Nowadays,the rapid development of the social economy inevitably leads to global energy and environmental crisis.For this reason,more and more scholars focus on the development of photocatalysis and/or electrocatalysis...Nowadays,the rapid development of the social economy inevitably leads to global energy and environmental crisis.For this reason,more and more scholars focus on the development of photocatalysis and/or electrocatalysis technology for the advantage in the sustainable production of high-value-added products,and the high efficiency in pollutants remediation.Although there is plenty of outstanding research has been put forward continuously,most of them focuses on catalysis performance and reaction mechanisms in laboratory conditions.Realizing industrial application of photo/electrocatalytic processes is still a challenge that needs to be overcome by social demand.In this regard,this review comprehensively summarized several explorations in thefield of photo/electrocatalytic reduction towards potential industrial applications in recent years.Special attention is paid to the successful attempts and the current status of photo/electrocatalytic water splitting,carbon dioxide conversion,resource utilization from waste,etc.,by using advanced reactors.The key problems and challenges of photo/electrocatalysis in future industrial practice are also discussed,and the possible development directions are also pointed out from the industry view.展开更多
In actual traffic scenarios,precise recognition of traffic participants,such as vehicles and pedestrians,is crucial for intelligent transportation.This study proposes an improved algorithm built on Mask-RCNN to enhanc...In actual traffic scenarios,precise recognition of traffic participants,such as vehicles and pedestrians,is crucial for intelligent transportation.This study proposes an improved algorithm built on Mask-RCNN to enhance the ability of autonomous driving systems to recognize traffic participants.The algorithmincorporates long and shortterm memory networks and the fused attention module(GSAM,GCT,and Spatial Attention Module)to enhance the algorithm’s capability to process both global and local information.Additionally,to increase the network’s initial operation stability,the original network activation function was replaced with Gaussian error linear unit.Experiments were conducted using the publicly available Cityscapes dataset.Comparing the test results,it was observed that the revised algorithmoutperformed the original algorithmin terms of AP_(50),AP_(75),and othermetrics by 8.7%and 9.6%for target detection and 12.5%and 13.3%for segmentation.展开更多
The work herein employed a rotating packed bed(RPB)to intensify the sulfonation process of 1,4-diaminoanthraquinone leuco(DL)in an attempt to improve the yield of the product 1,4-diaminoanthra quinone-2-sulfonic acid(...The work herein employed a rotating packed bed(RPB)to intensify the sulfonation process of 1,4-diaminoanthraquinone leuco(DL)in an attempt to improve the yield of the product 1,4-diaminoanthra quinone-2-sulfonic acid(DSA).First,the effects of operating conditions in a stirred tank reactor(STR),including stirring speed,chlorosulfonic acid/DL molar ratio(η),solvent/DL mass ratio(ζ),reaction temperature and dropping speed of chlorosulfonic acid,on the yield of DSA were investigated.The yield of DSA can reach 87.34%under the optimal operating conditions:stirring speed of 500 r·min^(-1),ηof 4.5,ζof 7,reaction temperature of 150℃,dropping speed of 0.61 ml·min^(-1).In addition,the kinetics of the sulfonation process via the shrinking core model revealed that the reaction is controlled by diffusion via a product layer under the reaction temperature of 140℃.Furthermore,the RPB was employed to intensify the mass transfer between liquid and solid phases during the sulfonation reaction process.The results showed that the DSA yield of 92.69%obtained by RPB was 5.35%higher than that by STR,indicating that RPB can significantly intensify the mass transfer in the liquid-solid phase sulfonation reaction process.展开更多
Water injection, as a widely used technique to prevent coal burst, can restrain the fractured coal seam and released the energy storage. In this study, laboratory tests were frstly carried out on standard coal specime...Water injection, as a widely used technique to prevent coal burst, can restrain the fractured coal seam and released the energy storage. In this study, laboratory tests were frstly carried out on standard coal specimens with fve diferent water contents (i.e., 0%, 0.6%, 1.08%, 1.5%, 2.0%, and 2.3%). The failure mode, fragment size, and energy distribution characteristics of coal specimens were investigated. Experimental results show that strength, elastic strain energy, dissipated energy, brittleness index, as well as impact energy index decrease with increasing water content. Besides, the failure mode transitions gradually from splitting ejection to tensile-shear mixed failure mode as water content increases, and average fragment size shows positively related to water content. Moreover, scanning electron microscope tests results indicate that water in coal sample mainly causes the mineral softening and defects increase. Furthermore, a numerical model containing roadway excavation was established considering the water on coal burst prevention. Modelling results revealed that water injection can reduce degree of coal burst and ejection velocity of coal blocks, while it will raise up the depth of crack zone and surface displacement of roadway. Combined with laboratory tests and numerical results, the micro mechanism, energy mechanism, and engineering signifcance of water injection on coal burst prevention were fnally analyzed.展开更多
