Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac diseases.Nevertheless,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic...Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac diseases.Nevertheless,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic effects.The objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat model.Methods:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of SZDP.The integration of network pharmacology and metabolomics was conducted to investigate the mechanisms.Molecular docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated targets.Results:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart damage.Metabolomics results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for CMI.Integrating network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl formamidocarboxamide.Conclusion:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.展开更多
Several studies have reported a relationship between the length of the CAG-repeat in the polymerase y （POLG） gene and male infertility. However, other studies have not reproduced this result. In our study, the POLG-...Several studies have reported a relationship between the length of the CAG-repeat in the polymerase y （POLG） gene and male infertility. However, other studies have not reproduced this result. In our study, the POLG-CAG-repeat length was analyzed in 535 healthy individuals from six Chinese Han populations living in different provinces. The frequencies of IO-CAG alleles and genotypes were high （97.38 and 94.13%, respectively）, with no significant difference among the six Chinese Han populations. Furthermore, we determined the distribution of the POLG-CAG-repeat in 150 infertile men and 126 fertile men. Our study suggested that the distributions of POLG-CAG-repeat alleles and genotypes were not significantly different between infertile （95.67 and 92.67%, respectively） and fertile men （97.22 and 94.44%, respectively）. In a subsequent meta-analysis, combining our data with data from previous studies, a comparison of the CAG-repeat alleles in fertile versus infertile men showed no obvious risk for male infertility associated with any particular allele （pooled odds ratio （0R）=0.94; 95% confidence interval （CI）： 0.60-1.48）. The significance level was not attained with any of the following genetic models： homozygote comparison （not lO/not 10 versus 10110： OR= 1.34; 95% Ch 0.66-2.72）, heterozygote comparison （lO/not 10 versus 10/10： OR= 1.04; 95% Ch 0.78-1.38）, dominant model comparison （not lO/not 10＋ 101 not 10 versus 10110. OR= 1.08; 95% Ch 0.79-1.47） and recessive genetic comparison （not lO/not 10 versus lO/not 10＋ 10/10- OR= 1.31; 95% Ch 0.68-2.55）. In conclusion, there is no significant difference of the frequencies of POLG-CAG-repeat variants among six Chinese Han populations, and this polymorphism may not be associated with Chinese male infertility. On the basis of a meta-analysis, there is no obvious association between CAG-repeat variants of the POLG gene and male infertility.展开更多
Infectious keratitis is the most common condition of corneal diseases in which a pathogen grows in the cornea leading to inflammation and destruction of the corneal tissues.Infectious keratitis is a medical emergency ...Infectious keratitis is the most common condition of corneal diseases in which a pathogen grows in the cornea leading to inflammation and destruction of the corneal tissues.Infectious keratitis is a medical emergency for which a rapid and accurate diagnosis is needed to ensure prompt and precise treatment to halt the disease progression and to limit the extent of corneal damage;otherwise,it may develop a sight-threatening and even eye-globe-threatening condition.In this paper,we propose a sequentiallevel deep model to effectively discriminate infectious corneal disease via the classification of clinical images.In this approach,we devise an appropriate mechanism to preserve the spatial structures of clinical images and disentangle the informative features for clinical image classification of infectious keratitis.In a comparison,the performance of the proposed sequential-level deep model achieved 80%diagnostic accuracy,far better than the 49.27%±11.5%diagnostic accuracy achieved by 421 ophthalmologists over 120 test images.展开更多
Objective: To explore the main chemical compounds in Xiaoer Qixing Cha Formulae (XQCF), and investigate its mechanisms for the treatment of infantile functional dyspepsia (IFD). Methods: The chemical components were i...Objective: To explore the main chemical compounds in Xiaoer Qixing Cha Formulae (XQCF), and investigate its mechanisms for the treatment of infantile functional dyspepsia (IFD). Methods: The chemical components were identified by UPLC-QTOF/MS analytic technique. Targets of the compounds were screened from TCMSP and SWISS database, and disease targets were screened from OMIM and TTD online database. Candidate targets of compounds were mapped to the disease targets as predict therapeutic targets for XQCF. Several networks were constructed and analyzed by Cytoscape ver. 3.2.1. Meanwhile, prescription compatibility in