In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which c...In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications.展开更多
Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were...Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were selected and divided into two groups according to the random number method:control group(n=48)and observation group(n=49).The observation group was under the practical teaching mode based on the virtual simulation teaching platform,while the control group was under the traditional multimedia teaching mode.Questionnaire survey and teaching assessment were carried out after the teaching period,and the application effects of the two teaching modes were compared.Results:The reading and theoretical scores of the students in the observation group were significantly higher than those of the students in the control group(P<0.01);there were statistically significant differences in the results of the questionnaire survey(improved learning interest,improved language expression,improved ability to comprehensively analyze problems,and improved teamwork awareness)between the two groups of students(P<0.05);the students in the observation group were markedly more satisfied with the teaching content,teaching methods,and teaching quality than the students in the control group(P<0.05).Conclusion:The medical imaging practical teaching mode based on virtual simulation platform not only helps improve students’theoretical understanding and practical ability in medical imaging technology,but also improves students’learning interest,language expression ability,ability to comprehensively analyze problems,communication skills,teamwork awareness,and satisfaction with the teaching content,teaching methods,and teaching quality.Therefore,it has wide application value in medical specialty education.展开更多
Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical ima...Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical imaging class of 2022 were divided into two groups;the control group(n=48)was taught by the traditional teaching method,whereas the research group was taught by virtual simulation experiment combined with PACS(n=49).The teaching achievements and teaching effects of the two groups were compared to define the advantages of the two teaching modes.Results:Initially,there were no significant differences in the basic theory,image analysis,report writing,and differential diagnosis scores between the two groups of students(P>0.05);however,after 16 weeks of teaching,the scores of the research group were better than those of the control group(P<0.05);the pass rate of students in the study group(93.88%)was higher than that in the control group(81.25%);the scores of students in the research group in terms of clinical inquiry skills,X-ray/computed tomography/magnetic resonance imaging(X-ray/CT/MRI)operation skills,and doctor-patient communication skills were significantly higher than those in the control group(P<0.05).Conclusion:In medical imaging practical teaching,the application of virtual simulation experiment combined with PACS can effectively address several problems in the traditional teaching mode,including the single teaching method,the single teaching content,and the lack of innovation,and,at the same time,improve students’basic theoretical knowledge,X-ray/CT/MRI operation skills,consultation skills,and doctor-patient communication skills,thereby effectively improving the teaching quality and learning effect.展开更多
Aqueous zinc battery has been regarded as one of the most promising energy storage systems due to its low cost and environmental benignity.However,the safety concern on Zn anodes caused by uncontrolled Zn dendrite gro...Aqueous zinc battery has been regarded as one of the most promising energy storage systems due to its low cost and environmental benignity.However,the safety concern on Zn anodes caused by uncontrolled Zn dendrite growth in aqueous electrolyte hinders their application.Herein,sucrose with multi-hydroxyl groups has been introduced into aqueous electrolyte to modify Zn^(2+)solvation environment and create a protection layer on Zn anode,thus effectively retarding the growth of zinc dendrites.Atomistic simulations and experiments confirm that sucrose molecules can enter into the solvation sheath of Zn^(2+),and the as-formed unique solvation structure enhances the mobility of Zn^(2+).Such fast Zn^(2+)kinetics in sucrose-modified electrolyte can successfully suppress the dendrite growth.With this sucrose-modified aqueous electrolyte,Zn/Zn symmetric cells present more stable cycle performance than those using pure aqueous electrolyte;Zn/C cells also deliver an impressive higher energy density of 129.7 Wh·kg^(−1)and improved stability,suggesting a great potential application of sucrose-modified electrolytes for future Zn batteries.展开更多
Cancer immunotherapy comprising of immune checkpoint blockade(ICB)therapy,immune cell therapies,cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers.However,the...Cancer immunotherapy comprising of immune checkpoint blockade(ICB)therapy,immune cell therapies,cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers.However,their overall clinical objective response rates,particularly against most solid tumors,are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens,limited tumor infiltration of effector immune cells,acquired tumor immunosuppression and some other factors.In recent years,various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms,presenting new promises in many published studies.This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.展开更多
Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-ce...Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions.展开更多
基金the National Natural Science Foundation of China(52102372,52162007,52163032)China Postdoctoral Science Foundation(2022M712321)the Jiangsu Province Postdoctoral Research Funding Program(2021K473C).
文摘In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications.
基金This work was supported by Xinjiang Medical University Education and Teaching Research Project“Virtual Simulation Technology Combined with PACS System in Medical Imaging Practice”(Project no.YG2021044).