As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective...As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective technology to convert lignin like sodium lignosulfonate(SL),a lignin derivative,into aromatic aldehydes such as vanillin and syringaldehyde.However,how to improve the yield of aromatic aldehyde and conversion efficiency is still a challenge,and many operating conditions that significantly affect the yield of these aromatic compounds have rarely been investigated systematically.In this work,we adopted the stirred tank reactor(STR)for the CWAO process with nano-CuO as catalyst to achieve the conversion of SL into vanillin and syringaldehyde.The effect of operating conditions including reaction time,oxygen partial pressure,reaction temperature,SL concentration,rotational speed,catalyst amount,and NaOH concentration on the yield of single phenolic compound was systematically investigated.The results revealed that all these operating conditions exhibit a significant effect on the aromatic aldehyde yield.Therefore,they should be regulated in an optimal value to obtain high yield of these aldehydes.More importantly,the reaction kinetics of the lignin oxidation was explored.This work could provide basic data for the optimization and design of industrial operation of lignin oxidation.展开更多
The catalytic hydrogenation of 2-nitro-4-acetylamino anisole(NMA)is a less-polluting and efficient method to produce 2-amino-4-acetamino anisole(AMA).However,the kinetics of catalytic hydrogenation of NMA to AMA remai...The catalytic hydrogenation of 2-nitro-4-acetylamino anisole(NMA)is a less-polluting and efficient method to produce 2-amino-4-acetamino anisole(AMA).However,the kinetics of catalytic hydrogenation of NMA to AMA remains obscure.In this work,the kinetic models including power-law model and Langmuir-Hinshelwood-Hougen-Watson(LHHW)model of NMA hydrogenation to AMA catalyzed by Raney nickel catalyst were investigated.All experiments were carried out under the elimination of mass transfer resistance within the temperature range of 70–100°C and the hydrogen pressure of 0.8–1.5 MPa.The reaction was found to follow 0.52-order kinetics with respect to the NMA concentration and 1.10-order kinetics in terms of hydrogen pressure.Based on the LHHW model,the dual-site dissociation adsorption of hydrogen was analyzed to be the rate determining step.The research of intrinsic kinetics of NMA to AMA provides the guidance for the reactor design and inspires the catalyst modification.展开更多
Chondroitin sulfate synthase 2(CHPF)is characterized as an oncogenic and poor prognosis-related gene in breast cancer.However,this gene has alternative splicing products encoding proteins of different lengths.Breast c...Chondroitin sulfate synthase 2(CHPF)is characterized as an oncogenic and poor prognosis-related gene in breast cancer.However,this gene has alternative splicing products encoding proteins of different lengths.Breast cancer is a group of heterogeneous tumors with distinct clinical and genomic characteristics.In this study,we explored the expression profile and prognostic value of the two transcripts of CHPF using data from The Cancer Genome Atlas(TCGA)-BRCA.The functional regulation of the two transcripts was also studied in MCF-7 and BT-474 cells.Among the two transcripts of CHPF,ENST00000535926 expression was significantly upregulated in the tumor samples and was the dominant isoform.ENST00000535926,but not ENST00000243776 upregulation,was associated with significantly worse progression-free survival(PFS)and disease-specific survival(DSS)in luminal A/B cases.However,no significant association was observed in PFS or DSS in other Prediction Analysis of Microarray 50(PAM50)subgroups.CHPF isoform 2 protein(encoded by ENST00000535926)significantly elevated the expression of P3H1 and RCN3 at the mRNA and protein levels in MCF-7 and BT-474 cells.The effect of ENST00000535926 was significantly stronger than ENST00000243776 in promoting tumor cell colony formation.The expression of P3H1 and RCN3 was negatively correlated with CD8+T cell infiltration but was positively correlated with cancer-associated fibroblast infiltration in luminal A/B tumors.In summary,this study revealed that ENST00000535926 is an unfavorable prognosis-related and tumor-promoting transcript of the CHPF gene in luminal A/B breast cancer.展开更多
