AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a ...AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular trauma.METHODS:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham injection.Left eyes were used as normal controls.The intraocular pressure(IOP)was monitored using an iCare tonometer.PVR severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence staining.RESULTS:During the observation period,PVR severity gradually increased.Intense Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR group.Ozurdex significantly alleviated PVR development and Müller cell gliosis.Post-traumatic inflammation fluctuated and was persistent.The interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after injury.The expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1βexpression.Ozurdex suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal limits.CONCLUSION:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over 6wk.Ozurdex treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR severity.This study highlights the important role of IL-1β,and Ozurdex inhibites inflammation presumably via the NF-κB/NLRP3/IL-1βinflammatory axis.In summary,Ozurdex provides a potential therapeutic option for traumatic PVR.展开更多
BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general population.It is characterized by vasodilation,which affects s...BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general population.It is characterized by vasodilation,which affects specific organs,such as the skin,mucous membranes,brain,lungs,gastrointestinal tract,liver,and others.However,HHT rarely involves the portal venous system to cause serious clinical compli-cations.CASE SUMMARY A 68-year-old woman was admitted to the emergency department due to four consecutive days of abdominal pain and bloody stool and was subsequently diagnosed with HHT.Computed tomography angiography confirmed the presence of an arteriovenous fistula(AVFs).Considering this specific manifestation,whole exome sequencing was performed.After a comprehensive evaluation,a selective superior mesenteric artery embolization was prioritized to avoid intestinal ischemia.The postoperative symptoms of the patient were quickly relieved.Unfortunately,two months post-procedure the patient died from intestinal necrosis and abdominal infection related to remaining AVFs.CONCLUSION For patients with diffuse superior mesenteric AVFs,selective mesenteric arterial embolization may lead to positive short-term outcomes.展开更多
Background:The role of the patient’s medication literacy is crucial in ensuring the efficacy of the treatment for nephrotic syndrome(NS).It is imperative to identify and examine instances of inadequate medication lit...Background:The role of the patient’s medication literacy is crucial in ensuring the efficacy of the treatment for nephrotic syndrome(NS).It is imperative to identify and examine instances of inadequate medication literacy in order to effectively manage NS.This study aimed to detect the low medication literacy in Chinese NS children using the 22-item Medication Literacy Scale(MLS-22)and to further analyze its influencing factors.Methods:This study involved consecutive sampling of 157 Chinese children with NS.Interviewer-led questionnaires were used to collect data.Firstly,the MLS-22 was evaluated for reliability and validity.Secondly,the medication literacy level was assessed,and factors related to low scores were examined using a multivariate logistic regression model.Results:MLS-22 proved reliable and valid for detection at a low level in NS children.The tertile was divided into low-level and medium/high-level medication literacy.It was found that the scores of NS children averaged 13.06.Multivariate logistic regression analysis revealed that parents of children with primary NS and congenital NS had lower medication literacy scores,which were related to parents with less than high school education.Conclusions:Healthcare providers should develop tailored strategies to effectively assist Chinese children with limited medication literacy in managing chronic diseases.展开更多
Background:Enhanced recovery after surgery(ERAS)has shown effectiveness in terms of reducing the hospital stay and cost.However,the benefit of ERAS in patients undergoing hepatectomy for benign liver lesions is still ...Background:Enhanced recovery after surgery(ERAS)has shown effectiveness in terms of reducing the hospital stay and cost.However,the benefit of ERAS in patients undergoing hepatectomy for benign liver lesions is still unclear.Methods:ERAS was implemented in our center since March 1st,2018.From September 2016 to Febru-ary 2018,109 patients were enrolled into the control group,and from March 2018 to June 2019,124 patients were enrolled into the ERAS group.All the indicators related to operation,liver functions,and postoperative outcomes were included in the analysis.Results:The clinicopathologic baselines were similar in these two groups.A significantly higher propor-tion of patients underwent laparoscopic surgery in the ERAS group.On the whole,intraoperative blood loss(100.00 mL vs.200.00 mL,P<0.001),blood transfusion(3.23%vs.10.09%,P=0.033),total bilirubin(17.10μmol/L vs.21.00μmol/L,P=0.041),D-dimer(2.08μg/mL vs.2.57μg/mL,P=0.031),postoperative hospital stay(5.00 d vs.6.00 d,P<0.001),and postoperative morbidity(16.13%vs.32.11%,P=0.008)were significantly shorter or less in the ERAS group than those in the control group.After stratified by operation methods,ERAS group showed significantly shorter postoperative hospital stay in both open and laparoscopic operation(both P<0.001).In patients underwent open surgery,ERAS group demonstrated significantly shorter operative duration(131.76±8.75 min vs.160.73±7.23 min,P=0.016),less intra-operative blood loss(200.00 mL vs.450.00 mL,P=0.008)and less postoperative morbidity(16.00%vs.44.44%,P=0.040).Conclusions:ERAS program may be safe and effective for the patients underwent hepatectomy,especially open surgery,for benign liver lesions.展开更多
