The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determinin...The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determining the quality of products.In this context,vocational colleges strive to cultivate high-quality skilled talents,making the cultivation of craftsmanship spirit a crucial component of vocational education.This study explores the cultivation path of craftsmanship spirit through the lens of skills competitions,with a special emphasis on developing students’perseverance.The research conclusions of this article hold significant reference value for the implementation of vocational education policies.展开更多
To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated an...To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated antibacterial properties was constructed.A small amount of Sn added to Mg-1Zn alloy reduces the biocorrosion rate,which can be attributed to Sn participation in outer-layer film formation,significantly reducing the biocorrosion rate and hydrogen evolution rate after implantation in vivo.These Mg alloys,which are susceptible to degradation in the acidic bacterial microenvironment,degrade by releasing Mg,Zn and Sn,producing favorably alkaline and antibacterial conditions.Samples with the composition of Mg-1Zn-0.5Sn were found to be beneficial for promoting initial cell adhesion and proliferation,resulting in improved biocompatibility and biosafety.The biocompatibility of this alloy was confirmed by the healthy behavior of animals and the absence of acute or chronic toxicity in the liver,spleen,and kidneys.Our results demonstrate that Mg-1Zn-0.5Sn is safe for biological systems,enabling its efficacious use in biomedical applications.展开更多
To analyze the psychometric performance of Learning Burnout Scale for Undergraduates(LBSU)in Guangdong province.LBSU was used to conduct the survey involving 1628 undergraduates who were selected with stratified rando...To analyze the psychometric performance of Learning Burnout Scale for Undergraduates(LBSU)in Guangdong province.LBSU was used to conduct the survey involving 1628 undergraduates who were selected with stratified random sampling from 7 colleges in Guangdong province.Cronbach’sαcoefficient and split-half reliability were used to analyze the internal consistency of the questionnaire.Convergent validity,discriminant validity and factor analysis were used to evaluate its structural validity.Ceiling and floor effect were used to analyze its sensitivity.Cronbach’sαcoefficient of the total questionnaire was 0.89 and cronbach’sαcoefficient of 3 dimensions were 0.73-0.78,which met with the requirements of the group comparison.Spearman-Brown split-half coefficient of the total questionnaire and 3 dimensions were 0.90,0.85,0.81,0.79,respectively,which also met with the requirements of the group comparison.Both the calibration success rate of convergent validity and discriminant validity of each dimension were 100%.Four components obtained from 20 items which cumulative variance contribution rate was 51.924%.The total score and score of each dimension were all normal distribution,without any floor or ceiling effect in dimensions.The psychometric performance of LBSU for assessing undergraduates in Guangdong province is valid and reliable.展开更多
5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive toxicity.However,the curative effect of 5-ALA is restricted by intracellular biotransformation i...5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive toxicity.However,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells.Inspired by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO co-delivery.MFLs@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of photosensitivity.Meanwhile,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor cells.Our findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA.展开更多
Poor stability of spiro-OMe TAD hole transport materials(HTMs)with dopant is a major obstacle for the commercialization of perovskite solar cells(pero-SCs).Herein,we demonstrate a series of quinoxaline-based D-A copol...Poor stability of spiro-OMe TAD hole transport materials(HTMs)with dopant is a major obstacle for the commercialization of perovskite solar cells(pero-SCs).Herein,we demonstrate a series of quinoxaline-based D-A copolymers PBQ5,PBQ6 and PBQ10 as the dopant-free polymer HTMs for high performance pero-SCs.The D-A copolymers are composed of fluorothienyl benzodithiophene(BDTT)as D-unit,difluoroquinoxaline(DFQ)with different side chains as A-unit,and thiophene asπ-bridge,where the side chains on the DFQ unit are bi-alkyl for PBQ5,bi-alkyl-fluorothienyl for PBQ6,and alkoxyl for PBQ10.All the three copolymers are adopted as the dopant-free HTM in the pero-SCs.The planar n-i-p structured pero-SCs based on(FAPb I_(3))_(0.98)(MAPb Br_(3))_(0.02)with PBQ6 HTM demonstrated the high power conversion efficiency(PCE)of 22.6%with Vocof1.13 V and FF of 80.8%,which is benefitted from the suitable energy level and high hole mobility of PBQ6.The PCE of 22.6%is the highest efficiency reported in the n-i-p structured pero-SCs based on dopant-free D-A copolymer HTM.In addition,the peroSCs show significantly enhanced ambient,thermal and light-soaking stability compared with the devices with traditional spiroOMe TAD HTM.展开更多
Conventional vision-based systems,such as cameras,have demonstrated their enormous versatility in sensing human activities and developing interactive environments.However,these systems have long been criticized for in...Conventional vision-based systems,such as cameras,have demonstrated their enormous versatility in sensing human activities and developing interactive environments.However,these systems have long been criticized for incurring privacy,power,and latency issues due to their underlying structure of pixel-wise analog signal acquisition,computation,and communication.In this research,we overcome these limitations by introducing in-sensor analog computation through the distribution of interconnected photodetectors in space,having a weighted responsivity,to create what we call a computational photodetector.Computational photodetectors can be used to extract mid-level vision features as a single continuous analog signal measured via a two-pin connection.We develop computational photodetectors using thin and flexible low-noise organic photodiode arrays coupled with a self-powered wireless system to demonstrate a set of designs that capture position,orientation,direction,speed,and identification information,in a range of applications from explicit interactions on everyday surfaces to implicit activity detection.展开更多
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project number:2022X305-SXZC).