With respect to the gamma spectrum, the energy resolution improves with increase in energy. The counts of full energy peak change with energy, and this approximately complies with the Gaussian distribution. This study...With respect to the gamma spectrum, the energy resolution improves with increase in energy. The counts of full energy peak change with energy, and this approximately complies with the Gaussian distribution. This study mainly examines a method to deconvolve the LaBr_3:Ce gamma spectrum with a detector response matrix constructing algorithm based on energy resolution calibration.In the algorithm, the full width at half maximum(FWHM)of full energy peak was calculated by the cubic spline interpolation algorithm and calibrated by a square root of a quadratic function that changes with the energy. Additionally, the detector response matrix was constructed to deconvolve the gamma spectrum. Furthermore, an improved SNIP algorithm was proposed to eliminate the background. In the experiment, several independent peaks of ^(152)Eu,^(137)Cs, and ^(60)Co sources were detected by a LaBr_3:Ce scintillator that were selected to calibrate the energy resolution. The Boosted Gold algorithm was applied to deconvolve the gamma spectrum. The results showed that the peak position difference between the experiment and the deconvolution was within ± 2 channels and the relative error of peak area was approximately within 0.96–6.74%. Finally, a ^(133) Ba spectrum was deconvolved to verify the efficiency and accuracy of the algorithm in unfolding the overlapped peaks.展开更多
The present study investigated the effects of catalpol, the main constituent of the Chinese herb Rehmannia root, on neurons following brain ischemia. A rat model of focal permanent brain ischemia was established using...The present study investigated the effects of catalpol, the main constituent of the Chinese herb Rehmannia root, on neurons following brain ischemia. A rat model of focal permanent brain ischemia was established using electrocoagulation. The rats were intraperitoneally injected with catalpol, at a dose of 5 mg/kg, daily for 1 week. Results showed that the number of neuronal synapses in the motor cortex and growth associated protein 43 expression were increased following catalpol treatment, indicating that catalpol might contribute to neuroplasticity and ameliorate functional neurological deficits induced by cerebral ischemia.展开更多
A two-stage blade-packing rotating packed bed(TSBP-RPB) was designed and developed for the intensification of continuous distillation. The mass transfer parameters of the TSBP-RPB were investigated using a chemisorpti...A two-stage blade-packing rotating packed bed(TSBP-RPB) was designed and developed for the intensification of continuous distillation. The mass transfer parameters of the TSBP-RPB were investigated using a chemisorption system. Continuous distillation experiments were conducted in the TSBP-RPB by the methanol–water binary system. Experimental results showed that values of the effective interfacial area and liquid-side mass transfer coefficient of the TSBP-RPB were 93–337 m^2·m^(-3) and 0.05–0.19 cm·s^(-1), respectively. The height of equivalent theoretical plate(HETP) of the TSBP-RPB ranged from 1.9 to 10 cm. Moreover, the TSBP-RPB is easy to be manufactured, which shows great potential for the application of continuous distillation.展开更多
Four groups of numerical models of Brazilian tests on rock-shotcrete interfaces were successfully conducted by PFC2D. The tensile strength and Young’s modulus of shotcrete were considered. Six different undulations o...Four groups of numerical models of Brazilian tests on rock-shotcrete interfaces were successfully conducted by PFC2D. The tensile strength and Young’s modulus of shotcrete were considered. Six different undulations of rock-shotcrete interface were set up. The influences of multiple parameters on the bearing characteristics of the rock-shotcrete interface were studied. The results showed that a better support performance can be obtained by increasing the Young’s modulus of shotcrete rather than the tensile strength of shotcrete. For different tensile strength and Young’s modulus, the increase of sawtooth height has different effects on the support performance. The failure mechanism of the rock-shotcrete interfaces was analysed in detail. The stress shielding effect and stress concentration effect caused by the shape characteristics of rock-shotcrete interface were observed. The influence of these parameters on the overall support performance should be fully considered in a reasonable support design.展开更多
This paper describes a strategy for merging daily precipitation information from gauge observations, satellite estimates(SEs), and numerical predictions at the global scale. The strategy is designed to remove systemic...This paper describes a strategy for merging daily precipitation information from gauge observations, satellite estimates(SEs), and numerical predictions at the global scale. The strategy is designed to remove systemic bias and random error from each individual daily precipitation source to produce a better gridded global daily precipitation product through three steps.First, a cumulative distribution function matching procedure is performed to remove systemic bias over gauge-located land areas. Then, the overall biases in SEs and model predictions(MPs) over ocean areas are corrected using a rescaled strategy based on monthly precipitation. Third, an optimal interpolation(OI)–based merging scheme(referred as the HL-OI scheme)is used to combine unbiased gauge observations, SEs, and MPs to reduce random error from each source and to produce a gauge—satellite–model merged daily precipitation analysis, called BMEP-d(Beijing Climate Center Merged Estimation of Precipitation with daily resolution), with complete global coverage. The BMEP-d data from a four-year period(2011–14) demonstrate the ability of the merging strategy to provide global daily precipitation of substantially improved quality.Benefiting from the advantages of the HL-OI scheme for quantitative error estimates, the better source data can obtain more weights during the merging processes. The BMEP-d data exhibit higher consistency with satellite and gauge source data at middle and low latitudes, and with model source data at high latitudes. Overall, independent validations against GPCP-1DD(GPCP one-degree daily) show that the consistencies between BMEP-d and GPCP-1DD are higher than those of each source dataset in terms of spatial pattern, temporal variability, probability distribution, and statistical precipitation events.展开更多