文摘Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were selected and divided into two groups according to the random number method:control group(n=48)and observation group(n=49).The observation group was under the practical teaching mode based on the virtual simulation teaching platform,while the control group was under the traditional multimedia teaching mode.Questionnaire survey and teaching assessment were carried out after the teaching period,and the application effects of the two teaching modes were compared.Results:The reading and theoretical scores of the students in the observation group were significantly higher than those of the students in the control group(P<0.01);there were statistically significant differences in the results of the questionnaire survey(improved learning interest,improved language expression,improved ability to comprehensively analyze problems,and improved teamwork awareness)between the two groups of students(P<0.05);the students in the observation group were markedly more satisfied with the teaching content,teaching methods,and teaching quality than the students in the control group(P<0.05).Conclusion:The medical imaging practical teaching mode based on virtual simulation platform not only helps improve students’theoretical understanding and practical ability in medical imaging technology,but also improves students’learning interest,language expression ability,ability to comprehensively analyze problems,communication skills,teamwork awareness,and satisfaction with the teaching content,teaching methods,and teaching quality.Therefore,it has wide application value in medical specialty education.
基金supported by Xinjiang Medical University Education and Teaching Research Project“Virtual Simulation Technology Combined with PACS System in Medical Imaging Practice”(Project No.YG2021044).
文摘Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical imaging class of 2022 were divided into two groups;the control group(n=48)was taught by the traditional teaching method,whereas the research group was taught by virtual simulation experiment combined with PACS(n=49).The teaching achievements and teaching effects of the two groups were compared to define the advantages of the two teaching modes.Results:Initially,there were no significant differences in the basic theory,image analysis,report writing,and differential diagnosis scores between the two groups of students(P>0.05);however,after 16 weeks of teaching,the scores of the research group were better than those of the control group(P<0.05);the pass rate of students in the study group(93.88%)was higher than that in the control group(81.25%);the scores of students in the research group in terms of clinical inquiry skills,X-ray/computed tomography/magnetic resonance imaging(X-ray/CT/MRI)operation skills,and doctor-patient communication skills were significantly higher than those in the control group(P<0.05).Conclusion:In medical imaging practical teaching,the application of virtual simulation experiment combined with PACS can effectively address several problems in the traditional teaching mode,including the single teaching method,the single teaching content,and the lack of innovation,and,at the same time,improve students’basic theoretical knowledge,X-ray/CT/MRI operation skills,consultation skills,and doctor-patient communication skills,thereby effectively improving the teaching quality and learning effect.
基金support from the National Natural Science Foundation of China(Nos.22075313 and 21975281)the National Key Research and Development Program of China(No.2020YFB1312902)+3 种基金the Science and Technology Project of Jiangxi Province(No.20192BCD40017)Outstanding Youth Fund of Jiangxi Province(No.20192BCB23028)Jiangxi Double Thousand Talent Program(No.JXSQ2019101072)Science Technology Major Project of Nanchang(No.2020BI47)is acknowledged.
文摘Aqueous zinc battery has been regarded as one of the most promising energy storage systems due to its low cost and environmental benignity.However,the safety concern on Zn anodes caused by uncontrolled Zn dendrite growth in aqueous electrolyte hinders their application.Herein,sucrose with multi-hydroxyl groups has been introduced into aqueous electrolyte to modify Zn^(2+)solvation environment and create a protection layer on Zn anode,thus effectively retarding the growth of zinc dendrites.Atomistic simulations and experiments confirm that sucrose molecules can enter into the solvation sheath of Zn^(2+),and the as-formed unique solvation structure enhances the mobility of Zn^(2+).Such fast Zn^(2+)kinetics in sucrose-modified electrolyte can successfully suppress the dendrite growth.With this sucrose-modified aqueous electrolyte,Zn/Zn symmetric cells present more stable cycle performance than those using pure aqueous electrolyte;Zn/C cells also deliver an impressive higher energy density of 129.7 Wh·kg^(−1)and improved stability,suggesting a great potential application of sucrose-modified electrolytes for future Zn batteries.
文摘Cancer immunotherapy comprising of immune checkpoint blockade(ICB)therapy,immune cell therapies,cancer vaccines and many others represents a profound arsenal in the fight against different types of cancers.However,their overall clinical objective response rates,particularly against most solid tumors,are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens,limited tumor infiltration of effector immune cells,acquired tumor immunosuppression and some other factors.In recent years,various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms,presenting new promises in many published studies.This perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.
基金supported by research grants from the National Natural Science Foundation of China(31600953 to X.Wang31530034 and 31330036 to F.Wang,31570791 and 91542205 to J.Min)+2 种基金the National Key R&D Program of China(2018YFA0507801 to J.Min and 2018YFA0507802 to F.Wang)the Zhejiang Provincial Natural Science Foundation of China(LQ15C110002 to X.Wang and LZ15H160002 to J.Min)the Nation Science and Technology Major Projects for Major New Drugs Innovation and Develop 2017ZX09101-005-004-002(L.Chen).
文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions.
