Atomically dispersed catalysts exhibit significant influence on facilitating the sluggish oxygen reduction reaction(ORR)kinetics with high atom economy,owing to remarkable attributes including nearly 100%atomic utiliz...Atomically dispersed catalysts exhibit significant influence on facilitating the sluggish oxygen reduction reaction(ORR)kinetics with high atom economy,owing to remarkable attributes including nearly 100%atomic utilization and exceptional catalytic functionality.Furthermore,accurately controlling atomic physical properties including spin,charge,orbital,and lattice degrees of atomically dispersed catalysts can realize the optimized chemical properties including maximum atom utilization efficiency,homogenous active centers,and satisfactory catalytic performance,but remains elusive.Here,through physical and chemical insight,we review and systematically summarize the strategies to optimize atomically dispersed ORR catalysts including adjusting the atomic coordination environment,adjacent electronic orbital and site density,and the choice of dual-atom sites.Then the emphasis is on the fundamental understanding of the correlation between the physical property and the catalytic behavior for atomically dispersed catalysts.Finally,an overview of the existing challenges and prospects to illustrate the current obstacles and potential opportunities for the advancement of atomically dispersed catalysts in the realm of electrocatalytic reactions is offered.展开更多
Widely used deep neural networks currently face limitations in achieving optimal performance for purchase intention prediction due to constraints on data volume and hyperparameter selection.To address this issue,based...Widely used deep neural networks currently face limitations in achieving optimal performance for purchase intention prediction due to constraints on data volume and hyperparameter selection.To address this issue,based on the deep forest algorithm and further integrating evolutionary ensemble learning methods,this paper proposes a novel Deep Adaptive Evolutionary Ensemble(DAEE)model.This model introduces model diversity into the cascade layer,allowing it to adaptively adjust its structure to accommodate complex and evolving purchasing behavior patterns.Moreover,this paper optimizes the methods of obtaining feature vectors,enhancement vectors,and prediction results within the deep forest algorithm to enhance the model’s predictive accuracy.Results demonstrate that the improved deep forest model not only possesses higher robustness but also shows an increase of 5.02%in AUC value compared to the baseline model.Furthermore,its training runtime speed is 6 times faster than that of deep models,and compared to other improved models,its accuracy has been enhanced by 0.9%.展开更多
Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in China.Our previous study showed that EB was a stronger inducer of melanogenesis and an a...Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in China.Our previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain unclear.Herein,as an extension to our previous investigation,we provide comprehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and stability.The results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glycogen synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin tissues.Furthermore,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and mice.Finally,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis processes.These data conclude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries.展开更多
Stiffened structures have great potential for improvingmechanical performance,and the study of their stability is of great interest.In this paper,the optimization of the critical buckling load factor for curved grid s...Stiffened structures have great potential for improvingmechanical performance,and the study of their stability is of great interest.In this paper,the optimization of the critical buckling load factor for curved grid stiffeners is solved by using the level set based density method,where the shape and cross section(including thickness and width)of the stiffeners can be optimized simultaneously.The grid stiffeners are a combination ofmany single stiffenerswhich are projected by the corresponding level set functions.The thickness and width of each stiffener are designed to be independent variables in the projection applied to each level set function.Besides,the path of each single stiffener is described by the zero iso-contour of the level set function.All the single stiffeners are combined together by using the p-norm method to obtain the stiffener grid.The proposed method is validated by several numerical examples to optimize the critical buckling load factor.展开更多
In order to better meet the objective requirements of the use safety of the high-rise glulam building floor structure and the living comfort of the residents,the transient excitation,environmental excitation and frequ...In order to better meet the objective requirements of the use safety of the high-rise glulam building floor structure and the living comfort of the residents,the transient excitation,environmental excitation and frequency spectrum identification methods were used to carry out experimental modal test in-site on the three rooms numbered A,B and C of the same glulam structural building.The three rooms have different functions,different floor sizes and different floor supporting structures.The research results have shown that the first-order bending frequency of the floor structure of Room A is 27.50 Hz,the transverse second-order bending frequency is 34.75 Hz,the longitudinal second-order bending frequency is 53.25 Hz,and the first-order torsional frequency is 56.25 Hz.The reinforced wooden beam at the bottom of the floor of Room A increases the transverse stiffness of the floor structure,but does not offset the anisotropy caused by the longitudinally installed glulam floors.The fundamental frequency values of the floor structures of the three rooms numbered A,B,and C are 27.5,13 and 18 Hz,respectively.This has a relatively high innovation and reference significance for integrating the theory of structural dynamic characteristics with the dynamic testing technology,improving the design level of high-rise glulam structure buildings,and improving the living comfort of residents.展开更多
