The deep earth,deep sea,and deep space are the main parts of the national“three deep”strategy,which is in the forefront of the strategic deployment clearly defined in China’s 14th Five-Year Plan(2021-2025)and the L...The deep earth,deep sea,and deep space are the main parts of the national“three deep”strategy,which is in the forefront of the strategic deployment clearly defined in China’s 14th Five-Year Plan(2021-2025)and the Long-Range Objectives Through the Year 2035.It is important to reveal the evolutionary process and mechanism of deep tectonics to understand the earth’s past,present and future.The academic con-notation of Geology in Time has been given for the first time,which refers to the multi-field evolution response process of geological bodies at different time and spatial scales caused by geological processes inside and outside the Earth.Based on the deep in situ detection space and the unique geological envi-ronment of China Jinping Underground Laboratory,the scientific issue of the correlation mechanism and law between deep internal time-varying and shallow geological response is given attention.Innovative research and frontier exploration on deep underground in situ geo-information detection experiments for Geology in Time are designed to be carried out,which will have the potential to explore the driving force of Geology in Time,reveal essential laws of deep earth science,and explore innovative technologies in deep underground engineering.展开更多
Rational design of efficient and robust earth-abundant alkaline hydrogen evolution reaction(HER)catalysts is a key factor for developing energy conversion technologies.Currently,antiperovskite nitride CuNMn_(3)has gar...Rational design of efficient and robust earth-abundant alkaline hydrogen evolution reaction(HER)catalysts is a key factor for developing energy conversion technologies.Currently,antiperovskite nitride CuNMn_(3)has garnered significant interest due to its remarkable properties such as negative/zero thermal expansion and magnetocaloric effects.However,when utilized as hydrogen evolution catalysts,it encounters large challenge resulting from excessively strong/weak interactions with adsorbed H on Mn/Cu active sites,which leads to low HER activity.In this study,we introduce an asymmetric orbital hybridization strategy in Zn-doped Cu_(1-x)Zn_(x)NMn_(3)by leveraging the localization of Zn electronic states to reconfigure the electronic structures of Cu and Mn,thereby reducing the energy barrier for water dissociation and optimizing Cu and Mn active sites for hydrogen adsorption and H_(2)production.Electrochemical evaluations reveal that Cu_(0.85)Zn_(0.15)NMn_(3)with x=0.15 demonstrates exceptional electrocatalytic activity in alkaline electrolytes.A low overpotential of 52 mV at 10 mA cm^(-2)and outstanding stability over a 150-h test period are achieved,surpassing commercial Pt/C.This research offers a novel strategy for enhancing HER performance by modulating asymmetric hybridization of electron orbitals between multiple metal atoms within a material structure.展开更多
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social environment.AIM To evaluate the significance of serum carbohydrate antigen 19-9(CA19...BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social environment.AIM To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer Hospital.This study specifically assessed CA19-9 levels and tumor size before and after NAT.RESULTS A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this study.The average age was 65.4±10.6 years and 72(46.2%)patients were female.Before survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR<0.5,CR>0.5 and<1 and CR>1.With regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR<0.5,TR>0.5 and<1 and TR>1.Based on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)analyses.Log-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(P<0.05).CR and TR after NAT were associated with increased odds of achieving a complete or near-complete pathologic response.Moreover,CR(hazard ratio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with OS.CONCLUSION This study demonstrated that post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.展开更多
植物光合作用是吸收光能,把CO_(2)和水转化成富能有机物,同时释放氧气的过程.受此启发,利用太阳光将CO_(2)转化为碳氢燃料的人工碳中和技术引起了广泛关注.人工光合作用能否成功实施取决于光催化剂的设计制备.无机半导体已被广泛研究用...植物光合作用是吸收光能,把CO_(2)和水转化成富能有机物,同时释放氧气的过程.受此启发,利用太阳光将CO_(2)转化为碳氢燃料的人工碳中和技术引起了广泛关注.人工光合作用能否成功实施取决于光催化剂的设计制备.无机半导体已被广泛研究用于CO_(2)光还原反应(CO_(2)PRR),但其存在金属氧化物的带隙较宽且难以调节、导致光吸收较差和金属硫化物的光腐蚀问题严重等明显的缺点.此外,高载流子复合率和低比表面积会影响光催化效率,从而限制光子利用.因此,基于有机聚合物的无金属催化剂因其突出的可设计调控性而被提出,其中,具有超高比表面积的材料—多孔芳香骨架(PAFs)聚合物是研究热点之一,但是传统PAFs材料多为二维平面结构,用于光催化的无金属三维PAFs报道较少.此外,具有孤对电子的杂原子(N,B,F)修饰的材料可以与CO_(2)分子产生特定的偶极-四极相互作用,提高材料对CO_(2)的吸附和活化能力,是提升有机聚合物光催化剂性能的有效策略.本文采用Sonogashira-Hagihara偶联将具有不同共轭程度的芳香炔烃(2,2’,7,7‘-四乙炔基-9,9’-螺二芴,SPF-T;四(4-乙炔基苯基)甲烷,TEPM-T;1,1,2,2-四(4-乙炔基苯基)乙烯,TEPE-T)与含有N杂原子的Tröger碱聚合制备了具有三维结构的多孔芳香骨架聚合物X-TB-PAFs(X=TEPE,TEPM,SPF).通过X-射线衍射、红外光谱、13C核磁共振(NMR)以及1H NMR等表征手段验证了目标聚合物的成功合成.通过紫外-可见光谱和Mott-Schottky曲线测试研究了聚合物具体的能带结构,发现三种PAFs聚合物材料在热力学上同时满足光催化CO_(2)-CO的还原反应条件(Eθ=-0.51 Vvs.NHE,pH=7)和光催化H2O-O_(2)的氧化条件(Eθ=0.82 V vs.NHE,pH=7).V形骨架结构的Tröger碱(TB)单元和芳炔的结合赋予了聚合物刚性稳定的孔隙率以及较高的比表面积,材料中的多孔结构可以使其暴露更多的活性位点,三维框架结构为反应物接近活性位点提供了丰富的开放式空腔,这些都有利于材料对CO_(2)的捕获,增强催化剂对CO_(2)的吸附/活化能力.此外,炔基充当连接通道还可以增强体系的载流子迁移率,提升材料的光催化性能.密度泛函理论计算和光电性能测试结果表明,TB官能团引入带来的分子内极化和电子陷阱位点的优势,其与三维共轭网络结构一起协同调节了光生载流子的分离和反应位点分布.三种三维PAFs中,基于全共轭结构TEPE-T的TEPE-TB-PAF表现出最高效的光生载流子传输与分离效率,在没有助催化剂和牺牲剂的情况下表现出较好的光催化CO产率(194.50μmolg^(-1)h^(-1))和近乎单一的选择性(99.74%).全共轭TEPE-T的引入和分子内极化的存在可以促进框架内载流子的分离和迁移.材料中的电偶极矩(从负电荷到正电荷)指向TB中含有叔氮官能团的桥接位点,使其成为明确的催化反应位点.光电流和阻抗测试结果表明,TEPE-TB-PAF具有更好的电子-空穴分离能力和更小的电荷迁移位阻.三维框架构建产生的多重散射截面可以促进材料中的光子吸收,从而提高其光催化性能.理论计算和原位漫反射傅立叶变换红外光谱结果表明,材料中CO解吸的低能垒和*CHO形成的高能垒是TEPE-TB-PAF高CO产率和选择性的根本机制.综上,本文为多功能高效有机聚合物光催化剂的合成提供了有效途径,并为同时改善光催化剂的转化率和选择性提供了借鉴.展开更多
Sepsis is a common complication of combat injuries and trauma,and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.It is also one of the significant causes of deat...Sepsis is a common complication of combat injuries and trauma,and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.It is also one of the significant causes of death and increased health care costs in modern intensive care units.The use of antibiotics,fluid resuscitation,and organ support therapy have limited prognostic impact in patients with sepsis.Although its pathophysiology remains elusive,immunosuppression is now recognized as one of the major causes of septic death.Sepsis-induced immunosuppression is resulted from disruption of immune homeostasis.It is characterized by the release of antiinflammatory cytokines,abnormal death of immune effector cells,hyperproliferation of immune suppressor cells,and expression of immune checkpoints.By targeting immunosuppression,especially with immune checkpoint inhibitors,preclinical studies have demonstrated the reversal of immunocyte dysfunctions and established host resistance.Here,we comprehensively discuss recent findings on the mechanisms,regulation and biomarkers of sepsis-induced immunosuppression and highlight their implications for developing effective strategies to treat patients with septic shock.展开更多
CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant resources.Iron catalysts are commonly...CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant resources.Iron catalysts are commonly used for the hydrogenation of carbon oxides to hydrocarbons.Iron-molybdenum catalysts have found numerous applications in catalysis,but have been never evaluated in the CO_(2)hydrogenation.In this work,the structural properties of iron-molybdenum catalysts without and with a promoting alkali metal(Li,Na,K,Rb,or Cs)were characterized using X-ray diffraction,hydrogen temperatureprogrammed reduction,CO_(2)temperature-programmed desorption,in-situ^(57)Fe Mossbauer spectroscopy and operando X-ray adsorption spectroscopy.Their catalytic performance was evaluated in the CO_(2)hydrogenation.During the reaction conditions,the catalysts undergo the formation of an iron(Ⅱ)molybdate structure,accompanied by a partial reduction of molybdenum and carbidization of iron.The rate of CO_(2)conversion and product selectivity strongly depend on the promoting alkali metals,and electronegativity was identified as an important factor affecting the catalytic performance.Higher CO_(2)conversion rates were observed with the promoters having higher electronegativity,while low electronegativity of alkali metals favors higher light olefin selectivity.展开更多
The further development of catalytic elements has been plagued by activation and binary problems.The automatic shift model that has emerged in recent years helps components achieve full range.However,the detection dat...The further development of catalytic elements has been plagued by activation and binary problems.The automatic shift model that has emerged in recent years helps components achieve full range.However,the detection data still remains unstable in the shift area(7%∼13%).This paper proposes a Catalytic Combustion and Thermal Conductivity(CCTC)model for the specified range,which can be explained fromtwo aspects based on the existing methods.On the one hand,it uses iterative location search to process heterogeneous data,judges the prediction position of data points,and then givesweight evaluation.On the other hand,it corrects the abnormal points,determines the abnormal points in the horizontal direction,and gives the replacement value through the data of adjacent points.The experimental results show that the CCTC model reduces the sum of variance from 17 of the automatic shift model to 13,and the comparison of experimental variance is reduced by 23%.In the full-scale real-time data,the experimental variance of CCTC model and automatic shift model is reduced by 18%.In conclusion,CCTC is a cross section stability framework for full-scale methane measurement,in which the specified heterogeneous combination and anomaly point correction methods improve the stability.展开更多
BACKGROUND Thymolipoma is a rare benign tumor arising from the anterior mediastinal thymus and is composed of mature fatty tissue and interspersed nonneoplastic thymic tissue. This tumor accounts for only a small perc...BACKGROUND Thymolipoma is a rare benign tumor arising from the anterior mediastinal thymus and is composed of mature fatty tissue and interspersed nonneoplastic thymic tissue. This tumor accounts for only a small percentage of mediastinal masses, and the majority of them are asymptomatic and found incidentally. To date, fewer than 200 cases have been published in the world literature, of which most excised tumors weighed less than 0.5 kg and the largest weighed 6 kg.CASE SUMMARY A 23-year-old man presented with a complaint of progressive breathlessness for 6mo. His forced vital capacity was only 23.6% of the predicted capacity, and his arterial partial pressure of oxygen and carbon dioxide were 51 and 60 mmHg,respectively, without oxygen inhalation. Chest computed tomography revealed a large fat-containing mass in the anterior mediastinum that measured 26 cm × 20cm × 30 cm in size and occupied most of the thoracic cavity. Percutaneous mass biopsy revealed only thymic tissue without signs of malignancy. A right posterolateral thoracotomy was successfully performed to remove the tumor along with the capsule, and the excised tumor weighed 7.5 kg, which to our knowledge, was the largest surgically removed tumor of thymic origin. Postoperatively, the patient’s shortness of breath was resolved, and the histopathological diagnosis was thymolipoma. No signs of recurrence were observed at the 6-mo follow-up.CONCLUSION Giant thymolipoma causing respiratory failure is rare and dangerous. Despite the high risks, surgical resection is feasible and effective.展开更多
When the Transformer proposed by Google in 2017,it was first used for machine translation tasks and achieved the state of the art at that time.Although the current neural machine translation model can generate high qu...When the Transformer proposed by Google in 2017,it was first used for machine translation tasks and achieved the state of the art at that time.Although the current neural machine translation model can generate high quality translation results,there are still mistranslations and omissions in the translation of key information of long sentences.On the other hand,the most important part in traditional translation tasks is the translation of key information.In the translation results,as long as the key information is translated accurately and completely,even if other parts of the results are translated incorrect,the final translation results’quality can still be guaranteed.In order to solve the problem of mistranslation and missed translation effectively,and improve the accuracy and completeness of long sentence translation in machine translation,this paper proposes a key information fused neural machine translation model based on Transformer.The model proposed in this paper extracts the keywords of the source language text separately as the input of the encoder.After the same encoding as the source language text,it is fused with the output of the source language text encoded by the encoder,then the key information is processed and input into the decoder.With incorporating keyword information from the source language sentence,the model’s performance in the task of translating long sentences is very reliable.In order to verify the effectiveness of the method of fusion of key information proposed in this paper,a series of experiments were carried out on the verification set.The experimental results show that the Bilingual Evaluation Understudy(BLEU)score of the model proposed in this paper on theWorkshop on Machine Translation(WMT)2017 test dataset is higher than the BLEU score of Transformer proposed by Google on the WMT2017 test dataset.The experimental results show the advantages of the model proposed in this paper.展开更多
