The crop seeds have been a staple food for humans,and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks.The phenomenon of pre-harvest sprouting(PHS),caused b...The crop seeds have been a staple food for humans,and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks.The phenomenon of pre-harvest sprouting(PHS),caused by seed dormancy deficiency,and the phenomenon of low seedling emergence caused by seed deep dormancy,will lead to a reduction in agricultural production.Therefore,it is particularly important to understand the regulation mechanisms of seed dormancy.There are many studies on the regulation of seed dormancy in rice,but there are few studies on the regulation of seed dormancy in other crops,and the research on its mechanism is not thorough enough.In this paper,we comprehensively summarize the regulation mechanisms of cereal seed dormancy,including rice,barley and wheat,discussing the integral mechanism of seed dormancy.This information should provide new insights for developing versatile cultivated lines to improve crop yield and economic benefits.展开更多
Active metasurfaces with dynamically reconfigurable functionalities are highly demanded in various practical applications.Here,we propose a wideband low-scattering metasurface that can realize an in-band reconfigurabl...Active metasurfaces with dynamically reconfigurable functionalities are highly demanded in various practical applications.Here,we propose a wideband low-scattering metasurface that can realize an in-band reconfigurable transparent window by altering the operation states of the PIN diodes loaded on the structures.The metasurface is composed of a band-pass frequency selective surface(FSS)sandwiched between two polarization conversion metasurfaces(PCMs).PIN diodes are integrated into the FSS to switch the transparent window,while a checkerboard configuration is applied in PCMs for the diffusive-reflective function.A sample with 20×20 elements is designed,fabricated,and experimentally verified.Both simulated and measured results show that the in-band functions can be dynamically switched between beam-splitting scattering and high transmission by controlling the biasing states of the diodes,while low backscattering can be attained outside the passband.Furthermore,the resonant structures of FSS also play the role of feeding lines,thus significantly eliminating extra interference compared with conventional feeding networks.We envision that the proposed metasurface may provide new possibilities for the development of an intelligent stealth platform and its antenna applications.展开更多
Purpose: Ischemia-reperfusion (I/R) injury exacerbates myocardial cell death (including apoptosis and necrosis), leading to complications such as arrhythmias, myocardial stenosis, microvascular obstruction and heart f...Purpose: Ischemia-reperfusion (I/R) injury exacerbates myocardial cell death (including apoptosis and necrosis), leading to complications such as arrhythmias, myocardial stenosis, microvascular obstruction and heart failure, and it is particularly important to seek new strategies to mitigate reperfusion injury. In this paper, we will investigate whether atorvastatin can alleviate myocardial ischemia-reperfusion injury and verify its molecular mechanism. Methods: We successfully constructed a hypoxia-reperfusion (H/R) H9c2 cell model and transfected miR-26a-5p mimic, miR-26a-5p inhibitor and its negative control NC-mimic or NC-inhibitor into H9c2 cells using a transfection kit. The expression of miR-26a-5p and FOXO1 were detected by RT-qPCR assay, the expression of related proteins by Western blot assay, the cell viability of H9c2 cells by CCK-8 assay, the apoptosis rate of H9c2 cells by flow cytometry, the CK and LDH activity in cells by CK and LDH assay kits. The targeting relationship between miR-26a-5p and FOXO1 was verified by dual luciferase reporter gene assay. Results: MiR-26a-5p expression was decreased in H/R-induced cells and FOXO1 expression was increased in H/R-induced cells. Atorvastatin alleviated H/R injury in cardiomyocytes and was most effective at a concentration of 1 μM. Atorvastatin alleviated H/R injury in cardiomyocytes by upregulating miR-26a-5p expression, miR-26a-5p and FOXO1 were negatively regulated by targeting. Conclusion: Atorvastatin can alleviate H/R injury in cardiomyocytes by regulating miR-26a-5p/FOXO1.展开更多
Three-dimensional(3D)cell spheroid models combined with mass spectrometry imaging(MSI)enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions.Her...Three-dimensional(3D)cell spheroid models combined with mass spectrometry imaging(MSI)enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions.Herein,airflow-assisted desorption electrospray ionization-MSI(AFADESI-MSI)was coupled with 3D HepG2 spheroids to assess the metabolism and hepatotoxicity of amiodarone(AMI).High-coverage imaging of>1100 endogenous metabolites in hepatocyte spheroids was achieved using AFADESI-MSI.Following AMI treatment at different times,15 metabolites of AMI involved in Ndesethylation,hydroxylation,deiodination,and desaturation metabolic reactions were identified,and according to their spatiotemporal dynamics features,the metabolic pathways of AMI were proposed.Subsequently,the temporal and spatial changes in metabolic disturbance within spheroids caused by drug exposure were obtained via metabolomic analysis.The main dysregulated metabolic pathways included arachidonic acid and glycerophospholipid metabolism,providing considerable evidence for the mechanism of AMI hepatotoxicity.In addition,a biomarker group of eight fatty acids was selected that provided improved indication of cell viability and could characterize the hepatotoxicity of AMI.The combination of AFADESI-MSI and HepG2 spheroids can simultaneously obtain spatiotemporal information for drugs,drug metabolites,and endogenous metabolites after AMI treatment,providing an effective tool for in vitro drug hepatotoxicity evaluation.展开更多