The dramatic changes in the Arctic climate system during recent decades are one of the most prominent features ofglobal climate change. Two most striking and fundamental characteristics are the amplified near-surface ...The dramatic changes in the Arctic climate system during recent decades are one of the most prominent features ofglobal climate change. Two most striking and fundamental characteristics are the amplified near-surface warming at a ratetwice the global average since the mid 20th century （e.g., Blunden and Arndt, 2012; Huang et al., 2017）, and the rapiddecline of sea-ice extent at a pace of 12.9% （10 yr）-l and thinning of ice thickness by 40% since 1979 （e.g., Kwok andRothrock, 2009; Meier et al., 2012）. In conjunction with these changes, the frequency of occurrence of extreme climate andweather events has ostensibly increased across the Northern Hemisphere mid-latitudes, including adverse cold spells, severeheat waves, destructive floods, and persistent droughts （e.g., Coumou and Rahmstorf, 2012）. The fact that Arctic climatechanges have coincided with an increase in the frequency of occurrence of extreme events has inspired broad interest inpossible linkages--not only in the climate community, but also the general public, media agencies, and decision makers--inparticular considering the projected future continuation and acceleration of Arctic warming and sea-ice decline （e.g., Zhangand Walsh, 2006; Zhang, 2010; Stroeve et al., 2012; Wang and Overland, 2012）.展开更多
Aim:As conflict caused by cultural diversity among patients in China continues to rise,hospitals are in urgent need for improvement of transcultural efficacy among nurses.This study aims to evaluate the transcultural ...Aim:As conflict caused by cultural diversity among patients in China continues to rise,hospitals are in urgent need for improvement of transcultural efficacy among nurses.This study aims to evaluate the transcultural self-efficacy of nurses working in the tertiary general hospital in Guizhou Province,an ethnic minority region in western China,and to identify whether nurses'demographic characteristics affect their transcultural self-efficacy.Method:We used the Chinese version of the Transcultural Self-Efficacy Tool(TSET-CV)to survey 1,190 inservice nurses.Results:Results showed that the level of transcultural self-efficacy of the nurses was generally moderate;few of the nurses had high or low transcultural self-efficacy.The nurses'transcultural self-efficacy was affected by demographic variables,including age,marital status,employment type,income,work experience,and whether or not they were head nurses.Having a stable work environment,a stable marriage,a good educational background,and a high-ranked professional title were associated with increased transcultural self-efficacy.Conclusion:Nursing administrators in hospitals should offer continuing education on transcuitural nursing according to nurses'demographic characteristics and the SEST scores.展开更多
基金supported by the National Natural Science Foundation of China(22278030,22090032,22090030,22288102,22242019)the Fundamental Research Funds for the Central Universities(buctrc202119,2312018RC07)+1 种基金Major Program of Qingyuan Innovation Laboratory(Grant No.001220005)the Experiments for Space Exploration Program and the Qian Xuesen Laboratory,China Academy of Space Technology。
文摘Nowadays,the rapid development of the social economy inevitably leads to global energy and environmental crisis.For this reason,more and more scholars focus on the development of photocatalysis and/or electrocatalysis technology for the advantage in the sustainable production of high-value-added products,and the high efficiency in pollutants remediation.Although there is plenty of outstanding research has been put forward continuously,most of them focuses on catalysis performance and reaction mechanisms in laboratory conditions.Realizing industrial application of photo/electrocatalytic processes is still a challenge that needs to be overcome by social demand.In this regard,this review comprehensively summarized several explorations in thefield of photo/electrocatalytic reduction towards potential industrial applications in recent years.Special attention is paid to the successful attempts and the current status of photo/electrocatalytic water splitting,carbon dioxide conversion,resource utilization from waste,etc.,by using advanced reactors.The key problems and challenges of photo/electrocatalysis in future industrial practice are also discussed,and the possible development directions are also pointed out from the industry view.
