Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluor...Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as autophagy.Subsequently,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic acid.Results:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell autophagy.It also targeted PTP1B and lowered PTP1B expression.However,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD cells.Conclusions:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.展开更多
The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate change.However,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are sti...The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate change.However,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still unclear.In this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to 2018.We found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after 2003.The interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea ice.In the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake Baikal.Two wave trains originating over the Barents-Kara Sea can be observed.The southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the TP.Negative HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the TPEP.The northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly distribution.Positive HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the region.When the SIC in the Barents-Kara Sea increases,the situation is opposite.The above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.展开更多
Owing to the scarcity of observation data in the western Tibetan Plateau(TP),the knowledge of precipitation changes over the entire plateau based only on the limited data in eastern TP is not reliable.Therefore,the al...Owing to the scarcity of observation data in the western Tibetan Plateau(TP),the knowledge of precipitation changes over the entire plateau based only on the limited data in eastern TP is not reliable.Therefore,the alternative high-resolution precipitation data of the China Meteorological Forcing Dataset(CMFD)are used for the comprehensive analysis of precipitation changes over the whole TP(including western and northern TP)to fill in the lack of understanding of precipitation in the western TP.Compared with observations,CMFD can broadly capture the spatial distributions and identify the temporal variabilities of precipitation over the TP.Results with CMFD data suggested that the annual precipitation over the whole TP did not show a uniform humidification trend in 1979-2018 and featured wetting and drying trends in the northern(NTP)and southern TP(STP),respectively.Additionally,the four seasonal regimes of precipitation over the northern TP(NTP,including most areas of western TP)all experienced a noticeable interdecadal shift around the late 1990s,followed by above-normal precipitation.Except for spring,the seasonal precipitation over the southern TP(STP)showed interannual variations.Spring precipitation over the STP has undergone moistening since the late 1990s,which was consistent with that over the NTP.Four different reanalysis datasets,namely JRA55,MERRA2,ERA5 and CRA40,were used to compare the water vapour budget of each boundary over the TP.The increase in spring precipitation over the NTP and STP was found to be related to the decrease in water vapour outflow from the north boundary.The interdecadal increase in summer precipitation over the NTP was mainly due to the reduction of outflow from the east boundary.Finally,the increase in autumn precipitation was related to the increase in inflow from the west boundary.展开更多
High temperature and high humidity pose notable threats to the health and survival of humans,and the impact of compound extreme events involving multiple meteorological elements is usually greater than the sum of the ...High temperature and high humidity pose notable threats to the health and survival of humans,and the impact of compound extreme events involving multiple meteorological elements is usually greater than the sum of the impacts of individual extreme events.However,there is limited research on the compound extreme meteorological events,defined based on the extreme of health risks rather than just the extreme of meteoro-logical elements,necessitating further investigation into their characteristics and underlying driving factors.Using daily records of emergency ambulance dispatches from selected Chinese cities,together with daily average temperature and relative humidity data,this study identified and quantified warm-wet compound extreme events with high health risks(HRWWs)that occurred in southern China during 1979-2022.Results revealed that HRWWs were most prevalent in the coastal region of southern China.The annual frequency of HRWWs across China underwent a marked shift in 2014,with the rapid increase in recent years primarily contributed by the increase in summer HRWWs and advance and extension of the period of occurrence of HRWWs in summer.Further analysis indicated that the changes in HRWWs in southern China during summer were primarily regulated by the EIl Nino-Southern Oscillation(ENSO)of the preceding winter and the springtime Indian Ocean basin-wide(IOBW)mode.El Nino and Indian Ocean warming force a reverse Walker