The shortage of personal protective equipment and lack of proper nursing training have been endangering health care workers dealing with coronavirus disease 2019(COVID-19).In our treatment center,the implementation of...The shortage of personal protective equipment and lack of proper nursing training have been endangering health care workers dealing with coronavirus disease 2019(COVID-19).In our treatment center,the implementation of a holistic care model of time-sharing management for severe and critical COVID-19 patients has further aggravated the shortage of intensive care unit(ICU)professional nurses.Therefore,we developed a short-term specialized and targeted nursing training program to help ICU nurses to cope with stress and become more efficient,thus reducing the number of nurses required in the ICU.In order to avoid possible human-to-human spread,small teaching classes and remote training were applied.The procedural training mode included four steps:preparation,plan,implementation,and evaluation.An evaluation was conducted throughout the process of nursing training.In this study,we documented and shared experiences in transitioning from traditional face-to-face programs to remote combined with proceduralization nursing training mode from our daily work experiences during the COVID-19 pandemic,which has shown to be helpful for nurses working in the ICU.展开更多
The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical ca...The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical care staff.A holistic care model on time-sharing management for severe and critical COVID-19 patients is proposed,which includes formulation of individualized care objectives and plans,identification of care tasks in each shift and making detailed checklist,and management of quality of care.This study was conducted in the COVID-19 treatment center of Harbin,Heilongjiang Province.The data collected from the treatment center were recorded and analyzed.From the results we can deduce that it is especially suitable for non-intensive care unit(non-ICU)nurses to adapt care management mode of ICU as soon as possible and ensure the quality and efficiency of care during the epidemic.The holistic care model on time-sharing management for severe and critical cases with COVID-19 proposed based on our daily work experiences can assist in improving the quality and efficiency of care,thus reducing the mortality rate of patients in ICU.展开更多
Objective:The clinical features and test results of 2019-nCoV pneumonia(COVID-19)were analyzed retrospectively in order to understand the diagnostic significance of clinical test index,and to summarize the experience ...Objective:The clinical features and test results of 2019-nCoV pneumonia(COVID-19)were analyzed retrospectively in order to understand the diagnostic significance of clinical test index,and to summarize the experience of clinical treatment.Methods:From February 10thto February 28th,2020,54 patients with COVID-19 from Wuhan Red Cross hospital were included,whose clinical data were analyzed and integrated.The clinical manifestation and laboratory examination were analyzed by descriptive statistical analysis.Results:The average age of the patients was 63.9 years(40–84 years).The median time from onset to diagnosis was 6.5 days(2–20 days),and the median time from onset to first hospitalization was 8 days(3–20 days).The main manifestations were that the percentage of neutrophil increased and the number of lymphocyte decreased in most cases.Most of them were combined with liver damage and myocardial cell damage,and chest CT showed lesion of bilateral lung.Conclusion:In addition to the nucleic acid test of 2019-nCoV,some laboratory tests may indicate COVID-19 in the early stages.The clinician may conduct repeated follow-up examinations to assess the progress and outcome of the disease.展开更多
High-Altitude Long-Endurance(HALE)solar-powered Unmanned Aircraft Vehicles(UAVs)can utilize solar energy as power source and maintain extremely long cruise endurance,which has attracted extensive attentions from resea...High-Altitude Long-Endurance(HALE)solar-powered Unmanned Aircraft Vehicles(UAVs)can utilize solar energy as power source and maintain extremely long cruise endurance,which has attracted extensive attentions from researchers.Trajectory optimization is a promising way to achieve superior flight time because of the finite solar energy absorbed in a day.In this work,a method of trajectory optimization and guidance for HALE solar-powered aircraft based on a Reinforcement Learning(RL)framework is introduced.According to flight and environment information,a neural network controller outputs commands of thrust,attack angle,and bank angle to realize an autonomous flight based on energy maximization.The validity of the proposed method was evaluated in a 5-km radius area in simulation,and results have shown that after one day-night cycle,the battery energy of the RL-controller was improved by 31%and 17%compared with those of a Steady-State(SS)strategy with a constant speed and a constant altitude and a kind of statemachine strategy,respectively.In addition,results of an uninterrupted flight test have shown that the endurance of the RL controller was longer than those of the control cases.展开更多
Graphene oxide(GO)has been increasingly utilized in the fields of food,biomedicine,environment and other fields because of its benign biocompatible.We encapsulated two kinds of GO with different sizes on yeast cells w...Graphene oxide(GO)has been increasingly utilized in the fields of food,biomedicine,environment and other fields because of its benign biocompatible.We encapsulated two kinds of GO with different sizes on yeast cells with the assistance of polyelectrolytes poly(styrene sulfonic acid)sodium salt(PSS)and polyglutamic acid(PGA)(termed as Y@GO).The result does not show a significant difference between the properties of the two types of Y@GO(namely Y@GO1 and Y@GO2).The encapsulation layers are optimized as Yeast/PGA/PSS/PGA/GO/PGA/PSS based on the morphology,dispersity,colony-forming unit,and zeta potential.The encapsulation of GO increases the roughness of the yeast.It is proved that the Y@GO increases the survival time and enhance the activity of yeast cells.The GO shell improves the resistance of yeast cells against pH and salt stresses and extends the storage time of yeast cells.展开更多
基金Supported by The National Natural Science Foundation of China,No.81772045 and No.81902000Teaching project of the First Affiliated Hospital of Harbin Medical University,No.2017014.