A power-supply system was developed for Ohmic heating(OH)to double×10^(18)the amount of change magnetic flux in the primary central solenoid(CS)on the QUEST spherical tokamak.Two power supplies are connected with...A power-supply system was developed for Ohmic heating(OH)to double×10^(18)the amount of change magnetic flux in the primary central solenoid(CS)on the QUEST spherical tokamak.Two power supplies are connected with stacks of insulated-gate bipolar transistors,and sequentially operated to generate positive and negative CS currents.This bipolar power-supply system is controlled via a field-programmable gate array,which guarantees the safety of the entire system operation.The new OH system,assisted by electron cyclotron heating,enables the stable generation of plasma currents exceeding 100 k A.Moreover,the achieved electron density over the wide range in the major radial direction exceeds the cut-off density for one of the highpower microwave sources in QUEST.This strategy yields target plasmas for future experiments with the electron Bernstein wave.展开更多
Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-E...Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC.展开更多
Flexible biosensors with high accuracy and reliable operation in detecting pH and uric acid levels in body fluids are fabricated using well-engineered metaldoped porous carbon as electrode material.The gold nanopartic...Flexible biosensors with high accuracy and reliable operation in detecting pH and uric acid levels in body fluids are fabricated using well-engineered metaldoped porous carbon as electrode material.The gold nanoparticles@N-doped carbon in situ are prepared using wool keratin as both a novel carbon precursor and a stabilizer.The conducting electrode material is fabricated at 500℃ under customized parameters,which mimics A-B type(two different repeating units) polymeric material and displays excellent deprotonation performance(pH sensitivity).The obtained pH sensor exhibits high pH sensitivity of 57 mV/pH unit and insignificant relative standard deviation of 0.088%.Conversely,the composite carbon material with sp^2 structure prepared at 700℃ is doped with nitrogen and gold nanoparticles,which exhibits good conductivity and electrocatalytic activity for uric acid oxidation.The uric acid sensor has linear response over a range of 1-150 μM and a limit of detection 0.1 μM.These results will provide new avenues where biological material will be the best start,which can be useful to target contradictory applications through molecular engineering at mesoscale.展开更多
In this paper,a space-time correlation based fast regional spectrum sensing(RSS)scheme is proposed to reduce the time and energy consumption of traditional spatial spectrum sensing. The target region is divided into s...In this paper,a space-time correlation based fast regional spectrum sensing(RSS)scheme is proposed to reduce the time and energy consumption of traditional spatial spectrum sensing. The target region is divided into small meshes,and all meshes are clustered into highly related groups using the spatial correlation among them. In each group,some representative meshes are selected as detecting meshes(DMs)using a multi-center mesh(MCM)clustering algorithm,while other meshes(EMs)are estimated according to their correlations with DMs and the Markov modeled dependence on history by MAP principle. Thus,detecting fewer meshes saves the sensing consumption. Since two independent estimation processes may provide contradictory results,minimum entropy principle is adopted to merge the results. Tested with data acquired by radio environment mapping measurement conducted in the downtown Beijing,our scheme is capable to reduce the consumption of traditional sensing method with acceptable sensing performance.展开更多
Urea oxidation reaction (UOR),which has favorable thermodynamic energy barriers compared with oxygen evolution reaction (OER),can provide more cost-effective electrons for the renewable energy systems,but is trapped b...Urea oxidation reaction (UOR),which has favorable thermodynamic energy barriers compared with oxygen evolution reaction (OER),can provide more cost-effective electrons for the renewable energy systems,but is trapped by its sluggish UOR kinetics and intricate reaction intermediates formation/desorption process.Herein,we report a novel and effective electrocatalyst consisting of carbon cloth supported nitrogen vacancies-enriched Ce-doped Ni_(3)N hierarchical nanosheets (Ce-Ni_(3)N @CC) to optimize the flat-footed UOR kinetics,especially the stiff rate-determine CO_(2)desorption step of UOR.Upon the introduction of valance state variable Ce,the resultant nitrogen vacancies enriched Ce-Ni_(3)N @CC exhibits an enhanced UOR performance where the operation voltage requires only 1.31 V to deliver the current density of 10 mA cm^(-2),which is superior to that of Ni_(3)N @CC catalyst (1.36 V) and other counterparts.Density functional theory (DFT) results demonstrate that the incorporation of Ce in Ni_(3)N lowers the formation energy of nitrogen vacancies,resulting in rich nitrogen vacancies in Ce-Ni_(3)N @CC.Moreover,the nitrogen vacancies together with Ce doping optimize the local charge distribution around Ni sites,and balance the adsorption energy of CO_(2)in the rate-determining step (RDS),as well as affect the initial adsorption structure of urea,leading to the superior UOR catalytic performance of Ce-Ni_(3)N @CC.When integrating the Ce-Ni_(3)N catalyst in UOR//HER and UOR//CO_(2)R flow electrolyzer,both of them perform well with low operation voltage and robust long-term stability,proofing that the thermodynamically favorable UOR can act as a suitable substitute anodic reaction compared with that of OER.Our findings here not only provide a novel UOR catalyst but also offer a promising design strategy for the future development of energy-related devices.展开更多
The uncontrolled formation of lithium(Li)dendrites and the unnecessary consumption of electrolyte during the Li plating/stripping process have been major obstacles in developing safe and stable Li metal batteries.Here...The uncontrolled formation of lithium(Li)dendrites and the unnecessary consumption of electrolyte during the Li plating/stripping process have been major obstacles in developing safe and stable Li metal batteries.Herein,we report a cucumber-like lithiophilic composite skeleton(CLCS)fabricated through a facile oxidationimmersion-reduction method.The stepwise Li deposition and stripping,determined using in situ Raman spectra during the galvanostatic Li charging/discharging process,promote the formation of a dendrite-free Li metal anode.Furthermore,numerous pyridinic N,pyrrolic N,and CuxN sites with excellent lithiophilicity work synergistically to distribute Li ions and suppress the formation of Li dendrites.Owing to these advantages,cells based on CLCS exhibit a high Coulombic efficiency of 97.3%for 700 cycles and an improved lifespan of 2000 h for symmetric cells.The full cells assembled with LiFePO_(4)(LFP),SeS_(2) cathodes and CLCS@Li anodes demonstrate high capacities of 110.1 mAh g^(−1) after 600 cycles at 0.2 A g^(−1) in CLCS@Li|LFP and 491.8 mAh g^(−1) after 500 cycles at 1 A g^(−1) in CLCS@Li|SeS2.The unique design of CLCS may accelerate the application of Li metal anodes in commercial Li metal batteries.展开更多
