BACKGROUND This case report presents a patient with pyogenic spondylitis(PS)associated with lactation-related osteoporosis during pregnancy.The 34-year-old female patient experienced low back pain for one month,beginn...BACKGROUND This case report presents a patient with pyogenic spondylitis(PS)associated with lactation-related osteoporosis during pregnancy.The 34-year-old female patient experienced low back pain for one month,beginning one month postpartum,with no history of trauma or fever.Dual-energy X-ray absorptiometry of the lumbar spine revealed a Z-score of-2.45,leading to a diagnosis of pregnancy and lactation-associated osteoporosis(PLO).The patient was advised to cease breastfeeding and take oral calcium and active vitamin D.Despite these interventions,her symptoms worsened,and she had difficulty walking one week later,prompting her to revisit our hospital.CASE SUMMARY Lumbar magnetic resonance imaging(MRI)scans showed abnormal signals in the L4 and L5 vertebral bodies and intervertebral space,while an enhancement scan displayed abnormal enhanced high signals around the L4/5 intervertebral disc,suggesting a lumbar infection.A needle biopsy was performed for bacterial culture and pathological examination,culminating in a final diagnosis of pregnancy and lactation-related osteoporosis with PS.Following treatment with antiosteoporotic medications and antibiotics,the patient’s pain gradually subsided,and she returned to normal life within five months.PLO is a rare condition that has garnered increasing attention in recent years.Spinal infections during lactation in pregnancy are also relatively uncommon.CONCLUSION Both conditions primarily manifest as low back pain but require distinct treatments.In clinical practice,when diagnosing patients with pregnancy and lactation-associated osteoporosis,the possibility of spinal infection should be considered.A lumbar MRI should be conducted as needed to prevent delays in diagnosis and treatment.展开更多
BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tis...BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI<FNH<HCC<metastasis <CCC (P<0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.展开更多
Semi-empirical molecular orbital theory AM1 method is employed to study the orthoposition substituent impact on intramolecular proton transfer reaction of perylenequinone. The calculation demonstrates that the perylen...Semi-empirical molecular orbital theory AM1 method is employed to study the orthoposition substituent impact on intramolecular proton transfer reaction of perylenequinone. The calculation demonstrates that the perylenequinone molecule is of stable structure. and all substituents may cause the decrease of barriers for the hydrogen transfer reaction.展开更多
The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions.To induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of...The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions.To induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of natural tissues.Aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair.We here review how various aligned structures are fabricated,including aligned electrospun nanofibers,aligned porous or channeled structures,micropatterns and combinations thereof,and their application in nerve,skeletal muscle,tendon,and tubular dentin regeneration.The future use of aligned structures in tissue engineering is also discussed.展开更多
Objective:The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Methods:Fourteen cases of patients diagnosed with non-sma...Objective:The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Methods:Fourteen cases of patients diagnosed with non-small cell lung cancer(NSCLC),the use of the B-,CT-guided,according to preoperative imaging and treatment planning system(TPS) program for radioactive particles interposed 125I interstitial radiotherapy.Results:All patients were successfully 125I interstitial radioactive particles interposed radiotherapy.Postoperative local complete tumor remission in 9 cases,partial remission in 5 cases,the efficiency of 100%.No case of serious complications.After 3 to 4 weeks of chemotherapy after 11 cases.4 cases of lung cancer with bone metastases,pain completely disappeared after treatment.Up to now,five cases have died due to tumor progression,survival time of 12 to 16 months.Nine cases still under follow-up observation and treatment.Conclusion:125 I radioactive particles interposed radiotherapy between organizations of lung cancer,simple operation,trauma,fewer complications,conformal high,high local tumor dose,efficacy,and is a supplement of modern radiotherapy techniques for the treatment of lung cancer provides a comprehensive line of the method of effective.展开更多