Background The high rate of long-term relapse is a major cause of smoking cessation failure.Recently,neurofeedback training has been widely used in the treatment of nicotine addiction;however,approximately 30%of subje...Background The high rate of long-term relapse is a major cause of smoking cessation failure.Recently,neurofeedback training has been widely used in the treatment of nicotine addiction;however,approximately 30%of subjects fail to benefit from this intervention.Our previous randomised clinical trial(RCT)examined cognition-guided neurofeedback and demonstrated a significant decrease in daily cigarette consumption at the 4-month follow-up.However,significant individual differences were observed in the 4-month follow-up effects of decreased cigarette consumption.Therefore,it is critical to identify who will benefit from pre-neurofeedback.Aims We examined whether the resting-state electroencephalography(EEG)characteristics from pre-neurofeedback predicted the 4-month follow-up effects and explored the possible mechanisms.Methods This was a double-blind RCT.A total of 60 participants with nicotine dependence were randomly assigned to either the real-feedback or yoked-feedback group.They underwent 6 min closed-eye resting EEG recordings both before and after two neurofeedback sessions.A follow-up assessment was conducted after 4 months.Results The frontal resting-state theta power spectral density(PSD)was significantly altered in the real-feedback group after two neurofeedback visits.Higher theta PSD in the real-feedback group before neurofeedback was the only predictor of decreased cigarette consumption at the 4-month follow-up.Further reliability analysis revealed a significant positive correlation between theta PSD pre-neurofeedback and post-neurofeedback.A leave-one-out cross-validated linear regression of the theta PSD pre-neurofeedback demonstrated a significant correlation between the predicted and observed reductions in cigarette consumption at the 4-month follow-up.Finally,source analysis revealed that the brain mechanisms of the theta PSD predictor were located in the orbital frontal cortex.Conclusions Our study demonstrated changes in the resting-state theta PSD following neurofeedback training.Moreover,the resting-state theta PSD may serve as a prognostic marker of neurofeedback effects.A higher resting-state theta PSD predicts a better long-term response to neurofeedback treatment,which may facilitate the selection of individualised interventions.展开更多
Neuromorphic computing is a brain-inspired computing paradigm that aims to construct efficient,low-power,and adaptive computing systems by emulating the information processing mechanisms of biological neural systems.A...Neuromorphic computing is a brain-inspired computing paradigm that aims to construct efficient,low-power,and adaptive computing systems by emulating the information processing mechanisms of biological neural systems.At the core of neuromorphic computing are neuromorphic devices that mimic the functions and dynamics of neurons and synapses,enabling the hardware implementation of artificial neural networks.Various types of neuromorphic devices have been proposed based on different physical mechanisms such as resistive switching devices and electric-double-layer transistors.These devices have demonstrated a range of neuromorphic functions such as multistate storage,spike-timing-dependent plasticity,dynamic filtering,etc.To achieve high performance neuromorphic computing systems,it is essential to fabricate neuromorphic devices compatible with the complementary metal oxide semiconductor(CMOS)manufacturing process.This improves the device’s reliability and stability and is favorable for achieving neuromorphic chips with higher integration density and low power consumption.This review summarizes CMOS-compatible neuromorphic devices and discusses their emulation of synaptic and neuronal functions as well as their applications in neuromorphic perception and computing.We highlight challenges and opportunities for further development of CMOS-compatible neuromorphic devices and systems.展开更多