Cooling, transportation and sale processes of spiced geese were studied, eight spiced geese meat samples with different sampling time, Airborne microorganism samples of three different workplaces and five different en...Cooling, transportation and sale processes of spiced geese were studied, eight spiced geese meat samples with different sampling time, Airborne microorganism samples of three different workplaces and five different environmental contact substance samples were test, measures of special mediums, biochemical identification and DNA sequencing were carried out, then Escherichia coli, Yeast, Mildew, Lactic acid bacteria, Staphylococcus aureus and Janthinobacterium were detected. For spiced geese meat samples, microorganisms were significant (p ) increased with the prolong of sampling time. Lactic acid bacteria, Staphylococcus aureus and Janthinobacterium were detected in each processing operation and the total aerobic counts of each sample was increased or significant (p ) increased with the prolong of sampling time;Escherichia coli, Yeast and Mildew were detected on samples entered into the retail outlet mainly and the total aerobic counts of each sample was increased or significant (p ) increased also. In the household workshop, Mildew and Janthinobacterium were the superior microorganisms. In the transport vehicle, Staphylococcus aureus and Janthinobacterium were the superior microorganisms;Staphylococcus aureus was the superior microorganism in the retail outlet. For environmental contact substances, Cooling platform, pallet, chopping block were the most serious contaminated environmental contact substances and the total bacteria counts were significant (p ) more than stainless steel barrel and chopper;Janthinobacterium was the superior microorganism on pallet, stainless steel barrel and chopper;Lactic acid bacteria was the superior microorganism on chopping block and stainless steel barrel;Staphylococcus aureus was the superior microorganism on cooling platform. Findings indicate that Escherichia coli, Yeast, Mildew, Lactic acid bacteria, Staphylococcus aureus, Janthinobacterium were the main microorganisms;Household workshop and the retail outlet were the main place microorganisms contaminated;Pallet, stainless steel barrel and chopper were the main environmental contact substances.展开更多
“Music Therapy”is an emerging interdisciplinary subject based on social development,which has merged together with psychology,medicine,neuroscience and musicology.Music therapy abandons the traditional diagnostic mo...“Music Therapy”is an emerging interdisciplinary subject based on social development,which has merged together with psychology,medicine,neuroscience and musicology.Music therapy abandons the traditional diagnostic model,which only focuses on patients’pathological changes.It simultaneously heals patients’body and mind,hence to achieve a better therapeutic effect.Music therapy has analgesic effect,which has been clinically applied to puerperia and used to divert puerperia’s attention from pain during labor.Applying music therapy during pregnancy to relieve tension and prevent negative emotions that may cause harmful effect to pregnant woman and the fetus.展开更多
Injury to the peripheral nerves can result in temporary or life-long neuronal dysfunction and subsequent economic or social disability. Acidic fibroblast growth factor(a FGF) promotes the growth and survival of neuron...Injury to the peripheral nerves can result in temporary or life-long neuronal dysfunction and subsequent economic or social disability. Acidic fibroblast growth factor(a FGF) promotes the growth and survival of neurons and is a possible treatment for peripheral nerve injury. Yet,the actual therapeutic utility of a FGF is limited by its short half-life and instability in vivo. In the present study,we prepared sulfated chitooligosaccharides(SCOS),which have heparinlike properties,to improve the bioactivity of a FGF. We investigated the protective effects of SCOS with or without a FGF on RSC96 cells exposed to Na2 S2 O4 hypoxia/reoxygenation injury. Cell viability was measured by MTT assay and cytotoxicity induced by Na2 S2 O4 was assessed by lactate dehydrogenase(LDH) release into the culture medium. Pretreatment with a FGF and SCOS dramatically decreased LDH release after injury compared to pretreatment with a FGF or SCOS alone. We subsequently prepared an a FGF/SCOS thermo-sensitive hydrogel with poloxamer and examined its effects in vivo. Paw withdrawal thresholds and thermal withdrawal latencies were measured in rats with sciatic nerve injury. Local injection of the a FGF/SCOS hydrogels(a FGF: 40,80 μg/kg) increased the efficiency of sciatic nerve repair compared to a FGF(80 μg/kg) hydrogel alone. Especially a FGF/SCOS thermo-sensitive hydrogel decreased paw withdrawal thresholds from 117.75 ± 8.38(g,4 d) to 65.74 ± 3.39(g,10 d),but a FGF alone group were 140.58 ± 27.54(g,4 d) to 89.12 ± 5.60(g,10 d)(a FGF dose was 80 μg/kg,P < 0.05,n = 8). The thermal withdrawal latencies decreased from 11.61 ± 2.26(s,4 d) to 2.37 ±0.67(s,10 d). However,a FGF alone group were from 17.69 ± 1.47(s,4 d) to4.65 ± 1.73(s,10 d)(P < 0.05,n = 8). Furthermore,the a FGF/SCOS hydrogels also exhibited good biocompatibility in mice. In summary,SCOS improved the protective effects of a FGF in RSC96 cells injured with Na2S2O4 and increased the efficiency of nerve repair and recovery of function in rats with sciatic nerve injury. These findings pave an avenue for the development of novel prophylactic and therapeutic strategies for peripheral nerve injury.展开更多