Objective: The aim of this study was to analysis raltitrexed by the safety and efficacy of intra-arterial infusion chemotherapy. Methods: Forty-seven cases in different parts of cancer patients, interventional methods...Objective: The aim of this study was to analysis raltitrexed by the safety and efficacy of intra-arterial infusion chemotherapy. Methods: Forty-seven cases in different parts of cancer patients, interventional methods, based on digital subtraction angiography(DSA) prompt, raltitrexed-based chemotherapy, the tumor nourish artery infusion chemotherapy.Patients with postoperative chemotherapy side effects and complications, and efficacy assessments. Results: Forty-seven patients, 2 patients had II-III degree of bone marrow suppression, the rate was 4.26%, 34 cases of I to II degree gastrointestinal reactions, 1 case of grade III gastrointestinal reactions, the incidence of 2.13%, and 1 case mild diarrhea. I degrees or more chemotherapy-related adverse reactions did not occur in this group of patients. All patients received at least 2 times arterial infusion chemotherapy, complete remission(CR) 3 cases, partial remission(PR) 11 cases, stable disease(SD) 17cases, disease progression(PD) 6 cases, total effective rate of treatment 87.23%. Conclusion: Raltitrexed for intra-arterial chemotherapy is safe and effective. However, due to the small number of this group of patients, time is short, its safety, efficacy and long-term efficacy needs further observation and validation.展开更多
Disease is a serious threat to human society.Understanding the characteristics of disease transmission is helpful for people to effectively control disease.In real life,it is natural to take various measures when peop...Disease is a serious threat to human society.Understanding the characteristics of disease transmission is helpful for people to effectively control disease.In real life,it is natural to take various measures when people are aware of disease.In this paper,a novel coupled model considering asymmetric activity is proposed to describe the interactions between information diffusion and disease transmission in multiplex networks.Then,the critical threshold for disease transmission is derived by using the micro-Markov chain method.Finally,the theoretical results are verified by numerical simulations.The results show that reducing the activity level of individuals in the physical contact layer will have a continuous impact on reducing the disease outbreak threshold and suppressing the disease.In addition,the activity level of individuals in the virtual network has little impact on the transmission of the disease.Meanwhile,when individuals are aware of more disease-related information,the higher their awareness of prevention will be,which can effectively inhibit the transmission of disease.Our research results can provide a useful reference for the control of disease transmission.展开更多
文摘BACKGROUND This case report presents a patient with pyogenic spondylitis(PS)associated with lactation-related osteoporosis during pregnancy.The 34-year-old female patient experienced low back pain for one month,beginning one month postpartum,with no history of trauma or fever.Dual-energy X-ray absorptiometry of the lumbar spine revealed a Z-score of-2.45,leading to a diagnosis of pregnancy and lactation-associated osteoporosis(PLO).The patient was advised to cease breastfeeding and take oral calcium and active vitamin D.Despite these interventions,her symptoms worsened,and she had difficulty walking one week later,prompting her to revisit our hospital.CASE SUMMARY Lumbar magnetic resonance imaging(MRI)scans showed abnormal signals in the L4 and L5 vertebral bodies and intervertebral space,while an enhancement scan displayed abnormal enhanced high signals around the L4/5 intervertebral disc,suggesting a lumbar infection.A needle biopsy was performed for bacterial culture and pathological examination,culminating in a final diagnosis of pregnancy and lactation-related osteoporosis with PS.Following treatment with antiosteoporotic medications and antibiotics,the patient’s pain gradually subsided,and she returned to normal life within five months.PLO is a rare condition that has garnered increasing attention in recent years.Spinal infections during lactation in pregnancy are also relatively uncommon.CONCLUSION Both conditions primarily manifest as low back pain but require distinct treatments.In clinical practice,when diagnosing patients with pregnancy and lactation-associated osteoporosis,the possibility of spinal infection should be considered.A lumbar MRI should be conducted as needed to prevent delays in diagnosis and treatment.
文摘BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI<FNH<HCC<metastasis <CCC (P<0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.
文摘Semi-empirical molecular orbital theory AM1 method is employed to study the orthoposition substituent impact on intramolecular proton transfer reaction of perylenequinone. The calculation demonstrates that the perylenequinone molecule is of stable structure. and all substituents may cause the decrease of barriers for the hydrogen transfer reaction.
