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Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer
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作者 Yu-Ming Rong Xiao-Ming Huang +7 位作者 De-Jun Fan Xu-Tao Lin Feng Zhang Jian-Cong Hu Ying-Xin Tan Xi Chen yi-feng zou Ping Lan 《World Journal of Gastroenterology》 SCIE CAS 2018年第41期4679-4690,共12页
AIM To investigate the expression of G protein-coupled receptor 31 (GPR31) and its clinical significance in human colorectal cancer (CRC).METHODS To determine the association between the GPR31 expression and the progn... AIM To investigate the expression of G protein-coupled receptor 31 (GPR31) and its clinical significance in human colorectal cancer (CRC).METHODS To determine the association between the GPR31 expression and the prognosis of patients, we obtained paraffin-embedded pathological specimens from 466 CRC patients who underwent initial resection. A total of 321 patients from the First Affiliated Hospital of Sun Yat-sen University from January 1996 to December 2008 were included as a training cohort, whereas 145 patients from the Sixth Affiliated Hospital of Sun Yat-sen University from January 2007 to November 2008 were included as a validation cohort. We examined GPR31 expression levels in CRC tissues from two independent cohorts via immunohistochemical staining. All patients were categorized into either a GPR31 low expression group or a GPR31 high expression group. The clinicopathological factors and the prognosis of patients in the GPR31 low expression group and GPR31 high expression group were compared.RESULTS We compared the clinicopathological factors and the prognosis of patients in the GPR31 low expression group and GPR31 high expression group. Significant differences were observed in the number of patients in pM classification between patients in the GPR31 low expression group and GPR31 high expression group (P = 0.007). The five-year survival and tumor-free survival rates of patients were 84.3% and 82.2% in the GPR31 low expression group, respectively, and both rates were 59.7% in the GPR31 high expression group (P < 0.05). Results of the Cox proportional hazard regression model revealed that GPR31 upregulation was associated with shorter overall survival and tumor-free survival of patients with CRC (P < 0.05). Multivariate analysis identified GPR31 expression in colorectal cancer as an independent predictive factor of CRC patient survival (P < 0.05).CONCLUSION High GPR31 expression levels were found to be correlated with pM classification of CRC and to serve as an independent predictive factor of poor survival of CRC patients. 展开更多
关键词 G protein-coupled receptor 31 COLORECTAL cancer Predictive factor METASTASIS Clinical SIGNIFICANCE
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Improving the Thermal Conductivity and Mechanical Properties of Twocomponent Room Temperature Vulcanized Silicone Rubber by Filling with Hydrophobically Modified SiO_2-Graphene Nanohybrids 被引量:9
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作者 Bo Yang Shuang-Hong Zhang +3 位作者 yi-feng zou Wen-Shi Ma Guo-Jia Huang Mao-Dong Li 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2019年第2期189-196,共8页
The SiO_2 nanoparticles were coated on the surface of graphene oxide(GO) by sol-gel method to get the SiO_2-G compound.The SiO_2-G was restored and oleophylically modified to prepare hydrophobic modified SiO_2-G(HM-Si... The SiO_2 nanoparticles were coated on the surface of graphene oxide(GO) by sol-gel method to get the SiO_2-G compound.The SiO_2-G was restored and oleophylically modified to prepare hydrophobic modified SiO_2-G(HM-SiO_2-G) which was subsequently added to silicone rubber matrix to prepare two-component room temperature vulcanized(RTV-2) thermal conductive silicone rubber. The morphology, chemical structure and dispersity of the modified graphene were characterized with SEM, FTIR, Raman, and XPS methods.In addition, the heat-resistance behavior, mechanical properties, thermal conductivity, and electrical conductivity of the RTV-2 silicone rubber were also studied systematically. The results showed that the SiO_2 nanoparticles were coated on graphene oxide successfully, and HM-SiO_2-G was uniformly dispersed in RTV-2 silicone rubber. The addition of HM-SiO_2-G could effectively improve the thermal stability, mechanical properties and thermal conductivity of RTV-2 silicone rubber and had no great influence on the electrical insulation performance. 展开更多
关键词 GRAPHENE Modification Two components ROOM temperature vulcanized SILICONE rubber Thermal CONDUCTIVITY
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Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients after total mesorectal excision 被引量:4
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作者 Jian-ping Wang and Ping Lan Chi Zhou +13 位作者 Xian-rui Wu Xuan-hui Liu Yu-feng Chen Jia Ke Xiao-wen He Xiao-sheng He Tuo Hu yi-feng zou Xiao-bin Zheng Hua-shan Liu Jian-cong Hu Xiao-jian Wu Jian-ping Wang Ping Lan 《Gastroenterology Report》 SCIE EI 2018年第2期137-143,I0003,共8页
Background:The impact of a patient’s gender on the development of anastomotic leak(AL)in rectal cancer patients following total mesorectal excision(TME)remains controversial.The aim of this study was to evaluate the ... Background:The impact of a patient’s gender on the development of anastomotic leak(AL)in rectal cancer patients following total mesorectal excision(TME)remains controversial.The aim of this study was to evaluate the association between patients’gender and the risk of AL.Methods:All rectal cancer patients following TME with a primary anastomosis during the study period from 2010 to 2014 were examined.Comparisons of the post-operative AL incidence rate between male and female patients were performed.Results:Of all patients examined(n¼956),587(61.4%)were males and 369(38.6%)were females.Male patients were more likely to have a history of smoking and drinking alcohol,but less likely to have a history of abdominal surgery compared to female patients.A higher incidence rate of pre-operative bowel obstruction and larger tumor volume in male patients was observed in our study.Of all the patients,81(8.5%)developed post-operative AL.More male patients(n¼62,10.6%)suffered from AL than females(n¼19,5.1%)(P¼0.003).Multivariate logistic regression analyses confirmed the association between male gender and AL[odds ratio(OR):2.41,95%confidence interval(CI):1.37–4.23,P¼0.002].Similar results were also obtained in patients who underwent laparoscopic TME(OR:2.11,95%CI:1.15–3.89,P¼0.016).Conclusions:Male patents were found to have an increased risk for AL following TME with a primary anastomosis.A temporary protecting stoma may help to protect the anastomosis and lessen the risk for AL especially in male patients. 展开更多