文摘The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determining the quality of products.In this context,vocational colleges strive to cultivate high-quality skilled talents,making the cultivation of craftsmanship spirit a crucial component of vocational education.This study explores the cultivation path of craftsmanship spirit through the lens of skills competitions,with a special emphasis on developing students’perseverance.The research conclusions of this article hold significant reference value for the implementation of vocational education policies.
文摘To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated antibacterial properties was constructed.A small amount of Sn added to Mg-1Zn alloy reduces the biocorrosion rate,which can be attributed to Sn participation in outer-layer film formation,significantly reducing the biocorrosion rate and hydrogen evolution rate after implantation in vivo.These Mg alloys,which are susceptible to degradation in the acidic bacterial microenvironment,degrade by releasing Mg,Zn and Sn,producing favorably alkaline and antibacterial conditions.Samples with the composition of Mg-1Zn-0.5Sn were found to be beneficial for promoting initial cell adhesion and proliferation,resulting in improved biocompatibility and biosafety.The biocompatibility of this alloy was confirmed by the healthy behavior of animals and the absence of acute or chronic toxicity in the liver,spleen,and kidneys.Our results demonstrate that Mg-1Zn-0.5Sn is safe for biological systems,enabling its efficacious use in biomedical applications.
文摘To analyze the psychometric performance of Learning Burnout Scale for Undergraduates(LBSU)in Guangdong province.LBSU was used to conduct the survey involving 1628 undergraduates who were selected with stratified random sampling from 7 colleges in Guangdong province.Cronbach’sαcoefficient and split-half reliability were used to analyze the internal consistency of the questionnaire.Convergent validity,discriminant validity and factor analysis were used to evaluate its structural validity.Ceiling and floor effect were used to analyze its sensitivity.Cronbach’sαcoefficient of the total questionnaire was 0.89 and cronbach’sαcoefficient of 3 dimensions were 0.73-0.78,which met with the requirements of the group comparison.Spearman-Brown split-half coefficient of the total questionnaire and 3 dimensions were 0.90,0.85,0.81,0.79,respectively,which also met with the requirements of the group comparison.Both the calibration success rate of convergent validity and discriminant validity of each dimension were 100%.Four components obtained from 20 items which cumulative variance contribution rate was 51.924%.The total score and score of each dimension were all normal distribution,without any floor or ceiling effect in dimensions.The psychometric performance of LBSU for assessing undergraduates in Guangdong province is valid and reliable.
基金supported by the National Natural Science Foundation of China(Nos.82073395,21904119 and 319009919)Innovation Talent Support Program of Henan Province(No.19HASTIT006,China)+1 种基金Key Scientific Research Projects,Education Department of Henan Province(No.20A350009,China)Key scientific research projects,Science and Technology Department of Henan Province(No.192102310147,China)。
文摘5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive toxicity.However,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells.Inspired by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO co-delivery.MFLs@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of photosensitivity.Meanwhile,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor cells.Our findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA.
基金supported by the National Key Research and Development Program of China(2019YFA0705900)the National Natural Science Foundation of China(51820105003,21734008,61904181)the Guangdong Major Project of Basic and Applied Basic Research(2019B030302007)。
文摘Poor stability of spiro-OMe TAD hole transport materials(HTMs)with dopant is a major obstacle for the commercialization of perovskite solar cells(pero-SCs).Herein,we demonstrate a series of quinoxaline-based D-A copolymers PBQ5,PBQ6 and PBQ10 as the dopant-free polymer HTMs for high performance pero-SCs.The D-A copolymers are composed of fluorothienyl benzodithiophene(BDTT)as D-unit,difluoroquinoxaline(DFQ)with different side chains as A-unit,and thiophene asπ-bridge,where the side chains on the DFQ unit are bi-alkyl for PBQ5,bi-alkyl-fluorothienyl for PBQ6,and alkoxyl for PBQ10.All the three copolymers are adopted as the dopant-free HTM in the pero-SCs.The planar n-i-p structured pero-SCs based on(FAPb I_(3))_(0.98)(MAPb Br_(3))_(0.02)with PBQ6 HTM demonstrated the high power conversion efficiency(PCE)of 22.6%with Vocof1.13 V and FF of 80.8%,which is benefitted from the suitable energy level and high hole mobility of PBQ6.The PCE of 22.6%is the highest efficiency reported in the n-i-p structured pero-SCs based on dopant-free D-A copolymer HTM.In addition,the peroSCs show significantly enhanced ambient,thermal and light-soaking stability compared with the devices with traditional spiroOMe TAD HTM.
基金supported by the Georgia Tech CRNCH (Center for Research into Novel Computing Hierarchies) Ph.D.Fellowship.
文摘Conventional vision-based systems,such as cameras,have demonstrated their enormous versatility in sensing human activities and developing interactive environments.However,these systems have long been criticized for incurring privacy,power,and latency issues due to their underlying structure of pixel-wise analog signal acquisition,computation,and communication.In this research,we overcome these limitations by introducing in-sensor analog computation through the distribution of interconnected photodetectors in space,having a weighted responsivity,to create what we call a computational photodetector.Computational photodetectors can be used to extract mid-level vision features as a single continuous analog signal measured via a two-pin connection.We develop computational photodetectors using thin and flexible low-noise organic photodiode arrays coupled with a self-powered wireless system to demonstrate a set of designs that capture position,orientation,direction,speed,and identification information,in a range of applications from explicit interactions on everyday surfaces to implicit activity detection.
