Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However...Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.展开更多
Halide perovskites with excellent piezoelectric properties,but their poor stability hinders their largescale application.Herein,a sandwich-structured halide perovskite flexible sensor with good stability was developed...Halide perovskites with excellent piezoelectric properties,but their poor stability hinders their largescale application.Herein,a sandwich-structured halide perovskite flexible sensor with good stability was developed according to a three-step procedure as follows:(ⅰ) in-situ growth of wool keratinCsPbBr_(3)(WK-CsPbBr_(3)) using wool keratin in interfacial passivation and coating,(ⅱ) electrospinning of a wool keratin-CsPbBr_(3)/polyacrylonitrile(WCP) nanofiber film,and(ⅲ) coating of the WCP nanofiber with polydimethylsiloxane(PDMS) to obtain a sensor(WCPP).The sensor could generate a piezoelectric voltage of 7.8 V at a pressure of 6 kPa in the stages of pressing and releasing,and the output characteristics did not decline even after 10,000 cycles.Compared to the 4-month stability of the perovskite sensor,WCPP sensor exhibited the output performance even after 16 months,which indicated that wool keratin as a multidentate improved the stability of the halide perovskite.Additionally,the sensor displayed a self-cleaning property and could also light up 14 commercial LEDs.The close-loop recycling of the lead halide perovskite was achieved by dissolving the WCP nanofiber film in DMF and then reelectrospinning.Therefore,the method proposed is a step forward for achieving the commercialization of WK-CsPbBr_(3) and providing new avenues for further utilization of wool waste.展开更多
The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the indus...The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the industrial sector.This paper,based on annual data,employs the entropy weight method to construct a comprehensive index reflecting the impact of green upgrading in industrial sectors.To delve deeper,it utilizes the DEA model to measure energy efficiency and its subdivision BCC model to break down energy efficiency into technical and scale efficiency.The financial support landscape is examined from the vantage points of both direct and indirect financing.Using a multivariate time series model,this paper thoroughly investigates the influence of energy efficiency and financial support on the green upgrading of the industrial sector.The findings reveal a significant positive impact of both energy efficiency and financial support on green upgrading in industrial industries.Notably,scale efficiency emerges as the primary driver of energy efficiency.Moreover,indirect financing proves to be more effective in promoting financial support than direct financing.The empirical results retain their robustness even after substituting explanatory variables.The study concludes by contextualizing the research findings within the current real-world scenario,offering practical insights,and proposing specific recommendations.展开更多
The enhancement of industrial green total factor productivity is pivotal for achieving high-quality and sustainable economic development.This study assesses China’s performance using the SBM-GML model,employing provi...The enhancement of industrial green total factor productivity is pivotal for achieving high-quality and sustainable economic development.This study assesses China’s performance using the SBM-GML model,employing province-level panel data spanning from 2004 to 2020.Furthermore,we examine the influence of green finance and technological progress on industrial green total factor productivity using a spatial econometric model.The findings uncover that the relationship between the level of green financial development and industrial green total factor productivity follows a U-shaped curve.Initially,low levels of green financial development exert a suppressive effect on industrial green total factor productivity,proving ineffective in the short term.However,with the progression of green finance development,a positive and significant long-term impact on industrial green total factor productivity emerges.Moreover,technological progress demonstrates a noteworthy promotional effect on industrial green total factor productivity.The analysis delves deeper into revealing that industrial structure and environmental regulation intensity exhibit a significant negative relationship with industrial green total factor productivity.In contrast,both energy structure and education level showcase a substantial positive relationship with industrial green total factor productivity.展开更多