Pepper(Capsicum annuum L.)is frequently challenged by various pathogens,among which Phytophthora capsici is the most devastating to pepper production.Red light signal acts as a positive induction of plant resistance a...Pepper(Capsicum annuum L.)is frequently challenged by various pathogens,among which Phytophthora capsici is the most devastating to pepper production.Red light signal acts as a positive induction of plant resistance against multiple pathogens.However,little is known about how the red light signal affects pepper resistance to P.capsici infection(PCI).Here,we report that red light regulates salicylic acid(SA)accumulation by activating elongated hypocotyl5(CaHY5),a basic leucine zipper(bZIP)transcription factor,thereby decreasing pepper susceptibility to PCI.Exogenous SA treatment reduced pepper susceptibility to PCI,while silencing of CaPHYB(a red light photoreceptor)increased its susceptibility.PCI significantly induced CaHY5 expression,and silencing of CaHY5 reduced SA accumulation,accompanied by decreases in the expression levels of phenylalanine ammonia-lyase 3(CaPAL3),CaPAL7,pathogenesis-related 1(CaPR1),and CaPR1L,which finally resulted in higher susceptibility of pepper to PCI.Moreover,CaHY5 was found to activate the expression of CaPAL3 and CaPAL7,which are essential for SA biosynthesis,by directly binding to their promoters.Further analysis revealed that exogenous SA treatment could restore the resistance of CaHY5-silenced pepper plants to PCI.Collectively,this study reveals a critical mechanism through which red light induces SA accumulation by regulating CaHY5-mediated CaPAL3 and CaPAL7 expression,leading to enhanced resistance to PCI.Moreover,red light-induced CaHY5 regulates pepper resistance to PCI,which may have implications for PCI control in protected vegetable production.展开更多
The current adversarial attacks against deep learning models have achieved incredible success in the white-box scenario.However,they often exhibit weak transferability in the black-box scenario,especially when attacki...The current adversarial attacks against deep learning models have achieved incredible success in the white-box scenario.However,they often exhibit weak transferability in the black-box scenario,especially when attacking those with defense mechanisms.In this work,we propose a new transfer-based blackbox attack called the channel decomposition attack method(CDAM).It can attack multiple black-box models by enhancing the transferability of the adversarial examples.On the one hand,it tunes the gradient and stabilizes the update direction by decomposing the channels of the input example and calculating the aggregate gradient.On the other hand,it helps to escape from local optima by initializing the data point with random noise.Besides,it could combine with other transfer-based attacks flexibly.Extensive experiments on the standard ImageNet dataset show that our method could significantly improve the transferability of adversarial attacks.Compared with the state-of-the-art method,our approach improves the average success rate from 88.2%to 96.6%when attacking three adversarially trained black-box models,demonstrating the remaining shortcomings of existing deep learning models.展开更多
Learning the Markov blanket(MB)of a given variable has received increasing attention in recent years because the MB of a variable predicts its local causal relationship with other variables.Online MB Learning can lear...Learning the Markov blanket(MB)of a given variable has received increasing attention in recent years because the MB of a variable predicts its local causal relationship with other variables.Online MB Learning can learn MB for a given variable on the fly.However,in some application scenarios,such as image analysis and spam filtering,features may arrive by groups.Existing online MB learning algorithms evaluate features individually,ignoring group structure.Motivated by this,we formulate the group MB learning with streaming features problem,and propose an Online MB learning with Group Structure algorithm,OMBGS,to identify the MB of a class variable within any feature group and under current feature space on the fly.Extensive experiments on benchmark Bayesian network datasets demonstrate that the proposed algorithm outperforms the state-of-the-art standard and online MB learning algorithms.展开更多
Summary What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in...Summary What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in China to historic lows.Worldwide,there has been a diversification of meningococcal serogroups,leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B,accompanied by a rise in reports of serogroups Y and W.展开更多
Citrus fruits are rich sources of several biologically active flavonoids such as hesperidin,naringin,and polymethoxylated flavones.We evaluated the evidence of associations between citrus fruit or hesperidin intake an...Citrus fruits are rich sources of several biologically active flavonoids such as hesperidin,naringin,and polymethoxylated flavones.We evaluated the evidence of associations between citrus fruit or hesperidin intake and multiple health outcomes.An umbrella review was conducted for studies performed in humans.Overall,246 articles were initially identified by searching in 4 databases.Twenty-two meta-analyses and systematic reviews with 28 health outcomes met the inclusion criteria.Citrus fruit intake had beneficial effects on all-cause mortality(relative risk[RR].0.90;95%confidence interval[95%CI],0.86 to 0.94),cardiovascular diseases(RR,0.78;95%CI,0.66 to 0.92),coronary heart disease(RR,0.91;95%CI,0.86 to 0.96),stroke(RR,0.74;95%CI,0.65 to 0.84),type 2 diabetes mellitus(RR,0.85;95%CI,0.78 to 0.92),and several cancers.Dose-response analyses indicated that each 100-g/d increase in citrus fruit intake could reduce the risks of all-cause mortality by 6%(RR,0.94;95%CI,0.88 to 1.00),stroke by 22%(RR,0.78;95%CI,0.69 to 0.90),and cardia gastric cancer by 40%(RR,0.60;95%CI,0.44 to 0.83).Citrus fruit intake also had beneficial effects on the lipid profile and body weight control(weighted mean difference,−1.28;95%CI,−1.82 to−0.74).Grapefruits could reduce the systolic blood pressure(weighted mean difference,−2.43,95%CI,−4.77 to−0.09).Hesperidin supplementation significantly improved inflammation.Citrus fruit intake was generally safe and beneficial for multiple health outcomes in humans.However,grapefruit and pomelo juice may affect the bioavailability of various medications,so care should be exercised before increasing the intake of these fruits or their juices.展开更多
Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-compu...Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography(18F-FDG PET/CT)imaging in Hodgkin’s lymphoma patients.Methods:A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good(125 cases)and poor(23 cases)prognosis groups.The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters;the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma;receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients.Results:Mean SUVmax,MTV,and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26±2.38,12.46±3.14 cm3,and 76.83±18.56 g,respectively.Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters(P<0.05).The semi-quantitative parameters were not correlated with age and gender(P>0.05)but positively correlated with Ann Arbor stage and clinical classification(P<0.05).These parameters in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of SUVmax,MTV,and TLG in predicting the poor prognosis group was 0.881,0.875,and 0.838,with cut-off values of 7.264,12.898 cm3,and 74.580g,as well as specificity of 88.8%,84.0%,and 78.4%,and sensitivity of 87.0%,87.0%,and 78.3%,respectively;the AUC of the combined prediction was 0.986,with a specificity of 97.6%and sensitivity of 86.3%.Conclusion:The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.展开更多
Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were...Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were selected and divided into two groups according to the random number method:control group(n=48)and observation group(n=49).The observation group was under the practical teaching mode based on the virtual simulation teaching platform,while the control group was under the traditional multimedia teaching mode.Questionnaire survey and teaching assessment were carried out after the teaching period,and the application effects of the two teaching modes were compared.Results:The reading and theoretical scores of the students in the observation group were significantly higher than those of the students in the control group(P<0.01);there were statistically significant differences in the results of the questionnaire survey(improved learning interest,improved language expression,improved ability to comprehensively analyze problems,and improved teamwork awareness)between the two groups of students(P<0.05);the students in the observation group were markedly more satisfied with the teaching content,teaching methods,and teaching quality than the students in the control group(P<0.05).Conclusion:The medical imaging practical teaching mode based on virtual simulation platform not only helps improve students’theoretical understanding and practical ability in medical imaging technology,but also improves students’learning interest,language expression ability,ability to comprehensively analyze problems,communication skills,teamwork awareness,and satisfaction with the teaching content,teaching methods,and teaching quality.Therefore,it has wide application value in medical specialty education.展开更多
Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical ima...Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical imaging class of 2022 were divided into two groups;the control group(n=48)was taught by the traditional teaching method,whereas the research group was taught by virtual simulation experiment combined with PACS(n=49).The teaching achievements and teaching effects of the two groups were compared to define the advantages of the two teaching modes.Results:Initially,there were no significant differences in the basic theory,image analysis,report writing,and differential diagnosis scores between the two groups of students(P>0.05);however,after 16 weeks of teaching,the scores of the research group were better than those of the control group(P<0.05);the pass rate of students in the study group(93.88%)was higher than that in the control group(81.25%);the scores of students in the research group in terms of clinical inquiry skills,X-ray/computed tomography/magnetic resonance imaging(X-ray/CT/MRI)operation skills,and doctor-patient communication skills were significantly higher than those in the control group(P<0.05).Conclusion:In medical imaging practical teaching,the application of virtual simulation experiment combined with PACS can effectively address several problems in the traditional teaching mode,including the single teaching method,the single teaching content,and the lack of innovation,and,at the same time,improve students’basic theoretical knowledge,X-ray/CT/MRI operation skills,consultation skills,and doctor-patient communication skills,thereby effectively improving the teaching quality and learning effect.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52125402 and 52174084)the Natural Science Foundation of Sichuan Province of China(No.2022NSFSC0005).
文摘The deep earth,deep sea,and deep space are the main parts of the national“three deep”strategy,which is in the forefront of the strategic deployment clearly defined in China’s 14th Five-Year Plan(2021-2025)and the Long-Range Objectives Through the Year 2035.It is important to reveal the evolutionary process and mechanism of deep tectonics to understand the earth’s past,present and future.The academic con-notation of Geology in Time has been given for the first time,which refers to the multi-field evolution response process of geological bodies at different time and spatial scales caused by geological processes inside and outside the Earth.Based on the deep in situ detection space and the unique geological envi-ronment of China Jinping Underground Laboratory,the scientific issue of the correlation mechanism and law between deep internal time-varying and shallow geological response is given attention.Innovative research and frontier exploration on deep underground in situ geo-information detection experiments for Geology in Time are designed to be carried out,which will have the potential to explore the driving force of Geology in Time,reveal essential laws of deep earth science,and explore innovative technologies in deep underground engineering.