基金This work was financially supported by the National Key Research and Development Program of China(2018YFA0703000)the NationalNatural Science Foundation of China(81670972,31872752)+1 种基金Key Research and Development Program of Zhejiang,China(2017C01054,2018C03062,2017C01063)Postdoctoral Science Foundation of China(2020TQ0257,2020M681896).
文摘The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions.To induce such an alignment,ideal scaffolds should simulate the characteristics and morphologies of natural tissues.Aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair.We here review how various aligned structures are fabricated,including aligned electrospun nanofibers,aligned porous or channeled structures,micropatterns and combinations thereof,and their application in nerve,skeletal muscle,tendon,and tubular dentin regeneration.The future use of aligned structures in tissue engineering is also discussed.
文摘Objective:The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Methods:Fourteen cases of patients diagnosed with non-small cell lung cancer(NSCLC),the use of the B-,CT-guided,according to preoperative imaging and treatment planning system(TPS) program for radioactive particles interposed 125I interstitial radiotherapy.Results:All patients were successfully 125I interstitial radioactive particles interposed radiotherapy.Postoperative local complete tumor remission in 9 cases,partial remission in 5 cases,the efficiency of 100%.No case of serious complications.After 3 to 4 weeks of chemotherapy after 11 cases.4 cases of lung cancer with bone metastases,pain completely disappeared after treatment.Up to now,five cases have died due to tumor progression,survival time of 12 to 16 months.Nine cases still under follow-up observation and treatment.Conclusion:125 I radioactive particles interposed radiotherapy between organizations of lung cancer,simple operation,trauma,fewer complications,conformal high,high local tumor dose,efficacy,and is a supplement of modern radiotherapy techniques for the treatment of lung cancer provides a comprehensive line of the method of effective.
文摘Objective: The aim of this study was to analysis raltitrexed by the safety and efficacy of intra-arterial infusion chemotherapy. Methods: Forty-seven cases in different parts of cancer patients, interventional methods, based on digital subtraction angiography(DSA) prompt, raltitrexed-based chemotherapy, the tumor nourish artery infusion chemotherapy.Patients with postoperative chemotherapy side effects and complications, and efficacy assessments. Results: Forty-seven patients, 2 patients had II-III degree of bone marrow suppression, the rate was 4.26%, 34 cases of I to II degree gastrointestinal reactions, 1 case of grade III gastrointestinal reactions, the incidence of 2.13%, and 1 case mild diarrhea. I degrees or more chemotherapy-related adverse reactions did not occur in this group of patients. All patients received at least 2 times arterial infusion chemotherapy, complete remission(CR) 3 cases, partial remission(PR) 11 cases, stable disease(SD) 17cases, disease progression(PD) 6 cases, total effective rate of treatment 87.23%. Conclusion: Raltitrexed for intra-arterial chemotherapy is safe and effective. However, due to the small number of this group of patients, time is short, its safety, efficacy and long-term efficacy needs further observation and validation.
基金partially supported by the Project for the National Natural Science Foundation of China(72174121,71774111)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning+2 种基金the Project for the Natural Science Foundation of Shanghai(21ZR1444100)Project soft science research of Shanghai(22692112600)National Social Science Foundation of China(21BGL217,22BGL240)。
文摘Disease is a serious threat to human society.Understanding the characteristics of disease transmission is helpful for people to effectively control disease.In real life,it is natural to take various measures when people are aware of disease.In this paper,a novel coupled model considering asymmetric activity is proposed to describe the interactions between information diffusion and disease transmission in multiplex networks.Then,the critical threshold for disease transmission is derived by using the micro-Markov chain method.Finally,the theoretical results are verified by numerical simulations.The results show that reducing the activity level of individuals in the physical contact layer will have a continuous impact on reducing the disease outbreak threshold and suppressing the disease.In addition,the activity level of individuals in the virtual network has little impact on the transmission of the disease.Meanwhile,when individuals are aware of more disease-related information,the higher their awareness of prevention will be,which can effectively inhibit the transmission of disease.Our research results can provide a useful reference for the control of disease transmission.
