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Groundwater flow through fractured rocks and seepage control in geotechnical engineering: Theories and practices
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作者 Chuang-Bing Zhou yi-feng chen +1 位作者 Ran Hu Zhibing Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第1期1-36,共36页
Groundwater flow through fractured rocks has been recognized as an important issue in many geotechnical engineering practices.Several key aspects of fundamental mechanisms,numerical modeling and engineering applicatio... Groundwater flow through fractured rocks has been recognized as an important issue in many geotechnical engineering practices.Several key aspects of fundamental mechanisms,numerical modeling and engineering applications of flow in fractured rocks are discussed.First,the microscopic mechanisms of fluid flow in fractured rocks,especially under the complex conditions of non-Darcian flow,multiphase flow,rock dissolution,and particle transport,have been revealed through a com-bined effort of visualized experiments and theoretical analysis.Then,laboratory and field methods of characterizing hydraulic properties(e.g.intrinsic permeability,inertial permeability,and unsaturated flow parameters)of fractured rocks in different flow regimes have been proposed.Subsequently,high-performance numerical simulation approaches for large-scale modeling of groundwater flow in frac-tured rocks and aquifers have been developed.Numerical procedures for optimization design of seepage control systems in various settings have also been proposed.Mechanisms of coupled hydro-mechanical processes and control of flow-induced deformation have been discussed.Finally,three case studies are presented to illustrate the applications of the improved theoretical understanding,characterization methods,modeling approaches,and seepage and deformation control strategies to geotechnical engi-neering projects. 展开更多
关键词 Fractured rock Groundwater flow Flow visualization Hydraulic property Hydromechanical coupling Groundwater flow modeling Seepage control
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胸水细胞蜡块在肺癌诊断和EGFR基因检测中的应用研究 被引量:12
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作者 陈一峰 陈婷 +4 位作者 陈玮姗 姚锡虎 张坤河 李辉 苏春阳 《中国现代医学杂志》 CAS 2018年第29期43-46,共4页
目的探讨胸水细胞蜡块结合免疫组织化学染色技术在肺癌诊断和EGFR基因检测中的应用价值。方法胸水标本常规离心、涂片后,沉渣包埋制成细胞蜡块,结合免疫组织化学染色明确诊断,应用ARMS-PCR法检测175例肺腺癌EGFR基因突变情况,并与同期... 目的探讨胸水细胞蜡块结合免疫组织化学染色技术在肺癌诊断和EGFR基因检测中的应用价值。方法胸水标本常规离心、涂片后,沉渣包埋制成细胞蜡块,结合免疫组织化学染色明确诊断,应用ARMS-PCR法检测175例肺腺癌EGFR基因突变情况,并与同期活检或手术的305例肺腺癌组织块的EGFR基因突变进行对比。结果细胞蜡块结合免疫组织化学染色的癌细胞检出率高于常规涂片者(P <0.05),且不确定构成比低于后者(P <0.05)。用细胞蜡块与组织块检测EGFR基因突变的阳性率及男女构成比比较,差异无统计学意义(P>0.05)。结论胸水细胞蜡块可作为实体瘤组织的良好替代样品,有助于明确肿瘤类型、来源,并可用于肺癌的EGFR基因突变检测,有效指导其分子靶向治疗。 展开更多
关键词 细胞蜡块 肺癌 诊断 EGFR
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多技巧辅助输尿管软镜治疗复杂性肾下盏结石的临床观察 被引量:5
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作者 陈一峰 庞桂建 +3 位作者 刘成倍 庞宽 谭宝飞 欧玉祥 《中国内镜杂志》 2020年第11期84-88,共5页
目的探讨3种技巧[套石篮移位结石、B超定位下细针穿刺辅助移位结石和超微通道经皮肾镜取石术(SMP)]辅助输尿管软镜治疗复杂性肾下盏结石的有效性及安全性。方法回顾性分析2017年5月-2019年6月该科采用3种技巧辅助输尿管软镜治疗102例肾... 目的探讨3种技巧[套石篮移位结石、B超定位下细针穿刺辅助移位结石和超微通道经皮肾镜取石术(SMP)]辅助输尿管软镜治疗复杂性肾下盏结石的有效性及安全性。方法回顾性分析2017年5月-2019年6月该科采用3种技巧辅助输尿管软镜治疗102例肾下盏结石患者的临床资料。常规采用输尿管软镜无法到达的结石,使用套石篮将其转移至中上盏再碎石,套石篮难以套取的结石行B超定位下细针穿刺移位结石再碎石,以上两种方法仍难以处理者,再经细针穿刺口采用SMP。术后第1天复查腹部泌尿系X线片明确双J管情况,1个月后拔除双J管,3个月后复查CT,了解结石清除情况。通过分析术中出血量和结石清除率等指标,评估疗效。结果102例患者中,60例使用套石篮将结石转移至肾中上盏,能成功粉碎结石,13例套石篮套不到的结石,采用B超定位下细针穿刺,能成功移位并粉碎结石,29例套石篮和细针穿刺均无法移位的结石,经细针穿刺通道行SMP成功碎石。手术时间0.5~3.0 h,平均2.1 h;术后住院时间2.0~3.0 d,平均1.5 d;术中出血0~50 mL,平均12 mL;术后3个月复查CT,结石清除率为91.2%(93/102)。无输尿管撕脱、输尿管穿孔和感染性休克等严重并发症发生。结论3种技巧(套石篮移位结石、B超定位下细针穿刺移位结石和SMP)辅助输尿管软镜治疗复杂性肾下盏结石,是安全有效的。 展开更多
关键词 肾下盏结石 输尿管软镜 套石篮 经皮肾穿刺 超细经皮肾镜
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Influence of a large dam on the longitudinal patterns of fish assem- blages in Qingyi Stream 被引量:5
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作者 Xiao-Yun SUI Zhi LU +2 位作者 Yun-Zhi YAN yi-feng chen Yin-Tao JIA 《Zoological Research》 CAS CSCD 北大核心 2014年第5期362-372,共11页
Using seasonally collected data(2009-2010) from 15 sampling sites that represent first- to fifth-order streams within the Qingyi watershed,we examined the spatio-temporal patterns of fish assemblages along two longitu... Using seasonally collected data(2009-2010) from 15 sampling sites that represent first- to fifth-order streams within the Qingyi watershed,we examined the spatio-temporal patterns of fish assemblages along two longitudinal gradients to explore the effects of a large dam on fish assemblages at the watershed scale.No significant variation was observed in either species richness or assemblage structure across seasons.Species richness significantly varied according to stream order and gradient.Dam construction appeared to decrease species richness upstream substantially,while a significant decrease between gradients only occurred within fourth-order streams.Along the gradient without the large dam,fish assemblage structures presented distinct separation between two neighboring stream orders,with the exception of fourth-order versus fifth-order streams.However,the gradient disrupted by a large dam displayed the opposite pattern in the spatial variation of fish assemblages related with stream orders.Significant between-gradient differences in fish assemblage structures were only observed within fourth-order streams.Species distributions were determined by local habitat environmental factors,including elevation,substrate,water depth,current discharge,wetted width,and conductivity.Our results suggested that dam construction might alter the longitudinal pattern in fish species richness and assemblage structure in Qingyi Stream,despite the localized nature of the ecological effect of dams. 展开更多