文摘The shortage of personal protective equipment and lack of proper nursing training have been endangering health care workers dealing with coronavirus disease 2019(COVID-19).In our treatment center,the implementation of a holistic care model of time-sharing management for severe and critical COVID-19 patients has further aggravated the shortage of intensive care unit(ICU)professional nurses.Therefore,we developed a short-term specialized and targeted nursing training program to help ICU nurses to cope with stress and become more efficient,thus reducing the number of nurses required in the ICU.In order to avoid possible human-to-human spread,small teaching classes and remote training were applied.The procedural training mode included four steps:preparation,plan,implementation,and evaluation.An evaluation was conducted throughout the process of nursing training.In this study,we documented and shared experiences in transitioning from traditional face-to-face programs to remote combined with proceduralization nursing training mode from our daily work experiences during the COVID-19 pandemic,which has shown to be helpful for nurses working in the ICU.
基金Supported by The National Natural Science Foundation of China,No.81770276and Nn10 Program of Harbin Medical University Cancer Hospital and Scientific Research Project of Heilongjiang Health and Family Planning Commission,No.2018086.
文摘The rapid global outbreak of coronavirus disease 2019(COVID-19)and the surge of infected patients have led to the verge of exhaustion of critical care medicine resources worldwide,especially with regard to critical care staff.A holistic care model on time-sharing management for severe and critical COVID-19 patients is proposed,which includes formulation of individualized care objectives and plans,identification of care tasks in each shift and making detailed checklist,and management of quality of care.This study was conducted in the COVID-19 treatment center of Harbin,Heilongjiang Province.The data collected from the treatment center were recorded and analyzed.From the results we can deduce that it is especially suitable for non-intensive care unit(non-ICU)nurses to adapt care management mode of ICU as soon as possible and ensure the quality and efficiency of care during the epidemic.The holistic care model on time-sharing management for severe and critical cases with COVID-19 proposed based on our daily work experiences can assist in improving the quality and efficiency of care,thus reducing the mortality rate of patients in ICU.
文摘Objective:The clinical features and test results of 2019-nCoV pneumonia(COVID-19)were analyzed retrospectively in order to understand the diagnostic significance of clinical test index,and to summarize the experience of clinical treatment.Methods:From February 10thto February 28th,2020,54 patients with COVID-19 from Wuhan Red Cross hospital were included,whose clinical data were analyzed and integrated.The clinical manifestation and laboratory examination were analyzed by descriptive statistical analysis.Results:The average age of the patients was 63.9 years(40–84 years).The median time from onset to diagnosis was 6.5 days(2–20 days),and the median time from onset to first hospitalization was 8 days(3–20 days).The main manifestations were that the percentage of neutrophil increased and the number of lymphocyte decreased in most cases.Most of them were combined with liver damage and myocardial cell damage,and chest CT showed lesion of bilateral lung.Conclusion:In addition to the nucleic acid test of 2019-nCoV,some laboratory tests may indicate COVID-19 in the early stages.The clinician may conduct repeated follow-up examinations to assess the progress and outcome of the disease.
基金Foundation of the Special Research Assistant of Chinese Academy of Sciences(No.E0290A0301)。
文摘High-Altitude Long-Endurance(HALE)solar-powered Unmanned Aircraft Vehicles(UAVs)can utilize solar energy as power source and maintain extremely long cruise endurance,which has attracted extensive attentions from researchers.Trajectory optimization is a promising way to achieve superior flight time because of the finite solar energy absorbed in a day.In this work,a method of trajectory optimization and guidance for HALE solar-powered aircraft based on a Reinforcement Learning(RL)framework is introduced.According to flight and environment information,a neural network controller outputs commands of thrust,attack angle,and bank angle to realize an autonomous flight based on energy maximization.The validity of the proposed method was evaluated in a 5-km radius area in simulation,and results have shown that after one day-night cycle,the battery energy of the RL-controller was improved by 31%and 17%compared with those of a Steady-State(SS)strategy with a constant speed and a constant altitude and a kind of statemachine strategy,respectively.In addition,results of an uninterrupted flight test have shown that the endurance of the RL controller was longer than those of the control cases.
基金This work is supported by the National Key Research and Development Project of China(Grant No.218YFA0903000)the National Natural Science Foundation of China(Grant Nos.21606013,21301015)+1 种基金National Mega-project for Innovative Drugs(Grant No.2019ZX09721001-007-002)Shenzhen Science and Technology Project(Grant No.JCYJ20180507183842516).
文摘Graphene oxide(GO)has been increasingly utilized in the fields of food,biomedicine,environment and other fields because of its benign biocompatible.We encapsulated two kinds of GO with different sizes on yeast cells with the assistance of polyelectrolytes poly(styrene sulfonic acid)sodium salt(PSS)and polyglutamic acid(PGA)(termed as Y@GO).The result does not show a significant difference between the properties of the two types of Y@GO(namely Y@GO1 and Y@GO2).The encapsulation layers are optimized as Yeast/PGA/PSS/PGA/GO/PGA/PSS based on the morphology,dispersity,colony-forming unit,and zeta potential.The encapsulation of GO increases the roughness of the yeast.It is proved that the Y@GO increases the survival time and enhance the activity of yeast cells.The GO shell improves the resistance of yeast cells against pH and salt stresses and extends the storage time of yeast cells.
