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Co-pyrolysis of soybean soapstock with iron slag/aluminum scrap,and characterization and analysis of their products
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作者 Xueguang Li Mengyan Yu +8 位作者 Changfa zhang Xiangtong Li Guangqing Liu Jianjun Dai Chunbao Zhou Yang Liu Jie Fu yingwen zhang Bang Yao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第1期25-36,共12页
Soybean soapstock(SS) is one of the main solid wastes produced in the refinery of edible oil processing. In this study, the co-pyrolysis of SS with iron slag(IS) and aluminum scrap(AS) was carried out in a tubular fur... Soybean soapstock(SS) is one of the main solid wastes produced in the refinery of edible oil processing. In this study, the co-pyrolysis of SS with iron slag(IS) and aluminum scrap(AS) was carried out in a tubular furnace. The gas, liquid and solid products were characterized and the char yield decreased with increasing IS/AS ratio. IS and AS can improve the gas yield, and when the ratio of SS/IS was 1:0.25, the total pyrolysis gas and hydrogen contents were significantly increased. The content of oxygen compounds in pyrolysis oil decreased during co-pyrolysis, while AS promoted the content of polycyclic aromatic hydrocarbons in pyrolysis oil. The co-pyrolysis reaction can be divided into four stages, the mass loss rate reaches the maximum at the third stage(390–575 ℃). The molar ratio of H/C was lower for pyrolysis,indicating good stability of pyrolysis char owing to the high degree of carbonization and aromaticity.The possible co-pyrolysis reaction mechanism was explored. 展开更多
关键词 PYROLYSIS Soybean soapstock Iron slag Aluminum scrap Adsorption CATALYST
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基于类芬顿反应的Mn_(3)O_(4)/DOX@Lip纳米递药体系的构建及应用 被引量:5
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作者 蔡政 张颖雯 +1 位作者 姜立萍 朱俊杰 《化学学报》 SCIE CAS CSCD 北大核心 2021年第4期481-489,共9页
利用肿瘤微环境与普通组织的差异,我们设计了一种基于类芬顿反应(Fenton-like reaction)的微环境响应的纳米递药体系(Mn_(3)O4/DOX@Lip).首先利用热分解法制备得到锰的氧化物(Mn_(3)O4)纳米粒子,基于化疗药物阿霉素(DOX)与Mn原子的配位... 利用肿瘤微环境与普通组织的差异,我们设计了一种基于类芬顿反应(Fenton-like reaction)的微环境响应的纳米递药体系(Mn_(3)O4/DOX@Lip).首先利用热分解法制备得到锰的氧化物(Mn_(3)O4)纳米粒子,基于化疗药物阿霉素(DOX)与Mn原子的配位作用,该纳米粒子可以负载并递送DOX,其最外层包裹的酸敏脂质体能有效防止药物在递送过程中的泄露.在肿瘤细胞的弱酸性和高浓度谷胱甘肽的微环境中,脂质体膜破裂,其中的Mn_(3)O4纳米粒子被谷胱甘肽还原、分解,并释放出DOX.共聚焦成像结果表明,MCF-7细胞与Mn_(3)O4/DOX@Lip共孵育后,细胞中活性氧探针的荧光显著增加,表明该递药体系可以通过下调细胞中的谷胱甘肽的含量引发细胞中的活性氧含量增加.噻唑蓝(MTT)和流式细胞实验结果表明,相比于单一的化疗药物,Mn_(3)O4/DOX@Lip的细胞毒性增强,这可能归因于还原产物Mn2+触发了类芬顿反应从而将细胞中内源性的H2O2转化为毒性更强的•OH.氧化活性物质介导的细胞凋亡与化疗药物的细胞毒性相互促进,增强了对细胞的凋亡能力.本体系利用外源性的物质激发内源性的细胞毒性,增强了化疗药物的治疗效果,为肿瘤治疗提供了新的研究策略. 展开更多
关键词 锰的氧化物 纳米递药体系 类芬顿反应 肿瘤微环境
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Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer:opportunities and challenges 被引量:1
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作者 Chaochao YU Yi LI +3 位作者 Guopeng CHEN Chaoyan WU Xiuping WANG yingwen zhang 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2022年第7期547-563,共17页
Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths.Surgery,radiotherapy,chemotherapy,immunotherapy,and endocrine therapy are currently the... Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths.Surgery,radiotherapy,chemotherapy,immunotherapy,and endocrine therapy are currently the main treatments for this cancer type.However,some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy,resulting in limited treatment efficacy.Consequently,traditional Chinese medicinal materials(TCMMs)as natural products have become an attractive source of novel drugs.In this review,we summarized the current knowledge on the active components of animal-derived TCMMs,including Ophiocordyceps sinensis-derived cordycepin,the aqueous and ethanolic extracts of O.sinensis,norcantharidin(NCTD),Chansu,bee venom,deer antlers,Ostrea gigas,and scorpion venom,with reference to marked anti-breast cancer effects due to regulating cell cycle arrest,proliferation,apoptosis,metastasis,and drug resistance.In future studies,the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies.Furthermore,large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment. 展开更多
关键词 Breast cancer Traditional Chinese medicinal material(TCMM) Bioactive constituent Anticancer effect
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