In the context of alienation of cooperative development in China,the concept of cooperative entrepreneurs' ability was expounded based on the theory of entrepreneurial competence,and then factors restricting the d...In the context of alienation of cooperative development in China,the concept of cooperative entrepreneurs' ability was expounded based on the theory of entrepreneurial competence,and then factors restricting the development of cooperative entrepreneurs' ability in China were analyzed. Finally,some countermeasures were put forward.展开更多
Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has become a global public health crisis.Some patients who have recovered from COVID-19 subsequently te...Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has become a global public health crisis.Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital.How such retest-positive(RTP)patients become infected again is not known.In this study,30 RTP patients,20 convalescent patients,and 20 healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear cells.We found that absolute numbers of CD4^(+)T cells,CD8^(+)T cells,and natural killer cells were not substantially decreased in RTP patients,but the expression of activation markers on these cells was significantly reduced.The percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent patients.Through transcriptome sequencing,we demonstrated that high expression of inhibitor of differentiation 1(ID1)and low expression of interferon-induced transmembrane protein 10(IFITM10)were associated with insufficient activation of immune cells and the occurrence of RTP.These findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP,which may contribute to a better understanding of the mechanisms underlying RTP.展开更多
Stroke is a common neurological condition and among the leading causes of death and disability worldwide.Depression is both a risk factor for and complication of stroke,and the two conditions may have a complex recipr...Stroke is a common neurological condition and among the leading causes of death and disability worldwide.Depression is both a risk factor for and complication of stroke,and the two conditions may have a complex reciprocal relationship over time.However,the secondary effects of depression on stroke are often overlooked,resulting in increased morbidity and mortality.In the previous concept of‘poststroke depression’,stroke and depression were considered as two independent diseases.It often delays the diagnosis and treatment of patients.The concept‘stroke depression’proposed in this article will emphasise more the necessity of aggressive treatment of depression in the overall management of stroke,thus to reduce the incidence of stroke and in the meantime,improve the prognosis of stroke.Hopefully,it will lead us into a new era of acute stroke intervention.展开更多
文摘In the context of alienation of cooperative development in China,the concept of cooperative entrepreneurs' ability was expounded based on the theory of entrepreneurial competence,and then factors restricting the development of cooperative entrepreneurs' ability in China were analyzed. Finally,some countermeasures were put forward.
基金supported by grants from the China National Center for Biotechnology Development(2020YFC0843800 and 2020YFC0846800)the Ministry of Science and Technology of China(2020TFC0844100)+1 种基金China Postdoctoral Science Foundation(2020T130112ZX)Postdoctoral Foundation of Hefei(2020130).
文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has become a global public health crisis.Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital.How such retest-positive(RTP)patients become infected again is not known.In this study,30 RTP patients,20 convalescent patients,and 20 healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear cells.We found that absolute numbers of CD4^(+)T cells,CD8^(+)T cells,and natural killer cells were not substantially decreased in RTP patients,but the expression of activation markers on these cells was significantly reduced.The percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent patients.Through transcriptome sequencing,we demonstrated that high expression of inhibitor of differentiation 1(ID1)and low expression of interferon-induced transmembrane protein 10(IFITM10)were associated with insufficient activation of immune cells and the occurrence of RTP.These findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP,which may contribute to a better understanding of the mechanisms underlying RTP.
基金supported by grants from the National Key R&D Program of China(Grant No.2017YFA0505700)the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(Grant No.2019PT320002)the Natural Science Foundation Project of China(Grant No.81820108015).
文摘Stroke is a common neurological condition and among the leading causes of death and disability worldwide.Depression is both a risk factor for and complication of stroke,and the two conditions may have a complex reciprocal relationship over time.However,the secondary effects of depression on stroke are often overlooked,resulting in increased morbidity and mortality.In the previous concept of‘poststroke depression’,stroke and depression were considered as two independent diseases.It often delays the diagnosis and treatment of patients.The concept‘stroke depression’proposed in this article will emphasise more the necessity of aggressive treatment of depression in the overall management of stroke,thus to reduce the incidence of stroke and in the meantime,improve the prognosis of stroke.Hopefully,it will lead us into a new era of acute stroke intervention.
