Background: Metabolic abnormalities have been widely studied in women with polycystic ovary syndrome (PCOS) and in patients with Type 2 diabetes mellitus (T2DM). However, there are few studies on the comparison of the...Background: Metabolic abnormalities have been widely studied in women with polycystic ovary syndrome (PCOS) and in patients with Type 2 diabetes mellitus (T2DM). However, there are few studies on the comparison of the metabolic disturbances between the two diseases although they have partly common pathogenesis. This study compares the metabolic parameters of PCOS and T2DM, and evaluates the association between metabolic parameters and gonadotropic hormones. Methods: Fifity newly diagnosed PCOS women and 56 newly diagnosed Type 2 diabetes women were enrolled in the study. The metabolic parameters including body mass index, waist to hip ratio, blood pressure, total cholesterol, triglycerides, high-density and low-density lipoprotein cholesterol, fasting and postprandial plasma glucose, fasting and postprandial plasma insulin, HOMA-IR index and uric acid, along with the gonadal and gonadotropic hormones were analyzed between the two groups. The lutein hormone (LH) responses to the GnRH stimulating test were compared between different glucose tolerance groups in PCOS women. The peak values of LH in the GnRH test are studied with metabolic parameters using Pearson correlation analysis. Results: PCOS patients have higher body weight index, waist to hip ratio, fasting and postprandial insulin, HOMA-IR and uric acid than T2DM patients. There are no significant differences in lipid metabolism excluding the age influence. On the other hand, T2DM patients have significantly higher systolic blood pressure and plasma glucose than those in PCOS patients. But there is less clinical significance in the level of plasma glucose. After GnRH injection in PCOS women, there are significant differences in LH reaction between the three groups with different glucose tolerance. Conclusion: Women with PCOS have more severe metabolic disturbance than women with T2DM except for systolic blood pressure. Insulin resistance affects the function of thalamus-pituitary-gonad axis.展开更多
Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly elucidated.Investigations of the d...Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly elucidated.Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression.Therefore,in the present study,we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three trimesters.We found that the variation trends of 38 metabolites were significantly changed during GDM development.Specifically,longitudinal analyses revealed that cysteine(Cys)levels significantly decreased over the course of GDM progression.Further study showed that Cys alleviated GDM in female mice at gestational day 14.5,possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis.Taken together,these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients.展开更多
文摘Background: Metabolic abnormalities have been widely studied in women with polycystic ovary syndrome (PCOS) and in patients with Type 2 diabetes mellitus (T2DM). However, there are few studies on the comparison of the metabolic disturbances between the two diseases although they have partly common pathogenesis. This study compares the metabolic parameters of PCOS and T2DM, and evaluates the association between metabolic parameters and gonadotropic hormones. Methods: Fifity newly diagnosed PCOS women and 56 newly diagnosed Type 2 diabetes women were enrolled in the study. The metabolic parameters including body mass index, waist to hip ratio, blood pressure, total cholesterol, triglycerides, high-density and low-density lipoprotein cholesterol, fasting and postprandial plasma glucose, fasting and postprandial plasma insulin, HOMA-IR index and uric acid, along with the gonadal and gonadotropic hormones were analyzed between the two groups. The lutein hormone (LH) responses to the GnRH stimulating test were compared between different glucose tolerance groups in PCOS women. The peak values of LH in the GnRH test are studied with metabolic parameters using Pearson correlation analysis. Results: PCOS patients have higher body weight index, waist to hip ratio, fasting and postprandial insulin, HOMA-IR and uric acid than T2DM patients. There are no significant differences in lipid metabolism excluding the age influence. On the other hand, T2DM patients have significantly higher systolic blood pressure and plasma glucose than those in PCOS patients. But there is less clinical significance in the level of plasma glucose. After GnRH injection in PCOS women, there are significant differences in LH reaction between the three groups with different glucose tolerance. Conclusion: Women with PCOS have more severe metabolic disturbance than women with T2DM except for systolic blood pressure. Insulin resistance affects the function of thalamus-pituitary-gonad axis.
基金supported by grants from the National Natural Science Foundation of China(81870610)Shanghai Science and Technology Commission Foundation(21Y11904800 and 23ZR1451500)+1 种基金the Clinical Research Plan of SHDC(SHDC2020CR3065B)the National Key Research and Development Program of China(2021YFC2501600 and 2021YFC2501601).
文摘Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly elucidated.Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression.Therefore,in the present study,we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three trimesters.We found that the variation trends of 38 metabolites were significantly changed during GDM development.Specifically,longitudinal analyses revealed that cysteine(Cys)levels significantly decreased over the course of GDM progression.Further study showed that Cys alleviated GDM in female mice at gestational day 14.5,possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis.Taken together,these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients.
