the diagnoses and identifies the underlying mechanisms.One of the key strengths of computational psychiatry is that it may identify patterns in large datasets that are not easily identifiable.This may help researchers develop more effective treatments and interventions for mental health problems.This paper is a narrative review that reviews the literature and produces an artificial intelligence ecosystem for computational psychiatry.The artificial intelligence ecosystem for computational psychiatry includes data acquisition,preparation,modeling,application,and evaluation.This approach allows researchers to integrate data from a variety of sources,such as brain imaging,genetics,and behavioral experiments,to obtain a more complete understanding of mental health conditions.Through the process of data preprocessing,training,and testing,the data that are required for model building can be prepared.By using machine learning,neural networks,artificial intelligence,and other methods,researchers have been able to develop diagnostic tools that can accurately identify mental health conditions based on a patient’s symptoms and other factors.Despite the continuous development and breakthrough of computational psychiatry,it has not yet influenced routine clinical practice and still faces many challenges,such as data availability and quality,biological risks,equity,and data protection.As we move progress in this field,it is vital to ensure that computational psychiatry remains accessible and inclusive so that all researchers may contribute to this significant and exciting field.展开更多
Al2O3/TiOe/FeeO3/Yb2O3 composite powder was synthesized via the sol-gel method. The structure, morphology, and ra- dar-absorption properties of the composite powder were characterized by transmission electron microsco...Al2O3/TiOe/FeeO3/Yb2O3 composite powder was synthesized via the sol-gel method. The structure, morphology, and ra- dar-absorption properties of the composite powder were characterized by transmission electron microscopy, X-ray diffraction analysis and RF impedance analysis. The results show that two types of particles exist in the composite powder. One is irregular flakes （100-200 rim） and the other is spherical A1203 particles （smaller than 80 rim）. Electromagnetic wave attenuation is mostly achieved by dielectric loss. The maximum value of the dissipation factor reaches 0.76 （at 15.68 GHz） in the frequency range of 2-18 GHz. The electromagnetic absorption of waves covers 2-18 GHz with the matching thicknesses of 1.5-4.5 mm. The absorption peak shifts to the lower-frequency area with increas- ing matching thickness. The effective absorption hand covers the frequency range of 2.16-9.76 GHz, and the maximum absorption peak reaches -20.18 dB with a matching thickness of 3.5 mm at a frequency of 3.52 GHz.展开更多
AIM: To describe the clinical characteristics and analyze prognostic factors that influence visual outcome in 669 patients with intraocular foreign bodies(IOFBs).METHODS: Medical records of 669 patients with IOFBs fro...AIM: To describe the clinical characteristics and analyze prognostic factors that influence visual outcome in 669 patients with intraocular foreign bodies(IOFBs).METHODS: Medical records of 669 patients with IOFBs from West China Hospital were reviewed. Best corrected visual acuity(BCVA) values were recorded using standard Snellen acuity chart and were converted to logarithm of the minimum angle of resolution(log MAR) scale for statistical analysis. The visual outcome was defined by the final BCVA(excellent visual outcome: final BCVA of 20/40 or better;poor visual outcome: final BCVA less than 20/200). Statistical analysis of collected data was performed using IBM SPSS Statistics version 23. A 2-tailed P value of less than 0.05 was considered statistically significant throughout the study. RESULTS: The average age ranged from 1 to 79 years old(mean age, 34.8±12.7 SD) and the majority of patients were men(626, 93.6%). The major cause of ocular injury was hammering(383, 57.2%). Almost all the patients(97.8%) underwent surgeries(97.8%) and the average time interval between injury and surgery was 26.4±322.3 d(0-7300), while 327 patients received surgeries within 24 h(48.9%) and 590 patients received surgeries within seven days(88.2%) after IOFBs injury. The poor BCVA was associated with older age(P=0.013), larger IOFBs size(P<0.001), presence of complications(P<0.001) and worse presenting BCVA(P<0.001). On the contrary, younger age(P=0.005), smaller IOFBs size(P<0.001), absence of complications(P<0.001) and better presenting BCVA(P<0.001) were considered to relate to excellent BCVA.CONCLUSION: Multiple prognostic factors may influence the final visual outcome, including age, size of IOFBs, complications and presenting BCVA. Meanwhile, further education and promotion on eye protection should be taken for the improvement on self-protection and selfhealth awareness.展开更多