基金supported by the National Key R&D Program of China(No.2021YFB2800700)National Natural Science Foundation of China(Nos.12274210,62227820,and 12174183)+1 种基金Partial support is from NSF of Jiangsu Province(No.BK20220006)the Fundamental Research Funds for the Central Universities and Jiangsu Key Laboratory of Advanced Techniques for Manipulating Electromagnetic Waves。
文摘Rational design of efficient and robust earth-abundant alkaline hydrogen evolution reaction(HER)catalysts is a key factor for developing energy conversion technologies.Currently,antiperovskite nitride CuNMn_(3)has garnered significant interest due to its remarkable properties such as negative/zero thermal expansion and magnetocaloric effects.However,when utilized as hydrogen evolution catalysts,it encounters large challenge resulting from excessively strong/weak interactions with adsorbed H on Mn/Cu active sites,which leads to low HER activity.In this study,we introduce an asymmetric orbital hybridization strategy in Zn-doped Cu_(1-x)Zn_(x)NMn_(3)by leveraging the localization of Zn electronic states to reconfigure the electronic structures of Cu and Mn,thereby reducing the energy barrier for water dissociation and optimizing Cu and Mn active sites for hydrogen adsorption and H_(2)production.Electrochemical evaluations reveal that Cu_(0.85)Zn_(0.15)NMn_(3)with x=0.15 demonstrates exceptional electrocatalytic activity in alkaline electrolytes.A low overpotential of 52 mV at 10 mA cm^(-2)and outstanding stability over a 150-h test period are achieved,surpassing commercial Pt/C.This research offers a novel strategy for enhancing HER performance by modulating asymmetric hybridization of electron orbitals between multiple metal atoms within a material structure.
基金Natural Science Foundation of Chongqing,China,No.cstc2021jcyj-msxmX0501Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2022QNXM074.
文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social environment.AIM To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer Hospital.This study specifically assessed CA19-9 levels and tumor size before and after NAT.RESULTS A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this study.The average age was 65.4±10.6 years and 72(46.2%)patients were female.Before survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR<0.5,CR>0.5 and<1 and CR>1.With regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR<0.5,TR>0.5 and<1 and TR>1.Based on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)analyses.Log-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(P<0.05).CR and TR after NAT were associated with increased odds of achieving a complete or near-complete pathologic response.Moreover,CR(hazard ratio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with OS.CONCLUSION This study demonstrated that post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.
基金supported by the National Natural Sci-ence Foundation of China(No.21973092 and No.21873004)the National Key Research and Develop-ment Program of China(No.2018YFA0208703)+1 种基金Chinese Academy of Sciences(YSBR-007)Dalian In-stitute of Chemical Physics(DICP I202205).
文摘植物光合作用是吸收光能,把CO_(2)和水转化成富能有机物,同时释放氧气的过程.受此启发,利用太阳光将CO_(2)转化为碳氢燃料的人工碳中和技术引起了广泛关注.人工光合作用能否成功实施取决于光催化剂的设计制备.无机半导体已被广泛研究用于CO_(2)光还原反应(CO_(2)PRR),但其存在金属氧化物的带隙较宽且难以调节、导致光吸收较差和金属硫化物的光腐蚀问题严重等明显的缺点.此外,高载流子复合率和低比表面积会影响光催化效率,从而限制光子利用.因此,基于有机聚合物的无金属催化剂因其突出的可设计调控性而被提出,其中,具有超高比表面积的材料—多孔芳香骨架(PAFs)聚合物是研究热点之一,但是传统PAFs材料多为二维平面结构,用于光催化的无金属三维PAFs报道较少.此外,具有孤对电子的杂原子(N,B,F)修饰的材料可以与CO_(2)分子产生特定的偶极-四极相互作用,提高材料对CO_(2)的吸附和活化能力,是提升有机聚合物光催化剂性能的有效策略.本文采用Sonogashira-Hagihara偶联将具有不同共轭程度的芳香炔烃(2,2’,7,7‘-四乙炔基-9,9’-螺二芴,SPF-T;四(4-乙炔基苯基)甲烷,TEPM-T;1,1,2,2-四(4-乙炔基苯基)乙烯,TEPE-T)与含有N杂原子的Tröger碱聚合制备了具有三维结构的多孔芳香骨架聚合物X-TB-PAFs(X=TEPE,TEPM,SPF).通过X-射线衍射、红外光谱、13C核磁共振(NMR)以及1H NMR等表征手段验证了目标聚合物的成功合成.通过紫外-可见光谱和Mott-Schottky曲线测试研究了聚合物具体的能带结构,发现三种PAFs聚合物材料在热力学上同时满足光催化CO_(2)-CO的还原反应条件(Eθ=-0.51 Vvs.NHE,pH=7)和光催化H2O-O_(2)的氧化条件(Eθ=0.82 V vs.NHE,pH=7).V形骨架结构的Tröger碱(TB)单元和芳炔的结合赋予了聚合物刚性稳定的孔隙率以及较高的比表面积,材料中的多孔结构可以使其暴露更多的活性位点,三维框架结构为反应物接近活性位点提供了丰富的开放式空腔,这些都有利于材料对CO_(2)的捕获,增强催化剂对CO_(2)的吸附/活化能力.此外,炔基充当连接通道还可以增强体系的载流子迁移率,提升材料的光催化性能.密度泛函理论计算和光电性能测试结果表明,TB官能团引入带来的分子内极化和电子陷阱位点的优势,其与三维共轭网络结构一起协同调节了光生载流子的分离和反应位点分布.三种三维PAFs中,基于全共轭结构TEPE-T的TEPE-TB-PAF表现出最高效的光生载流子传输与分离效率,在没有助催化剂和牺牲剂的情况下表现出较好的光催化CO产率(194.50μmolg^(-1)h^(-1))和近乎单一的选择性(99.74%).全共轭TEPE-T的引入和分子内极化的存在可以促进框架内载流子的分离和迁移.材料中的电偶极矩(从负电荷到正电荷)指向TB中含有叔氮官能团的桥接位点,使其成为明确的催化反应位点.光电流和阻抗测试结果表明,TEPE-TB-PAF具有更好的电子-空穴分离能力和更小的电荷迁移位阻.三维框架构建产生的多重散射截面可以促进材料中的光子吸收,从而提高其光催化性能.理论计算和原位漫反射傅立叶变换红外光谱结果表明,材料中CO解吸的低能垒和*CHO形成的高能垒是TEPE-TB-PAF高CO产率和选择性的根本机制.综上,本文为多功能高效有机聚合物光催化剂的合成提供了有效途径,并为同时改善光催化剂的转化率和选择性提供了借鉴.