Two dissimilar steel plates,structural steel and mild steel,were joined by explosion welding to form a composite.The composite was then heat-treated by quenching at 840℃ for 30 min followed by tempering at 200℃ for ...Two dissimilar steel plates,structural steel and mild steel,were joined by explosion welding to form a composite.The composite was then heat-treated by quenching at 840℃ for 30 min followed by tempering at 200℃ for 3 h.The microstructure was investigated under an optical microscope and a scanning electron microscope.The mechanical properties were measured using Vickers microhardness and Charpy impact tests.The results show a deformed interface with typical wave features at the welding zone,but no defects were observed.Moreover,the ferrite in the parent plate in the weld zone was elongated due to the strong plastic deformation from the explosion.After heat treatment,the hardness of the flyer plate(structural steel)was over HV0.2800,while that of the parent plate(mild steel)was HV0.2200.The increase in hardness was due to the presence of martensite.Moreover,the average impact energy was increased from 18.5 to 44.0 J following heat treatment;this is because of the formation of recrystallized grains at the weld interface,which is due to the dynamic recovery and local recrystallization,and the strong elemental diffusion that occurred between the two plates.展开更多
Objective:To explore correlation between red blood cell distribution width(RDW)and cervical carcinoma.Methods:50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow Univer...Objective:To explore correlation between red blood cell distribution width(RDW)and cervical carcinoma.Methods:50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow University from June 2020 to December 2020 were involved as the patients group and the control group respectively.Demographic data were collected from routine blood tests and biochemistry examination,the correlation of RDW with hemoglobin(Hb)and c-reactive protein(CRP)was evaluated by Spearman rank correlation,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of RDW for cervical carcinoma.Result:The levels of RDW,squamous cell carcinoma antigen(SCCA)and carcinoembryonic antigen(CEA)in patients with cervical carcinoma were higher than those in the controls.The levels of high-density lipoprotein(HDL),Albumin,Prealbumin,Hb,RBC and neuron-specific enolase(NSE)in patients were lower than those in the controls(all P<0.05).There was no statistical significance on the difference in other markers between the two groups(P>0.05).The AUC of RDW in the diagnosis of cervical carcinoma was 0.834.Based on Spearman's rank correlation coefficient analysis,RDW was positively correlated with Hb(r=0.434,P<0.05)and CRP(r=0.366,P<0.05)RDW,and was negatively correlated with hematocrit(r=-0.363,P<0.05),in cervical carcinoma group,cervical carcinoma subgroupⅠ-ⅡandⅢ-Ⅳwere higher than the control group(P<0.05).Conclusions:Elevated RDW is associated with the occurrence of cervical carcinoma,and it may have clinical value in the diagnosis of cervical carcinoma and the course of reaction.展开更多
Recent advances in molecular and cellular tumor immunology have demonstrated that immunotherapy might have great potential,which would be another important treatment strategy after surgery,radiotherapy and chemotherap...Recent advances in molecular and cellular tumor immunology have demonstrated that immunotherapy might have great potential,which would be another important treatment strategy after surgery,radiotherapy and chemotherapy.Therefore,this review mainly summarizes and discusses the classification of tumor immune microenvironment and the existing main immunotherapies,in order to provide some guidance and suggestions for accurate individualized immunotherapy.展开更多
Objective:To develop a medication literacy scale for the pediatric population with nephrotic syndrome(NS)in order to evaluate its reliability and validity.Methods:According to the medication belief scale,specific medi...Objective:To develop a medication literacy scale for the pediatric population with nephrotic syndrome(NS)in order to evaluate its reliability and validity.Methods:According to the medication belief scale,specific medication beliefs,and self-set dimensions,the NS pediatric population health literacy scale was designed to evaluate the medication literacy of 120 children with NS.Items,homogeneity,reliability,and validity of the scale were analyzed.Results:There were statistically significant differences in the Levene F test between the top 27%and the last 27%of the 22 items(P<0.001).The differences in the t-test were statistically significant(P<0.001).Content validity I-CVI:after deletion of item 4,the I-CVI of other items were all higher than 0.91.S-CVI was higher than 0.80,and S-CVI/AVE was higher than 0.90.The internal consistency coefficient(Cronbach'sα)was 0.868.Structural validity:KMO(Kaiser-Meyer-Olkin)statistical value was 0.862,and Bartlett's spherical test value was 1578.172(P<0.001).The extracted 6 common factors explain 70.21%of the variance variation.The loads of 22 items on their main factors are all greater than 0.427 except items 2 and 5.Conclusion:The medication literacy scale for the NS pediatric population has proved its good practicability,but some items of cognition need to be further explored.展开更多
