The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used ...The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector geometry.This paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation framework.The geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV level.The overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.展开更多
Objective To investigate the efficacy of hematopoietic stem cell （HSC） transplantation via the hepatic artery vs. the portal vein for end-stage liver disease （ESLD）. Methods Patients with hepatic decompensation w...Objective To investigate the efficacy of hematopoietic stem cell （HSC） transplantation via the hepatic artery vs. the portal vein for end-stage liver disease （ESLD）. Methods Patients with hepatic decompensation were prospectively recruited from September 2010 to September 2012 to receive HSC transplantation via the hepatic artery or the portal vein. Liver function was examined at 3, 6, and 12 months after transplantation. Liver biopsy results were analyzed using the Knodell score. Results Eighty patients （58 males and 22 females） were enrolled in the study. The Child-Pugh score was grade B in 69 cases, and grade C in the remaining 11 cases. HSC transplantation was performed via the portal vein in 36 patients and via the hepatic artery in 44 patients. ALT levels decreased while serum albumin levels increased significantly in both groups at 6 and 12 months after HSC transplantation （P〈0.05 compared with pre-transplantation levels）. Total biliruhin levels decreased significandy in both groups at 3, 6, and 12 months after HSC transplantation （P〈0.05 compared with pre-transplantation levels）. Additionally, prothromhin time decreased in both groups at 12 months after HSC transplantation （P〈0.05 compared with pre-transplantation level）. There were no significant differences in ALT, total bilirubin and prothromhin time between the two groups either before or after transplantation. Moreover, Knodell score decreased significantly at 6 and 12 months. Histological examination showed that liver cell edema, degeneration, necrosis, and inflammation were significantly relieved at 3, 6, and 12 months after transplantation. The incidence of portal vein thrombosis, upper gastrointestinal bleeding, and hepatic encephalopathy were 1.25%, 3.75%, and 2.5% respectively. The one-year survival rate was 100%. Conclusions Autologous HSC transplantation improves liver function and histology in ESLD patients The administration route of HSC has no significant impact on the efficacy of transplantation.展开更多
Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary ap...Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.展开更多
Invisibility or unhearability cloaks have been made possible by using metamaterials enabling light or sound to fow around obstacle without the trace of refections or shadows.Metamaterials are known for being fexible b...Invisibility or unhearability cloaks have been made possible by using metamaterials enabling light or sound to fow around obstacle without the trace of refections or shadows.Metamaterials are known for being fexible building units that can mimic a host of unusual and extreme material responses,which are essential when engineering artifcial material properties to realize a coordinate transforming cloak.Bending and stretching the coordinate grid in space require stringent material parameters;therefore,small inaccuracies and inevitable material losses become sources for unwanted scattering that are decremental to the desired efect.Tese obstacles further limit the possibility of achieving a robust concealment of sizeable objects from either radar or sonar detection.By using an elaborate arrangement of gain and lossy acoustic media respecting parity-time symmetry,we built a one-way unhearability cloak able to hide objects seven times larger than the acoustic wavelength.Generally speaking,our approach has no limits in terms of working frequency,shape,or size,specifcally though we demonstrate how,in principle,an object of the size of a human can be hidden from audible sound.展开更多
In this letter,we propose a novel three-dimensional conceptual model for an emerging service-oriented simulation paradigm. The model can be used as a guideline or an analytic means to find the potential and possible f...In this letter,we propose a novel three-dimensional conceptual model for an emerging service-oriented simulation paradigm. The model can be used as a guideline or an analytic means to find the potential and possible future directions of the current simulation frameworks. In particular, the model inspects the crossover between the disciplines of modeling and simulation, service-orientation,and software/systems engineering. Finally, two specific simulation frameworks are studied as examples.展开更多
Integrated photonic quantum circuits(IPQCs)have attracted increasing attention in recent years due to their widespread applications in quantum information science.While the most envisioned quantum technologies such as...Integrated photonic quantum circuits(IPQCs)have attracted increasing attention in recent years due to their widespread applications in quantum information science.While the most envisioned quantum technologies such as quantum communications,quantum computer and quantum simulations have placed a strict constraint on the scalability of chip-integrated quantum light sources.By introducing sizeconfined nanostructures or crystal imperfections,low-dimensional semiconductors have been broadly explored as chip-scale deterministic single-photon sources(SPSs).Thus far a variety of chip-integrated deterministic SPSs have been investigated across both monolithic and hybrid photonic platforms,including molecules,quantum dots,color centers and two-dimensional materials.With the rapid development of the chip-scale generation of single photons with deterministic quantum emitters,the field of IPQCs has raised new challenges and opportunities.In this paper,we highlight recent progress in the development of waveguide-coupled deterministic SPSs towards scalable IPQCs,and review the post-growth tuning techniques that are specifically developed to engineer the optical properties of these WG-coupled SPSs.Future prospects on stringent requirement for the quantum engineering toolbox in the burgeoning field of integrated photonics are also discussed.展开更多
基金supported by National Key R&D Program of China(Nos.2023YFA1606904 and 2023YFA1606900)National Natural Science Foundation of China(No.12150006)Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(No.21TQ1400209).
文摘The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector geometry.This paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation framework.The geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV level.The overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.