There is an urgent need to break through the trade-off between proton conductivity and ion selectivity of proton exchange membrane(PEM)in vanadium flow battery(VFB).Proton channels in PEM are the key to controlling th...There is an urgent need to break through the trade-off between proton conductivity and ion selectivity of proton exchange membrane(PEM)in vanadium flow battery(VFB).Proton channels in PEM are the key to controlling the ion sieving and proton conductivity in VFB.Herein,two types of proton channels are reconstructed in the hybrid membrane via introducing modified Zr-MOFs(IM-UIO-66-AS)into SPEEK matrix.Internal proton channels in IM-UIO-66-AS and interfacial proton channels between grafted imidazole groups on Zr-MOFs and SPEEK greatly improve the conductivity of the IM-UIO-66-AS/SPEEK hybrid membrane.More importantly,both reconstructed proton channels block the vanadium-ion permeation to realize enhanced ion selectivity according to the size sieving and Donnan exclusion effects,respectively.Moreover,the hybrid membrane exhibits good mechanical property and dimensional stability.Benefiting from such rational design,a VFB loading with the optimized membrane exhibits enhanced voltage efficiency of 79.9%and outstanding energy efficiency of 79.6%at 200 m A cm^(-2),and keeps a notable cycle stability for 300 cycles in the long-term cycling test.Therefore,this study provides inspiration for preparing next-generation PEMs with high ion selectivity and proton conductivity for VFB application.展开更多
To describe the dynamic cracking process of the CLT vertical layer,the correlation between a load-displacement curve,specimen cracking,and planar shear failure mechanism of the CLT were explored.A three-point bending ...To describe the dynamic cracking process of the CLT vertical layer,the correlation between a load-displacement curve,specimen cracking,and planar shear failure mechanism of the CLT were explored.A three-point bending test and an improved planar shear test are used to evaluate the shear performance of the CLT.In this study,the load-displacement curve is recorded,the experimental part is synchronized with the video,the dynamic process of cracking of the vertical layer is observed and analyzed throughout the test.From the load-displacement curve,the image characteristics of the initial cracking and the sudden increase of the cracking of the specimen are summar-ized.The description results of the whole dynamic process of the CLT vertical layer cracking are analyzed by pla-nar shear strength value,cracking phenomenon,and azimuth angle of cracking surface.The main conclusions show that the three-point bending test and the improved plain shear test can be used to test the plain shear strength of the CLT,with a difference of only 5.7%.The original crack and the new crack expansion account for 18.9%and 81.1%of the main cracking surface,respectively.And the vertical layer of the CLT specimen under three-point bending has three cracking morphologies,such as radial shake,ring shake,neither along with the radial shake nor along with the ring shake.The azimuth angle of the cracking surface of the CLT vertical layer under planar shear is quite consistent with the first main plane azimuth of the vertical layer of the CLT specimens under the three-point bending test and the shearing test.The shape in the cracking direction of the left half-span or the right half-span of the vertical layer of the specimen is similar to the Chinese character eight.展开更多
Objective:Glypican-3(GPC3)is a promising therapeutic target in hepatocellular carcinoma(HCC).We have generated the HN3 and h YP7 antibodies that recognize the N-lobe and C-lobe of GPC3,respectively.Here,we engineered ...Objective:Glypican-3(GPC3)is a promising therapeutic target in hepatocellular carcinoma(HCC).We have generated the HN3 and h YP7 antibodies that recognize the N-lobe and C-lobe of GPC3,respectively.Here,we engineered human T cells that express GPC3-specific chimeric antigen receptors(CARs)and evaluated their potential for the treatment of HCC.展开更多
[Objectives]To examine the effects of Wumen Qingyi Decoction on inflammatory responses in patients with acute pancreatitis(AP).[Methods]Eighty patients with mild or severe AP were randomly allocated to a treatment gro...[Objectives]To examine the effects of Wumen Qingyi Decoction on inflammatory responses in patients with acute pancreatitis(AP).[Methods]Eighty patients with mild or severe AP were randomly allocated to a treatment group(Wumen Qingyi Decoction+baseline treated)or a control group(baseline treated).All patients were managed conservatively.In addition,the Group A received Wumen Qingyi Decoction for 400 mL/d for 7 d.Laboratory parameters,condition of disease and therapeutic effect indexes,and so on,between the two groups were compared.[Results]The recovery of serum levels of amylase(AMS),C reaction protein(CRP),and tumor necrosis factor(TNF-α),interleukin1(IL-1),IL-6,IL-10,as well as the scores of Balthazar and BISAP in Treatment group were quicker than those in Control group(P<0.05).In addition,the improvement of organic dysfunction in Treatment group was better than that in Control group.[Conclusions]The course of combined Wumen Qingyi Decoction and basic treatment of western medicine could effectively adjust the body's inflammatory response to promote the recovery process of acute pancreatitis.展开更多
基金supported by the National Natural Science Foundation of China(22234005,21974070)the Natural Science Foundation of Jiangsu Province(BK20222015)。
文摘Atomically dispersed catalysts exhibit significant influence on facilitating the sluggish oxygen reduction reaction(ORR)kinetics with high atom economy,owing to remarkable attributes including nearly 100%atomic utilization and exceptional catalytic functionality.Furthermore,accurately controlling atomic physical properties including spin,charge,orbital,and lattice degrees of atomically dispersed catalysts can realize the optimized chemical properties including maximum atom utilization efficiency,homogenous active centers,and satisfactory catalytic performance,but remains elusive.Here,through physical and chemical insight,we review and systematically summarize the strategies to optimize atomically dispersed ORR catalysts including adjusting the atomic coordination environment,adjacent electronic orbital and site density,and the choice of dual-atom sites.Then the emphasis is on the fundamental understanding of the correlation between the physical property and the catalytic behavior for atomically dispersed catalysts.Finally,an overview of the existing challenges and prospects to illustrate the current obstacles and potential opportunities for the advancement of atomically dispersed catalysts in the realm of electrocatalytic reactions is offered.
