Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumo...Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s disease.Methods CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December 2020.The serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before treatment.The diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)curves.Results The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,respectively.The diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.展开更多
Background and aims:Nonalcoholic steatohepatitis(NASH),an inflammatory form of non-alcoholic fatty liver disease,can progress to advanced liver fibrosis,cirrhosis,and liver cancer.Metabolic syndrome(MetS)parallels the...Background and aims:Nonalcoholic steatohepatitis(NASH),an inflammatory form of non-alcoholic fatty liver disease,can progress to advanced liver fibrosis,cirrhosis,and liver cancer.Metabolic syndrome(MetS)parallels the prevalence of non-alcoholic fatty liver disease/NASH and increases patients’risk of advanced liver disease.This study aimed to determine whether MetS was associated with the histological progression of NASH.Methods:Patients with liver biopsy-proven NASH were retrospectively screened and categorized into two groups for each histological feature:with(<2 points)or without(2 points)significant hepatic steatosis/inflammation/fibrosis.Multivariable logistic regression was used to explore the association between MetS and histological features.Results:In total,386 patients with a median age of 33.0 years were enrolled;among them,35.2%were female,and 41.2%had MetS.The proportion of significant hepatic fibrosis and steatosis in those with MetS was significantly higher than in those without MetS(p<0.05).Multivariable logistic regression analyses showed that MetS remained significantly associated with significant hepatic fibrosis(adjusted odds ratio:1.852,95%confidence interval:1.042-3.292,p=0.036),and severe hepatic steatosis(adjusted odds ratio:2.008,95%confidence interval:1.030-3.914,p=0.041).Conclusion:MetS was associated with significant hepatic fibrosis and steatosis in patients with NASH.Our results suggest that NASH patients with MetS should be closely monitored and given targeted intervention and treatment,which may help to prevent disease progression and mitigate the growing burden of NASH.展开更多
基金This research was funded by Guangzhou Science and Technology Plan Projects(No.202002020066)the Young Scientists to the NSFC Application of Guangdong Provincial People’s Hospital(No.8210120306)the Open Foundation of the State Key Laboratory of Bioactive Seaweed Substance(No.SKL-BMSG2022-03)。
文摘Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s disease.Methods CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December 2020.The serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before treatment.The diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)curves.Results The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,respectively.The diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.
基金supported by the Youth Independent Innovation Project of PLA General Hospital(No.22QNCZ023).
文摘Background and aims:Nonalcoholic steatohepatitis(NASH),an inflammatory form of non-alcoholic fatty liver disease,can progress to advanced liver fibrosis,cirrhosis,and liver cancer.Metabolic syndrome(MetS)parallels the prevalence of non-alcoholic fatty liver disease/NASH and increases patients’risk of advanced liver disease.This study aimed to determine whether MetS was associated with the histological progression of NASH.Methods:Patients with liver biopsy-proven NASH were retrospectively screened and categorized into two groups for each histological feature:with(<2 points)or without(2 points)significant hepatic steatosis/inflammation/fibrosis.Multivariable logistic regression was used to explore the association between MetS and histological features.Results:In total,386 patients with a median age of 33.0 years were enrolled;among them,35.2%were female,and 41.2%had MetS.The proportion of significant hepatic fibrosis and steatosis in those with MetS was significantly higher than in those without MetS(p<0.05).Multivariable logistic regression analyses showed that MetS remained significantly associated with significant hepatic fibrosis(adjusted odds ratio:1.852,95%confidence interval:1.042-3.292,p=0.036),and severe hepatic steatosis(adjusted odds ratio:2.008,95%confidence interval:1.030-3.914,p=0.041).Conclusion:MetS was associated with significant hepatic fibrosis and steatosis in patients with NASH.Our results suggest that NASH patients with MetS should be closely monitored and given targeted intervention and treatment,which may help to prevent disease progression and mitigate the growing burden of NASH.