Metastasis and paclitaxel(PTX)resistance are the main reason for the poor prognosis of ovarian cancer(OC).Evidence showed that RNA-binding proteins(RBPs)and long noncoding RNAs(lncRNAs)can modulate post-transcriptiona...Metastasis and paclitaxel(PTX)resistance are the main reason for the poor prognosis of ovarian cancer(OC).Evidence showed that RNA-binding proteins(RBPs)and long noncoding RNAs(lncRNAs)can modulate post-transcriptional regulation.The aim of this study was to determine the relationship among RBP,lncRNA and OC and to further guide clinical therapy.Immunohistochemistry revealed that pre-mRNA processing factor 6(PRPF6)was upregulated in OC chemoresistant tissues and was closely related to advanced(Federation of International of Gynecologists and Obstetricians)FIGO stages and chemo-resistance.PRPF6 promoted progression,and PTX resistance in vitro and in vivo.And the transcripts of small nucleolar RNA host gene SNHG16-L/S were differentially expressed in OC cells and tissues as detected through real-time PCR(RT-PCR).SNHG16-L/S had opposite effects on progression and PTX resistance in OC.Mechanistically,SNHG16-L inhibited GATA-binding protein 3(GATA3)transcription by binding to CCAAT/enhancer-binding protein B(CEBPB).Moreover,PRPF6 induced the alternative splicing of SNHG16,causing downregulation of SNHG16-L and,leading to the upregulation of GATA3 expression to further promote metastasis and PTX-resistance in OC.Totally,these data unveiled that PRPF6 promotes metastasis and PTX resistance of OC through SNHG16-L/CEBPB/GATA3 axis,which provides a new direction for OC treatment.展开更多
Customized and personalized healthcare,being self-administered by patients,is highly sought after in light of the increasing burdens of chronic illnesses and aging populations.Outside clinics that empower individuals ...Customized and personalized healthcare,being self-administered by patients,is highly sought after in light of the increasing burdens of chronic illnesses and aging populations.Outside clinics that empower individuals to have a more prominent role in managing their health are becoming a trend due to many benefits.For example,they can reduce hospital visits and infection risk during a pandemic like COVID-19.展开更多
As an outstanding two-dimensional material,black phosphorene,has attracted significant attention in the biomedicine field due to its large surface area,strong optical absorption,distinct bioactivity,excellent biocompa...As an outstanding two-dimensional material,black phosphorene,has attracted significant attention in the biomedicine field due to its large surface area,strong optical absorption,distinct bioactivity,excellent biocompatibility,and high biodegradability.In this review,the preparation and properties of black phosphorene are summarized first.Thereafter,black phosphorene-based multifunctional platforms employed for the diagnosis and treatment of diseases,including cancer,bone injuries,brain diseases,progressive oxidative diseases,and kidney injury,are reviewed in detail.This review provides a better understanding of the exciting properties of black phosphorene,such as its high drug-loading efficiency,photothermal conversion capability,high'O2 generation efficiency,and high electrical conductivity,as well as how these properties can be exploited in biomedicine.Finally,the research perspectives of black phosphorene are discussed.展开更多
Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media.Most of these implementations rely on the usage of ballistic o...Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media.Most of these implementations rely on the usage of ballistic or quasi-ballistic photons to achieve high spatial resolution.However,the inherent scattering nature of light in biological tissues or tissue-like scattering media constitutes a critical obstacle that has restricted the penetration depth of non-scattered photons and hence limited the implementation of most optical techniques for wider applications.In addition,the components of an optical system are usually designed and manufactured for a fixed function or performance.Recent advances in wavefront shaping have demonstrated that scattering-or component-induced phase distortions can be compensated by optimizing the wavefront of the input light pattern through iteration or by conjugating the transmission matrix of the scattering medium.展开更多
The formation and evolution of deformation texture in polycrystalline materials are studied by phase-field dynamic model.In addition,the driving force of texture evolution is also discussed.In this model,grains with d...The formation and evolution of deformation texture in polycrystalline materials are studied by phase-field dynamic model.In addition,the driving force of texture evolution is also discussed.In this model,grains with different orientation are defined by a set of continuous non-conserved order parameter fields.Simulation results show that grains with preferred orientation grow at the expense of those with unfavorable orientations.It is more important that,elastic potential rather than elastic energy plays a crucial role in the evolution of texture whether the polycrystalline system is subjected to uniaxial stress or shear stress.展开更多