基金supported by Ningxia Key R&D Program (Key)Project (2023BDE02001)Ningxia Key R&D Program (Talent Introduction Special)Project (2022YCZX0013)+2 种基金North Minzu University 2022 School-Level Research Platform“Digital Agriculture Empowering Ningxia Rural Revitalization Innovation Team”,Project Number:2022PT_S10Yinchuan City School-Enterprise Joint Innovation Project (2022XQZD009)“Innovation Team for Imaging and Intelligent Information Processing”of the National Ethnic Affairs Commission.
文摘Widely used deep neural networks currently face limitations in achieving optimal performance for purchase intention prediction due to constraints on data volume and hyperparameter selection.To address this issue,based on the deep forest algorithm and further integrating evolutionary ensemble learning methods,this paper proposes a novel Deep Adaptive Evolutionary Ensemble(DAEE)model.This model introduces model diversity into the cascade layer,allowing it to adaptively adjust its structure to accommodate complex and evolving purchasing behavior patterns.Moreover,this paper optimizes the methods of obtaining feature vectors,enhancement vectors,and prediction results within the deep forest algorithm to enhance the model’s predictive accuracy.Results demonstrate that the improved deep forest model not only possesses higher robustness but also shows an increase of 5.02%in AUC value compared to the baseline model.Furthermore,its training runtime speed is 6 times faster than that of deep models,and compared to other improved models,its accuracy has been enhanced by 0.9%.
基金supported by the Open Project of National Major Science and Technology Infrastructure of Translational Medicine,China(Grant No.:TMSK-2021−404)the SIMM-SHUTCM Joint Innovation Research Program,China(2022)+1 种基金the Youth Innovation Research Foundation,China(Grant No.:A1-U21-205-01010109)the National Natural Science Foundation of China(Grant No.:81972932).
文摘Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in China.Our previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain unclear.Herein,as an extension to our previous investigation,we provide comprehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and stability.The results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glycogen synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin tissues.Furthermore,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and mice.Finally,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis processes.These data conclude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries.
基金supported by the National Natural Science Foundation of China(Grant Nos.51975227 and 12272144).
文摘Stiffened structures have great potential for improvingmechanical performance,and the study of their stability is of great interest.In this paper,the optimization of the critical buckling load factor for curved grid stiffeners is solved by using the level set based density method,where the shape and cross section(including thickness and width)of the stiffeners can be optimized simultaneously.The grid stiffeners are a combination ofmany single stiffenerswhich are projected by the corresponding level set functions.The thickness and width of each stiffener are designed to be independent variables in the projection applied to each level set function.Besides,the path of each single stiffener is described by the zero iso-contour of the level set function.All the single stiffeners are combined together by using the p-norm method to obtain the stiffener grid.The proposed method is validated by several numerical examples to optimize the critical buckling load factor.
文摘In order to better meet the objective requirements of the use safety of the high-rise glulam building floor structure and the living comfort of the residents,the transient excitation,environmental excitation and frequency spectrum identification methods were used to carry out experimental modal test in-site on the three rooms numbered A,B and C of the same glulam structural building.The three rooms have different functions,different floor sizes and different floor supporting structures.The research results have shown that the first-order bending frequency of the floor structure of Room A is 27.50 Hz,the transverse second-order bending frequency is 34.75 Hz,the longitudinal second-order bending frequency is 53.25 Hz,and the first-order torsional frequency is 56.25 Hz.The reinforced wooden beam at the bottom of the floor of Room A increases the transverse stiffness of the floor structure,but does not offset the anisotropy caused by the longitudinally installed glulam floors.The fundamental frequency values of the floor structures of the three rooms numbered A,B,and C are 27.5,13 and 18 Hz,respectively.This has a relatively high innovation and reference significance for integrating the theory of structural dynamic characteristics with the dynamic testing technology,improving the design level of high-rise glulam structure buildings,and improving the living comfort of residents.
基金supported by the NIFS Bilateral Collaboration Research Program(Nos.NIFS19-KUTR136,NIFS22KUTR169)Grant-in-Aid for Scientific Research(C)(No.21K03510)Collaborative Research Program of the RIAM in Kyushu University。
文摘A power-supply system was developed for Ohmic heating(OH)to double×10^(18)the amount of change magnetic flux in the primary central solenoid(CS)on the QUEST spherical tokamak.Two power supplies are connected with stacks of insulated-gate bipolar transistors,and sequentially operated to generate positive and negative CS currents.This bipolar power-supply system is controlled via a field-programmable gate array,which guarantees the safety of the entire system operation.The new OH system,assisted by electron cyclotron heating,enables the stable generation of plasma currents exceeding 100 k A.Moreover,the achieved electron density over the wide range in the major radial direction exceeds the cut-off density for one of the highpower microwave sources in QUEST.This strategy yields target plasmas for future experiments with the electron Bernstein wave.