基金the National Natural Science Foundation of China(52175236)Qingdao People’s Livelihood Science and Technology Plan(19-6-1-88-nsh).
文摘In actual traffic scenarios,precise recognition of traffic participants,such as vehicles and pedestrians,is crucial for intelligent transportation.This study proposes an improved algorithm built on Mask-RCNN to enhance the ability of autonomous driving systems to recognize traffic participants.The algorithmincorporates long and shortterm memory networks and the fused attention module(GSAM,GCT,and Spatial Attention Module)to enhance the algorithm’s capability to process both global and local information.Additionally,to increase the network’s initial operation stability,the original network activation function was replaced with Gaussian error linear unit.Experiments were conducted using the publicly available Cityscapes dataset.Comparing the test results,it was observed that the revised algorithmoutperformed the original algorithmin terms of AP_(50),AP_(75),and othermetrics by 8.7%and 9.6%for target detection and 12.5%and 13.3%for segmentation.
基金financially supported by the National Key Research and Development Program of China(2016YFB0301500)the National Natural Science Foundation of China(21878009)。
文摘The work herein employed a rotating packed bed(RPB)to intensify the sulfonation process of 1,4-diaminoanthraquinone leuco(DL)in an attempt to improve the yield of the product 1,4-diaminoanthra quinone-2-sulfonic acid(DSA).First,the effects of operating conditions in a stirred tank reactor(STR),including stirring speed,chlorosulfonic acid/DL molar ratio(η),solvent/DL mass ratio(ζ),reaction temperature and dropping speed of chlorosulfonic acid,on the yield of DSA were investigated.The yield of DSA can reach 87.34%under the optimal operating conditions:stirring speed of 500 r·min^(-1),ηof 4.5,ζof 7,reaction temperature of 150℃,dropping speed of 0.61 ml·min^(-1).In addition,the kinetics of the sulfonation process via the shrinking core model revealed that the reaction is controlled by diffusion via a product layer under the reaction temperature of 140℃.Furthermore,the RPB was employed to intensify the mass transfer between liquid and solid phases during the sulfonation reaction process.The results showed that the DSA yield of 92.69%obtained by RPB was 5.35%higher than that by STR,indicating that RPB can significantly intensify the mass transfer in the liquid-solid phase sulfonation reaction process.
基金supported by the National Natural Science Foundation of China(Grant No:51974289)Natural Science Foundation of Anhui Province(Grant No:2108085ME155).
文摘Water injection, as a widely used technique to prevent coal burst, can restrain the fractured coal seam and released the energy storage. In this study, laboratory tests were frstly carried out on standard coal specimens with fve diferent water contents (i.e., 0%, 0.6%, 1.08%, 1.5%, 2.0%, and 2.3%). The failure mode, fragment size, and energy distribution characteristics of coal specimens were investigated. Experimental results show that strength, elastic strain energy, dissipated energy, brittleness index, as well as impact energy index decrease with increasing water content. Besides, the failure mode transitions gradually from splitting ejection to tensile-shear mixed failure mode as water content increases, and average fragment size shows positively related to water content. Moreover, scanning electron microscope tests results indicate that water in coal sample mainly causes the mineral softening and defects increase. Furthermore, a numerical model containing roadway excavation was established considering the water on coal burst prevention. Modelling results revealed that water injection can reduce degree of coal burst and ejection velocity of coal blocks, while it will raise up the depth of crack zone and surface displacement of roadway. Combined with laboratory tests and numerical results, the micro mechanism, energy mechanism, and engineering signifcance of water injection on coal burst prevention were fnally analyzed.
