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预测儿童Ⅱ期人工晶状体植入术后青光眼相关不良事件的风险:一项为期3年的研究 被引量:1
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作者 Hui Chen Chaoqun Xu +13 位作者 Ling Jin Zhenyu Wang Jingmin Xu yingshi zou Guangming Jin Lixia Luo Haotian Lin Weirong Chen Danying Zheng Yizhi Liu Zhenzhen Liu 金佳昕(审校) 陈子东(审校) 《眼科学报》 CAS 2024年第5期234-245,共12页
目的:建立并评估儿童Ⅱ期人工晶状体(intraocular lens,IOL)植入术后青光眼相关不良事件(glaucomarelated adverse events,GRAEs)的预测模型。方法:选取于中山大学中山眼科中心行Ⅱ期IOL植入术的无晶状体眼患儿205例(356眼),并在术后对... 目的:建立并评估儿童Ⅱ期人工晶状体(intraocular lens,IOL)植入术后青光眼相关不良事件(glaucomarelated adverse events,GRAEs)的预测模型。方法:选取于中山大学中山眼科中心行Ⅱ期IOL植入术的无晶状体眼患儿205例(356眼),并在术后对其随访3年。采用Cox比例风险模型确定GRAEs的预测因子,并建立列线图预测模型。采用随时间变化的受试者工作特征(receiver operating characteristic,ROC)曲线、决策曲线分析、Kaplan-Meier曲线评估模型性能,并通过Bootstrapping的C指数和校准图进行内部验证。结果:行Ⅱ期IOL植入术时年龄较大(HR=1.50,95%CI:1.03~2.19)、术后一过性高眼压(HR=9.06,95%CI:2.97~27.67)和IOL睫状沟植入术(HR=14.55,95%CI:2.11~100.57)是GRAEs的危险因素(均P<0.05),并据此建立了两个列线图预测模型。在术后1、2、3年,模型1的ROC曲线下面积(area under curve,AUC)分别为0.747(95%CI:0.776~0.935)、0.765(95%CI:0.804~0.936)和0.748(95%CI:0.736~0.918),模型2的AUC分别为0.881(95%CI:0.836~0.926)、0.895(95%CI:0.852~0.938)和0.848(95%CI:0.752~0.945)。在内部验证和评价中,两种模型均表现出良好的性能和临床净效益。Kaplan-Meier曲线显示两个不同的风险组在两个模型中都能被显著且稳健地区分。此外,本研究也构建了在线风险计算器。结论:两种列线图均能灵敏、准确地识别Ⅱ期IOL植入术后GRAEs的高危患儿,有助对其进行早期识别和及时干预。 展开更多
关键词 儿童健康(儿科) 青光眼 晶状体和悬韧带 视力
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Evolution and trends of high myopia research from 2002 to 2021: a scientometric analysis
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作者 Yuan Tan Weining Zhu +7 位作者 yingshi zou Bowen Zhang Yinglin Yu Wei Li Chaoqun Xu Leyi Hu Guangming Jin Zhenzhen Liu 《Annals of Eye Science》 2023年第4期22-35,共14页
Background:Research on high myopia has gradually formed a complex network of knowledge,but a panorama of evolutionary trends is lacking.By conducting a scientometric analysis,we can gain a deeper understanding of the ... Background:Research on high myopia has gradually formed a complex network of knowledge,but a panorama of evolutionary trends is lacking.By conducting a scientometric analysis,we can gain a deeper understanding of the development and evolution of this field.Methods:The global literature on high myopia published from 2002 to 2021 was extracted from the Science Citation Index Expanded in the Web of Science Core Collection.Microsoft Excel,VOSviewer,and CiteSpace were used to analyse and visualize the bibliometric data.Publication-related information,including countries,journals,authors,citations,subject categories,and its’time trends,was analysed.Results:A total of 4,226 included publications showed an annually increasing trend during the past 20 years.The high myopia research hotspots were refractive error correction,epidemiology,ocular biometry,drug and laser treatment of myopic fundus lesions,and surgical treatment of myopic fundus lesions.Cocitation analysis showed that high myopia genetics and myopic fundus lesion research were the research frontiers.A total of 116 disciplines were involved in high myopia research.Ophthalmology(n=3,338)was the most dominant subject category.Engineering(betweenness centrality=0.65)was the discipline with the most obvious bridge role.Science&technology—other topics(burst years:2015–2021;strength=14.88)had the greatest strength as of 2021,which was the hottest subject category.Conclusions:High myopia genetics and myopic fundus lesion research showed a potential for breakthroughs.Medical-engineering cross-innovation is a cutting-edge technology trend. 展开更多
关键词 High myopia theme change EVOLUTION research hotspot
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The statusquo and advances in categorization of congenital cataract
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作者 邹颖诗 李芸倩 刘臻臻 《Eye Science》 2024年第1期56-66,共11页
Congenital cataract(CC)is one of the most common causes of pediatric visual impairment.As our understanding of CC's etiology,clinical manifestations,and pathogenic genes deepens,various CC categorization systems b... Congenital cataract(CC)is one of the most common causes of pediatric visual impairment.As our understanding of CC's etiology,clinical manifestations,and pathogenic genes deepens,various CC categorization systems based on different classification criteria have been proposed.Regrettably,the application of the CC category in clinical practice and scientific research is limited.It is challenging to obtain precise information that could guide the timely treatment decision-making for pediatric cataract patients or predict their prognosis from a specific CC classification.This review aims to discuss the status quo of CC categorization systems and the potential directions for future research in this field,focusing on categorization principles and scientific application in clinical practice.Additionally,it aims to propose the potential directions for future research in this domain. 展开更多
关键词 CONGENITAL CATARACT CATEGORIZATION morphology ETIOLOGY genotype-phenoty
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