期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
A paternal protein facilitates sperm RNA delivery to regulate zygotic development
1
作者 Dongdong Li Shijing Huang +5 位作者 yongping chai Ruiqian Zhao Jing Gong Qiangfeng Cliff Zhang Guangshuo Ou Wenyu Wen 《Science China(Life Sciences)》 SCIE CAS CSCD 2023年第10期2342-2353,共12页
Sperm contributes essential paternal factors,including the paternal genome,centrosome,and oocyte-activation signals,to sexual reproduction.However,it remains unresolved how sperm contributes its RNA molecules to regul... Sperm contributes essential paternal factors,including the paternal genome,centrosome,and oocyte-activation signals,to sexual reproduction.However,it remains unresolved how sperm contributes its RNA molecules to regulate early embryonic development.Here,we show that the Caenorhabditis elegans paternal protein SPE-11 assembles into granules during meiotic divisions of spermatogenesis and later matures into a perinuclear structure where sperm RNAs localize.We reconstitute an SPE-11 liquid-phase scaffold in vitro and find that SPE-11 condensates incorporate the nematode RNA,which,in turn,promotes SPE-11 phase separation.Loss of SPE-11 does not affect sperm motility or fertilization but causes pleiotropic development defects in early embryos,and spe-11 mutant males reduce m RNA levels of genes crucial for an oocyte-to-embryo transition or embryonic development.These results reveal that SPE-11 undergoes phase separation and associates with sperm RNAs that are delivered to oocytes during fertilization,providing insights into how a paternal protein regulates early embryonic development. 展开更多
关键词 SPE-11 phase separation paternal factor early embryonic development
原文传递
A Pd_(2)L_(4) Metallacage-Cored Supramolecular Amphiphile and Its Application in Dual-Responsive Controllable Release
2
作者 yongping chai Peng Qin +6 位作者 Xupeng Li Tai-Bao Wei Qi Lin You-Ming Zhang Hong Yao Wen-Juan Qu Bingbing Shi 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第20期2421-2427,共7页
The construction of multi-responsive supramolecular systems for drug delivery is a challenging task.In this work,a Pd_(2)L_(4) metallacage 1·([BF_(4)]^(−))_(4) with four pyrene units was first designed and synthe... The construction of multi-responsive supramolecular systems for drug delivery is a challenging task.In this work,a Pd_(2)L_(4) metallacage 1·([BF_(4)]^(−))_(4) with four pyrene units was first designed and synthesized through coordination-driven self-assembly.After the introduction ofγ-CD,a supramolecular amphiphile 1–γ-CD was successfully constructed based on the host–guest molecular recognition betweenγ-CD and the pyrene unit of 1·([BF_(4)]^(−))_(4),which further self-assembled into dual-responsive supramolecular vesicles in aqueous solution.DOX·HCl was used as a model molecule to study the drug encapsulation and release behavior of the supramolecular vesicles.By adjusting the pH of the solution to acidic condition or adding a certain amount ofα-amylase,the vesicle structure was destroyed to achieve rapid and effective release of the drug molecules.This study provides an example for the rational design of efficient dual-responsive supramolecular nanocarriers,which have potential application value in the field of controlled drug delivery. 展开更多
关键词 SELF-ASSEMBLY Molecular recognition Metallacages Host-Guest systems Controllable release
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部