Understanding the diet of threatened wildlife is vital for species-specific conservation and habitat management measures.The Red-crowned Crane(Grus japonensis)is a vulnerable bird distributed in Northeast Asia.Previou...Understanding the diet of threatened wildlife is vital for species-specific conservation and habitat management measures.The Red-crowned Crane(Grus japonensis)is a vulnerable bird distributed in Northeast Asia.Previous dietary studies of this bird focused mainly on its plant food composition based on field observations and microhistological identification.Herein,a total of 45 fecal samples were collected in November,December and January(15 fecal samples each month)from wintering cranes,and then subjected to a high throughput sequencing meta-barcoding approach to determine the primary plant(rbcL)and animal(COI)food items in their diet.A total of 230 operational taxonomic units(OTUs)of plant foods and 371 OTUs of animal foods were obtained.The main plant foods in the wintering period were Miscanthus,Zea,and Hordeum genera,which were similar to those in the breeding and the migration periods.Both agricultural and natural plants were detected,indicating a relatively broad dietary niche for this crane species.However,the main animal foods were representatives of Theridiidae,Megascolecidae,and Agelenidae,in sharp contrast to previous studies.The higher number of small terrestrial arthropods in animal foods might be due to the indirect intake of plants.The composition of both plant and animal foods in the diet showed the highest diversity in December,while it was homogeneous in January.The plant of Zea genus became the main source of nutrition in late winter,as supplementary feeding was performed in the reserve,which could help Red-crowned Cranes to get through the cold season.The results obtained in this work would contribute to the development of effective conservation strategies for the Red-crowned Crane.展开更多
The trench diamond junction barrier Schottky(JBS)diode with a sidewall enhanced structure is designed by Silvaco simulation.Comparing with the conventional trench JBS diode,Schottky contact areas are introduced on the...The trench diamond junction barrier Schottky(JBS)diode with a sidewall enhanced structure is designed by Silvaco simulation.Comparing with the conventional trench JBS diode,Schottky contact areas are introduced on the sidewall of the trench beside the top cathode.The sidewall Schottky contact weakens the junction field-effect transistor effect between the trenches to realize a low on-resistance and a high Baliga's figure of merit(FOM)value.In addition,the existence of the n-type diamond helps to suppress the electric field crowding effect and enhance the reverse breakdown voltage.With the optimal parameters of device structure,a high Baliga's FOM value of 2.28 GW/cm^(2) is designed.Therefore,the proposed sidewall-enhanced trench JBS diode is a promising component for the applications in diamond power electronics.展开更多
Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence h...Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer.展开更多
Lung cancer is a malignant tumor with high incidence and mortality rates in China and worldwide.Approximately 10%of these diseases are caused by multiple primary non-small cell lung cancers(NSCLC).Traditional antitumo...Lung cancer is a malignant tumor with high incidence and mortality rates in China and worldwide.Approximately 10%of these diseases are caused by multiple primary non-small cell lung cancers(NSCLC).Traditional antitumor therapies,such as chemotherapy,radiotherapy,and targeted therapy,have limited efficacy in the treatment of advanced synchronous multiple primary NSCLC.Immunotherapy is considered the standard of care for advanced or recurrent NSCLC,however,approximately 60%of patients develop primary or secondary resistance to treatment.There are no standard recommendations for overcoming immune resistance.We describe a case of simultaneous multiple primary NSCLC in a patient who received programmed death factor-1(PD-1)inhibitor monotherapy and developed brain metastases.After receiving second-line treatment with a combination of another PD-1 inhibitor,pemetrexed,and bevacizumab,the patient achieved complete remission,although they experienced grade 3 immune-related adverse reactions.Immune re-challenge is safe and feasible,and choosing a synergistic combination regimen is one of the options to overcome immune resistance.A larger sample size is needed to confirm the effectiveness and safety of this strategy in patients with NSCLC resistant to prior PD-1 inhibitors.展开更多
基金funded by the National Natural Science Foundation of China(Grant No.32170562).
文摘The crop seeds have been a staple food for humans,and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks.The phenomenon of pre-harvest sprouting(PHS),caused by seed dormancy deficiency,and the phenomenon of low seedling emergence caused by seed deep dormancy,will lead to a reduction in agricultural production.Therefore,it is particularly important to understand the regulation mechanisms of seed dormancy.There are many studies on the regulation of seed dormancy in rice,but there are few studies on the regulation of seed dormancy in other crops,and the research on its mechanism is not thorough enough.In this paper,we comprehensively summarize the regulation mechanisms of cereal seed dormancy,including rice,barley and wheat,discussing the integral mechanism of seed dormancy.This information should provide new insights for developing versatile cultivated lines to improve crop yield and economic benefits.