基金Supported by the Science&Technology Department of Sichuan Province(2010FZ0098,2011HH0022)Chengdu Bureau of Science and Technology(10GGYB883SF)the Scientific Research Foundation of the Health Department of Sichuan Province(100487,100489)
文摘Objective To investigate the efficacy of hematopoietic stem cell （HSC） transplantation via the hepatic artery vs. the portal vein for end-stage liver disease （ESLD）. Methods Patients with hepatic decompensation were prospectively recruited from September 2010 to September 2012 to receive HSC transplantation via the hepatic artery or the portal vein. Liver function was examined at 3, 6, and 12 months after transplantation. Liver biopsy results were analyzed using the Knodell score. Results Eighty patients （58 males and 22 females） were enrolled in the study. The Child-Pugh score was grade B in 69 cases, and grade C in the remaining 11 cases. HSC transplantation was performed via the portal vein in 36 patients and via the hepatic artery in 44 patients. ALT levels decreased while serum albumin levels increased significantly in both groups at 6 and 12 months after HSC transplantation （P〈0.05 compared with pre-transplantation levels）. Total biliruhin levels decreased significandy in both groups at 3, 6, and 12 months after HSC transplantation （P〈0.05 compared with pre-transplantation levels）. Additionally, prothromhin time decreased in both groups at 12 months after HSC transplantation （P〈0.05 compared with pre-transplantation level）. There were no significant differences in ALT, total bilirubin and prothromhin time between the two groups either before or after transplantation. Moreover, Knodell score decreased significantly at 6 and 12 months. Histological examination showed that liver cell edema, degeneration, necrosis, and inflammation were significantly relieved at 3, 6, and 12 months after transplantation. The incidence of portal vein thrombosis, upper gastrointestinal bleeding, and hepatic encephalopathy were 1.25%, 3.75%, and 2.5% respectively. The one-year survival rate was 100%. Conclusions Autologous HSC transplantation improves liver function and histology in ESLD patients The administration route of HSC has no significant impact on the efficacy of transplantation.
基金supported by the National Natural Science Foundation of China(Grant No.12150006)Shanghai Pilot Program for Basic Research—Shanghai Jiao Tong University(Grant No.21TQ1400209)。
文摘Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.
基金This work was supported by the National Key R&D Program of China(Grant No.2017YFA0303700)the National Natural Science Foundation of China(Grant No.11634006)+2 种基金the Innovation Special Zone of National Defense Science and Technology.Te authors would like to thank Prof.Jing Lu and Prof.Jian-cheng Tao for fruitful discussions.Daniel Torrent acknowledges the support from the MINECO through a Ramon y Cajal grant(Grant no.RYC-2016-21188)Johan Christensen acknowledges the support from the European Research Council(ERC)through the Starting Grant no.714577 PHONOMETA and from the MINECO through a Ramon y Cajal grant(Grant no.RYC-2015-17156)Johan Christensen would like to thank Romain Fleury and Andrea Alu for helpful suggestions and stimulating discussions.
文摘Invisibility or unhearability cloaks have been made possible by using metamaterials enabling light or sound to fow around obstacle without the trace of refections or shadows.Metamaterials are known for being fexible building units that can mimic a host of unusual and extreme material responses,which are essential when engineering artifcial material properties to realize a coordinate transforming cloak.Bending and stretching the coordinate grid in space require stringent material parameters;therefore,small inaccuracies and inevitable material losses become sources for unwanted scattering that are decremental to the desired efect.Tese obstacles further limit the possibility of achieving a robust concealment of sizeable objects from either radar or sonar detection.By using an elaborate arrangement of gain and lossy acoustic media respecting parity-time symmetry,we built a one-way unhearability cloak able to hide objects seven times larger than the acoustic wavelength.Generally speaking,our approach has no limits in terms of working frequency,shape,or size,specifcally though we demonstrate how,in principle,an object of the size of a human can be hidden from audible sound.
基金Project (Nos.60574056 and 60674069) supported by the National Natural Science Foundation of China
文摘In this letter,we propose a novel three-dimensional conceptual model for an emerging service-oriented simulation paradigm. The model can be used as a guideline or an analytic means to find the potential and possible future directions of the current simulation frameworks. In particular, the model inspects the crossover between the disciplines of modeling and simulation, service-orientation,and software/systems engineering. Finally, two specific simulation frameworks are studied as examples.
基金supported by National Key R&D Program of China(No.2017YFE0131300)Science and Technology Commission of Shanghai Municipality(Nos.16ZR1442600,20JC1416200)+3 种基金Shanghai Rising-Star Program(No.19QA1410600)Program of Shanghai Academic/Technology Research Leader(No.19XD1404600)National Natural Science Foundation of China(Nos.12074400,U1732268,61874128,61851406,11705262,11774326)Frontier Science Key Program of Chinese Academy of Sciences(No.QYZDY-SSW-JSC032).
文摘Integrated photonic quantum circuits(IPQCs)have attracted increasing attention in recent years due to their widespread applications in quantum information science.While the most envisioned quantum technologies such as quantum communications,quantum computer and quantum simulations have placed a strict constraint on the scalability of chip-integrated quantum light sources.By introducing sizeconfined nanostructures or crystal imperfections,low-dimensional semiconductors have been broadly explored as chip-scale deterministic single-photon sources(SPSs).Thus far a variety of chip-integrated deterministic SPSs have been investigated across both monolithic and hybrid photonic platforms,including molecules,quantum dots,color centers and two-dimensional materials.With the rapid development of the chip-scale generation of single photons with deterministic quantum emitters,the field of IPQCs has raised new challenges and opportunities.In this paper,we highlight recent progress in the development of waveguide-coupled deterministic SPSs towards scalable IPQCs,and review the post-growth tuning techniques that are specifically developed to engineer the optical properties of these WG-coupled SPSs.Future prospects on stringent requirement for the quantum engineering toolbox in the burgeoning field of integrated photonics are also discussed.