基金supported by the National Key Research and Development Program of China(2019YFA0210302)the National Natural Science Foundation of China(21878009).
文摘As one of the few renewable aromatic resources,the research of depolymerization of lignin into highvalue chemicals has attracted extensive attention in recent years.Catalytic wet aerobic oxidation(CWAO)is an effective technology to convert lignin like sodium lignosulfonate(SL),a lignin derivative,into aromatic aldehydes such as vanillin and syringaldehyde.However,how to improve the yield of aromatic aldehyde and conversion efficiency is still a challenge,and many operating conditions that significantly affect the yield of these aromatic compounds have rarely been investigated systematically.In this work,we adopted the stirred tank reactor(STR)for the CWAO process with nano-CuO as catalyst to achieve the conversion of SL into vanillin and syringaldehyde.The effect of operating conditions including reaction time,oxygen partial pressure,reaction temperature,SL concentration,rotational speed,catalyst amount,and NaOH concentration on the yield of single phenolic compound was systematically investigated.The results revealed that all these operating conditions exhibit a significant effect on the aromatic aldehyde yield.Therefore,they should be regulated in an optimal value to obtain high yield of these aldehydes.More importantly,the reaction kinetics of the lignin oxidation was explored.This work could provide basic data for the optimization and design of industrial operation of lignin oxidation.
基金the National Natural Science Foun-dation of China(22022802 and 22288102).
文摘The catalytic hydrogenation of 2-nitro-4-acetylamino anisole(NMA)is a less-polluting and efficient method to produce 2-amino-4-acetamino anisole(AMA).However,the kinetics of catalytic hydrogenation of NMA to AMA remains obscure.In this work,the kinetic models including power-law model and Langmuir-Hinshelwood-Hougen-Watson(LHHW)model of NMA hydrogenation to AMA catalyzed by Raney nickel catalyst were investigated.All experiments were carried out under the elimination of mass transfer resistance within the temperature range of 70–100°C and the hydrogen pressure of 0.8–1.5 MPa.The reaction was found to follow 0.52-order kinetics with respect to the NMA concentration and 1.10-order kinetics in terms of hydrogen pressure.Based on the LHHW model,the dual-site dissociation adsorption of hydrogen was analyzed to be the rate determining step.The research of intrinsic kinetics of NMA to AMA provides the guidance for the reactor design and inspires the catalyst modification.
基金supported by the Science and Technology Plan Project of Sichuan Province(Provincial Academy and Provincial University Cooperation Project)(2020YFSY0025).
文摘Chondroitin sulfate synthase 2(CHPF)is characterized as an oncogenic and poor prognosis-related gene in breast cancer.However,this gene has alternative splicing products encoding proteins of different lengths.Breast cancer is a group of heterogeneous tumors with distinct clinical and genomic characteristics.In this study,we explored the expression profile and prognostic value of the two transcripts of CHPF using data from The Cancer Genome Atlas(TCGA)-BRCA.The functional regulation of the two transcripts was also studied in MCF-7 and BT-474 cells.Among the two transcripts of CHPF,ENST00000535926 expression was significantly upregulated in the tumor samples and was the dominant isoform.ENST00000535926,but not ENST00000243776 upregulation,was associated with significantly worse progression-free survival(PFS)and disease-specific survival(DSS)in luminal A/B cases.However,no significant association was observed in PFS or DSS in other Prediction Analysis of Microarray 50(PAM50)subgroups.CHPF isoform 2 protein(encoded by ENST00000535926)significantly elevated the expression of P3H1 and RCN3 at the mRNA and protein levels in MCF-7 and BT-474 cells.The effect of ENST00000535926 was significantly stronger than ENST00000243776 in promoting tumor cell colony formation.The expression of P3H1 and RCN3 was negatively correlated with CD8+T cell infiltration but was positively correlated with cancer-associated fibroblast infiltration in luminal A/B tumors.In summary,this study revealed that ENST00000535926 is an unfavorable prognosis-related and tumor-promoting transcript of the CHPF gene in luminal A/B breast cancer.