基金Project supported by the Joint Fund of Ministry of Education for Equipment Pre-research (Grant No. 8091B032112)the National Natural Science Foundation of China (Grant Nos. 62271243 and 62071215)+2 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Fundamental Research Funds for the Central UniversitiesJiangsu Provincial Key Laboratory of Advanced Manipulating Technique of Electromagnetic Wave
文摘Active metasurfaces with dynamically reconfigurable functionalities are highly demanded in various practical applications.Here,we propose a wideband low-scattering metasurface that can realize an in-band reconfigurable transparent window by altering the operation states of the PIN diodes loaded on the structures.The metasurface is composed of a band-pass frequency selective surface(FSS)sandwiched between two polarization conversion metasurfaces(PCMs).PIN diodes are integrated into the FSS to switch the transparent window,while a checkerboard configuration is applied in PCMs for the diffusive-reflective function.A sample with 20×20 elements is designed,fabricated,and experimentally verified.Both simulated and measured results show that the in-band functions can be dynamically switched between beam-splitting scattering and high transmission by controlling the biasing states of the diodes,while low backscattering can be attained outside the passband.Furthermore,the resonant structures of FSS also play the role of feeding lines,thus significantly eliminating extra interference compared with conventional feeding networks.We envision that the proposed metasurface may provide new possibilities for the development of an intelligent stealth platform and its antenna applications.
文摘Purpose: Ischemia-reperfusion (I/R) injury exacerbates myocardial cell death (including apoptosis and necrosis), leading to complications such as arrhythmias, myocardial stenosis, microvascular obstruction and heart failure, and it is particularly important to seek new strategies to mitigate reperfusion injury. In this paper, we will investigate whether atorvastatin can alleviate myocardial ischemia-reperfusion injury and verify its molecular mechanism. Methods: We successfully constructed a hypoxia-reperfusion (H/R) H9c2 cell model and transfected miR-26a-5p mimic, miR-26a-5p inhibitor and its negative control NC-mimic or NC-inhibitor into H9c2 cells using a transfection kit. The expression of miR-26a-5p and FOXO1 were detected by RT-qPCR assay, the expression of related proteins by Western blot assay, the cell viability of H9c2 cells by CCK-8 assay, the apoptosis rate of H9c2 cells by flow cytometry, the CK and LDH activity in cells by CK and LDH assay kits. The targeting relationship between miR-26a-5p and FOXO1 was verified by dual luciferase reporter gene assay. Results: MiR-26a-5p expression was decreased in H/R-induced cells and FOXO1 expression was increased in H/R-induced cells. Atorvastatin alleviated H/R injury in cardiomyocytes and was most effective at a concentration of 1 μM. Atorvastatin alleviated H/R injury in cardiomyocytes by upregulating miR-26a-5p expression, miR-26a-5p and FOXO1 were negatively regulated by targeting. Conclusion: Atorvastatin can alleviate H/R injury in cardiomyocytes by regulating miR-26a-5p/FOXO1.
基金funded by the National Natural Science Foundation of China(Grant No.:21874156)the Chinese Academy of Medical Science(CAMS)Innovation Fund for Medical Sciences(Grant No.:2021-1-I2M-028).
文摘Three-dimensional(3D)cell spheroid models combined with mass spectrometry imaging(MSI)enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions.Herein,airflow-assisted desorption electrospray ionization-MSI(AFADESI-MSI)was coupled with 3D HepG2 spheroids to assess the metabolism and hepatotoxicity of amiodarone(AMI).High-coverage imaging of>1100 endogenous metabolites in hepatocyte spheroids was achieved using AFADESI-MSI.Following AMI treatment at different times,15 metabolites of AMI involved in Ndesethylation,hydroxylation,deiodination,and desaturation metabolic reactions were identified,and according to their spatiotemporal dynamics features,the metabolic pathways of AMI were proposed.Subsequently,the temporal and spatial changes in metabolic disturbance within spheroids caused by drug exposure were obtained via metabolomic analysis.The main dysregulated metabolic pathways included arachidonic acid and glycerophospholipid metabolism,providing considerable evidence for the mechanism of AMI hepatotoxicity.In addition,a biomarker group of eight fatty acids was selected that provided improved indication of cell viability and could characterize the hepatotoxicity of AMI.The combination of AFADESI-MSI and HepG2 spheroids can simultaneously obtain spatiotemporal information for drugs,drug metabolites,and endogenous metabolites after AMI treatment,providing an effective tool for in vitro drug hepatotoxicity evaluation.
