A novel Mg-Al LDH film was in-situ prepared hydrothermally in an alkaline aqueous solution on an Al-alloyed AZ31 substrate.The structural,chemical and functional characteristics of the film were explored by means of s...A novel Mg-Al LDH film was in-situ prepared hydrothermally in an alkaline aqueous solution on an Al-alloyed AZ31 substrate.The structural,chemical and functional characteristics of the film were explored by means of scanning electron microscope(SEM),X-ray diffraction(XRD),energy dispersive spectrometer(EDS),polarization curve,AC impedance and salt immersion tests,respectively.The anti-corrosion results indicated that the Mg-Al LDH film on the Al-alloyed AZ31 surface could effectively protect the AZ31 from corrosion attack even after 90 days of immersion in 3.5 wt.%NaCl solution.The protection performance is surprisingly better than most of the reported coatings on Mg alloys.More interestingly,when the Mg-Al LDH film was scratched,the exposed Al-alloyed surface might gradually release metal ions and re-generate dense LDH nano-sheets in the corrosive environment to inhibit the further corrosion there,exhibiting a self-repairing behavior.The combination of the benign long-term protection and desirable self-repairing performance in this new process of surface-alloying and LDH-formation may significantly extend the practical application of magnesium alloys.展开更多
AIM:To identify and analyze the genotype of the patients with special ocular manifestations of familial vitreous amyloidosis(FVA)in a Chinese Han family.METHODS:Pars plana vitrectomy(PPV)surgery was performed on a 52-...AIM:To identify and analyze the genotype of the patients with special ocular manifestations of familial vitreous amyloidosis(FVA)in a Chinese Han family.METHODS:Pars plana vitrectomy(PPV)surgery was performed on a 52-year-old Chinese woman presented with vitreous amyloidosis and progressive visual impairment,without evidence of cardiac,renal,gastrointestinal,central nervous system or peripheral nervous system dysfunction.During the surgery,the patient presented with a gray-white dense and thick cotton woollike change in the vitreous body,accompanied by complete retinal detachment.Additionally,hard,free and movable yellow-white deposits were observed in the posterior pole and surrounding retina,the vitreous and subretinal deposits were examined by Congo red staining and immunohistochemical pathological examination,and whole exome sequencing was performed on blood samples from the patient and her cousin.RESULTS:During the operation,it was discovered that there was a complete detachment of the retina and a significant amount of hard,free-floating yellow-white deposits were observed beneath the posterior pole and surrounding retina.This is an exceedingly rare ocular manifestation.Pathological examination of the vitreous and subretinal deposit specimens revealed positive Congo red staining,as well as elevated vascular endothelial growth factor(VEGF)expression in vascular endothelial cells within the sediment specimens upon immunohistochemical examination.The patient and her cousin both exhibited a heterozygous mutation in Glyl03Arg within the transthyretin(TTR)gene,resulting in a substitution of glycine(Gly)at position 103 with arginine(Arg).CONCLUSION:FVA may present with various ocular manifestations,but panretinal detachment is a rare occurrence.In cases where retinal detachment persists for an extended period of time,amyloid deposits may form under the retina through retinal tears,leading to subretinal deposits that can impede retinal reattachment and negatively impact visual prognosis.Elevated levels of VEGF in the eyes of FVA patients may indicate an overexpression state,necessitating careful postoperative follow-up.The heterozygous mutation Gly103Arg may represent a unique pathogenic site in Chinese individuals.展开更多
Layered double hydroxides(LDHs),a class of two-dimensional(2D)brucite-like layers,have been effectively applied in diverse fields.However,the current synthesis methods restrict the in situ scaling-up and tunable produ...Layered double hydroxides(LDHs),a class of two-dimensional(2D)brucite-like layers,have been effectively applied in diverse fields.However,the current synthesis methods restrict the in situ scaling-up and tunable production of LDH-based materials.Inspired by the growing characteristic of“Bryophyllum pinnatum”,a sacrificial co-sputtered Zn-Al transition layer was introduced for the first time to in situ grow a scalable-manufactured and thickness-controllable LDH film on arbitrary substrate materials with flexible shapes through“partial dissolution”and“solution infiltration”processes.Diverse LDH films could be tailored by the creative regulation of the component,structure and surface state of the transition layer.Results showed that the as-prepared LDH film had strong mechanical robustness under harsh abrasion conditions due to its large thickness and multi-level microstructure.Moreover,a series of galvanic couple model experiments based on Zn/Al single-metal transition layers were designed to solve the real-time monitoring issue in the complex hydrothermal solution.This work not only develops a new strategy to design and grow in situ LDH films with multifaceted features,but also reveals sophisticated LDH formation mechanisms.Hence,the findings of this study may broaden the practical application of LDH-based materials toward advanced and smart devices.展开更多
基金The research is supported by the National Science Foundation of China(key project grant No.51731008 and general project grant No.51671163).
