In this study,we aim to investigate the reciprocal influence between language motivation and English speaking fluency among language learners,and to draw implications for effective teaching methodologies.By analyzing ...In this study,we aim to investigate the reciprocal influence between language motivation and English speaking fluency among language learners,and to draw implications for effective teaching methodologies.By analyzing multiple cases of language learners in conjunction with relevant theories and practical insights,the study uncovers a dynamic correlation between language motivation and speaking fluency.The research findings indicate that heightened language motivation can positively impact learners’speaking fluency,while improved oral skills,in turn,bolster learners’language confidence and motivation.Building on these insights,the study proposes impactful teaching approaches,such as cultivating learners’enthusiasm for language acquisition,providing diverse opportunities for oral practice,and fostering active engagement in language communication.These strategies are designed to enhance language motivation and speaking fluency among learners,offering valuable guidance and reference for educators.展开更多
Telecommunication has undergone significant transformations due to the continuous advancements in internet technology,mobile devices,competitive pricing,and changing customer preferences.Specifically,the most recent i...Telecommunication has undergone significant transformations due to the continuous advancements in internet technology,mobile devices,competitive pricing,and changing customer preferences.Specifically,the most recent iteration of OpenAI’s large language model chat generative pre-trained transformer(ChatGPT)has the potential to propel innovation and bolster operational performance in the telecommunications sector.Nowadays,the exploration of network resource management,control,and operation is still in the initial stage.In this paper,we propose a novel network artificial intelligence architecture named language model for network traffic(NetLM),a large language model based on a transformer designed to understand sequence structures in the network packet data and capture their underlying dynamics.The continual convergence of knowledge space and artificial intelligence(AI)technologies constitutes the core of intelligent network management and control.Multi-modal representation learning is used to unify the multi-modal information of network indicator data,traffic data,and text data into the same feature space.Furthermore,a NetLM-based control policy generation framework is proposed to refine intent incrementally through different abstraction levels.Finally,some potential cases are provided that NetLM can benefit the telecom industry.展开更多
ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models...ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect.展开更多
Group 2 innate lymphoid cells(ILC2s)are now known to play prominent roles in many inflammatory responses involving the production of Th2-type cytokines,which contribute to parasitic infections,tissue repair,and metabo...Group 2 innate lymphoid cells(ILC2s)are now known to play prominent roles in many inflammatory responses involving the production of Th2-type cytokines,which contribute to parasitic infections,tissue repair,and metabolic homeostasis[1].More recently,it has emerged that ILC2s may act as antigen-presenting cells,although corresponding evidence of phagocytic activity of these cells is currently scarce[2,3].Herein,we investigated whether ILC2s can phagocytose bacteria,through in vitro experiments.展开更多
文摘In this study,we aim to investigate the reciprocal influence between language motivation and English speaking fluency among language learners,and to draw implications for effective teaching methodologies.By analyzing multiple cases of language learners in conjunction with relevant theories and practical insights,the study uncovers a dynamic correlation between language motivation and speaking fluency.The research findings indicate that heightened language motivation can positively impact learners’speaking fluency,while improved oral skills,in turn,bolster learners’language confidence and motivation.Building on these insights,the study proposes impactful teaching approaches,such as cultivating learners’enthusiasm for language acquisition,providing diverse opportunities for oral practice,and fostering active engagement in language communication.These strategies are designed to enhance language motivation and speaking fluency among learners,offering valuable guidance and reference for educators.
基金This work was supported by the National Natural Science Foundation of China under Grants of 62071067,62101064,62201072,62171057,and 62001054,Beijing University of Posts and Telecommunications-China Mobile Research Institute Joint Innovation Center。
文摘Telecommunication has undergone significant transformations due to the continuous advancements in internet technology,mobile devices,competitive pricing,and changing customer preferences.Specifically,the most recent iteration of OpenAI’s large language model chat generative pre-trained transformer(ChatGPT)has the potential to propel innovation and bolster operational performance in the telecommunications sector.Nowadays,the exploration of network resource management,control,and operation is still in the initial stage.In this paper,we propose a novel network artificial intelligence architecture named language model for network traffic(NetLM),a large language model based on a transformer designed to understand sequence structures in the network packet data and capture their underlying dynamics.The continual convergence of knowledge space and artificial intelligence(AI)technologies constitutes the core of intelligent network management and control.Multi-modal representation learning is used to unify the multi-modal information of network indicator data,traffic data,and text data into the same feature space.Furthermore,a NetLM-based control policy generation framework is proposed to refine intent incrementally through different abstraction levels.Finally,some potential cases are provided that NetLM can benefit the telecom industry.
基金the National Natural Science Foundation of China(81373177,81471594,and 81700026).
文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect.
基金This work was supported by grants from the National Natural Science Foundation of China(81471594,81700026,81971510,and 82071805).
文摘Group 2 innate lymphoid cells(ILC2s)are now known to play prominent roles in many inflammatory responses involving the production of Th2-type cytokines,which contribute to parasitic infections,tissue repair,and metabolic homeostasis[1].More recently,it has emerged that ILC2s may act as antigen-presenting cells,although corresponding evidence of phagocytic activity of these cells is currently scarce[2,3].Herein,we investigated whether ILC2s can phagocytose bacteria,through in vitro experiments.