基金This work was supported by the National Natural Science Foundation of China(32000750,32171080,71942003,and 32161143022)Grants for Scientific Research of BSKY(XJ201907)from Anhui Medical University+4 种基金Scientific Research Improvement Project of Anhui Medical University(2021xkjT018)Research Fund of Anhui Institute of Translational Medicine(2022zhyx-C02)Basic and Clinical Collaborative Research Improvement Project of Anhui Medical University(2020xkjT020)The Chinese National Programs for Brain Science and Brain-like Intelligence Technology(2021ZD0202101)CAS-VPST Silk Road Science Fund 2021(GLHZ202128).The numerical calculations in this paper have been done on the Medical Big Data Supercomputing Center System of Anhui Medical University and Bioinformatics Center of the University of Science and Technology of China.
文摘Background The high rate of long-term relapse is a major cause of smoking cessation failure.Recently,neurofeedback training has been widely used in the treatment of nicotine addiction;however,approximately 30%of subjects fail to benefit from this intervention.Our previous randomised clinical trial(RCT)examined cognition-guided neurofeedback and demonstrated a significant decrease in daily cigarette consumption at the 4-month follow-up.However,significant individual differences were observed in the 4-month follow-up effects of decreased cigarette consumption.Therefore,it is critical to identify who will benefit from pre-neurofeedback.Aims We examined whether the resting-state electroencephalography(EEG)characteristics from pre-neurofeedback predicted the 4-month follow-up effects and explored the possible mechanisms.Methods This was a double-blind RCT.A total of 60 participants with nicotine dependence were randomly assigned to either the real-feedback or yoked-feedback group.They underwent 6 min closed-eye resting EEG recordings both before and after two neurofeedback sessions.A follow-up assessment was conducted after 4 months.Results The frontal resting-state theta power spectral density(PSD)was significantly altered in the real-feedback group after two neurofeedback visits.Higher theta PSD in the real-feedback group before neurofeedback was the only predictor of decreased cigarette consumption at the 4-month follow-up.Further reliability analysis revealed a significant positive correlation between theta PSD pre-neurofeedback and post-neurofeedback.A leave-one-out cross-validated linear regression of the theta PSD pre-neurofeedback demonstrated a significant correlation between the predicted and observed reductions in cigarette consumption at the 4-month follow-up.Finally,source analysis revealed that the brain mechanisms of the theta PSD predictor were located in the orbital frontal cortex.Conclusions Our study demonstrated changes in the resting-state theta PSD following neurofeedback training.Moreover,the resting-state theta PSD may serve as a prognostic marker of neurofeedback effects.A higher resting-state theta PSD predicts a better long-term response to neurofeedback treatment,which may facilitate the selection of individualised interventions.
基金supported by the National Natural Science Foundation of China(Grant Nos.62074075,62174082,and 61834001).
文摘Neuromorphic computing is a brain-inspired computing paradigm that aims to construct efficient,low-power,and adaptive computing systems by emulating the information processing mechanisms of biological neural systems.At the core of neuromorphic computing are neuromorphic devices that mimic the functions and dynamics of neurons and synapses,enabling the hardware implementation of artificial neural networks.Various types of neuromorphic devices have been proposed based on different physical mechanisms such as resistive switching devices and electric-double-layer transistors.These devices have demonstrated a range of neuromorphic functions such as multistate storage,spike-timing-dependent plasticity,dynamic filtering,etc.To achieve high performance neuromorphic computing systems,it is essential to fabricate neuromorphic devices compatible with the complementary metal oxide semiconductor(CMOS)manufacturing process.This improves the device’s reliability and stability and is favorable for achieving neuromorphic chips with higher integration density and low power consumption.This review summarizes CMOS-compatible neuromorphic devices and discusses their emulation of synaptic and neuronal functions as well as their applications in neuromorphic perception and computing.We highlight challenges and opportunities for further development of CMOS-compatible neuromorphic devices and systems.
