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印记基因Igf2r和RB-1在代谢综合征不孕患者子宫内膜表达水平的研究
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作者 王俊豪 阮钰 李蓉 《临床医学进展》 2012年第4期27-31,共5页
目的:研究印记基因Igf2r和RB-1在代谢综合征(MS)不孕患者子宫内膜的表达。方法:选择2011年7月至2011年12月因不孕症来我院生殖中心就诊的MS患者11例作为实验组,代谢正常女性15例作为对照组,收集分泌期的子宫内膜组织,采用实时定量聚合... 目的:研究印记基因Igf2r和RB-1在代谢综合征(MS)不孕患者子宫内膜的表达。方法:选择2011年7月至2011年12月因不孕症来我院生殖中心就诊的MS患者11例作为实验组,代谢正常女性15例作为对照组,收集分泌期的子宫内膜组织,采用实时定量聚合酶链反应方法(RT-PCR)测定子宫内膜组织Igf2r和RB-1的表达水平。结果:Igf2r和RB-1在MS患者和代谢正常妇女子宫内膜中均有表达,与正常女性相比较,MS患者子宫内膜Igf2r表达水平下降(P = 0.0051),RB-1表达水平升高(P = 0.0364),具有显著性差异。结论:MS不孕患者子宫内膜组织印记基因Igf2r表达水平明显下降,RB-1表达水平明显升高,两者可能影响MS患者的子宫内膜容受性。 展开更多
关键词 印迹基因 Igf2r RB-1 代谢综合征
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Site testing campaign for the Large Optical/infrared Telescope of China:general introduction of the Daocheng site 被引量:5
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作者 Teng-Fei Song yu Liu +8 位作者 Jing-Xing Wang Xue-Fei Zhang Shun-Qing Liu Ming-yu Zhao Xiao-Bo Li Zhan-Chuan Cai Qi-Wu Song Zi-Huang Cao yu ruan 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2020年第6期151-161,共11页
The Daocheng site is one of the three candidate sites for the Large Optical/infrared Telescope(LOT)of China.It was discovered by Yunnan Observatories during the survey of potential sites for the next-generation large-... The Daocheng site is one of the three candidate sites for the Large Optical/infrared Telescope(LOT)of China.It was discovered by Yunnan Observatories during the survey of potential sites for the next-generation large-aperture solar telescopes of China.This paper describes the overview of the site,the observation platform and the monitor instrument.In addition,simple statistical results are presented(from November,2016 up to December,2017).Detailed data results can refer to the overview of LOT site testing and data analysis articles,which were published during the same period. 展开更多
关键词 site testing LOT Daocheng site observation platform
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Non-contact air-coupled transducers Lamb wave signal multipath effect and blind separation for different modes using PZT as receiver
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作者 Desheng WU Zhibo YANG +3 位作者 yu ruan Wenbo LI Lijuan YANG Xuefeng CHEN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第10期424-434,共11页
Due to the complexity and faintness of the detection wave patterns obtained by aircoupled transducers,if it is possible to effectively separate the various modes and obtain nondispersive signals for more accurate dete... Due to the complexity and faintness of the detection wave patterns obtained by aircoupled transducers,if it is possible to effectively separate the various modes and obtain nondispersive signals for more accurate detection and positioning,it will help to improve the accuracy and reliability of air-coupled ultrasonic Lamb wave detection,providing better technical support for the application and development of related fields.Because of the increased complexity of aircoupled signals,there is no definite theoretical formula to describe the mode changes of aircoupled signals,so the method based on blind separation has unique value.To address these challenges,the paper proposes a single-channel blind source separation(SCBSS)method.The effectiveness of this method is evaluated through simulations and experiments,demonstrating favorable separation results and efficient computational speed.This work first conducts an in-depth analysis of the signal characteristics of air-coupled ultrasonic non-destructive testing,and simulates the ultrasonic excitation conditions of air-coupled sensors through finite element software.The study of modal changes and multipath effects caused by the variation of the incidence angle of the ACT signal is carried out,and the situation of the Lamb wave signal excited by ACT at the receiving end is analyzed.By combining ACT with PZT signals,the ultrasonic signals of air-coupled Lamb waves are compared and studied,and their modal purification is carried out. 展开更多
关键词 Air-coupled transducers Lamb wave Mode separation Blind source separation Non-destructive testing
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Comparison of two methods for detection of fecal indicator bacteria used in water quality monitoring of the Three Gorges Reservoir 被引量:4
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作者 Zhaodan Wang Guosheng Xiao +5 位作者 Nong Zhou Wenhua Qi Lin Han yu ruan Dongqin Guo Hong Zhou 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2015年第12期42-51,共10页
Scientifically sound methods to rapidly measure fecal indicator bacteria are important to ensure safe water for drinking and recreational purposes.A total of 200 water samples obtained from the Three Gorges Reservoir ... Scientifically sound methods to rapidly measure fecal indicator bacteria are important to ensure safe water for drinking and recreational purposes.A total of 200 water samples obtained from the Three Gorges Reservoir during three successive one-year study periods(October 2009 to September 2012) were analyzed using multiple-tube fermentation(MTF)and most probable numbers combined with polymerase chain reaction(MPN-PCR).The MPN-PCR method was found to be significantly more sensitive than the MTF method for detecting Escherichia coli and Enterococcus spp.,and of equal sensitivity for detecting total coliforms when all surface water samples were grouped together.The two analytical methods had a strong,significant relationship,but MPN-PCR took only 12-18 hr,compared with the 3-8 days needed using the MTF method.Bacterial concentrations varied per sampling site but were significantly lower in the mainstream of the Yangtze River than those in the backwater areas of tributaries.The water quality of 85.8% of water samples from the mainstream was suitable for use as a centralized potable water source,while the water quality of 52.5% of water samples from the backwater areas was unsuitable for recreational activities.Relationships between fecal indicator bacteria showed significant correlation(r = 0.636-0.909,p 〈 0.01,n = 200),while a weak but significant correlation was found between fecal indicators and water turbidity,water temperature,daily inflow,and total dissolved solids(r = 0.237-0.532,p 〈 0.05,n = 200).The study indicated that MPN-PCR is a rapid and easily performed deoxyribonucleic acid(DNA)-based method for quantitative detection of viable total coliforms,E.coli,and Enterococcus spp.in surface water. 展开更多
关键词 Three Gorges Reservoir Fecal indicator bacteria Multiple-tube fermentation MPN-PCR Surface water
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A novel homozygous RAG1 mutation in a girl presenting with granulomas and alopecia capitis totalis
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作者 yu ruan Qin Zhao +4 位作者 Qing Liu Hong-Yi Zhao Zhi-Yong Zhang yuan Ding Xiao-Dong Zhao 《World Journal of Pediatrics》 SCIE CAS CSCD 2022年第4期294-299,共6页
Recombination-activating gene 1(RAG1)mutations in humans vary in residual recombination activity and result in heterogeneous clinical phenotypes[1,2].In recent years,RAG deficiency with a milder clinical course and de... Recombination-activating gene 1(RAG1)mutations in humans vary in residual recombination activity and result in heterogeneous clinical phenotypes[1,2].In recent years,RAG deficiency with a milder clinical course and delayed presentation has been reported.These patients present with generalized granulomas,severe complications after viral infections,hypogammaglobulinemia,and various autoimmune manifestations(such as cytopenias,vitiligo,psoriasis,myasthenia gravis,and Guillain-Barre syndrome)[3-17]. 展开更多
关键词 GRANULOMA clinical GRAVIS
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