In this paper, we investigate the disparities of China's insurance market from the viewpoint of geography and enterprise by using the monthly data from January 2006 to December 2015. We divide the whole insurance ...In this paper, we investigate the disparities of China's insurance market from the viewpoint of geography and enterprise by using the monthly data from January 2006 to December 2015. We divide the whole insurance market into two parts, namely property insurance and personal insurance.By constructing and analyzing minimum spanning trees of insurance market, we obtain the results as follows:(i) The connections between provinces are much closer than those of firms, and there are regional links between neighboring provinces in the minimum spanning tree(MST); and(ii) the domestic funded firms and foreign funded firms form two explicit clusters in the MSTs of property and personal insurance market.展开更多
基金financially supported by the National Natural Science Foundation of China,No.81303115,81774042 (both to XC)the Pearl River S&T Nova Program of Guangzhou,No.201806010025 (to XC)+3 种基金the Specialty Program of Guangdong Province Hospital of Chinese Medicine of China,No.YN2018ZD07 (to XC)the Natural Science Foundatior of Guangdong Province of China,No.2023A1515012174 (to JL)the Science and Technology Program of Guangzhou of China,No.20210201 0268 (to XC),20210201 0339 (to JS)Guangdong Provincial Key Laboratory of Research on Emergency in TCM,Nos.2018-75,2019-140 (to JS)
文摘Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.
基金funded by the National Natural Science Foundation of China (22178210)the Innovation Capability Support Program of Shaanxi (2021TD-16)+1 种基金Key Project of Natural Science Basic Research Program of Shaanxi Province (2023JC-XJ-12)the Shaanxi Provincial “Special Support Plan for High-level Talents”。
文摘Halide perovskites with excellent piezoelectric properties,but their poor stability hinders their largescale application.Herein,a sandwich-structured halide perovskite flexible sensor with good stability was developed according to a three-step procedure as follows:(ⅰ) in-situ growth of wool keratinCsPbBr_(3)(WK-CsPbBr_(3)) using wool keratin in interfacial passivation and coating,(ⅱ) electrospinning of a wool keratin-CsPbBr_(3)/polyacrylonitrile(WCP) nanofiber film,and(ⅲ) coating of the WCP nanofiber with polydimethylsiloxane(PDMS) to obtain a sensor(WCPP).The sensor could generate a piezoelectric voltage of 7.8 V at a pressure of 6 kPa in the stages of pressing and releasing,and the output characteristics did not decline even after 10,000 cycles.Compared to the 4-month stability of the perovskite sensor,WCPP sensor exhibited the output performance even after 16 months,which indicated that wool keratin as a multidentate improved the stability of the halide perovskite.Additionally,the sensor displayed a self-cleaning property and could also light up 14 commercial LEDs.The close-loop recycling of the lead halide perovskite was achieved by dissolving the WCP nanofiber film in DMF and then reelectrospinning.Therefore,the method proposed is a step forward for achieving the commercialization of WK-CsPbBr_(3) and providing new avenues for further utilization of wool waste.
基金General Research Fund of Philosophy and Social Sciences in Colleges and Universities of Jiangsu Province in 2020(Grant No.2020SJA1008)Fundamental Research Funds for the Central Universities(Grant No.2023SK04)。
文摘The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the industrial sector.This paper,based on annual data,employs the entropy weight method to construct a comprehensive index reflecting the impact of green upgrading in industrial sectors.To delve deeper,it utilizes the DEA model to measure energy efficiency and its subdivision BCC model to break down energy efficiency into technical and scale efficiency.The financial support landscape is examined from the vantage points of both direct and indirect financing.Using a multivariate time series model,this paper thoroughly investigates the influence of energy efficiency and financial support on the green upgrading of the industrial sector.The findings reveal a significant positive impact of both energy efficiency and financial support on green upgrading in industrial industries.Notably,scale efficiency emerges as the primary driver of energy efficiency.Moreover,indirect financing proves to be more effective in promoting financial support than direct financing.The empirical results retain their robustness even after substituting explanatory variables.The study concludes by contextualizing the research findings within the current real-world scenario,offering practical insights,and proposing specific recommendations.