Background： Complex noise and its relation to hearing loss are difficult to measure and evaluate. In complex noise measurement, individual exposure results may not accurately represent lifetime noise exposure. Thus, ...Background： Complex noise and its relation to hearing loss are difficult to measure and evaluate. In complex noise measurement, individual exposure results may not accurately represent lifetime noise exposure. Thus, the mean LAcq.8h values of individuals in the same workgroup were also used to represent LAcq.8h in our study. Our study aimed to explore whether the mean exposure levels of workers in the same workgroup represented real noise exposure better than individual exposure levels did. Methods： A cross-sectional study was conducted to establish a model for cumulative noise exposure （CNE） and hearing loss in 205 occupational noise-exposed workers who were recruited from two large automobile manufacturers in China. We used a personal noise dosimeter and a questionnaire to determine the workers＇ occupational noise exposure levels and exposure times, respectively. A qualified audiologist used standardized audiometric procedures to assess hearing acuity after at least 16 h of noise avoidance. Results： We observed that 88.3% of workers were exposed to more than 85 dB（A） of occupational noise （mean： 89.3 ± 4.2 dB（A））. The personal CNE （CNEp） and workgroup CNE （CNEg） were 100.5 ± 4.7 dB（A） and 100.5 ± 2.9 dB（A）, respectively. In the binary logistic regression analysis, we established a regression model with high-frequency hearing loss as the dependent variable and CNE as the independent variable. The Wald value was 5.014 with CNEp as the independent variable and 8.653 with CNEg as the independent variable. Furthermore, we found that the figure for CNEg was more similar to the stationary noise reference than CNEp was. The CNEg model was better than the CNEp model. In this circumstance, we can measure some subjects instead of the whole workgroup and save manpower. Conclusions： In a complex noise environment, the measurements of average noise exposure level of the workgroup can improve the accuracy and save manpower.展开更多
To the Editor:Psoriasis is a chronic,recurrent,systemic,immune-mediated inflammatory disease that mainly affects the skin,nails,and joints.Plaque psoriasis is the most common type of psoriasis,accounting for more than...To the Editor:Psoriasis is a chronic,recurrent,systemic,immune-mediated inflammatory disease that mainly affects the skin,nails,and joints.Plaque psoriasis is the most common type of psoriasis,accounting for more than 80%to 90%of all cases.Secukinumab,a human IgG monoclonal antibody that antagonizes interleukin 17A(IL-17A),was approved by the US Food and Drug Administration in 2015 to treat moderate-to-severe plaque psoriasis.A Chinese multicenter,double-blind,placebo-controlled phase III randomized clinical trial(RCT)demonstrated excellent efficacy and safety.[1]Secukinumab has been available on the Chinese market since May 2019,with a recommended dose of 300 mg.It is well-known that RCTs,due to their rigorous,normalized design schemes,cannot fully reflect what happens in clinical practice settings.The concept of the"efficacy-effectiveness gap"was also introduced,[2]which supports the importance of real-world study.Here,we retrospectively summarized all the inpatients with plaque psoriasis who were treated with secukinumab at Peking University Third Hospital from June to December 2019.General information(sex,age,weight,body mass index,etc.)and clinical features(disease duration,family history,comorbidities,laboratory tests,previous treatments,concomitant treatments,etc.)were collected from clinical records.The psoriasis area severity index(PASI),body surface area(BSA),dermatology life quality index(DLQI),psoriasis scalp severity index(PSSI),nail psoriasis severity index(NAPSI),and palmoplantar psoriasis area and severity index(ppPASI)were also recorded.展开更多
基金Supported by National Natural Science Foundation of China(No.81974135,No.81900851)。
文摘AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular trauma.METHODS:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham injection.Left eyes were used as normal controls.The intraocular pressure(IOP)was monitored using an iCare tonometer.PVR severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence staining.RESULTS:During the observation period,PVR severity gradually increased.Intense Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR group.Ozurdex significantly alleviated PVR development and Müller cell gliosis.Post-traumatic inflammation fluctuated and was persistent.The interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after injury.The expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1βexpression.Ozurdex suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal limits.CONCLUSION:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over 6wk.Ozurdex treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR severity.This study highlights the important role of IL-1β,and Ozurdex inhibites inflammation presumably via the NF-κB/NLRP3/IL-1βinflammatory axis.In summary,Ozurdex provides a potential therapeutic option for traumatic PVR.