The Square Kilometre Array(SKA) will be the world’s largest synthesis radio telescope, which is designed to answer major scientific questions such as those relating to the cosmic origin and fundamental forces in the ...The Square Kilometre Array(SKA) will be the world’s largest synthesis radio telescope, which is designed to answer major scientific questions such as those relating to the cosmic origin and fundamental forces in the universe. With the SKA entering into the phase of pre-construction, more than 100 institutes in about 20 countries including China have been involved in the associated key technology development.The Dish Verification Antenna China(DVA-C) is a concept prototype which has been built to meet the requirements of the SKA’s scientific goals. It utilizes a unique skin-and-rib structure with single-piece panel reflectors. This paper presents details on the design and measured performances of DVA-C, as well as the preliminary observational results. Current applications of the DVA-C are also introduced.展开更多
The effect of pH value and different kinds of anions on the corrosion behavior of Cu/Al casting-rolled clad plates in the alkaline solution was evaluated by means of scanning electron microscopy(SEM),energy dispersive...The effect of pH value and different kinds of anions on the corrosion behavior of Cu/Al casting-rolled clad plates in the alkaline solution was evaluated by means of scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD),weight loss analysis,3D confocal laser scanning microscopy(CLSM)and electrochemical test.Results show the corrosion mainly occurs on the aluminum side.The corrosion resistance of the Cu/Al decreases as the pH value increases.When pH≥12,the dissolution of the film layer is faster than the passivation process.The addition of Cl^(-)ions reduces the corrosion resistance of the Cu/Al clad plates,which leads to pitting corrosion.The higher the concentration of Cl^(-)ions,the more prone the pitting to occur.The addition of SO_(4)^(2-)ions causes the denudation of the samples.The corrosion resistance of the Cu/Al is better in the alkaline solution containing NO_(3)^(-)ions than that in the solution containing Cl^(-)ions or SO_(4)^(2-)ions.When adding SO_(4)^(2-),NO^(3)^(-)and Cl^(-)to the pure alkaline solution,the corrosion resistance of the Cu/Al clad plates decreases.展开更多
Ag@Pt core-shell nanoparticles（Ag@Pt NPs） were prepared by a co-reduction method. Pt nanocapsules with diameters of less than 10 nm were obtained by an electrochemical method. Cyclic voltammetry（CV） scanning was u...Ag@Pt core-shell nanoparticles（Ag@Pt NPs） were prepared by a co-reduction method. Pt nanocapsules with diameters of less than 10 nm were obtained by an electrochemical method. Cyclic voltammetry（CV） scanning was used to cavitate the Ag@Pt NPs, and the morphology, structure, and cavitation conditions were studied. The results indicate that the effective cavitation conditions to obtain Pt nanoparticles from Ag@Pt NPs are a scanning voltage of 0 to 0.8 V and continuous CV scanning over 2 h. This cavitation method is also applicable for the syntheses of Ir, Ru, and Ru-Pt nanocapsules.展开更多
Linear carbon chains as new one-dimensional(1D)nanomaterials attract attention for the predicted outstanding properties.However,the high reactivity of linear carbon chains hampers further experimental research.To date...Linear carbon chains as new one-dimensional(1D)nanomaterials attract attention for the predicted outstanding properties.However,the high reactivity of linear carbon chains hampers further experimental research.To date,different methods have been developed to synthesize new materials containing linear carbon chains.Among them,the arc-discharge method is a practical way to prepare both finite and infinite linear carbon chains.This review provides a brief discussion of the recent progress in the techniques to prepare carbon chain-based materials and then focuses on the arc-discharge method.The configuration of apparatus,optimal conditions,and the corresponding mechanism of arc-discharge method to prepare long linear carbon chain inside multi-walled carbon nanotubes are summarized in detail.The characterization techniques are introduced to evaluate the quality of products.Moreover,remaining challenges and perspectives are presented for further investigation of long linear carbon chains.展开更多
Cytokines play an important role in the pathological process of atherosclerosis(AS),affecting the progression and prognosis of cerebrovascular diseases concerned with AS.Cytokines mainly include C-reactive protein,int...Cytokines play an important role in the pathological process of atherosclerosis(AS),affecting the progression and prognosis of cerebrovascular diseases concerned with AS.Cytokines mainly include C-reactive protein,interleukin,tumor necrosis factor,chemotactic cytokines,matrix metalloproteinases,etc.These These cytokines promote or inhibit the inflammatory response and plaque formation during AS process through different targets and mechanisms.A comprehensive understanding of the cytokines in the occurrence and development of AS is conducive to search for new therapeutic targets and drugs.展开更多
