In view of the serious threat to people's health caused by the Coronavirus Disease 2019(COVID-19),according to the relevant spirit of the Notice on Establishing the Cooperation Mechanism of traditional Chinese and...In view of the serious threat to people's health caused by the Coronavirus Disease 2019(COVID-19),according to the relevant spirit of the Notice on Establishing the Cooperation Mechanism of traditional Chinese and Western Medicine in the Prevention and Treatment of COVID-19 and other Infectious Diseases issued by the National Health Commission of the People's Republic of China,National Administration of Traditional Chinese Medicine of the People's Republic of China,on the basis of our early clinical research of using press needle embedding(intradermal acupuncture)to prevent and treat related diseases,the symptoms,etiology and pathogenesis of the disease were analyzed.We try to use the simple and easy intradermal acupuncture therapy to prevent and assist the treatment of the disease and its complications,hoping to make a modest contribution to help patients relieve part of suffering,and also provide advice for the doctors in the treatment of the disease.展开更多
Objective: To determine the feasibility of conducting a full-scale randomized controlled trial(RCT)and investigate the basic information and safety of acupuncture for patients with chronic spontaneous urticaria(CSU). ...Objective: To determine the feasibility of conducting a full-scale randomized controlled trial(RCT)and investigate the basic information and safety of acupuncture for patients with chronic spontaneous urticaria(CSU). Methods: A total of 80 participants with CSU from July 2018 to July 2019 were randomly assigned to receive active acupuncture(n=41) on a fixed prescription of acupoints or sham acupuncture(n=39) with superficial acupuncture on non-acupuncture points through the completely randomized design. Patients in both groups received 5 sessions per week for 2 weeks, and participants were followed for a further 2 weeks.Feasibility was assessed by recruitment and randomization rates, retention of participants, treatment protocol adherence, and the incidence of adverse events(AEs). The clinical primary outcome was the changes from baseline weekly urticaria activity scores(UAS7) after treatment at 2 weeks. Secondary outcomes included the Visual Analogue Scale(VAS) score of itching intensity, Dermatology Life Quality Index(DLQI), Hamilton Depression Scale(HAMD), and Hamilton Anxiety Scale(HAMA). Results: A total of 80 participants were enrolled. The recruitment rate of 24.02%, randomization rate of 100%, a loss rate of 6.25%, and no obvious AEs were observed in either group. The decrease from baseline in the mean UAS7 total score at week 2 in the active acupuncture group was –8.63(95%CI, –11.78 to –5.49) and –6.21(95%CI, –9.43 to –2.98) in the sham acupuncture group for a between-group difference of –2.42(95% CI, –6.93 to 2.07). The change in the DLQI,VAS of itching intensity, HAMA, and HAMD were a slightly better improvement trend in the active acupuncture group than the sham acupuncture group, but the between-group difference was not significant. Conclusion:Active acupuncture had a better improvement trend in alleviating symptoms, improving quality of life and regulating the mood of anxiety and depression in patients with CSU than sham acupuncture.(Registration Nos.AMCTR-ICR-18000190 and ChiCTR2100054776)展开更多
Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus me...Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus medication, etc., and to analyze the current problems. Methods： The clinical and laboratory studies related to the treatment of HT with acupuncture-moxibustion therapies published before June 2015 were retrieved from MEDLINE, Excerpta Medica Database（EMBASE）, China National Knowledge Infrastructure（CNKI）, Wanfang Academic Journal Full-text Database（Wanfang） and Chongqing VIP Database（CQVIP）. Results： Moxibustion, moxibustion plus medication, and acupuncture plus medication can produce certain therapeutic effects in treating HT. Conclusion： The research on the treatment of HT with acupuncture-moxibustion therapies is rather limited in the amount and content. In the future, standardization should be fortified, specific moxibustion research needs deepening, and the action mechanism of moxibustion should be emphasized.展开更多
Objective: To observe the effect of electroacupuncture(EA) on cytochrome c oxidase(COX) activity of hippocampal mitochondria in senescence-accelerated mouse prone 8(SAMP8) mice, and to explore the EA mechanism on Alzh...Objective: To observe the effect of electroacupuncture(EA) on cytochrome c oxidase(COX) activity of hippocampal mitochondria in senescence-accelerated mouse prone 8(SAMP8) mice, and to explore the EA mechanism on Alzheimer disease(AD) in improving energy metabolic disorder. Methods: Twelve SAMP8 mice were randomly divided into a model group and an EA group, with six in each group. Six senescence-accelerated mouse resistance 1(SAMR1) mice were prepared as blank group. Mice in the EA group received EA on Baihui(GV 20) and Yongquan(KI 1), once a day for 7 d as a course, altogether 3 courses with one day interval between two courses. Mice in the model group and the blank group were manipulated and fixed as those in the EA group. After interventions, Morris water maze was employed to test spatial learning and memory ability to evaluate EA effect; spectrophotometry was used to detect the activity of hippocampal mitochondria COX. Results: Compared with the blank group, mean escape latencies of the EA group and model group were prolonged significantly in Morris water maze tests(P<0.01), the residue duration in the former platform quadrant significantly decreased(P<0.01). Compared with the model group, mean escape latencies on 1 d, 2 d and 3 d of the EA group were significantly reduced(P<0.05), and those on 4 d and 5 d continued the decreasing tendency(P<0.01), the residue duration on the former platform quadrant was significantly prolonged(P<0.05). The COX activity tests showed that, compared with the blank group, COX activities of the model group and the EA group were significantly decreased(P<0.01); compared with the model group, COX activity of the EA group was significantly elevated(P<0.01). Conclusion: It's plausible that EA improves AD learning and memory ability by increasing mitochondria COX activity, protecting the structure and function, and improving energy metabolism.展开更多
基金Supported by 2011 Special Projects in Scientific Research of TCM Profession(201107006)2018 Preventive Treatment of Disease in Tianjin University of Traditional Chinese Medicine(XJ201801)。
文摘In view of the serious threat to people's health caused by the Coronavirus Disease 2019(COVID-19),according to the relevant spirit of the Notice on Establishing the Cooperation Mechanism of traditional Chinese and Western Medicine in the Prevention and Treatment of COVID-19 and other Infectious Diseases issued by the National Health Commission of the People's Republic of China,National Administration of Traditional Chinese Medicine of the People's Republic of China,on the basis of our early clinical research of using press needle embedding(intradermal acupuncture)to prevent and treat related diseases,the symptoms,etiology and pathogenesis of the disease were analyzed.We try to use the simple and easy intradermal acupuncture therapy to prevent and assist the treatment of the disease and its complications,hoping to make a modest contribution to help patients relieve part of suffering,and also provide advice for the doctors in the treatment of the disease.