文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC.
基金supported by the National Natural Science Foundation of China(Grant Nos.51502253,U1405226,21503175,51773171,and 21705135)Natural Science Foundation of Guangdong Province(Grant No.2016A030310369)+5 种基金Natural Science Foundation of Fujian Province(Grant No.2017J01104)the Fundamental Research Funds for the Central Universities of China(Grant Nos.20720160127 and 20720180013)Doctoral Fund of the Ministry of Education(Grant No.20130121110018)NUS Ac RF Tier 1(Grant No.R-144-000-367-112)the “111” Project(Grant No.B16029)the 1000 Talents Program funding from the Xiamen University。
文摘Flexible biosensors with high accuracy and reliable operation in detecting pH and uric acid levels in body fluids are fabricated using well-engineered metaldoped porous carbon as electrode material.The gold nanoparticles@N-doped carbon in situ are prepared using wool keratin as both a novel carbon precursor and a stabilizer.The conducting electrode material is fabricated at 500℃ under customized parameters,which mimics A-B type(two different repeating units) polymeric material and displays excellent deprotonation performance(pH sensitivity).The obtained pH sensor exhibits high pH sensitivity of 57 mV/pH unit and insignificant relative standard deviation of 0.088%.Conversely,the composite carbon material with sp^2 structure prepared at 700℃ is doped with nitrogen and gold nanoparticles,which exhibits good conductivity and electrocatalytic activity for uric acid oxidation.The uric acid sensor has linear response over a range of 1-150 μM and a limit of detection 0.1 μM.These results will provide new avenues where biological material will be the best start,which can be useful to target contradictory applications through molecular engineering at mesoscale.
基金supported in part by National Natural Science Foundation of China under Grants(61525101,61227801 and 61601055)in part by the National Key Technology R&D Program of China under Grant 2015ZX03002008
文摘In this paper,a space-time correlation based fast regional spectrum sensing(RSS)scheme is proposed to reduce the time and energy consumption of traditional spatial spectrum sensing. The target region is divided into small meshes,and all meshes are clustered into highly related groups using the spatial correlation among them. In each group,some representative meshes are selected as detecting meshes(DMs)using a multi-center mesh(MCM)clustering algorithm,while other meshes(EMs)are estimated according to their correlations with DMs and the Markov modeled dependence on history by MAP principle. Thus,detecting fewer meshes saves the sensing consumption. Since two independent estimation processes may provide contradictory results,minimum entropy principle is adopted to merge the results. Tested with data acquired by radio environment mapping measurement conducted in the downtown Beijing,our scheme is capable to reduce the consumption of traditional sensing method with acceptable sensing performance.
基金financially supported by the National Natural Science Foundation of China (22109073, 22072067 and 21875112)the supports from National and Local Joint Engineering Research Center of Biomedical Functional Materialsa project sponsored by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Urea oxidation reaction (UOR),which has favorable thermodynamic energy barriers compared with oxygen evolution reaction (OER),can provide more cost-effective electrons for the renewable energy systems,but is trapped by its sluggish UOR kinetics and intricate reaction intermediates formation/desorption process.Herein,we report a novel and effective electrocatalyst consisting of carbon cloth supported nitrogen vacancies-enriched Ce-doped Ni_(3)N hierarchical nanosheets (Ce-Ni_(3)N @CC) to optimize the flat-footed UOR kinetics,especially the stiff rate-determine CO_(2)desorption step of UOR.Upon the introduction of valance state variable Ce,the resultant nitrogen vacancies enriched Ce-Ni_(3)N @CC exhibits an enhanced UOR performance where the operation voltage requires only 1.31 V to deliver the current density of 10 mA cm^(-2),which is superior to that of Ni_(3)N @CC catalyst (1.36 V) and other counterparts.Density functional theory (DFT) results demonstrate that the incorporation of Ce in Ni_(3)N lowers the formation energy of nitrogen vacancies,resulting in rich nitrogen vacancies in Ce-Ni_(3)N @CC.Moreover,the nitrogen vacancies together with Ce doping optimize the local charge distribution around Ni sites,and balance the adsorption energy of CO_(2)in the rate-determining step (RDS),as well as affect the initial adsorption structure of urea,leading to the superior UOR catalytic performance of Ce-Ni_(3)N @CC.When integrating the Ce-Ni_(3)N catalyst in UOR//HER and UOR//CO_(2)R flow electrolyzer,both of them perform well with low operation voltage and robust long-term stability,proofing that the thermodynamically favorable UOR can act as a suitable substitute anodic reaction compared with that of OER.Our findings here not only provide a novel UOR catalyst but also offer a promising design strategy for the future development of energy-related devices.
基金This work is well supported by National Natural Science Foundation of China(52073170,21975154)Shanghai Municipal Education Commission(Innovation Program(2019-01-07-00-09-E00021)Innovative Research Team of High-level Local Universities in Shanghai.The authors also acknowledge Lab for Microstructure,Instrumental Analysis&Research Center,Shanghai University,for their help on materials characterization.Moreover,the authors thank High Performance Computing Center of Shanghai University,and Shanghai Engineering Research Center of Intelligent Computing System(No.19DZ2252600)for the assistance of computing resources and technical support.