In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane moieties.This strategy involves the formation of metal-carbene templates,photo...In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane moieties.This strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal ions.Driven by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane units.The obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.展开更多
In recent years,perovskite has received increasing attention in the medical field.However,there has been a lack of related bibliometric analysis in this research field.This study aims to analyse the research status an...In recent years,perovskite has received increasing attention in the medical field.However,there has been a lack of related bibliometric analysis in this research field.This study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of perovskite.This study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science(WOS)database.The country,institution,journal,cited references,and keywords were analysed using CiteSpace,VOS viewer,and Bibliometrix software.The number of articles related to perovskite research in the medical field has been increasing every year.China and USA have published the most papers and are the main forces in this research field.The University of London Imperial College of Science,Technology,and Medicine is the most active institution and has contributed the most publications.ACS Applied Materials&Interfaces is the most prolific journal in this field.“Medical electronic devices”,“X-rays”,and“piezoelectric materials”are the most researched directions of perovskite in the medical field.“Performance”,“perovskite”,and“solar cells”are the most frequently used keywords in this field.Advanced Materials is the most relevant and academically influential journal for perovskite research.Halide perovskites have been a hot topic in this field in recent years and will be a future research trend.X-ray,electronic medical equipment,and medical stents are the main research directions.展开更多
文摘As one of the most famous large language models,ChatGPT has great potential for application in physical education.It can provide personalized exercise plans,a variety of exercise options,and interactive support.The integration of ChatGPT into the teaching process can promote college students’participation in physical activities and improve their mental health while expanding the traditional teaching environment and promoting the reform of traditional teaching methods.However,the application of ChatGPT faces challenges and obstacles in physical education.To make full use of ChatGPT in physical education,it can be combined with wearable devices and sports equipment to enhance the efficiency of interactions with users.Relevant policies are urgently needed to avoid the improper use of users’data.
基金supported by the National Key Research and Development Program of China(No.2019YFE03120002)the Natural Science Foundation of Anhui Province,China(Nos.2108085J21,S202202a04021990)+1 种基金the National Key Research and Development Program of Anhui Province,China(No.202103a05020002)the Higher Education Discipline Innovation Project(No.B18018).
基金Supported by National Natural Science Foundation of China,No.81772103 and No.82172234Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality,China,No.22MC1940300。
文摘Pathological scarring and scleroderma,which are the most common conditions of skin fibrosis,pathologically manifest as fibroblast proliferation and extracellular matrix(ECM)hyperplasia.Fibroblast proliferation and ECM hyperplasia lead to fibrotic tissue remodeling,causing an exaggerated and prolonged wound-healing response.The pathogenesis of these diseases has not been fully clarified and is unfortunately accompanied by exceptionally high medical needs and poor treatment effects.Currently,a promising and relatively low-cost treatment has emerged-adipose-derived stem cell(ASC)therapy as a branch of stem cell therapy,including ASCs and their derivatives-purified ASC,stromal vascular fraction,ASC-conditioned medium,ASC exosomes,etc.,which are rich in sources and easy to obtain.ASCs have been widely used in therapeutic settings for patients,primarily for the defection of soft tissues,such as breast enhancement and facial contouring.In the field of skin regeneration,ASC therapy has become a hot research topic because it is beneficial for reversing skin fibrosis.The ability of ASCs to control profibrotic factors as well as anti-inflammatory and immunomodulatory actions will be discussed in this review,as well as their new applications in the treatment of skin fibrosis.Although the long-term effect of ASC therapy is still unclear,ASCs have emerged as one of the most promising systemic antifibrotic therapies under development.