circulation in the tropical Indian Ocean-western Pacific,strengthening the Philippine anticyclone(PAC)in summer.This weakens convection in the northwestern Pacific and enables the western Pacific subtropical high to extend westward over coastal areas of southern China.The resulting abnormal atmospheric circulation causes prevailing subsidence over southern China,which is unfavorable for precipitation but conducive to maintaining high surface temperatures.Despite reduced precipitation,water vapor flux is increased owing to strengthened southwesterlies associated with the PAC that enhance regional humidity.Consequently,as temperature and humidity levels rise,HRWWs occur more frequently in southern China,as evidenced since 2014.Further analysis suggested that the contribution of intensification of IOBW warming to the sudden increase in HRWW occurrence over the past decade has been greater than that of ENSO.展开更多
The changes in near-surface wind speed(NWS)have a crucial influence on the wind power industry,and previous studies have indicated that NWS on global and China has declined continuously for decades under global warmin...The changes in near-surface wind speed(NWS)have a crucial influence on the wind power industry,and previous studies have indicated that NWS on global and China has declined continuously for decades under global warming.However,recently,the decreasing trend of global NWS has slowed down and even showed a recovery trend.Using the observation data of 831 weather stations of the China Meteorological Administration and the Japanese 55-year reanalysis data from 1970 to 2019,NWS changes in eastern China were analyzed and the possible influencing factors were discussed.Results show that winter NWS presented a decreasing trend from−0.29 m s^(−1) per decade(p<0.001)in 1970-1989 to−0.05 m s^(−1) per decade(p<0.01)in 1990-2019.Moreover,NWS exhibited a significant upward trend of 0.18 m s^(−1) per decade(p<0.1)in 2011-2019,resulting in a 19.6%per decade recovery of the wind power generation.A possible cause is asymmetric changes of the sea level pressure and near-surface air temperature differences between the mid-high latitudes(40°-60°N,80°-120°E)and low latitudes(20°-40°N,110°-140°E)altered the horizontal air pressure gradient.Furthermore,NWS changes were closely associated with the large-scale ocean-atmosphere circulations(LOACs).NWS at 77.4%of the stations in eastern China shows significant correlation(p<0.05)with the East Asian winter monsoon index,besides,the inter/multidecadal variability of NWS was considerably correlated to four LOACs,including Arctic oscillation(AO),North Atlantic oscillation(NAO),Pacific decadal oscillation(PDO),and El Niño-Southern Oscillation(ENSO).The time-series reconstructed by a multiple linear regression model based on above five LOACs matches well with the NWS.Interannual variability of NWS were significantly correlated to AO(−0.45,p<0.01)and NAO(−0.28,p<0.05),while the correlation between NWS and ENSO was weak.展开更多
It is of practical significance to use the updated Coupled Model Intercomparison Project Phase 6(CMIP6)models to study the impact of changes in land‒sea thermodynamic contrast(TC)on the Asian summer monsoon under diff...It is of practical significance to use the updated Coupled Model Intercomparison Project Phase 6(CMIP6)models to study the impact of changes in land‒sea thermodynamic contrast(TC)on the Asian summer monsoon under different scenarios and to compare the similarities and differences of the impact mechanisms between different monsoon regions.In this study,we investigated future changes of the Asian summer monsoon under four Shared Socioeconomic Pathway(SSP)scenarios using 19 CMIP6 models.The intensity of the South Asian summer monsoon(SASM)is projected to decrease by 2.6%,6.3%,10.1%,and 11.1%,while the East Asian summer monsoon(EASM)intensity is projected to increase by 4.6%,7.9%,7.4%,and 9.8%until the end of the 21st century for SSP126,SSP245,SSP370,and SSP585 scenarios,respectively.Moreover,summer precipitation in Asia is projected to increase remarkably in 2015-2099 under all four scenarios.The inconsistent warming trends over the Tibetan Plateau(TP),Northwest Pacific,and tropical Indian Ocean would greatly impact the monsoon circulations.The upper-troposphere warming trend over the surrounding oceans is remarkably greater than that over the TP,while the near-surface warming trend over the surrounding oceans is smaller than that over the TP.The decrease of upper-troposphere TC between the TP and tropical Indian Ocean results in a weakening of the SASM circulation.The enhancement of the lower-troposphere TC between the TP and Northwest Pacific would strengthen the EASM circulation.Moisture budget analysis shows that the water-vapor would increase in the future,which would thermodynamically enhance summer precipitation through the anomalous vertical moisture transport associated with mean flow.The strengthening of the meridional circulation of the EASM would increase monsoon precipitation,while the weakening of zonal circulation of the SASM would dynamically reduce South Asian summer precipitation.展开更多
基金supported by the Zhejiang Province Traditional Chinese Medicine Health Science and Technology Program(2023ZL570).