基金supported by the National Natural Science Foundation of China(No.31800453)the Biodiversity Investigation,Observation and Assessment Program(2019-2023)+1 种基金the Ministry of Ecology and Environment of China(2110404)the Science and Technology Department of Sichuan Province(No.2022YFS0487).
文摘Understanding the diet of threatened wildlife is vital for species-specific conservation and habitat management measures.The Red-crowned Crane(Grus japonensis)is a vulnerable bird distributed in Northeast Asia.Previous dietary studies of this bird focused mainly on its plant food composition based on field observations and microhistological identification.Herein,a total of 45 fecal samples were collected in November,December and January(15 fecal samples each month)from wintering cranes,and then subjected to a high throughput sequencing meta-barcoding approach to determine the primary plant(rbcL)and animal(COI)food items in their diet.A total of 230 operational taxonomic units(OTUs)of plant foods and 371 OTUs of animal foods were obtained.The main plant foods in the wintering period were Miscanthus,Zea,and Hordeum genera,which were similar to those in the breeding and the migration periods.Both agricultural and natural plants were detected,indicating a relatively broad dietary niche for this crane species.However,the main animal foods were representatives of Theridiidae,Megascolecidae,and Agelenidae,in sharp contrast to previous studies.The higher number of small terrestrial arthropods in animal foods might be due to the indirect intake of plants.The composition of both plant and animal foods in the diet showed the highest diversity in December,while it was homogeneous in January.The plant of Zea genus became the main source of nutrition in late winter,as supplementary feeding was performed in the reserve,which could help Red-crowned Cranes to get through the cold season.The results obtained in this work would contribute to the development of effective conservation strategies for the Red-crowned Crane.
基金Project supported by the Key Research and Development Program of Guangdong Province,China(Grant No.2020B0101690001)the Natural Science Foundation of Sichuan Province,China(Grant No.2022NSFSC0886)the Open Project of State Key Laboratory of Superhard Materials,Jilin Province,China(Grant No.202314)。
文摘The trench diamond junction barrier Schottky(JBS)diode with a sidewall enhanced structure is designed by Silvaco simulation.Comparing with the conventional trench JBS diode,Schottky contact areas are introduced on the sidewall of the trench beside the top cathode.The sidewall Schottky contact weakens the junction field-effect transistor effect between the trenches to realize a low on-resistance and a high Baliga's figure of merit(FOM)value.In addition,the existence of the n-type diamond helps to suppress the electric field crowding effect and enhance the reverse breakdown voltage.With the optimal parameters of device structure,a high Baliga's FOM value of 2.28 GW/cm^(2) is designed.Therefore,the proposed sidewall-enhanced trench JBS diode is a promising component for the applications in diamond power electronics.
基金This research was funded by The National Key Research and Development Program of China(No.2020YFC2005900)The Key Research and Development Program Jointly Implemented by Sichuan and Chongqing(No.cstc2020jscx-cylhX002).
基金supported by grants from the National Key Research and Development Program of China(Grant No.2021YFC2500400)the National Natural Science Foundation of China(Grant Nos.81974439&82204121)+2 种基金the Beijing-Tianjin-Hebei Basic Research Cooperation Special Project(20JCZXJC00090)the Tianjin Health Committee Foundation(Grant No.TJWJ2021MS008)the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-009A).
文摘Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer.
文摘Lung cancer is a malignant tumor with high incidence and mortality rates in China and worldwide.Approximately 10%of these diseases are caused by multiple primary non-small cell lung cancers(NSCLC).Traditional antitumor therapies,such as chemotherapy,radiotherapy,and targeted therapy,have limited efficacy in the treatment of advanced synchronous multiple primary NSCLC.Immunotherapy is considered the standard of care for advanced or recurrent NSCLC,however,approximately 60%of patients develop primary or secondary resistance to treatment.There are no standard recommendations for overcoming immune resistance.We describe a case of simultaneous multiple primary NSCLC in a patient who received programmed death factor-1(PD-1)inhibitor monotherapy and developed brain metastases.After receiving second-line treatment with a combination of another PD-1 inhibitor,pemetrexed,and bevacizumab,the patient achieved complete remission,although they experienced grade 3 immune-related adverse reactions.Immune re-challenge is safe and feasible,and choosing a synergistic combination regimen is one of the options to overcome immune resistance.A larger sample size is needed to confirm the effectiveness and safety of this strategy in patients with NSCLC resistant to prior PD-1 inhibitors.