基金the Youth Independent Innovation Science Project of PLA General Hospital,No.22QNFC058.
文摘BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general population.It is characterized by vasodilation,which affects specific organs,such as the skin,mucous membranes,brain,lungs,gastrointestinal tract,liver,and others.However,HHT rarely involves the portal venous system to cause serious clinical compli-cations.CASE SUMMARY A 68-year-old woman was admitted to the emergency department due to four consecutive days of abdominal pain and bloody stool and was subsequently diagnosed with HHT.Computed tomography angiography confirmed the presence of an arteriovenous fistula(AVFs).Considering this specific manifestation,whole exome sequencing was performed.After a comprehensive evaluation,a selective superior mesenteric artery embolization was prioritized to avoid intestinal ischemia.The postoperative symptoms of the patient were quickly relieved.Unfortunately,two months post-procedure the patient died from intestinal necrosis and abdominal infection related to remaining AVFs.CONCLUSION For patients with diffuse superior mesenteric AVFs,selective mesenteric arterial embolization may lead to positive short-term outcomes.
文摘Background:The role of the patient’s medication literacy is crucial in ensuring the efficacy of the treatment for nephrotic syndrome(NS).It is imperative to identify and examine instances of inadequate medication literacy in order to effectively manage NS.This study aimed to detect the low medication literacy in Chinese NS children using the 22-item Medication Literacy Scale(MLS-22)and to further analyze its influencing factors.Methods:This study involved consecutive sampling of 157 Chinese children with NS.Interviewer-led questionnaires were used to collect data.Firstly,the MLS-22 was evaluated for reliability and validity.Secondly,the medication literacy level was assessed,and factors related to low scores were examined using a multivariate logistic regression model.Results:MLS-22 proved reliable and valid for detection at a low level in NS children.The tertile was divided into low-level and medium/high-level medication literacy.It was found that the scores of NS children averaged 13.06.Multivariate logistic regression analysis revealed that parents of children with primary NS and congenital NS had lower medication literacy scores,which were related to parents with less than high school education.Conclusions:Healthcare providers should develop tailored strategies to effectively assist Chinese children with limited medication literacy in managing chronic diseases.
文摘Background:Enhanced recovery after surgery(ERAS)has shown effectiveness in terms of reducing the hospital stay and cost.However,the benefit of ERAS in patients undergoing hepatectomy for benign liver lesions is still unclear.Methods:ERAS was implemented in our center since March 1st,2018.From September 2016 to Febru-ary 2018,109 patients were enrolled into the control group,and from March 2018 to June 2019,124 patients were enrolled into the ERAS group.All the indicators related to operation,liver functions,and postoperative outcomes were included in the analysis.Results:The clinicopathologic baselines were similar in these two groups.A significantly higher propor-tion of patients underwent laparoscopic surgery in the ERAS group.On the whole,intraoperative blood loss(100.00 mL vs.200.00 mL,P<0.001),blood transfusion(3.23%vs.10.09%,P=0.033),total bilirubin(17.10μmol/L vs.21.00μmol/L,P=0.041),D-dimer(2.08μg/mL vs.2.57μg/mL,P=0.031),postoperative hospital stay(5.00 d vs.6.00 d,P<0.001),and postoperative morbidity(16.13%vs.32.11%,P=0.008)were significantly shorter or less in the ERAS group than those in the control group.After stratified by operation methods,ERAS group showed significantly shorter postoperative hospital stay in both open and laparoscopic operation(both P<0.001).In patients underwent open surgery,ERAS group demonstrated significantly shorter operative duration(131.76±8.75 min vs.160.73±7.23 min,P=0.016),less intra-operative blood loss(200.00 mL vs.450.00 mL,P=0.008)and less postoperative morbidity(16.00%vs.44.44%,P=0.040).Conclusions:ERAS program may be safe and effective for the patients underwent hepatectomy,especially open surgery,for benign liver lesions.