基金supported by the National Natural Science Foundation of China(82222038,82020108021 and 82260372)the Chongqing Special Project for Academicians(cstc2020yszx-jcyjX0004)the Chongqing Outstanding Youth Foundation and Science Foundation for Outstanding Youth of the Army Medical Centre(2019CXJSB004)。
文摘Sepsis is a common complication of combat injuries and trauma,and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.It is also one of the significant causes of death and increased health care costs in modern intensive care units.The use of antibiotics,fluid resuscitation,and organ support therapy have limited prognostic impact in patients with sepsis.Although its pathophysiology remains elusive,immunosuppression is now recognized as one of the major causes of septic death.Sepsis-induced immunosuppression is resulted from disruption of immune homeostasis.It is characterized by the release of antiinflammatory cytokines,abnormal death of immune effector cells,hyperproliferation of immune suppressor cells,and expression of immune checkpoints.By targeting immunosuppression,especially with immune checkpoint inhibitors,preclinical studies have demonstrated the reversal of immunocyte dysfunctions and established host resistance.Here,we comprehensively discuss recent findings on the mechanisms,regulation and biomarkers of sepsis-induced immunosuppression and highlight their implications for developing effective strategies to treat patients with septic shock.
基金financial support from European Union(Interreg FWVL V project PSYCHE)from the French National Research Agency(Multiprobe project,ANR-20-CE42-0007)。
文摘CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant resources.Iron catalysts are commonly used for the hydrogenation of carbon oxides to hydrocarbons.Iron-molybdenum catalysts have found numerous applications in catalysis,but have been never evaluated in the CO_(2)hydrogenation.In this work,the structural properties of iron-molybdenum catalysts without and with a promoting alkali metal(Li,Na,K,Rb,or Cs)were characterized using X-ray diffraction,hydrogen temperatureprogrammed reduction,CO_(2)temperature-programmed desorption,in-situ^(57)Fe Mossbauer spectroscopy and operando X-ray adsorption spectroscopy.Their catalytic performance was evaluated in the CO_(2)hydrogenation.During the reaction conditions,the catalysts undergo the formation of an iron(Ⅱ)molybdate structure,accompanied by a partial reduction of molybdenum and carbidization of iron.The rate of CO_(2)conversion and product selectivity strongly depend on the promoting alkali metals,and electronegativity was identified as an important factor affecting the catalytic performance.Higher CO_(2)conversion rates were observed with the promoters having higher electronegativity,while low electronegativity of alkali metals favors higher light olefin selectivity.
基金supported by Major Science and Technology Project of Sichuan Province[No.2022YFG0315,2022YFG0174]Sichuan Gas Turbine Research Institute stability support project of China Aero Engine Group Co.,Ltd[GJCZ-2019-59]Key project of Chengdu[No.2019-YF09-00044-CG].
文摘The further development of catalytic elements has been plagued by activation and binary problems.The automatic shift model that has emerged in recent years helps components achieve full range.However,the detection data still remains unstable in the shift area(7%∼13%).This paper proposes a Catalytic Combustion and Thermal Conductivity(CCTC)model for the specified range,which can be explained fromtwo aspects based on the existing methods.On the one hand,it uses iterative location search to process heterogeneous data,judges the prediction position of data points,and then givesweight evaluation.On the other hand,it corrects the abnormal points,determines the abnormal points in the horizontal direction,and gives the replacement value through the data of adjacent points.The experimental results show that the CCTC model reduces the sum of variance from 17 of the automatic shift model to 13,and the comparison of experimental variance is reduced by 23%.In the full-scale real-time data,the experimental variance of CCTC model and automatic shift model is reduced by 18%.In conclusion,CCTC is a cross section stability framework for full-scale methane measurement,in which the specified heterogeneous combination and anomaly point correction methods improve the stability.
基金Supported by Hunan Provincial Natural Science Foundation of China,No. 2022JJ40246Hunan Cancer Hospital Climb Plan,No. 2021NSFC-B005。
文摘BACKGROUND Thymolipoma is a rare benign tumor arising from the anterior mediastinal thymus and is composed of mature fatty tissue and interspersed nonneoplastic thymic tissue. This tumor accounts for only a small percentage of mediastinal masses, and the majority of them are asymptomatic and found incidentally. To date, fewer than 200 cases have been published in the world literature, of which most excised tumors weighed less than 0.5 kg and the largest weighed 6 kg.CASE SUMMARY A 23-year-old man presented with a complaint of progressive breathlessness for 6mo. His forced vital capacity was only 23.6% of the predicted capacity, and his arterial partial pressure of oxygen and carbon dioxide were 51 and 60 mmHg,respectively, without oxygen inhalation. Chest computed tomography revealed a large fat-containing mass in the anterior mediastinum that measured 26 cm × 20cm × 30 cm in size and occupied most of the thoracic cavity. Percutaneous mass biopsy revealed only thymic tissue without signs of malignancy. A right posterolateral thoracotomy was successfully performed to remove the tumor along with the capsule, and the excised tumor weighed 7.5 kg, which to our knowledge, was the largest surgically removed tumor of thymic origin. Postoperatively, the patient’s shortness of breath was resolved, and the histopathological diagnosis was thymolipoma. No signs of recurrence were observed at the 6-mo follow-up.CONCLUSION Giant thymolipoma causing respiratory failure is rare and dangerous. Despite the high risks, surgical resection is feasible and effective.