文摘A novel Mg-Al LDH film was in-situ prepared hydrothermally in an alkaline aqueous solution on an Al-alloyed AZ31 substrate.The structural,chemical and functional characteristics of the film were explored by means of scanning electron microscope(SEM),X-ray diffraction(XRD),energy dispersive spectrometer(EDS),polarization curve,AC impedance and salt immersion tests,respectively.The anti-corrosion results indicated that the Mg-Al LDH film on the Al-alloyed AZ31 surface could effectively protect the AZ31 from corrosion attack even after 90 days of immersion in 3.5 wt.%NaCl solution.The protection performance is surprisingly better than most of the reported coatings on Mg alloys.More interestingly,when the Mg-Al LDH film was scratched,the exposed Al-alloyed surface might gradually release metal ions and re-generate dense LDH nano-sheets in the corrosive environment to inhibit the further corrosion there,exhibiting a self-repairing behavior.The combination of the benign long-term protection and desirable self-repairing performance in this new process of surface-alloying and LDH-formation may significantly extend the practical application of magnesium alloys.
基金Supported by Zhejiang Provincial Health Science and Technology Program of Traditional Chinese Medicine(No.2021ZB284,No.2023ZR053)Science and Technology Bureau of Jiaxing City(No.2021AY30007,No.2021AY30008)Jiaxing Key Laboratory of Diabetic Angiopathy Research(No.2019ZDSYS)。
文摘AIM:To identify and analyze the genotype of the patients with special ocular manifestations of familial vitreous amyloidosis(FVA)in a Chinese Han family.METHODS:Pars plana vitrectomy(PPV)surgery was performed on a 52-year-old Chinese woman presented with vitreous amyloidosis and progressive visual impairment,without evidence of cardiac,renal,gastrointestinal,central nervous system or peripheral nervous system dysfunction.During the surgery,the patient presented with a gray-white dense and thick cotton woollike change in the vitreous body,accompanied by complete retinal detachment.Additionally,hard,free and movable yellow-white deposits were observed in the posterior pole and surrounding retina,the vitreous and subretinal deposits were examined by Congo red staining and immunohistochemical pathological examination,and whole exome sequencing was performed on blood samples from the patient and her cousin.RESULTS:During the operation,it was discovered that there was a complete detachment of the retina and a significant amount of hard,free-floating yellow-white deposits were observed beneath the posterior pole and surrounding retina.This is an exceedingly rare ocular manifestation.Pathological examination of the vitreous and subretinal deposit specimens revealed positive Congo red staining,as well as elevated vascular endothelial growth factor(VEGF)expression in vascular endothelial cells within the sediment specimens upon immunohistochemical examination.The patient and her cousin both exhibited a heterozygous mutation in Glyl03Arg within the transthyretin(TTR)gene,resulting in a substitution of glycine(Gly)at position 103 with arginine(Arg).CONCLUSION:FVA may present with various ocular manifestations,but panretinal detachment is a rare occurrence.In cases where retinal detachment persists for an extended period of time,amyloid deposits may form under the retina through retinal tears,leading to subretinal deposits that can impede retinal reattachment and negatively impact visual prognosis.Elevated levels of VEGF in the eyes of FVA patients may indicate an overexpression state,necessitating careful postoperative follow-up.The heterozygous mutation Gly103Arg may represent a unique pathogenic site in Chinese individuals.
基金supported by the National Natural Science Foundation of China(51731008 and 51671163)China Scholarship Council for providing support(202006310139)。
文摘Layered double hydroxides(LDHs),a class of two-dimensional(2D)brucite-like layers,have been effectively applied in diverse fields.However,the current synthesis methods restrict the in situ scaling-up and tunable production of LDH-based materials.Inspired by the growing characteristic of“Bryophyllum pinnatum”,a sacrificial co-sputtered Zn-Al transition layer was introduced for the first time to in situ grow a scalable-manufactured and thickness-controllable LDH film on arbitrary substrate materials with flexible shapes through“partial dissolution”and“solution infiltration”processes.Diverse LDH films could be tailored by the creative regulation of the component,structure and surface state of the transition layer.Results showed that the as-prepared LDH film had strong mechanical robustness under harsh abrasion conditions due to its large thickness and multi-level microstructure.Moreover,a series of galvanic couple model experiments based on Zn/Al single-metal transition layers were designed to solve the real-time monitoring issue in the complex hydrothermal solution.This work not only develops a new strategy to design and grow in situ LDH films with multifaceted features,but also reveals sophisticated LDH formation mechanisms.Hence,the findings of this study may broaden the practical application of LDH-based materials toward advanced and smart devices.