文摘Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying mechanism.Methods:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as autophagy.Subsequently,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic acid.Results:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell autophagy.It also targeted PTP1B and lowered PTP1B expression.However,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD cells.Conclusions:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program of China (2019QZKK0208)the National Key Research and Development Program of China (2022YFE0136000,2023YFF0805104)+2 种基金the National Natural Science Foundation of China (U2242207,42305018,42105037)the Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies (2020B1212060025)the Innovative Development Special Project of China Meteorological Administration (CXFZ2022J039,CXFZ2023J003).
文摘The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate change.However,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still unclear.In this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to 2018.We found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after 2003.The interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea ice.In the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake Baikal.Two wave trains originating over the Barents-Kara Sea can be observed.The southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the TP.Negative HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the TPEP.The northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly distribution.Positive HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the region.When the SIC in the Barents-Kara Sea increases,the situation is opposite.The above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research(STEP)programme(2019QZKK0102 and 2019QZKK0208)China Three Gorges Corporation(0704181)+1 种基金Innovation and development special project of China Meteorological Administration(CXFZ 2022J039)Key Innovation Team of China Meteorological Administration Climate Change Detection,Impact and Response(CMA2022ZD03).
文摘Owing to the scarcity of observation data in the western Tibetan Plateau(TP),the knowledge of precipitation changes over the entire plateau based only on the limited data in eastern TP is not reliable.Therefore,the alternative high-resolution precipitation data of the China Meteorological Forcing Dataset(CMFD)are used for the comprehensive analysis of precipitation changes over the whole TP(including western and northern TP)to fill in the lack of understanding of precipitation in the western TP.Compared with observations,CMFD can broadly capture the spatial distributions and identify the temporal variabilities of precipitation over the TP.Results with CMFD data suggested that the annual precipitation over the whole TP did not show a uniform humidification trend in 1979-2018 and featured wetting and drying trends in the northern(NTP)and southern TP(STP),respectively.Additionally,the four seasonal regimes of precipitation over the northern TP(NTP,including most areas of western TP)all experienced a noticeable interdecadal shift around the late 1990s,followed by above-normal precipitation.Except for spring,the seasonal precipitation over the southern TP(STP)showed interannual variations.Spring precipitation over the STP has undergone moistening since the late 1990s,which was consistent with that over the NTP.Four different reanalysis datasets,namely JRA55,MERRA2,ERA5 and CRA40,were used to compare the water vapour budget of each boundary over the TP.The increase in spring precipitation over the NTP and STP was found to be related to the decrease in water vapour outflow from the north boundary.The interdecadal increase in summer precipitation over the NTP was mainly due to the reduction of outflow from the east boundary.Finally,the increase in autumn precipitation was related to the increase in inflow from the west boundary.
基金supported by Guangdong Major Project of Basic and Applied Basic Research (2020B0301030004)the National Natural Science Foundation of China (42075040)+2 种基金Key Innovation Team of China Meteorological Administration (CMA2022ZD03)the National Natural Science Foundation of China under (41930967)the National Key Research and Development Program of China (2018YFA0606203).
文摘High temperature and high humidity pose notable threats to the health and survival of humans,and the impact of compound extreme events involving multiple meteorological elements is usually greater than the sum of the impacts of individual extreme events.However,there is limited research on the compound extreme meteorological events,defined based on the extreme of health risks rather than just the extreme of meteoro-logical elements,necessitating further investigation into their characteristics and underlying driving factors.Using daily records of emergency ambulance dispatches from selected Chinese cities,together with daily average temperature and relative humidity data,this study identified and quantified warm-wet compound extreme events with high health risks(HRWWs)that occurred in southern China during 1979-2022.Results revealed that HRWWs were most prevalent in the coastal region of southern China.The annual frequency of HRWWs across China underwent a marked shift in 2014,with the rapid increase in recent years primarily contributed by the increase in summer HRWWs and advance and extension of the period of occurrence of HRWWs in summer.Further analysis indicated that the changes in HRWWs in southern China during summer were primarily regulated by the EIl Nino-Southern Oscillation(ENSO)of the preceding winter and the springtime Indian Ocean basin-wide(IOBW)mode.El Nino and Indian Ocean warming force a reverse Walker circulation in the tropical Indian Ocean-western Pacific,strengthening the Philippine anticyclone(PAC)in summer.This weakens convection in the northwestern Pacific and enables the western Pacific subtropical high to extend westward over coastal areas of southern China.The resulting abnormal atmospheric circulation causes prevailing subsidence over southern China,which is unfavorable for precipitation but conducive to maintaining high surface temperatures.Despite reduced precipitation,water vapor flux is increased owing to strengthened southwesterlies associated with the PAC that enhance regional humidity.Consequently,as temperature and humidity levels rise,HRWWs occur more frequently in southern China,as evidenced since 2014.Further analysis suggested that the contribution of intensification of IOBW warming to the sudden increase in HRWW occurrence over the past decade has been greater than that of ENSO.