基金financially supported by the State Key Laboratory of Solidification Processing of Northwestern Polytechnical University(2019-QZ-01)。
文摘Two dissimilar steel plates,structural steel and mild steel,were joined by explosion welding to form a composite.The composite was then heat-treated by quenching at 840℃ for 30 min followed by tempering at 200℃ for 3 h.The microstructure was investigated under an optical microscope and a scanning electron microscope.The mechanical properties were measured using Vickers microhardness and Charpy impact tests.The results show a deformed interface with typical wave features at the welding zone,but no defects were observed.Moreover,the ferrite in the parent plate in the weld zone was elongated due to the strong plastic deformation from the explosion.After heat treatment,the hardness of the flyer plate(structural steel)was over HV0.2800,while that of the parent plate(mild steel)was HV0.2200.The increase in hardness was due to the presence of martensite.Moreover,the average impact energy was increased from 18.5 to 44.0 J following heat treatment;this is because of the formation of recrystallized grains at the weld interface,which is due to the dynamic recovery and local recrystallization,and the strong elemental diffusion that occurred between the two plates.
基金National Natural Science Foundation of China(No.81873431)。
文摘Objective:To explore correlation between red blood cell distribution width(RDW)and cervical carcinoma.Methods:50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow University from June 2020 to December 2020 were involved as the patients group and the control group respectively.Demographic data were collected from routine blood tests and biochemistry examination,the correlation of RDW with hemoglobin(Hb)and c-reactive protein(CRP)was evaluated by Spearman rank correlation,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of RDW for cervical carcinoma.Result:The levels of RDW,squamous cell carcinoma antigen(SCCA)and carcinoembryonic antigen(CEA)in patients with cervical carcinoma were higher than those in the controls.The levels of high-density lipoprotein(HDL),Albumin,Prealbumin,Hb,RBC and neuron-specific enolase(NSE)in patients were lower than those in the controls(all P<0.05).There was no statistical significance on the difference in other markers between the two groups(P>0.05).The AUC of RDW in the diagnosis of cervical carcinoma was 0.834.Based on Spearman's rank correlation coefficient analysis,RDW was positively correlated with Hb(r=0.434,P<0.05)and CRP(r=0.366,P<0.05)RDW,and was negatively correlated with hematocrit(r=-0.363,P<0.05),in cervical carcinoma group,cervical carcinoma subgroupⅠ-ⅡandⅢ-Ⅳwere higher than the control group(P<0.05).Conclusions:Elevated RDW is associated with the occurrence of cervical carcinoma,and it may have clinical value in the diagnosis of cervical carcinoma and the course of reaction.
文摘Recent advances in molecular and cellular tumor immunology have demonstrated that immunotherapy might have great potential,which would be another important treatment strategy after surgery,radiotherapy and chemotherapy.Therefore,this review mainly summarizes and discusses the classification of tumor immune microenvironment and the existing main immunotherapies,in order to provide some guidance and suggestions for accurate individualized immunotherapy.
文摘Objective:To develop a medication literacy scale for the pediatric population with nephrotic syndrome(NS)in order to evaluate its reliability and validity.Methods:According to the medication belief scale,specific medication beliefs,and self-set dimensions,the NS pediatric population health literacy scale was designed to evaluate the medication literacy of 120 children with NS.Items,homogeneity,reliability,and validity of the scale were analyzed.Results:There were statistically significant differences in the Levene F test between the top 27%and the last 27%of the 22 items(P<0.001).The differences in the t-test were statistically significant(P<0.001).Content validity I-CVI:after deletion of item 4,the I-CVI of other items were all higher than 0.91.S-CVI was higher than 0.80,and S-CVI/AVE was higher than 0.90.The internal consistency coefficient(Cronbach'sα)was 0.868.Structural validity:KMO(Kaiser-Meyer-Olkin)statistical value was 0.862,and Bartlett's spherical test value was 1578.172(P<0.001).The extracted 6 common factors explain 70.21%of the variance variation.The loads of 22 items on their main factors are all greater than 0.427 except items 2 and 5.Conclusion:The medication literacy scale for the NS pediatric population has proved its good practicability,but some items of cognition need to be further explored.