基金Major Science and Technology Project of Sichuan Province[No.2022YFG0315,2022YFG0174]Sichuan Gas Turbine Research Institute stability support project of China Aero Engine Group Co.,Ltd.[No.GJCZ-2019-71].
文摘When the Transformer proposed by Google in 2017,it was first used for machine translation tasks and achieved the state of the art at that time.Although the current neural machine translation model can generate high quality translation results,there are still mistranslations and omissions in the translation of key information of long sentences.On the other hand,the most important part in traditional translation tasks is the translation of key information.In the translation results,as long as the key information is translated accurately and completely,even if other parts of the results are translated incorrect,the final translation results’quality can still be guaranteed.In order to solve the problem of mistranslation and missed translation effectively,and improve the accuracy and completeness of long sentence translation in machine translation,this paper proposes a key information fused neural machine translation model based on Transformer.The model proposed in this paper extracts the keywords of the source language text separately as the input of the encoder.After the same encoding as the source language text,it is fused with the output of the source language text encoded by the encoder,then the key information is processed and input into the decoder.With incorporating keyword information from the source language sentence,the model’s performance in the task of translating long sentences is very reliable.In order to verify the effectiveness of the method of fusion of key information proposed in this paper,a series of experiments were carried out on the verification set.The experimental results show that the Bilingual Evaluation Understudy(BLEU)score of the model proposed in this paper on theWorkshop on Machine Translation(WMT)2017 test dataset is higher than the BLEU score of Transformer proposed by Google on the WMT2017 test dataset.The experimental results show the advantages of the model proposed in this paper.
基金supported by grants from the National Natural Science Foundation of China(32002030)Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province,China-Young Talents Project(20204BCJL23044)+3 种基金the China Postdoctoral Science Foundation(2020 M682732)the Yan’an University Doctoral Research Initiation Project(YAU202313800)China Agriculture Research System of MOF and MARA(CARS-24-B-01)the earmarked fund for Jiangxi Agriculture Research System(JXARS-06).
文摘Pepper(Capsicum annuum L.)is frequently challenged by various pathogens,among which Phytophthora capsici is the most devastating to pepper production.Red light signal acts as a positive induction of plant resistance against multiple pathogens.However,little is known about how the red light signal affects pepper resistance to P.capsici infection(PCI).Here,we report that red light regulates salicylic acid(SA)accumulation by activating elongated hypocotyl5(CaHY5),a basic leucine zipper(bZIP)transcription factor,thereby decreasing pepper susceptibility to PCI.Exogenous SA treatment reduced pepper susceptibility to PCI,while silencing of CaPHYB(a red light photoreceptor)increased its susceptibility.PCI significantly induced CaHY5 expression,and silencing of CaHY5 reduced SA accumulation,accompanied by decreases in the expression levels of phenylalanine ammonia-lyase 3(CaPAL3),CaPAL7,pathogenesis-related 1(CaPR1),and CaPR1L,which finally resulted in higher susceptibility of pepper to PCI.Moreover,CaHY5 was found to activate the expression of CaPAL3 and CaPAL7,which are essential for SA biosynthesis,by directly binding to their promoters.Further analysis revealed that exogenous SA treatment could restore the resistance of CaHY5-silenced pepper plants to PCI.Collectively,this study reveals a critical mechanism through which red light induces SA accumulation by regulating CaHY5-mediated CaPAL3 and CaPAL7 expression,leading to enhanced resistance to PCI.Moreover,red light-induced CaHY5 regulates pepper resistance to PCI,which may have implications for PCI control in protected vegetable production.
基金This work was supported by Sichuan Science and Technology Program[No.2022YFG0315,2022YFG0174]Sichuan Gas Turbine Research Institute stability support project of China Aero Engine Group Co.,Ltd.[GJCZ-2019-71]Key project of Chengdu[No.2019-YF09-00044-CG].
文摘The current adversarial attacks against deep learning models have achieved incredible success in the white-box scenario.However,they often exhibit weak transferability in the black-box scenario,especially when attacking those with defense mechanisms.In this work,we propose a new transfer-based blackbox attack called the channel decomposition attack method(CDAM).It can attack multiple black-box models by enhancing the transferability of the adversarial examples.On the one hand,it tunes the gradient and stabilizes the update direction by decomposing the channels of the input example and calculating the aggregate gradient.On the other hand,it helps to escape from local optima by initializing the data point with random noise.Besides,it could combine with other transfer-based attacks flexibly.Extensive experiments on the standard ImageNet dataset show that our method could significantly improve the transferability of adversarial attacks.Compared with the state-of-the-art method,our approach improves the average success rate from 88.2%to 96.6%when attacking three adversarially trained black-box models,demonstrating the remaining shortcomings of existing deep learning models.
基金supported by the National Natural Science Foundation of China[No.62272001,No.U1936220,No.61872002,No.61876206 and No.62006003]The National Key Research and Development Program of China[No.2019YFB1704101]the Natural Science Foundation of Anhui Province of China[No.2108085QF270].
文摘Learning the Markov blanket(MB)of a given variable has received increasing attention in recent years because the MB of a variable predicts its local causal relationship with other variables.Online MB Learning can learn MB for a given variable on the fly.However,in some application scenarios,such as image analysis and spam filtering,features may arrive by groups.Existing online MB learning algorithms evaluate features individually,ignoring group structure.Motivated by this,we formulate the group MB learning with streaming features problem,and propose an Online MB learning with Group Structure algorithm,OMBGS,to identify the MB of a class variable within any feature group and under current feature space on the fly.Extensive experiments on benchmark Bayesian network datasets demonstrate that the proposed algorithm outperforms the state-of-the-art standard and online MB learning algorithms.