基金sponsored by the National Natural Science Foundation of China(41790471)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA20100304).
文摘The changes in near-surface wind speed(NWS)have a crucial influence on the wind power industry,and previous studies have indicated that NWS on global and China has declined continuously for decades under global warming.However,recently,the decreasing trend of global NWS has slowed down and even showed a recovery trend.Using the observation data of 831 weather stations of the China Meteorological Administration and the Japanese 55-year reanalysis data from 1970 to 2019,NWS changes in eastern China were analyzed and the possible influencing factors were discussed.Results show that winter NWS presented a decreasing trend from−0.29 m s^(−1) per decade(p<0.001)in 1970-1989 to−0.05 m s^(−1) per decade(p<0.01)in 1990-2019.Moreover,NWS exhibited a significant upward trend of 0.18 m s^(−1) per decade(p<0.1)in 2011-2019,resulting in a 19.6%per decade recovery of the wind power generation.A possible cause is asymmetric changes of the sea level pressure and near-surface air temperature differences between the mid-high latitudes(40°-60°N,80°-120°E)and low latitudes(20°-40°N,110°-140°E)altered the horizontal air pressure gradient.Furthermore,NWS changes were closely associated with the large-scale ocean-atmosphere circulations(LOACs).NWS at 77.4%of the stations in eastern China shows significant correlation(p<0.05)with the East Asian winter monsoon index,besides,the inter/multidecadal variability of NWS was considerably correlated to four LOACs,including Arctic oscillation(AO),North Atlantic oscillation(NAO),Pacific decadal oscillation(PDO),and El Niño-Southern Oscillation(ENSO).The time-series reconstructed by a multiple linear regression model based on above five LOACs matches well with the NWS.Interannual variability of NWS were significantly correlated to AO(−0.45,p<0.01)and NAO(−0.28,p<0.05),while the correlation between NWS and ENSO was weak.
基金funded by the Second Tibetan Plateau Scientific Expedition and Research Program of China(2019QZKK0208)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA20100304)+1 种基金the National Natural Science Foundation of China(41790471)the National Key Research and Development Program of China(2016YFA0602200,2019YFC1510400).
文摘It is of practical significance to use the updated Coupled Model Intercomparison Project Phase 6(CMIP6)models to study the impact of changes in land‒sea thermodynamic contrast(TC)on the Asian summer monsoon under different scenarios and to compare the similarities and differences of the impact mechanisms between different monsoon regions.In this study,we investigated future changes of the Asian summer monsoon under four Shared Socioeconomic Pathway(SSP)scenarios using 19 CMIP6 models.The intensity of the South Asian summer monsoon(SASM)is projected to decrease by 2.6%,6.3%,10.1%,and 11.1%,while the East Asian summer monsoon(EASM)intensity is projected to increase by 4.6%,7.9%,7.4%,and 9.8%until the end of the 21st century for SSP126,SSP245,SSP370,and SSP585 scenarios,respectively.Moreover,summer precipitation in Asia is projected to increase remarkably in 2015-2099 under all four scenarios.The inconsistent warming trends over the Tibetan Plateau(TP),Northwest Pacific,and tropical Indian Ocean would greatly impact the monsoon circulations.The upper-troposphere warming trend over the surrounding oceans is remarkably greater than that over the TP,while the near-surface warming trend over the surrounding oceans is smaller than that over the TP.The decrease of upper-troposphere TC between the TP and tropical Indian Ocean results in a weakening of the SASM circulation.The enhancement of the lower-troposphere TC between the TP and Northwest Pacific would strengthen the EASM circulation.Moisture budget analysis shows that the water-vapor would increase in the future,which would thermodynamically enhance summer precipitation through the anomalous vertical moisture transport associated with mean flow.The strengthening of the meridional circulation of the EASM would increase monsoon precipitation,while the weakening of zonal circulation of the SASM would dynamically reduce South Asian summer precipitation.