关键词 rectal cancer anastomotic leak GENDER risk factor total mesorectal excision primary anastomosis
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Antitumor immunity of low-dose cyclophosphamide:changes in T cells and cytokines TGF-beta and IL-10 in mice with colon-cancer liver metastasis 被引量:1
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作者 Xiao-Ming Huang Nan-Rong Zhang +7 位作者 Xu-Tao Lin Cai-Yan Zhu yi-feng zou Xiao-Jian Wu Xiao-Sheng He Xiao-Wen He Yun-Le Wan Ping Lan 《Gastroenterology Report》 SCIE EI 2020年第1期56-65,I0002,共11页
Background:The tumor immune microenvironment is one of the most important prognostic factors in liver metastasis from colorectal cancer.Low-dose cyclophosphamide(CTX)is widely believed to be involved in the modulation... Background:The tumor immune microenvironment is one of the most important prognostic factors in liver metastasis from colorectal cancer.Low-dose cyclophosphamide(CTX)is widely believed to be involved in the modulation of the immune system.However,the underlying mechanism of low-dose CTX remains unknown.This study aimed to investigate the antitumor immunity of low-dose CTX in the treatment of colon-cancer liver metastasis.Methods:Thirty mice were randomly divided into five groups.After liver metastasis was established in colon-cancer models,mice in the treatment groups were injected with low-dose CTX(20 mg/kg)at different time points.Liver and spleen tissues were examined for T-cell markers via flow cytometry.Interleukin(IL)-10 and transforming growth factor(TGF)-b1 expression levels in liver tissues were analysed by immunohistochemistry.Serum interferon(IFN)-c and IL-10 levels were detected by enzyme-linked immunosorbent assay.An additional 20 mice were randomly allocated into two groups and the survival times were recorded.Results:The expression levels of CD4^(+)T cells,CD8^(+)T cells,and IFN-c were down-regulated,whereas those of IL-10 and TGF-b1 were up-regulated in liver metastasis from colon cancer in mice.Furthermore,the local and systemic microenvironments of the liver were altered,which led to reduced antitumor immune responses and subsequently liver metastasis.However,treatment with low-dose CTX reversed these effects.The survival times of mice treated with low-dose CTX were significantly longer than those of the other groups.Conclusions:Low-dose CTX exerts its antitumor activity by changing the systemic and local immune microenvironments and enhancing immune regulation inmice.CTX could be used as a drug to prevent and treat livermetastasis from colon cancer. 展开更多
关键词 colon cancer liver metastasis CYCLOPHOSPHAMIDE immune microenvironment
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An 11-gene signature for the prediction of systemic recurrences in colon adenocarcinoma
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作者 Jia-Wei Cai Xiao-Ming Huang +6 位作者 Xiao-Lan Li Si Qin Yu-Ming Rong Xi Chen Jing-Rong Weng yi-feng zou Xu-Tao Lin 《Gastroenterology Report》 SCIE EI 2021年第5期451-460,I0002,I0003,共12页
Background Prognosis varies among patients within the same colon adenocarcinoma(COAD)stage,indicating the need for reliable molecular markers to enable individualized treatment.This study aimed to investigate gene sig... Background Prognosis varies among patients within the same colon adenocarcinoma(COAD)stage,indicating the need for reliable molecular markers to enable individualized treatment.This study aimed to investigate gene signatures that can be used for better prognostic prediction of COAD.Methods Gene-expression profiles of COAD patients were obtained from the Gene Expression Omnibus database(n=332)and The Cancer Genome Atlas database(n=431).The relationship between gene signature and relapse-free survival was analysed in the training set(n=93)and validated in the internal validation set(n=94)and external validation sets(n=145 and 431).Results Overall,11 genes(N-myc downstream regulated gene 1[NDRG1],fms-like tyrosine kinase 1[FLT1],lipopolysaccharide binding protein[LBP],fatty acid binding protein 4[FABP4],adiponectin gene[ADIPOQ],angiotensinogen gene[AGT],activin A receptor,type II-like kinase 1[ACVRL1],CC chemokine ligand 11[CCL11],cell division cycle 42[CDC42],T-cell receptor alpha variable 9_2[TRAV9_2],and proopiomelanocortin[POMC])were identified by univariable and least absolute shrinkage and selection operator(LASSO)Cox regression analyses.Based on the risk-score model,the patients were grouped into the high-risk or low-risk groups using the median risk score as the cut-off.The area under the curve(AUC)values for 1-,3-,and 5-year recurrence were 0.970,0.849,and 0.859,respectively.Patients in the high-risk group had significantly poorer relapsefree survival than did those in the low-risk group.The predictive accuracy of the 11-gene signature was proven in the validation sets.Our gene signature showed better predictive performance for 1-,3-,and 5-year recurrence than did the other four models.Conclusions The 11-gene signature showed good performance in predicting recurrence in COAD.The accuracy of the signature for prognostic classification requires further confirmation. 展开更多
关键词 colon cancer gene signature RECURRENCE PROGNOSIS
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