基金the National Key R&D Program of China(2018YFA0305800)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000)+2 种基金the National Natural Science Foundation of China(11834014)Beijing Municipal Science and Technology Commission(Z191100007219013)University of Chinese Academy of Sciences。
基金This study was supported in part by the grants from the National Natural Science Foundation of China （No. 81370968, No. 81670744）, the Chinese Society of Endocrinology （No. 13040620447）, and the Science Technology Department of Zhejiang Province of China （No. 2012R10038）.
文摘Background： Complex noise and its relation to hearing loss are difficult to measure and evaluate. In complex noise measurement, individual exposure results may not accurately represent lifetime noise exposure. Thus, the mean LAcq.8h values of individuals in the same workgroup were also used to represent LAcq.8h in our study. Our study aimed to explore whether the mean exposure levels of workers in the same workgroup represented real noise exposure better than individual exposure levels did. Methods： A cross-sectional study was conducted to establish a model for cumulative noise exposure （CNE） and hearing loss in 205 occupational noise-exposed workers who were recruited from two large automobile manufacturers in China. We used a personal noise dosimeter and a questionnaire to determine the workers＇ occupational noise exposure levels and exposure times, respectively. A qualified audiologist used standardized audiometric procedures to assess hearing acuity after at least 16 h of noise avoidance. Results： We observed that 88.3% of workers were exposed to more than 85 dB（A） of occupational noise （mean： 89.3 ± 4.2 dB（A））. The personal CNE （CNEp） and workgroup CNE （CNEg） were 100.5 ± 4.7 dB（A） and 100.5 ± 2.9 dB（A）, respectively. In the binary logistic regression analysis, we established a regression model with high-frequency hearing loss as the dependent variable and CNE as the independent variable. The Wald value was 5.014 with CNEp as the independent variable and 8.653 with CNEg as the independent variable. Furthermore, we found that the figure for CNEg was more similar to the stationary noise reference than CNEp was. The CNEg model was better than the CNEp model. In this circumstance, we can measure some subjects instead of the whole workgroup and save manpower. Conclusions： In a complex noise environment, the measurements of average noise exposure level of the workgroup can improve the accuracy and save manpower.
基金National Natural Science Foundation of China(No.81972560)Beijing Municipal Natural Science Foundation(No.7202231)。
文摘To the Editor:Psoriasis is a chronic,recurrent,systemic,immune-mediated inflammatory disease that mainly affects the skin,nails,and joints.Plaque psoriasis is the most common type of psoriasis,accounting for more than 80%to 90%of all cases.Secukinumab,a human IgG monoclonal antibody that antagonizes interleukin 17A(IL-17A),was approved by the US Food and Drug Administration in 2015 to treat moderate-to-severe plaque psoriasis.A Chinese multicenter,double-blind,placebo-controlled phase III randomized clinical trial(RCT)demonstrated excellent efficacy and safety.[1]Secukinumab has been available on the Chinese market since May 2019,with a recommended dose of 300 mg.It is well-known that RCTs,due to their rigorous,normalized design schemes,cannot fully reflect what happens in clinical practice settings.The concept of the"efficacy-effectiveness gap"was also introduced,[2]which supports the importance of real-world study.Here,we retrospectively summarized all the inpatients with plaque psoriasis who were treated with secukinumab at Peking University Third Hospital from June to December 2019.General information(sex,age,weight,body mass index,etc.)and clinical features(disease duration,family history,comorbidities,laboratory tests,previous treatments,concomitant treatments,etc.)were collected from clinical records.The psoriasis area severity index(PASI),body surface area(BSA),dermatology life quality index(DLQI),psoriasis scalp severity index(PSSI),nail psoriasis severity index(NAPSI),and palmoplantar psoriasis area and severity index(ppPASI)were also recorded.