基金supported by the National Natural Science Foundation of China(Nos.41374130 and 41604154)
文摘With respect to the gamma spectrum, the energy resolution improves with increase in energy. The counts of full energy peak change with energy, and this approximately complies with the Gaussian distribution. This study mainly examines a method to deconvolve the LaBr_3:Ce gamma spectrum with a detector response matrix constructing algorithm based on energy resolution calibration.In the algorithm, the full width at half maximum(FWHM)of full energy peak was calculated by the cubic spline interpolation algorithm and calibrated by a square root of a quadratic function that changes with the energy. Additionally, the detector response matrix was constructed to deconvolve the gamma spectrum. Furthermore, an improved SNIP algorithm was proposed to eliminate the background. In the experiment, several independent peaks of ^(152)Eu,^(137)Cs, and ^(60)Co sources were detected by a LaBr_3:Ce scintillator that were selected to calibrate the energy resolution. The Boosted Gold algorithm was applied to deconvolve the gamma spectrum. The results showed that the peak position difference between the experiment and the deconvolution was within ± 2 channels and the relative error of peak area was approximately within 0.96–6.74%. Finally, a ^(133) Ba spectrum was deconvolved to verify the efficiency and accuracy of the algorithm in unfolding the overlapped peaks.
基金the National Natural Science Foundation of China, No. 81073084the Fundamental Research Funds for the Central Universities, No.XDJK2009C081+1 种基金the Natural Science Foundation Project of CQ CSTC, No.2010BB5127Science and Technology Innovative Capacity Construction Program of Chongqing(CSTC) No.2009CB1010
文摘The present study investigated the effects of catalpol, the main constituent of the Chinese herb Rehmannia root, on neurons following brain ischemia. A rat model of focal permanent brain ischemia was established using electrocoagulation. The rats were intraperitoneally injected with catalpol, at a dose of 5 mg/kg, daily for 1 week. Results showed that the number of neuronal synapses in the motor cortex and growth associated protein 43 expression were increased following catalpol treatment, indicating that catalpol might contribute to neuroplasticity and ameliorate functional neurological deficits induced by cerebral ischemia.
基金Acknowledgments The authors wish to thank the National Natural Science Foundation of China （Grant No. 51005234 and 50905180）, the Foundation of China University of Mining and Technology （Grant No. 2009A056） and the Natural Science Foundation of Jiangsu Province （Grant No. BK2008005）.
基金Supported by the Fundamental Research Funds for the Central Universities(ZY1403)the National Natural Science Foundation of China(No.21406008 and No.U1462127)
文摘A two-stage blade-packing rotating packed bed(TSBP-RPB) was designed and developed for the intensification of continuous distillation. The mass transfer parameters of the TSBP-RPB were investigated using a chemisorption system. Continuous distillation experiments were conducted in the TSBP-RPB by the methanol–water binary system. Experimental results showed that values of the effective interfacial area and liquid-side mass transfer coefficient of the TSBP-RPB were 93–337 m^2·m^(-3) and 0.05–0.19 cm·s^(-1), respectively. The height of equivalent theoretical plate(HETP) of the TSBP-RPB ranged from 1.9 to 10 cm. Moreover, the TSBP-RPB is easy to be manufactured, which shows great potential for the application of continuous distillation.
基金We acknowledge the financial supports of the National Natural Science Foundation of China(No.41630642)Project of Innovationdriven Plan in Central South University(No.2018CX020)the Funded by Open Research Fund Program of Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring(Central South University),Ministry of Education(No.2017YSJS14).