基金General Research Fund of Philosophy and Social Sciences in Colleges and Universities of Jiangsu Province in 2020(Grant Number 2020SJA1008)Fundamental Research Funds for the Central Universities(Grant Number 2023SK04)。
文摘The enhancement of industrial green total factor productivity is pivotal for achieving high-quality and sustainable economic development.This study assesses China’s performance using the SBM-GML model,employing province-level panel data spanning from 2004 to 2020.Furthermore,we examine the influence of green finance and technological progress on industrial green total factor productivity using a spatial econometric model.The findings uncover that the relationship between the level of green financial development and industrial green total factor productivity follows a U-shaped curve.Initially,low levels of green financial development exert a suppressive effect on industrial green total factor productivity,proving ineffective in the short term.However,with the progression of green finance development,a positive and significant long-term impact on industrial green total factor productivity emerges.Moreover,technological progress demonstrates a noteworthy promotional effect on industrial green total factor productivity.The analysis delves deeper into revealing that industrial structure and environmental regulation intensity exhibit a significant negative relationship with industrial green total factor productivity.In contrast,both energy structure and education level showcase a substantial positive relationship with industrial green total factor productivity.
基金supported by The Outstanding Scientific Fund of Shengjing Hospital(Grant No.201705).
文摘Metastasis and paclitaxel(PTX)resistance are the main reason for the poor prognosis of ovarian cancer(OC).Evidence showed that RNA-binding proteins(RBPs)and long noncoding RNAs(lncRNAs)can modulate post-transcriptional regulation.The aim of this study was to determine the relationship among RBP,lncRNA and OC and to further guide clinical therapy.Immunohistochemistry revealed that pre-mRNA processing factor 6(PRPF6)was upregulated in OC chemoresistant tissues and was closely related to advanced(Federation of International of Gynecologists and Obstetricians)FIGO stages and chemo-resistance.PRPF6 promoted progression,and PTX resistance in vitro and in vivo.And the transcripts of small nucleolar RNA host gene SNHG16-L/S were differentially expressed in OC cells and tissues as detected through real-time PCR(RT-PCR).SNHG16-L/S had opposite effects on progression and PTX resistance in OC.Mechanistically,SNHG16-L inhibited GATA-binding protein 3(GATA3)transcription by binding to CCAAT/enhancer-binding protein B(CEBPB).Moreover,PRPF6 induced the alternative splicing of SNHG16,causing downregulation of SNHG16-L and,leading to the upregulation of GATA3 expression to further promote metastasis and PTX-resistance in OC.Totally,these data unveiled that PRPF6 promotes metastasis and PTX resistance of OC through SNHG16-L/CEBPB/GATA3 axis,which provides a new direction for OC treatment.
基金supported by the National High Level Hospital Clinical Research Funding(Grant No.2023-GSP-QN-23)the National Natural Science Foundation of China(Grant No.52105575)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.QTZX23063)the Proof of Concept Foundation of Xidian University Hangzhou Institute of Technology(Grant No.GNYZ2023YL0302).
文摘Customized and personalized healthcare,being self-administered by patients,is highly sought after in light of the increasing burdens of chronic illnesses and aging populations.Outside clinics that empower individuals to have a more prominent role in managing their health are becoming a trend due to many benefits.For example,they can reduce hospital visits and infection risk during a pandemic like COVID-19.