基金funded by the National Natural Science Foundation of China(No.81672573)Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2021D01F21)Natural Science Foundation of Hubei Province(No.2021CFB474)。
文摘Objective:Histone modification has a significant effect on gene expression.Enhancer of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltransferase enzyme.The development of anoikis resistance in tumor cells is considered to be a critical step in the metastatic process of primary malignant tumors.The purpose of this study was to investigate the effect and mechanism of anoikis resistance in ovarian adenocarcinoma peritoneal metastasis.Methods:In addition to examining EZH2 protein expression in ovarian cancer omental metastatic tissues,we established a model of ovarian cancer cell anoikis and a xenograft tumor model in nude mice.Anoikis resistance and ovarian cancer progression were tested after EZH2 and N6-methyladenosine(m6A)levels were modified.Results:EZH2 expression was significantly higher in ovarian cancer omental metastatic tissues than in normal ovarian tissues.Reducing the level of EZH2 decreased the level of m6A and ovarian cancer cell anoikis resistance in vitro and inhibited ovarian cancer progression in vivo.M6a regulation altered the effect of EZH2 on anoikis resistance.Conclusion:Our results indicate that EZH2 contributes to anoikis resistance and promotes ovarian adenocarcinoma abdominal metastasis by m6A modification.Our findings imply the potential of the clinical application of m6A and EZH2 for patients with ovarian cancer.
基金Supported by the Tianjin Philosophy and Social Science Planning Project“Research on Value-added Evaluation of Career Adaptability for Engineering Students Oriented towards Outstanding Engineers”,No.TJJXQN22-001.
文摘With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently necessary.Digital interventions offer advantages such as high accessibility,anonymity,and accurate identification,which can promote the reconstruction of students’mental health through the provision of psychological support platforms,psychological assessment tools,and online mental health activities.However,we recognize that digital interventions must undergo many adjustments,and corresponding ethical norms require further clarification.It is crucial for different stakeholders to collaborate and work toward maximizing the effectiveness of digital interventions for the reconstruction of mental health after the COVID-19 pandemic.
基金supported by the National Natural Science Foundation of China No.82074534College Students’Innovative Entrepreneurial Training Plan No.202210063027.
文摘Background:Traumatic brain injury(TBI)is a leading cause of death and disability worldwide,and consciousness disorder is a common problem in TBI patients.Acupuncture has been used to improve neurological deficits in patients with TBI.This meta-analysis aims to evaluate the effects and safety of acupuncture in improving consciousness in patients with TBI when compared with other therapies.Methods:A systematic search was conducted in electronic databases PubMed,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Allied and Complementary Medicine Database,WHO International Clinical Trials Registry Platform,ClinicalTrials.gov,and Google Scholar for randomized controlled trials that investigated the effect of acupuncture on patients with TBI.From the inception of databases to March 2023.Results:A total of 653 participants were included in nine trials.We found that acupuncture adjunct to routine treatment significantly improved the wakeup rate of patients in TBI when compared with routine treatment alone(relative risk=1.36,95%confidence interval:1.16 to 1.59,I2=4.78%,P=0).Additionally,we found that acupuncture is significantly associated with reduced impaired consciousness after TBI when adjunct to medicine therapy.As a safe intervention,acupuncture can also improve the activities of daily living for people with TBI(mean difference=15.71,95%confidence interval:9.19 to 22.22,I2=0%,P=0).Conclusion:Acupuncture can improve consciousness and braise wakeup of patients with TBI when adjunct to conventional treatment compared with routine treatment alone.Further high-quality studies are needed to confirm these findings and to determine the optimal acupuncture treatment parameter for TBI.
基金This study was supported by grants from the National Nat-ural Science Foundation of China(82070539 and 81873549)the Youth Innovation Foundation of Aerospace Center Hospital(2021QN02).
