High-precision vertex and energy reconstruction are crucial for large liquid scintillator detectors such as that at the Jiangmen Underground Neutrino Observatory(JUNO),especially for the determination of neutrino mass...High-precision vertex and energy reconstruction are crucial for large liquid scintillator detectors such as that at the Jiangmen Underground Neutrino Observatory(JUNO),especially for the determination of neutrino mass ordering by analyzing the energy spectrum of reactor neutrinos.This paper presents a data-driven method to obtain a more realistic and accurate expected PMT response of positron events in JUNO and develops a simultaneous vertex and energy reconstruction method that combines the charge and time information of PMTs.For the JUNO detector,the impact of the vertex inaccuracy on the energy resolution is approximately 0.6%.展开更多
Hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT) is a disease that is not uncommon, but the treatments vary drastically between Eastern and Western countries. In Europe and America, the first line o...Hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT) is a disease that is not uncommon, but the treatments vary drastically between Eastern and Western countries. In Europe and America, the first line of treatment is systemic therapy such as sorafenib and the surgical treatment is not a recommend option. While an increasing number of studies from China and Japan have suggested that surgical treatment results in better outcomes when compared to transcatheter arterial chemoembolization(TACE), sorafenib, or other nonsurgical treatments, and two classification systems, Japanese Vp classification and Chinese Cheng's classification, were very useful to guide the surgical treatment. We have also found that surgical treatment may be more effective, as we have performed surgical treatment for HCC-PVTT patients over a period of approximately 15 years and achieved good results with the longest surviving time being 13 years and onward. In this study, we review the efficacy and principles of current surgical treatments and introduce our new, more effective surgical technique named "thrombectomy first", which means the tumor thrombus in the main portal vein, the bifurcation or the contralateral portal vein should be removed prior to liver resection. Thus, compression and crushing of PVTT during the operation could be avoided and new intrahepatic metastases caused by tumor thrombus to the remnant liver minimized. The new technique is even beneficial to the prognosis of Cheng's classification Types Ⅲ and Ⅳ PVTT. The vital tips and tricks for the surgical approach are described.展开更多
Objective:Mumps is a seasonal infectious disease,always occurring in winter and spring.In this study,we aim to analyze its epidemiological characteristics,transmissibility,and its correlation with meteorological varia...Objective:Mumps is a seasonal infectious disease,always occurring in winter and spring.In this study,we aim to analyze its epidemiological characteristics,transmissibility,and its correlation with meteorological variables.Method:A seasonal Susceptiblee Exposede Infectious/Asymptomatice Recovered model and a next-generation matrix method were applied to estimate the time-dependent reproduction number(Rt).Results:The seasonal double peak of annual incidence was mainly in May to July and November to December.There was high transmission at the median of Rt¼1.091(ranged:0 to 4.393).Rt was seasonally distributed mainly from February to April and from September to November.Correlations were found between temperature(Pearson correlation coefficient[r]ranged:from 0.101 to 0.115),average relative humidity(r¼0.070),average local pressure(r¼-0.066),and the number of new cases.In addition,average local pressure(r¼0.188),average wind speed(r¼0.111),air temperature(r ranged:-0.128 to-0.150),average relative humidity(r¼-0.203)and sunshine duration(r¼-0.075)were all correlated with Rt.Conclusion:A relatively high level of transmissibility has been found in Xiamen City,leading to a continuous epidemic of mumps.Meteorological factors,especially air temperature and relative humidity,may be more closely associated with mumps than other factors.展开更多
基金supported by the National Key R&D Program of China(No.2018YFA0404100)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.12175257)+1 种基金the National Natural Science Foundation of China(No.12175257)the Science Foundation of High-Level Talents of Wuyi University(No.2021AL027).
文摘High-precision vertex and energy reconstruction are crucial for large liquid scintillator detectors such as that at the Jiangmen Underground Neutrino Observatory(JUNO),especially for the determination of neutrino mass ordering by analyzing the energy spectrum of reactor neutrinos.This paper presents a data-driven method to obtain a more realistic and accurate expected PMT response of positron events in JUNO and develops a simultaneous vertex and energy reconstruction method that combines the charge and time information of PMTs.For the JUNO detector,the impact of the vertex inaccuracy on the energy resolution is approximately 0.6%.
基金Supported by Shanghai Pujiang Program,No.17PJD025Shanghai Natural Science Foundation,No.17ZR1418500
文摘Hepatocellular carcinoma(HCC) with portal vein tumor thrombus(PVTT) is a disease that is not uncommon, but the treatments vary drastically between Eastern and Western countries. In Europe and America, the first line of treatment is systemic therapy such as sorafenib and the surgical treatment is not a recommend option. While an increasing number of studies from China and Japan have suggested that surgical treatment results in better outcomes when compared to transcatheter arterial chemoembolization(TACE), sorafenib, or other nonsurgical treatments, and two classification systems, Japanese Vp classification and Chinese Cheng's classification, were very useful to guide the surgical treatment. We have also found that surgical treatment may be more effective, as we have performed surgical treatment for HCC-PVTT patients over a period of approximately 15 years and achieved good results with the longest surviving time being 13 years and onward. In this study, we review the efficacy and principles of current surgical treatments and introduce our new, more effective surgical technique named "thrombectomy first", which means the tumor thrombus in the main portal vein, the bifurcation or the contralateral portal vein should be removed prior to liver resection. Thus, compression and crushing of PVTT during the operation could be avoided and new intrahepatic metastases caused by tumor thrombus to the remnant liver minimized. The new technique is even beneficial to the prognosis of Cheng's classification Types Ⅲ and Ⅳ PVTT. The vital tips and tricks for the surgical approach are described.
基金supported by the Bill&Melinda Gates Foundation(Grant INV-005834 to T.C.).
文摘Objective:Mumps is a seasonal infectious disease,always occurring in winter and spring.In this study,we aim to analyze its epidemiological characteristics,transmissibility,and its correlation with meteorological variables.Method:A seasonal Susceptiblee Exposede Infectious/Asymptomatice Recovered model and a next-generation matrix method were applied to estimate the time-dependent reproduction number(Rt).Results:The seasonal double peak of annual incidence was mainly in May to July and November to December.There was high transmission at the median of Rt¼1.091(ranged:0 to 4.393).Rt was seasonally distributed mainly from February to April and from September to November.Correlations were found between temperature(Pearson correlation coefficient[r]ranged:from 0.101 to 0.115),average relative humidity(r¼0.070),average local pressure(r¼-0.066),and the number of new cases.In addition,average local pressure(r¼0.188),average wind speed(r¼0.111),air temperature(r ranged:-0.128 to-0.150),average relative humidity(r¼-0.203)and sunshine duration(r¼-0.075)were all correlated with Rt.Conclusion:A relatively high level of transmissibility has been found in Xiamen City,leading to a continuous epidemic of mumps.Meteorological factors,especially air temperature and relative humidity,may be more closely associated with mumps than other factors.