基金This work was supported in part by the National Natural Science Foundation of China(NSFC)(Grant Nos.8193004&81627805,and 81671726)Guangdong Science and Technology Commission(Nos.2019BT02X105,2019A1515011374)+4 种基金Hong Kong Research Grant Council(Nos.25204416,R5029-19)Hong Kong Innovation and Technology Commission(Nos.ITS/022/18,GHP/043/19SZ,GHP/044/19GD)Shenzhen Science and Technology Innovation Commission(No.JCYJ20170818104421564)Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars(No.2020B1515020027)Guangzhou Science and Technology Bureau(No.202002020070).
文摘As an outstanding two-dimensional material,black phosphorene,has attracted significant attention in the biomedicine field due to its large surface area,strong optical absorption,distinct bioactivity,excellent biocompatibility,and high biodegradability.In this review,the preparation and properties of black phosphorene are summarized first.Thereafter,black phosphorene-based multifunctional platforms employed for the diagnosis and treatment of diseases,including cancer,bone injuries,brain diseases,progressive oxidative diseases,and kidney injury,are reviewed in detail.This review provides a better understanding of the exciting properties of black phosphorene,such as its high drug-loading efficiency,photothermal conversion capability,high'O2 generation efficiency,and high electrical conductivity,as well as how these properties can be exploited in biomedicine.Finally,the research perspectives of black phosphorene are discussed.
基金supported by National Natural Science Foundation of China(NSFC)(81930048,81627805)Hong Kong Research Grant Council(15217721,R5029-19,C7074-21GF)+3 种基金Hong Kong Innovation and Technology Commission(GHP/043/19SZ,GHP/044/19GD)Guangdong Science and Technology Commission(2019A1515011374,2019BT02X105)National Research Foundation of Korea(2015R1A3A2066550,2021R1A2C3012903)Institute of Information&Communications Technology Planning&Evaluation(IITP,2021-0-00745)grant funded by the Korea government(MSIT).
文摘Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media.Most of these implementations rely on the usage of ballistic or quasi-ballistic photons to achieve high spatial resolution.However,the inherent scattering nature of light in biological tissues or tissue-like scattering media constitutes a critical obstacle that has restricted the penetration depth of non-scattered photons and hence limited the implementation of most optical techniques for wider applications.In addition,the components of an optical system are usually designed and manufactured for a fixed function or performance.Recent advances in wavefront shaping have demonstrated that scattering-or component-induced phase distortions can be compensated by optimizing the wavefront of the input light pattern through iteration or by conjugating the transmission matrix of the scattering medium.
基金the National Natural Science Foundation of China (Grant Nos.51174168,51274167)NPU Foundation for Fundamental Research (Grant No.JC20120222)
文摘The formation and evolution of deformation texture in polycrystalline materials are studied by phase-field dynamic model.In addition,the driving force of texture evolution is also discussed.In this model,grains with different orientation are defined by a set of continuous non-conserved order parameter fields.Simulation results show that grains with preferred orientation grow at the expense of those with unfavorable orientations.It is more important that,elastic potential rather than elastic energy plays a crucial role in the evolution of texture whether the polycrystalline system is subjected to uniaxial stress or shear stress.
基金Supported by National Natural Science Foundation of China(71373072,71340014 and 71501066)the China Scholarship Council(201506135022)+1 种基金the Specialized Research Fund for the Doctoral Program of Higher Education(20130161110031)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(71521061)
文摘In this paper, we investigate the disparities of China's insurance market from the viewpoint of geography and enterprise by using the monthly data from January 2006 to December 2015. We divide the whole insurance market into two parts, namely property insurance and personal insurance.By constructing and analyzing minimum spanning trees of insurance market, we obtain the results as follows:(i) The connections between provinces are much closer than those of firms, and there are regional links between neighboring provinces in the minimum spanning tree(MST); and(ii) the domestic funded firms and foreign funded firms form two explicit clusters in the MSTs of property and personal insurance market.