文摘Background:Nonalcoholic fatty liver disease(NAFLD)is an independent risk factor for severe acute pancreatitis(AP).The underlying mechanism remains unclear.We sought to determine how bacterial translocation and cholesterol metabolism in the liver and pancreas affect the severity of AP in NAFLD mice.Methods:C57BL/6N mice were fed on a high-fat diet(HFD)to generate the NAFLD model,and mice in the control group were provided with a normal diet(ND).After being anesthetized with ketamine/xylazine,mice got a retrograde infusion of taurocholic acid sodium into the pancreatic duct to induce AP,and sham operation(SO)was used as control.Serum amylase and Schmidt’s pathological score system were used to evaluate AP severity.Bacterial loads,total cholesterol level,and cholesterol metabolic-associated molecules[low-density lipoprotein receptor(LDLR)and ATP-binding cassette transporter A1(ABCA1)]were analyzed in the liver and pancreas.Results:Compared with the ND-AP group,mice in the HFD-AP group had severer pancreatitis,manifested with higher serum amylase levels and higher AP pathologic scores,especially the inflammation and hemorrhage scores.Compared with the HFD-SO group and ND-AP group,bacterial loads in the liver and pancreas were significantly higher in the HFD-AP group.Mice in the HFD-AP group showed a decreased LDLR expression and an increased ABCA1 expression in the pancreas,although there was no significant difference in pancreas total cholesterol between the HFD-AP group and the ND-AP group.Conclusions:NAFLD aggravates AP via increasing bacterial translocation in the liver and pancreas and affecting pancreas cholesterol metabolism in mice.
文摘Computational psychiatry is an emerging field that not only explores the biological basis of mental illness but also considers the diagnoses and identifies the underlying mechanisms.One of the key strengths of computational psychiatry is that it may identify patterns in large datasets that are not easily identifiable.This may help researchers develop more effective treatments and interventions for mental health problems.This paper is a narrative review that reviews the literature and produces an artificial intelligence ecosystem for computational psychiatry.The artificial intelligence ecosystem for computational psychiatry includes data acquisition,preparation,modeling,application,and evaluation.This approach allows researchers to integrate data from a variety of sources,such as brain imaging,genetics,and behavioral experiments,to obtain a more complete understanding of mental health conditions.Through the process of data preprocessing,training,and testing,the data that are required for model building can be prepared.By using machine learning,neural networks,artificial intelligence,and other methods,researchers have been able to develop diagnostic tools that can accurately identify mental health conditions based on a patient’s symptoms and other factors.Despite the continuous development and breakthrough of computational psychiatry,it has not yet influenced routine clinical practice and still faces many challenges,such as data availability and quality,biological risks,equity,and data protection.As we move progress in this field,it is vital to ensure that computational psychiatry remains accessible and inclusive so that all researchers may contribute to this significant and exciting field.
基金financially supported by the National Natural Science Foundation of China (No.51471023)the Major State Basic Research Development Program of China (No.2014GB120000)
文摘Al2O3/TiOe/FeeO3/Yb2O3 composite powder was synthesized via the sol-gel method. The structure, morphology, and ra- dar-absorption properties of the composite powder were characterized by transmission electron microscopy, X-ray diffraction analysis and RF impedance analysis. The results show that two types of particles exist in the composite powder. One is irregular flakes （100-200 rim） and the other is spherical A1203 particles （smaller than 80 rim）. Electromagnetic wave attenuation is mostly achieved by dielectric loss. The maximum value of the dissipation factor reaches 0.76 （at 15.68 GHz） in the frequency range of 2-18 GHz. The electromagnetic absorption of waves covers 2-18 GHz with the matching thicknesses of 1.5-4.5 mm. The absorption peak shifts to the lower-frequency area with increas- ing matching thickness. The effective absorption hand covers the frequency range of 2.16-9.76 GHz, and the maximum absorption peak reaches -20.18 dB with a matching thickness of 3.5 mm at a frequency of 3.52 GHz.