XQCF was interpreted from the network perspective based on distribution of the number of targets. Furthermore, Gene Ontology (GO) enrichment analysis and KEGG pathway analysis were operated via Clue Go to illustrate complex relationships between the potential targets and pharmacological mechanisms. Results: A total of fifty-three compounds were recognized or tentatively characterized belonging to XQCF based on MS data and online chemical database. Sixty-three therapeutic targets were screened. AKT1, FOS, SLC6A4, COMT and 5-HT receptors were focused as therapeutic targets of XQCF. Pathways including carbohydrate digestion and absorption, serotonergic synapse, calcium signaling pathway and cAMP signaling pathway were predicted as significant regulatory pathways. The results indicated that the predicted targets and pathways related in brain-gut axis to a great extent, which could be potential pharmacological mechanism of XQCF for the treatment of IFD. Conclusions: The findings in this study provided the experimental and theoretical basis for further research for XQCF. Those also illustrated a reasonable method worth intensive study on pharmacodynamic mechanisms of TCM Formulae.展开更多
The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjo...The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjogren’s syndrome(pSS) cannot be completely cured. Human studies have revealed that GM species and diversity are altered in patients with p SS compared with healthy individuals. Animal studies have provided possible mechanisms for the association between pSS and GM. The potential role of GM in pSS is exerted through several mechanisms. GM dysbiosis leads to increased intestinal permeability, which increases the risk of GM antigen exposure and activates specific autoreactive T lymphocytes via “molecular mimicry”. In addition, GM antigen exposure and intestinal immune tolerance loss caused by GM dysbiosis together induce chronic local gut mucosal inflammation, which deteriorates to systemic chronic non-specific inflammation with the circulation of pro-inflammatory lymphocytes and cytokines. These factors eventually activate autoreactive B lymphocytes and lead to pSS. If GM plays a key role in the pathogenesis of pSS, clarifying the underlying mechanisms will be helpful for the development of new therapies targeting GM for dry eye associated with pSS. This review summarizes the latest knowledge about the relationship between GM and p SS,with the aim of contributing to future research and to the development of new clinical applications.展开更多
An improved name disambiguation method based on atom cluster. Aiming at the method of character-related properties of similarity based on information extraction depends on the character information, a new name disambi...An improved name disambiguation method based on atom cluster. Aiming at the method of character-related properties of similarity based on information extraction depends on the character information, a new name disambiguation method is proposed, and improved k-means algorism for name disambiguation is proposed in this paper. The cluster analysis cluster is introduced to the name disambiguation process. Experiment results show that the proposed method having the high implementation efficiency and can distinguish the different people with the same name.展开更多
A name disambiguation method is proposed based on attribute match and link analysis applying in the field of insurance. Aiming at the former name disambiguation methods such as text clustering method needs to be consi...A name disambiguation method is proposed based on attribute match and link analysis applying in the field of insurance. Aiming at the former name disambiguation methods such as text clustering method needs to be considered in a lot of useless words, a new name disambiguation method is advanced. Firstly, the same attribute matching is applied, merging the identity of a successful match, secondly, the link analysis is used, structural analysis of customers network is analyzed, Finally, the same cooperating information is merged. Experiment results show that the proposed method can realize name disambiguation successfully.展开更多
Objective: To compare postoperative outcomes of full-bed deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in treating keratoconus. Methods: Seventy-five eyes of 64 patients who received fu...Objective: To compare postoperative outcomes of full-bed deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in treating keratoconus. Methods: Seventy-five eyes of 64 patients who received full-bed DALK and 52 eyes of 51 patients who received PK between June 2000 and August 2010 were included in this retrospective study. Full-bed DALK was performed using Yao's hooking-detaching technique. PK was performed using a standard technique. Intraoperative and postoperative complications, visual acuity, rejection, graft survival, endothelial cell density, corneal sensation recovery, and re-innervation were compared between the two groups. Results: A best correct visual acuity of 0.5 or better was achieved in 90.7% of eyes after full-bed DALK