文摘The uncontrolled formation of lithium(Li)dendrites and the unnecessary consumption of electrolyte during the Li plating/stripping process have been major obstacles in developing safe and stable Li metal batteries.Herein,we report a cucumber-like lithiophilic composite skeleton(CLCS)fabricated through a facile oxidationimmersion-reduction method.The stepwise Li deposition and stripping,determined using in situ Raman spectra during the galvanostatic Li charging/discharging process,promote the formation of a dendrite-free Li metal anode.Furthermore,numerous pyridinic N,pyrrolic N,and CuxN sites with excellent lithiophilicity work synergistically to distribute Li ions and suppress the formation of Li dendrites.Owing to these advantages,cells based on CLCS exhibit a high Coulombic efficiency of 97.3%for 700 cycles and an improved lifespan of 2000 h for symmetric cells.The full cells assembled with LiFePO_(4)(LFP),SeS_(2) cathodes and CLCS@Li anodes demonstrate high capacities of 110.1 mAh g^(−1) after 600 cycles at 0.2 A g^(−1) in CLCS@Li|LFP and 491.8 mAh g^(−1) after 500 cycles at 1 A g^(−1) in CLCS@Li|SeS2.The unique design of CLCS may accelerate the application of Li metal anodes in commercial Li metal batteries.
文摘Cooling, transportation and sale processes of spiced geese were studied, eight spiced geese meat samples with different sampling time, Airborne microorganism samples of three different workplaces and five different environmental contact substance samples were test, measures of special mediums, biochemical identification and DNA sequencing were carried out, then Escherichia coli, Yeast, Mildew, Lactic acid bacteria, Staphylococcus aureus and Janthinobacterium were detected. For spiced geese meat samples, microorganisms were significant (p ) increased with the prolong of sampling time. Lactic acid bacteria, Staphylococcus aureus and Janthinobacterium were detected in each processing operation and the total aerobic counts of each sample was increased or significant (p ) increased with the prolong of sampling time;Escherichia coli, Yeast and Mildew were detected on samples entered into the retail outlet mainly and the total aerobic counts of each sample was increased or significant (p ) increased also. In the household workshop, Mildew and Janthinobacterium were the superior microorganisms. In the transport vehicle, Staphylococcus aureus and Janthinobacterium were the superior microorganisms;Staphylococcus aureus was the superior microorganism in the retail outlet. For environmental contact substances, Cooling platform, pallet, chopping block were the most serious contaminated environmental contact substances and the total bacteria counts were significant (p ) more than stainless steel barrel and chopper;Janthinobacterium was the superior microorganism on pallet, stainless steel barrel and chopper;Lactic acid bacteria was the superior microorganism on chopping block and stainless steel barrel;Staphylococcus aureus was the superior microorganism on cooling platform. Findings indicate that Escherichia coli, Yeast, Mildew, Lactic acid bacteria, Staphylococcus aureus, Janthinobacterium were the main microorganisms;Household workshop and the retail outlet were the main place microorganisms contaminated;Pallet, stainless steel barrel and chopper were the main environmental contact substances.
文摘“Music Therapy”is an emerging interdisciplinary subject based on social development,which has merged together with psychology,medicine,neuroscience and musicology.Music therapy abandons the traditional diagnostic model,which only focuses on patients’pathological changes.It simultaneously heals patients’body and mind,hence to achieve a better therapeutic effect.Music therapy has analgesic effect,which has been clinically applied to puerperia and used to divert puerperia’s attention from pain during labor.Applying music therapy during pregnancy to relieve tension and prevent negative emotions that may cause harmful effect to pregnant woman and the fetus.
基金supported by the Science and Technology Program of Guangzhou (201508020001)the Major Scientific and Technological Special Project of the Administration of Ocean and Fisheries of Guangdong Province (Yuecainong, 2017, no. 17)+2 种基金the Operating fund of Guangdong Provincial Key Laboratory of Bioengineering Medicine (No. 2014B030301050)a project of the Research Development and Industrialization of Guangdong Province (2013B090500046)the Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme (2012)
文摘Injury to the peripheral nerves can result in temporary or life-long neuronal dysfunction and subsequent economic or social disability. Acidic fibroblast growth factor(a FGF) promotes the growth and survival of neurons and is a possible treatment for peripheral nerve injury. Yet,the actual therapeutic utility of a FGF is limited by its short half-life and instability in vivo. In the present study,we prepared sulfated chitooligosaccharides(SCOS),which have heparinlike properties,to improve the bioactivity of a FGF. We investigated the protective effects of SCOS with or without a FGF on RSC96 cells exposed to Na2 S2 O4 hypoxia/reoxygenation injury. Cell viability was measured by MTT assay and cytotoxicity induced by Na2 S2 O4 was assessed by lactate dehydrogenase(LDH) release into the culture medium. Pretreatment with a FGF and SCOS dramatically decreased LDH release after injury compared to pretreatment with a FGF or SCOS alone. We subsequently prepared an a FGF/SCOS thermo-sensitive hydrogel with poloxamer and examined its effects in vivo. Paw withdrawal thresholds and thermal withdrawal latencies were measured in rats with sciatic nerve injury. Local injection of the a FGF/SCOS hydrogels(a FGF: 40,80 μg/kg) increased the efficiency of sciatic nerve repair compared to a FGF(80 μg/kg) hydrogel alone. Especially a FGF/SCOS thermo-sensitive hydrogel decreased paw withdrawal thresholds from 117.75 ± 8.38(g,4 d) to 65.74 ± 3.39(g,10 d),but a FGF alone group were 140.58 ± 27.54(g,4 d) to 89.12 ± 5.60(g,10 d)(a FGF dose was 80 μg/kg,P < 0.05,n = 8). The thermal withdrawal latencies decreased from 11.61 ± 2.26(s,4 d) to 2.37 ±0.67(s,10 d). However,a FGF alone group were from 17.69 ± 1.47(s,4 d) to4.65 ± 1.73(s,10 d)(P < 0.05,n = 8). Furthermore,the a FGF/SCOS hydrogels also exhibited good biocompatibility in mice. In summary,SCOS improved the protective effects of a FGF in RSC96 cells injured with Na2S2O4 and increased the efficiency of nerve repair and recovery of function in rats with sciatic nerve injury. These findings pave an avenue for the development of novel prophylactic and therapeutic strategies for peripheral nerve injury.