基金the National Key Research and Development Program of the Ministry of Science and Technology of the People’s Republic of China-Key Project“Research on Modernization of Traditional Chinese Medicine”-“International Cooperation Research on Evaluation of Acupuncture Advantage Diseases”(No.2017YFC1703605)。
文摘Objective: To determine the feasibility of conducting a full-scale randomized controlled trial(RCT)and investigate the basic information and safety of acupuncture for patients with chronic spontaneous urticaria(CSU). Methods: A total of 80 participants with CSU from July 2018 to July 2019 were randomly assigned to receive active acupuncture(n=41) on a fixed prescription of acupoints or sham acupuncture(n=39) with superficial acupuncture on non-acupuncture points through the completely randomized design. Patients in both groups received 5 sessions per week for 2 weeks, and participants were followed for a further 2 weeks.Feasibility was assessed by recruitment and randomization rates, retention of participants, treatment protocol adherence, and the incidence of adverse events(AEs). The clinical primary outcome was the changes from baseline weekly urticaria activity scores(UAS7) after treatment at 2 weeks. Secondary outcomes included the Visual Analogue Scale(VAS) score of itching intensity, Dermatology Life Quality Index(DLQI), Hamilton Depression Scale(HAMD), and Hamilton Anxiety Scale(HAMA). Results: A total of 80 participants were enrolled. The recruitment rate of 24.02%, randomization rate of 100%, a loss rate of 6.25%, and no obvious AEs were observed in either group. The decrease from baseline in the mean UAS7 total score at week 2 in the active acupuncture group was –8.63(95%CI, –11.78 to –5.49) and –6.21(95%CI, –9.43 to –2.98) in the sham acupuncture group for a between-group difference of –2.42(95% CI, –6.93 to 2.07). The change in the DLQI,VAS of itching intensity, HAMA, and HAMD were a slightly better improvement trend in the active acupuncture group than the sham acupuncture group, but the between-group difference was not significant. Conclusion:Active acupuncture had a better improvement trend in alleviating symptoms, improving quality of life and regulating the mood of anxiety and depression in patients with CSU than sham acupuncture.(Registration Nos.AMCTR-ICR-18000190 and ChiCTR2100054776)
基金supported by National Basic Research Program of China(973 Program,No.2009CB522900)Scientific Research Project for Traditional Chinese Medicine of Shanghai Municipal Commission of Health and Family Planning(No.2016LQ013)~~
文摘Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus medication, etc., and to analyze the current problems. Methods： The clinical and laboratory studies related to the treatment of HT with acupuncture-moxibustion therapies published before June 2015 were retrieved from MEDLINE, Excerpta Medica Database（EMBASE）, China National Knowledge Infrastructure（CNKI）, Wanfang Academic Journal Full-text Database（Wanfang） and Chongqing VIP Database（CQVIP）. Results： Moxibustion, moxibustion plus medication, and acupuncture plus medication can produce certain therapeutic effects in treating HT. Conclusion： The research on the treatment of HT with acupuncture-moxibustion therapies is rather limited in the amount and content. In the future, standardization should be fortified, specific moxibustion research needs deepening, and the action mechanism of moxibustion should be emphasized.
基金supported by National Natural Science Foundation of China (No.30472235)Scientific Science Foundation for the Youth of the Education Department of Sichuan Province (No. 2006B023)
文摘Objective: To observe the effect of electroacupuncture(EA) on cytochrome c oxidase(COX) activity of hippocampal mitochondria in senescence-accelerated mouse prone 8(SAMP8) mice, and to explore the EA mechanism on Alzheimer disease(AD) in improving energy metabolic disorder. Methods: Twelve SAMP8 mice were randomly divided into a model group and an EA group, with six in each group. Six senescence-accelerated mouse resistance 1(SAMR1) mice were prepared as blank group. Mice in the EA group received EA on Baihui(GV 20) and Yongquan(KI 1), once a day for 7 d as a course, altogether 3 courses with one day interval between two courses. Mice in the model group and the blank group were manipulated and fixed as those in the EA group. After interventions, Morris water maze was employed to test spatial learning and memory ability to evaluate EA effect; spectrophotometry was used to detect the activity of hippocampal mitochondria COX. Results: Compared with the blank group, mean escape latencies of the EA group and model group were prolonged significantly in Morris water maze tests(P<0.01), the residue duration in the former platform quadrant significantly decreased(P<0.01). Compared with the model group, mean escape latencies on 1 d, 2 d and 3 d of the EA group were significantly reduced(P<0.05), and those on 4 d and 5 d continued the decreasing tendency(P<0.01), the residue duration on the former platform quadrant was significantly prolonged(P<0.05). The COX activity tests showed that, compared with the blank group, COX activities of the model group and the EA group were significantly decreased(P<0.01); compared with the model group, COX activity of the EA group was significantly elevated(P<0.01). Conclusion: It's plausible that EA improves AD learning and memory ability by increasing mitochondria COX activity, protecting the structure and function, and improving energy metabolism.