文摘Four groups of numerical models of Brazilian tests on rock-shotcrete interfaces were successfully conducted by PFC2D. The tensile strength and Young’s modulus of shotcrete were considered. Six different undulations of rock-shotcrete interface were set up. The influences of multiple parameters on the bearing characteristics of the rock-shotcrete interface were studied. The results showed that a better support performance can be obtained by increasing the Young’s modulus of shotcrete rather than the tensile strength of shotcrete. For different tensile strength and Young’s modulus, the increase of sawtooth height has different effects on the support performance. The failure mechanism of the rock-shotcrete interfaces was analysed in detail. The stress shielding effect and stress concentration effect caused by the shape characteristics of rock-shotcrete interface were observed. The influence of these parameters on the overall support performance should be fully considered in a reasonable support design.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41275076, 41305057, 41175066, 41175086, and 40905046)the Beijing Natural Science Foundation (Grant No. 8144046)+1 种基金the National High Technology Research and Development Program of China (Grant Nos. 2009AA122005 and 2009BAC51B03)the National Basic Research Program of China (Grant No. 2010CB 951902)
文摘This paper describes a strategy for merging daily precipitation information from gauge observations, satellite estimates(SEs), and numerical predictions at the global scale. The strategy is designed to remove systemic bias and random error from each individual daily precipitation source to produce a better gridded global daily precipitation product through three steps.First, a cumulative distribution function matching procedure is performed to remove systemic bias over gauge-located land areas. Then, the overall biases in SEs and model predictions(MPs) over ocean areas are corrected using a rescaled strategy based on monthly precipitation. Third, an optimal interpolation(OI)–based merging scheme(referred as the HL-OI scheme)is used to combine unbiased gauge observations, SEs, and MPs to reduce random error from each source and to produce a gauge—satellite–model merged daily precipitation analysis, called BMEP-d(Beijing Climate Center Merged Estimation of Precipitation with daily resolution), with complete global coverage. The BMEP-d data from a four-year period(2011–14) demonstrate the ability of the merging strategy to provide global daily precipitation of substantially improved quality.Benefiting from the advantages of the HL-OI scheme for quantitative error estimates, the better source data can obtain more weights during the merging processes. The BMEP-d data exhibit higher consistency with satellite and gauge source data at middle and low latitudes, and with model source data at high latitudes. Overall, independent validations against GPCP-1DD(GPCP one-degree daily) show that the consistencies between BMEP-d and GPCP-1DD are higher than those of each source dataset in terms of spatial pattern, temporal variability, probability distribution, and statistical precipitation events.
基金supported by the opening fund from the State Key Laboratory of Cryospheric Sciences, Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences(SKLCS 08-07)the National Postdoctoral Scientific Foundation (20080440342)
文摘The dramatic changes in the Arctic climate system during recent decades are one of the most prominent features ofglobal climate change. Two most striking and fundamental characteristics are the amplified near-surface warming at a ratetwice the global average since the mid 20th century （e.g., Blunden and Arndt, 2012; Huang et al., 2017）, and the rapiddecline of sea-ice extent at a pace of 12.9% （10 yr）-l and thinning of ice thickness by 40% since 1979 （e.g., Kwok andRothrock, 2009; Meier et al., 2012）. In conjunction with these changes, the frequency of occurrence of extreme climate andweather events has ostensibly increased across the Northern Hemisphere mid-latitudes, including adverse cold spells, severeheat waves, destructive floods, and persistent droughts （e.g., Coumou and Rahmstorf, 2012）. The fact that Arctic climatechanges have coincided with an increase in the frequency of occurrence of extreme events has inspired broad interest inpossible linkages--not only in the climate community, but also the general public, media agencies, and decision makers--inparticular considering the projected future continuation and acceleration of Arctic warming and sea-ice decline （e.g., Zhangand Walsh, 2006; Zhang, 2010; Stroeve et al., 2012; Wang and Overland, 2012）.
文摘Aim:As conflict caused by cultural diversity among patients in China continues to rise,hospitals are in urgent need for improvement of transcultural efficacy among nurses.This study aims to evaluate the transcultural self-efficacy of nurses working in the tertiary general hospital in Guizhou Province,an ethnic minority region in western China,and to identify whether nurses'demographic characteristics affect their transcultural self-efficacy.Method:We used the Chinese version of the Transcultural Self-Efficacy Tool(TSET-CV)to survey 1,190 inservice nurses.Results:Results showed that the level of transcultural self-efficacy of the nurses was generally moderate;few of the nurses had high or low transcultural self-efficacy.The nurses'transcultural self-efficacy was affected by demographic variables,including age,marital status,employment type,income,work experience,and whether or not they were head nurses.Having a stable work environment,a stable marriage,a good educational background,and a high-ranked professional title were associated with increased transcultural self-efficacy.Conclusion:Nursing administrators in hospitals should offer continuing education on transcuitural nursing according to nurses'demographic characteristics and the SEST scores.