关键词 鱼类群落 水坝 江流 物种丰富度 大坝建设 流域尺度 组合结构 群落结构
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Modeling unsaturated flow in fractured rocks with scaling relationships between hydraulic parameters 被引量:4
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作者 yi-feng chen Yuke Ye +2 位作者 Ran Hu Zhibing Yang Chuang-Bing Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第6期1697-1709,共13页
Modeling unsaturated flow in fractured rocks is essential in various subsurface engineering applications,but it remains a great challenge due to the difficulties in determining the unsaturated hydraulic properties of ... Modeling unsaturated flow in fractured rocks is essential in various subsurface engineering applications,but it remains a great challenge due to the difficulties in determining the unsaturated hydraulic properties of rocks that contain various scales of fractures.It is generally accepted that the van Genuchten(VG)model can be applied to fractured rocks,provided that the hydraulic parameters could be representatively determined.In this study,scaling relationships between the VG parameters(a and n)and hydraulic conductivity(K)across 8 orders of magnitude,from 10^(-10)m/s to 10^(-2)m/s,were proposed by statistical analysis of data obtained from 1416 soil samples.The correlations were then generalized to predict the upper bounds of VG parameters for fractured rocks from the K data that could be obtained more easily under field conditions,and were validated against a limited set of data from cores,fractures and fractured rocks available in the literature.The upper bound estimates significantly narrow the ranges of VG parameters,and the representative values of a and n for fractured rocks at the field scale can then be determined with confidence by inverse modeling using groundwater observations in saturated zones.The proposed methodology was applied to saturated-unsaturated flow modeling in the right-bank slope at the Baihetan dam site with a continuum approach,showing that most of the flow behaviors in fractured rocks in this complex hydrogeological condition could be properly reproduced.The proposed method overcomes difficulties in suction measurement in fractured rocks with strong heterogeneity,and provides a feasible way for modeling of saturated-unsaturated flow in fractured rocks with acceptable engineering accuracy. 展开更多
关键词 Unsaturated flow van genuchten model Hydraulic properties Fractured rocks Continuum approach
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Variation in hydraulic conductivity of fractured rocks at a dam foundation during operation 被引量:3
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作者 yi-feng chen Jun Zeng +4 位作者 Hongtao Shi Yifan Wang Ran Hu Zhibing Yang Chuang-Bing Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2021年第2期351-367,共17页
Characterizing the permeability variation in fractured rocks is important in various subsurface applications,but how the permeability evolves in the foundation rocks of high dams during operation remains poorly unders... Characterizing the permeability variation in fractured rocks is important in various subsurface applications,but how the permeability evolves in the foundation rocks of high dams during operation remains poorly understood.This permeability change is commonly evidenced by a continuous decrease in the amount of discharge(especially for dams on sediment-laden rivers),and can be attributed to fracture clogging and/or hydromechanical coupling.In this study,the permeability evolution of fractured rocks at a high arch dam foundation during operationwas evaluated by inverse modeling based on the field timeseries data of both pore pressure and discharge.A procedure combining orthogonal design,transient flow modeling,artificial neural network,and genetic algorithm was adopted to efficiently estimate the hydraulic conductivity values in each annual cycle after initial reservoir filling.The inverse results show that the permeability of the dam foundation rocks follows an exponential decay annually during operation(i.e.K/K0=0.97e^(-0.59t)+0.03),with good agreement between field observations and numerical simulations.The significance of the obtained permeability decay function was manifested by an assessment of the long-term seepage control performance and groundwater flow behaviors at the dam site.The proposed formula is also of merit for characterizing the permeability change in riverbed rocks induced by sediment transport and deposition. 展开更多
关键词 Permeability variation Fractured rock Fracture clogging Seepage control Dam engineering
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