and in 92.3% of eyes after PK (P=0.75). By the fifth postoperative year, graft endothelial cell loss reached 34.6% in the PK group vs. 13.9% in the full-bed DALK group (P<0.001). There were no statistical differences in corneal sensitivity recovery or corneal re-innervation between the groups (P>0.05). Intraoperative microperforation occurred in seven out of 75 (9.3%) eyes with a temporally postoperative double anterior chamber in two eyes in the full-bed DALK group. Postoperative complications in the PK vs. the full-bed DALK groups respectively were: rejection (7.7% vs. 0%, P=0.015), high intraocular pressure (IOP) (46.2% vs. 1.3%, P<0.001), secondary glaucoma (9.6% vs. 0%, P=0.006), complicated cataract (19.2% vs. 0%, P<0.001), and wound dehiscence (9.6% vs. 0%, P=0.006). Conclusions: Both full-bed DALK and PK can offer long-term satisfactory visual outcomes for keratoconus. Graft rejection, secondary glaucoma, complicated cataracts, and constant endothelial cell loss were observed in eyes only after PK.展开更多
Objective: To evaluate the safety and effectiveness of eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye. Methods: This was a prospective, randomized...Objective: To evaluate the safety and effectiveness of eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye. Methods: This was a prospective, randomized, open-label, investigator-masked, and self-controlled study. We randomly assigned one eye of patients with meibomian gland dysfunction-associated dry eye to the treatment group, and the other eye to the control group. Both groups received artificial tears and lid warming;the treatment group received an additional one-time in-office eyelid margin cleaning using Deep Cleaning Device. Non-invasive tear break-up time(NITBUT) and tear meniscus height(TMH) of each eye, and Standard Patient Evaluation for Eye Dryness II(SPEED II) score of each patient were evaluated before and at one week after treatment. Results: Thirty eyes of 15 patients were enrolled. No adverse effects occurred during the treatment. Compared with the baseline values, the SPEED score decreased significantly at one week after treatment(mean±95% confidence interval, 11.00±0.99 vs. 5.67±1.67, P<0.0001), the NITBUT-first in the treatment group increased significantly at one week after treatment((4.74±1.27) s vs.(7.49±2.22) s, P=0.01). The NITBUT-first was significantly longer in the treatment group((7.49±2.22) s) than in the control group((5.17±0.91) s) at one week after treatment(P=0.042). No significant differences were found in other tear film parameters between the two groups. Conclusions: Eyelid margin cleaning using the novel Deep Cleaning Device is a convenient, effective, and safe treatment for patients with meibomian gland dysfunction-associated dry eye.展开更多
Background:The shortage of donor corneas is a severe global issue,and hence the development of corneal alternatives is imperative and urgent.Although attempts to produce artificial cornea substitutes by tissue enginee...Background:The shortage of donor corneas is a severe global issue,and hence the development of corneal alternatives is imperative and urgent.Although attempts to produce artificial cornea substitutes by tissue engineering have made some positive progress,many problems remain that hamper their clinical application worldwide.For example,the curvature of tissue-engineered cornea substitutes cannot be designed to fit the bulbus oculi of patients.Objective:To overcome these limitations,in this paper,we present a novel integrated three-dimensional(3 D) bioprintingbased cornea substitute fabrication strategy to realize design,customized fabrication,and evaluation of multi-layer hollow structures with complicated surfaces.Methods:The key rationale for this method is to combine digital light processing(DLP) and extrusion bioprinting into an integrated 3 D cornea bioprinting system.A designable and personalized corneal substitute was designed based on mathematical modelling and a computer tomography scan of a natural cornea.The printed corneal substitute was evaluated based on biomechanical analysis,weight,structural integrity,and fit.Results:The results revealed that the fabrication of high water content and highly transparent curved films with geometric features designed according to the natural human cornea can be achieved using a rapid,simple,and low-cost manufacturing process with a high repetition rate and quality.Conclusions:This study demonstrated the feasibility of customized design,analysis,and fabrication of a corneal substitute.The programmability of this method opens up the possibility of producing substitutes for other cornea-like shell structures with different scale and geometry features,such as the glomerulus,atrium,and oophoron.展开更多
