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Delayed development of hepatocellular carcinoma during long-term follow-up after eradication of hepatitis C virus by interferon therapy 被引量:1
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作者 Yukiko Ito Natsuyo Yamamoto +8 位作者 Ryo Nakata yoshihisa kato Masashi Iori Keisuke Sakai Tamiko Takemura Ryosuke Tateishi Haruhiko Yoshida Takao Kawabe Masao Omata 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第45期7218-7221,共4页
A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink... A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink more than 100 g/d of alcohol as before. In June 2003, a 5-cm tumor was found in the posterior segment of the liver. The tumor was curatively resected and the surgical specimen showed a well-differentiated hepatocellular carcinoma (HCC). Non-cancerous lesions of the liver revealed fibrosis at stage F3 with minimal to mild inflammation of grade A1. Heavy drinking may retard the dissolution of fibrosis and accelerate HCC development in patients with sustained virological response. 展开更多
关键词 Hepatocellular carcinoma INTERFERON HCV ERADICATION
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