文摘AIM: To describe the clinical characteristics and analyze prognostic factors that influence visual outcome in 669 patients with intraocular foreign bodies(IOFBs).METHODS: Medical records of 669 patients with IOFBs from West China Hospital were reviewed. Best corrected visual acuity(BCVA) values were recorded using standard Snellen acuity chart and were converted to logarithm of the minimum angle of resolution(log MAR) scale for statistical analysis. The visual outcome was defined by the final BCVA(excellent visual outcome: final BCVA of 20/40 or better;poor visual outcome: final BCVA less than 20/200). Statistical analysis of collected data was performed using IBM SPSS Statistics version 23. A 2-tailed P value of less than 0.05 was considered statistically significant throughout the study. RESULTS: The average age ranged from 1 to 79 years old(mean age, 34.8±12.7 SD) and the majority of patients were men(626, 93.6%). The major cause of ocular injury was hammering(383, 57.2%). Almost all the patients(97.8%) underwent surgeries(97.8%) and the average time interval between injury and surgery was 26.4±322.3 d(0-7300), while 327 patients received surgeries within 24 h(48.9%) and 590 patients received surgeries within seven days(88.2%) after IOFBs injury. The poor BCVA was associated with older age(P=0.013), larger IOFBs size(P<0.001), presence of complications(P<0.001) and worse presenting BCVA(P<0.001). On the contrary, younger age(P=0.005), smaller IOFBs size(P<0.001), absence of complications(P<0.001) and better presenting BCVA(P<0.001) were considered to relate to excellent BCVA.CONCLUSION: Multiple prognostic factors may influence the final visual outcome, including age, size of IOFBs, complications and presenting BCVA. Meanwhile, further education and promotion on eye protection should be taken for the improvement on self-protection and selfhealth awareness.
基金supported by the Chinese Ministry of Science and Technology under Projects of International Cooperation and Exchange (11261140641)the State Key Development Program for Basic Research (2013CB837900)+1 种基金the State Program for High-Tech Research and Development (SS2014AA122001)the National Natural Science Foundation of China (Grant No. 11673031)
文摘The Square Kilometre Array(SKA) will be the world’s largest synthesis radio telescope, which is designed to answer major scientific questions such as those relating to the cosmic origin and fundamental forces in the universe. With the SKA entering into the phase of pre-construction, more than 100 institutes in about 20 countries including China have been involved in the associated key technology development.The Dish Verification Antenna China(DVA-C) is a concept prototype which has been built to meet the requirements of the SKA’s scientific goals. It utilizes a unique skin-and-rib structure with single-piece panel reflectors. This paper presents details on the design and measured performances of DVA-C, as well as the preliminary observational results. Current applications of the DVA-C are also introduced.
基金financially supported by the National Natural Science Foundation of China(No.52001216)。
文摘The effect of pH value and different kinds of anions on the corrosion behavior of Cu/Al casting-rolled clad plates in the alkaline solution was evaluated by means of scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD),weight loss analysis,3D confocal laser scanning microscopy(CLSM)and electrochemical test.Results show the corrosion mainly occurs on the aluminum side.The corrosion resistance of the Cu/Al decreases as the pH value increases.When pH≥12,the dissolution of the film layer is faster than the passivation process.The addition of Cl^(-)ions reduces the corrosion resistance of the Cu/Al clad plates,which leads to pitting corrosion.The higher the concentration of Cl^(-)ions,the more prone the pitting to occur.The addition of SO_(4)^(2-)ions causes the denudation of the samples.The corrosion resistance of the Cu/Al is better in the alkaline solution containing NO_(3)^(-)ions than that in the solution containing Cl^(-)ions or SO_(4)^(2-)ions.When adding SO_(4)^(2-),NO^(3)^(-)and Cl^(-)to the pure alkaline solution,the corrosion resistance of the Cu/Al clad plates decreases.