基金supported by the National Natural Science Foundation of China(Grant No.21975267)the Central Guidance on Local Science and Technology Development Fund of Liaoning Province(No:2022JH6/100100001)。
文摘There is an urgent need to break through the trade-off between proton conductivity and ion selectivity of proton exchange membrane(PEM)in vanadium flow battery(VFB).Proton channels in PEM are the key to controlling the ion sieving and proton conductivity in VFB.Herein,two types of proton channels are reconstructed in the hybrid membrane via introducing modified Zr-MOFs(IM-UIO-66-AS)into SPEEK matrix.Internal proton channels in IM-UIO-66-AS and interfacial proton channels between grafted imidazole groups on Zr-MOFs and SPEEK greatly improve the conductivity of the IM-UIO-66-AS/SPEEK hybrid membrane.More importantly,both reconstructed proton channels block the vanadium-ion permeation to realize enhanced ion selectivity according to the size sieving and Donnan exclusion effects,respectively.Moreover,the hybrid membrane exhibits good mechanical property and dimensional stability.Benefiting from such rational design,a VFB loading with the optimized membrane exhibits enhanced voltage efficiency of 79.9%and outstanding energy efficiency of 79.6%at 200 m A cm^(-2),and keeps a notable cycle stability for 300 cycles in the long-term cycling test.Therefore,this study provides inspiration for preparing next-generation PEMs with high ion selectivity and proton conductivity for VFB application.
文摘To describe the dynamic cracking process of the CLT vertical layer,the correlation between a load-displacement curve,specimen cracking,and planar shear failure mechanism of the CLT were explored.A three-point bending test and an improved planar shear test are used to evaluate the shear performance of the CLT.In this study,the load-displacement curve is recorded,the experimental part is synchronized with the video,the dynamic process of cracking of the vertical layer is observed and analyzed throughout the test.From the load-displacement curve,the image characteristics of the initial cracking and the sudden increase of the cracking of the specimen are summar-ized.The description results of the whole dynamic process of the CLT vertical layer cracking are analyzed by pla-nar shear strength value,cracking phenomenon,and azimuth angle of cracking surface.The main conclusions show that the three-point bending test and the improved plain shear test can be used to test the plain shear strength of the CLT,with a difference of only 5.7%.The original crack and the new crack expansion account for 18.9%and 81.1%of the main cracking surface,respectively.And the vertical layer of the CLT specimen under three-point bending has three cracking morphologies,such as radial shake,ring shake,neither along with the radial shake nor along with the ring shake.The azimuth angle of the cracking surface of the CLT vertical layer under planar shear is quite consistent with the first main plane azimuth of the vertical layer of the CLT specimens under the three-point bending test and the shearing test.The shape in the cracking direction of the left half-span or the right half-span of the vertical layer of the specimen is similar to the Chinese character eight.
文摘Objective:Glypican-3(GPC3)is a promising therapeutic target in hepatocellular carcinoma(HCC).We have generated the HN3 and h YP7 antibodies that recognize the N-lobe and C-lobe of GPC3,respectively.Here,we engineered human T cells that express GPC3-specific chimeric antigen receptors(CARs)and evaluated their potential for the treatment of HCC.
基金Supported by the Science and Technology Project of Suzhou Municipal Health Commission(Special Technical Project for Diagnosis and Treatment of Key Clinical Diseases:LCZX201917)2020 Science and Technology Development Plan Project of Suzhou Science and Technology Bureau(SYSD2020149).
文摘[Objectives]To examine the effects of Wumen Qingyi Decoction on inflammatory responses in patients with acute pancreatitis(AP).[Methods]Eighty patients with mild or severe AP were randomly allocated to a treatment group(Wumen Qingyi Decoction+baseline treated)or a control group(baseline treated).All patients were managed conservatively.In addition,the Group A received Wumen Qingyi Decoction for 400 mL/d for 7 d.Laboratory parameters,condition of disease and therapeutic effect indexes,and so on,between the two groups were compared.[Results]The recovery of serum levels of amylase(AMS),C reaction protein(CRP),and tumor necrosis factor(TNF-α),interleukin1(IL-1),IL-6,IL-10,as well as the scores of Balthazar and BISAP in Treatment group were quicker than those in Control group(P<0.05).In addition,the improvement of organic dysfunction in Treatment group was better than that in Control group.[Conclusions]The course of combined Wumen Qingyi Decoction and basic treatment of western medicine could effectively adjust the body's inflammatory response to promote the recovery process of acute pancreatitis.