文摘Summary What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in China to historic lows.Worldwide,there has been a diversification of meningococcal serogroups,leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B,accompanied by a rise in reports of serogroups Y and W.
基金This work was supported by a Chinese Medical Board Grant on Evidence-Based Medicine,New York(No.98-680)the National Natural Science Foundation of China(No.30901427)a Sichuan Provincial Science and Technology Support Project(No.2016SZ0047).
文摘Citrus fruits are rich sources of several biologically active flavonoids such as hesperidin,naringin,and polymethoxylated flavones.We evaluated the evidence of associations between citrus fruit or hesperidin intake and multiple health outcomes.An umbrella review was conducted for studies performed in humans.Overall,246 articles were initially identified by searching in 4 databases.Twenty-two meta-analyses and systematic reviews with 28 health outcomes met the inclusion criteria.Citrus fruit intake had beneficial effects on all-cause mortality(relative risk[RR].0.90;95%confidence interval[95%CI],0.86 to 0.94),cardiovascular diseases(RR,0.78;95%CI,0.66 to 0.92),coronary heart disease(RR,0.91;95%CI,0.86 to 0.96),stroke(RR,0.74;95%CI,0.65 to 0.84),type 2 diabetes mellitus(RR,0.85;95%CI,0.78 to 0.92),and several cancers.Dose-response analyses indicated that each 100-g/d increase in citrus fruit intake could reduce the risks of all-cause mortality by 6%(RR,0.94;95%CI,0.88 to 1.00),stroke by 22%(RR,0.78;95%CI,0.69 to 0.90),and cardia gastric cancer by 40%(RR,0.60;95%CI,0.44 to 0.83).Citrus fruit intake also had beneficial effects on the lipid profile and body weight control(weighted mean difference,−1.28;95%CI,−1.82 to−0.74).Grapefruits could reduce the systolic blood pressure(weighted mean difference,−2.43,95%CI,−4.77 to−0.09).Hesperidin supplementation significantly improved inflammation.Citrus fruit intake was generally safe and beneficial for multiple health outcomes in humans.However,grapefruit and pomelo juice may affect the bioavailability of various medications,so care should be exercised before increasing the intake of these fruits or their juices.
基金Social Science Foundation of Xinjiang Uygur Autonomous Region(Project No.:19BGL110)State Key Laboratory of Pathogenesis,Prevention,Treatment of Central Asian High Incidence Diseases Fund(SKL-HIDCA-2021-28).
文摘Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography(18F-FDG PET/CT)imaging in Hodgkin’s lymphoma patients.Methods:A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good(125 cases)and poor(23 cases)prognosis groups.The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters;the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma;receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients.Results:Mean SUVmax,MTV,and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26±2.38,12.46±3.14 cm3,and 76.83±18.56 g,respectively.Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters(P<0.05).The semi-quantitative parameters were not correlated with age and gender(P>0.05)but positively correlated with Ann Arbor stage and clinical classification(P<0.05).These parameters in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of SUVmax,MTV,and TLG in predicting the poor prognosis group was 0.881,0.875,and 0.838,with cut-off values of 7.264,12.898 cm3,and 74.580g,as well as specificity of 88.8%,84.0%,and 78.4%,and sensitivity of 87.0%,87.0%,and 78.3%,respectively;the AUC of the combined prediction was 0.986,with a specificity of 97.6%and sensitivity of 86.3%.Conclusion:The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.
基金This work was supported by Xinjiang Medical University Education and Teaching Research Project“Virtual Simulation Technology Combined with PACS System in Medical Imaging Practice”(Project no.YG2021044).
文摘Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were selected and divided into two groups according to the random number method:control group(n=48)and observation group(n=49).The observation group was under the practical teaching mode based on the virtual simulation teaching platform,while the control group was under the traditional multimedia teaching mode.Questionnaire survey and teaching assessment were carried out after the teaching period,and the application effects of the two teaching modes were compared.Results:The reading and theoretical scores of the students in the observation group were significantly higher than those of the students in the control group(P<0.01);there were statistically significant differences in the results of the questionnaire survey(improved learning interest,improved language expression,improved ability to comprehensively analyze problems,and improved teamwork awareness)between the two groups of students(P<0.05);the students in the observation group were markedly more satisfied with the teaching content,teaching methods,and teaching quality than the students in the control group(P<0.05).Conclusion:The medical imaging practical teaching mode based on virtual simulation platform not only helps improve students’theoretical understanding and practical ability in medical imaging technology,but also improves students’learning interest,language expression ability,ability to comprehensively analyze problems,communication skills,teamwork awareness,and satisfaction with the teaching content,teaching methods,and teaching quality.Therefore,it has wide application value in medical specialty education.
基金supported by Xinjiang Medical University Education and Teaching Research Project“Virtual Simulation Technology Combined with PACS System in Medical Imaging Practice”(Project No.YG2021044).
文摘Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical imaging class of 2022 were divided into two groups;the control group(n=48)was taught by the traditional teaching method,whereas the research group was taught by virtual simulation experiment combined with PACS(n=49).The teaching achievements and teaching effects of the two groups were compared to define the advantages of the two teaching modes.Results:Initially,there were no significant differences in the basic theory,image analysis,report writing,and differential diagnosis scores between the two groups of students(P>0.05);however,after 16 weeks of teaching,the scores of the research group were better than those of the control group(P<0.05);the pass rate of students in the study group(93.88%)was higher than that in the control group(81.25%);the scores of students in the research group in terms of clinical inquiry skills,X-ray/computed tomography/magnetic resonance imaging(X-ray/CT/MRI)operation skills,and doctor-patient communication skills were significantly higher than those in the control group(P<0.05).Conclusion:In medical imaging practical teaching,the application of virtual simulation experiment combined with PACS can effectively address several problems in the traditional teaching mode,including the single teaching method,the single teaching content,and the lack of innovation,and,at the same time,improve students’basic theoretical knowledge,X-ray/CT/MRI operation skills,consultation skills,and doctor-patient communication skills,thereby effectively improving the teaching quality and learning effect.