基金The financial support by the National Basic Research and Development program of China(Grant No.2014GB120000)
文摘Ag@Pt core-shell nanoparticles（Ag@Pt NPs） were prepared by a co-reduction method. Pt nanocapsules with diameters of less than 10 nm were obtained by an electrochemical method. Cyclic voltammetry（CV） scanning was used to cavitate the Ag@Pt NPs, and the morphology, structure, and cavitation conditions were studied. The results indicate that the effective cavitation conditions to obtain Pt nanoparticles from Ag@Pt NPs are a scanning voltage of 0 to 0.8 V and continuous CV scanning over 2 h. This cavitation method is also applicable for the syntheses of Ir, Ru, and Ru-Pt nanocapsules.
基金Project supported by the Fund from the Huzhou Key Laboratory of Environmental Functional Materials and Pollution Control at Huzhou University
文摘Linear carbon chains as new one-dimensional(1D)nanomaterials attract attention for the predicted outstanding properties.However,the high reactivity of linear carbon chains hampers further experimental research.To date,different methods have been developed to synthesize new materials containing linear carbon chains.Among them,the arc-discharge method is a practical way to prepare both finite and infinite linear carbon chains.This review provides a brief discussion of the recent progress in the techniques to prepare carbon chain-based materials and then focuses on the arc-discharge method.The configuration of apparatus,optimal conditions,and the corresponding mechanism of arc-discharge method to prepare long linear carbon chain inside multi-walled carbon nanotubes are summarized in detail.The characterization techniques are introduced to evaluate the quality of products.Moreover,remaining challenges and perspectives are presented for further investigation of long linear carbon chains.
基金National Natural Foundation(No.81873117)Subproject of Threeyear Planning for Traditional Chinese Medicine of Shanghai(2018-2020)[No.ZY(2018-2020)-CCCX-2002-04]。
文摘Cytokines play an important role in the pathological process of atherosclerosis(AS),affecting the progression and prognosis of cerebrovascular diseases concerned with AS.Cytokines mainly include C-reactive protein,interleukin,tumor necrosis factor,chemotactic cytokines,matrix metalloproteinases,etc.These These cytokines promote or inhibit the inflammatory response and plaque formation during AS process through different targets and mechanisms.A comprehensive understanding of the cytokines in the occurrence and development of AS is conducive to search for new therapeutic targets and drugs.
基金supported by the National Natural Science Fund for Distinguished Young Scholars of China(22025107)Shaanxi Fundamental Science Research Project for Chemistry&Biology(22JHZ003)+2 种基金the National Youth Top-notch Talent Support Program of ChinaXi’an Key Laboratory of Functional Supramolecular Structure and Materialsthe FM&EM International Joint Laboratory of Northwest University。
文摘In this study,we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane moieties.This strategy involves the formation of metal-carbene templates,photochemical cycloaddition,and subsequent demetallation of metal ions.Driven by the host-guest chemistry between crown ether units and ammonium salts,we successfully fabricated a supramolecular polymer SPN1,which features imidazolium receptors and cyclobutane units.The obtained SPN1 demonstrates outstanding reversible stimulus-response,antibacterial behavior and conductivity.
基金Key Supported Projects of the Joint Fund of the National Natural Science Foundation of China,No.U22A20357the National Key R&D Program of China,No.2020YFC1107601the Natural Science Foundation of Hebei Province-for Distinguished Young Scholars,No.H2021206329.
文摘In recent years,perovskite has received increasing attention in the medical field.However,there has been a lack of related bibliometric analysis in this research field.This study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of perovskite.This study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science(WOS)database.The country,institution,journal,cited references,and keywords were analysed using CiteSpace,VOS viewer,and Bibliometrix software.The number of articles related to perovskite research in the medical field has been increasing every year.China and USA have published the most papers and are the main forces in this research field.The University of London Imperial College of Science,Technology,and Medicine is the most active institution and has contributed the most publications.ACS Applied Materials&Interfaces is the most prolific journal in this field.“Medical electronic devices”,“X-rays”,and“piezoelectric materials”are the most researched directions of perovskite in the medical field.“Performance”,“perovskite”,and“solar cells”are the most frequently used keywords in this field.Advanced Materials is the most relevant and academically influential journal for perovskite research.Halide perovskites have been a hot topic in this field in recent years and will be a future research trend.X-ray,electronic medical equipment,and medical stents are the main research directions.