Objective:To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber angle.Methods:Among the general physical c...Objective:To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber angle.Methods:Among the general physical check-up population,subjects with shallow anterior chambers,as judged by van Herick technique,were recruited for further investigation.Ultrasound biomicroscope(UBM) was used to detect and measure the cysts located in the iris and/or ciliary body,the anterior chamber depth(ACD),the angle opening distance at 500 μm(AOD500),and the trabecular-iris angle(TIA).A-scan ultrasonography was used to measure the ocular biometry,including lens thickness,axial length,lens/axial length factor(LAF),and relative lens position(RLP).The effect of the cyst on narrowing the corresponding anterior chamber angle and the entire angle was evaluated by the UBM images,ocular biometry,and gonioscopic grading.The eye with unilateral cyst was compared with the eye without the cyst for further analysis.Results:Among the 727 subjects with shallow anterior chamber,primary iris and ciliary body cysts were detected in 250(34.4%) patients;among them 96(38.4%) patients showed unilateral single cyst,21(8.4%) patients had unilateral double cysts,and 42(16.8%) patients manifested unilateral multiple and multi-quadrants cysts.Plateau iris configuration was found in 140 of 361(38.8%) eyes with cysts.The mean size of total cysts was(0.6547±0.2319) mm.In evaluation of the effect of the cyst size and location on narrowing the corresponding angle to their position,the proportion of the cysts causing corresponding angle narrowing or closure among the cysts larger than 0.8 mm(113/121,93.4%) was found to be significantly higher than that of the cysts smaller than 0.8 mm(373/801,46.6%),and a significant higher proportion was also found in the cysts located at iridociliary sulcus(354/437,81.0%) than in that at the pars plicata(131/484,27.1%).In evaluating the effect of the cyst on the entire anterior chamber angle,the eyes with multiple and multi-quadrants cysts manifested significant narrowing of the entire anterior chamber angle as compared with the eyes without cysts,based on the data analysis in comparison of TIA,AOD500,and gonioscopic grading evaluation.The unilateral single or double cysts in the eyes had no significant effect on narrowing of anterior chamber angle as compared with eyes without cysts.The iris and/or ciliary body cysts did not seem to affect the axial length,ACD,lens thickness,RLP,LAF.Conclusions:The prevalence of primary iris and ciliary body cyst was 34.4% in the subjects with shallow anterior chamber.The cysts larger than 0.8 mm,locating at iridociliary sulcus,or multiple and extensive cysts were inclined to cause the angle narrowing or closure.展开更多
A study of the human leukocyte antigen （HLA） genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, ...A study of the human leukocyte antigen （HLA） genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A＊11：01, A^＊02：07, A^＊24：02, A^＊02：03, and A^＊33：03 on A loci, B^＊15：02, B^＊58：01, B^＊46：01, and B^＊13：01 on B loci, C^＊03：04, C^＊08：01, C^＊01：02, C^＊03：02, and C^＊07：02 on C loci, and DRBl＊15：01, DRBl^＊16：02, DRB1^＊14：01, DRBl^＊15：02, and DRBI^＊03：01 on the DRB1 loci were 〉10%. The A^＊33：03-C^＊03：02-B^＊58：01-DRBl^＊03：01 and A^＊02：07-C^＊01：02- B^＊46：01-DRB1^＊14：01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.展开更多
Objective： To evaluate the clinical efficacy of peripheral deep anterior lamellar keratoplasty （DALK） using a cryopreserved donor cornea for Terrien＇s marginal degeneration （TMD）. Methods： Thirty-one eyes of 27...Objective： To evaluate the clinical efficacy of peripheral deep anterior lamellar keratoplasty （DALK） using a cryopreserved donor cornea for Terrien＇s marginal degeneration （TMD）. Methods： Thirty-one eyes of 27 patients with TMD underwent peripheral DALK using cryopreserved donor corneas, According to the distance between the inner edge of the lesion and the limbus, a ring-shaped or D-shaped DALK was performed. All grafts were stored at -20 ℃. Cryopreserved comeoscleral rims were prepared for ring-shaped grafts and cryopreserved whole eyeballs were prepared for D-shaped grafts. The general conditions, intraoperative performance, postoperative corneal reconstruc- tion, astigmatism, best corrected visual acuity （BCVA）, and various complications were analyzed. Results： Ring-shaped DALK was performed in 28 eyes and D-shaped DALK was performed in 3 eyes. Postoperative follow-up time was （28.4±24.8） months. There was evidence of inflammation before surgery in 12 eyes （38.7%） and intraoper- ative perforation occurred in 13 eyes （41.9%）. The corneal structures of all eyes were reconstructed. Postoperative astigmatism and BCVA showed improvement （both P=0.00） except for cases that underwent D-shaped DALK. Ten eyes （32.2%） developed transient ocular hypertension and one eye （3.2%） developed secondary glaucoma. No pri- mary disease recurrence or corneal allograft rejection was observed. Conclusions： Peripheral DALK for TMD using cryopreserved donor tissue is an effective technique that eliminates rejection and extends the use of donor eyes. Inflammatory history or intraoperative perforation has no adverse effect on graft recovery. However, D-shaped DALK did not achieve good visual outcomes.展开更多
Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮（g） = {（x,y） ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie...Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮（g） = {（x,y） ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie algebras of P. Levy [J. Algebra, 2002, 250： 473-484], we show that the variety ∮（g） is reducible, and not equidimensional. Irreducible components of ∮（g） and their dimensions are precisely given. As a consequence, the variety ∮（g） is not normal.展开更多
Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was...Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography（HD-OCT）. Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results： Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye（P=0.024）. For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures（R=-0.579, P=0.008）, and was significantly positively correlated with time following surgery（R=0.636, P=0.003）. In the fellow eye, a significant positive correlation was found between age and CCET（R=0.551, P=0.012）, and a significant negative correlation between age and CTFT（R=-0.491, P=0.028）. LTMH was found to be significantly correlated between operated and fellow eyes（R=0.554, P=0.011）. There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures（all possible correlations, P0.05）. Conclusions： Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual＇s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.展开更多
Objective:To investigate gene mutations associated with three different types of corneal dystrophies(CDs),and to establish a phenotype-genotype correlation.Methods:Two patients with Avellino corneal dystrophy(ACD),fou...Objective:To investigate gene mutations associated with three different types of corneal dystrophies(CDs),and to establish a phenotype-genotype correlation.Methods:Two patients with Avellino corneal dystrophy(ACD),four patients with lattice corneal dystrophy type I(LCD I) from one family,and three patients with macular corneal dystrophy type I(MCD I) were subjected to both clinical and genetic examinations.Slit lamp examination was performed for all the subjects to assess their corneal phenotypes.Genomic DNA was extracted from peripheral blood leukocytes.The coding regions of the human transforming growth factor β-induced(TGFBI) gene and carbohydrate sulfotransferase 6(CHST6) gene were amplified by polymerase chain reaction(PCR) and subjected to direct sequencing.DNA samples from 50 healthy volunteers were used as controls.Results:Clinical examination showed three different phenotypes of CDs.Genetic examination identified that two ACD subjects were associated with homozygous R124H mutation of TGFBI,and four LCD I subjects were all associated with R124C heterozygous mutation.One MCD I subject was associated with a novel S51X homozygous mutation in CHST6,while the other two MCD I subjects harbored a previously reported W232X homozygous mutation.Conclusions:Our study highlights the prevalence of codon 124 mutations in the TGFBI gene among the Chinese ACD and LCD I patients.Moreover,we found a novel mutation among MCD I patients.展开更多
Let F be an algebraically closed field of prime characteristic, and W(m, n, 1) be the simple restricted Lie superalgebra of Witt type over F, which is the Lie superalgebra of superderivations of the superalgebra ■(m;...Let F be an algebraically closed field of prime characteristic, and W(m, n, 1) be the simple restricted Lie superalgebra of Witt type over F, which is the Lie superalgebra of superderivations of the superalgebra ■(m;1) ■∧(n), where ■(m;1) is the truncated polynomial algebra with m indeterminants and ∧(n) is the Grassmann algebra with n indeterminants. In this paper, the author determines the character formulas for a class of simple restricted modules of W(m, n, 1) with atypical weights of type Ⅰ.展开更多
Objective： To investigate the effects of corneal thickness distribution and apex position on postoperative refractive status after full-bed deep anterior lamellar keratoplasty （FBDALK）. Methods： This is a retrospe...Objective： To investigate the effects of corneal thickness distribution and apex position on postoperative refractive status after full-bed deep anterior lamellar keratoplasty （FBDALK）. Methods： This is a retrospective analysis of patients who were diagnosed with advanced keratoconus between 2011 and 2014 in our hospital. The base of the cone in all patients did not exceed the central cornea at a 6-mm range. The FBDALK was performed by a same surgeon. All patients had a complete corneal suture removal and the follow-up records were intact. Patients who had graft-bed misalignment or who were complicated with a cataract or glaucoma were excluded. Uncorrected visual acuity （UCVA）, best spectacle corrected visual acuity （BSCVA）, and Pentacam examination data were recorded at two years postoperatively. The recorded data included the superior-inferior （S-I） and nasal-temporal （N-T） corneal thickness differences in 2, 4, 6, and 8 mm diameter concentric circles with the corneal apex as the center （S-I2 mm, S-14 mm, S-I6mm,, S-I8mm, N-T2mm, N-T4 mm, N-T6 mm, and N-T8 mm）, the linear, X-axis, and Y-axis distance between the corneal pupillary center and the cornea apex, total corneal astigmatism at a zone of 3 mm diameter from the corneal apex （TA3 mm）, the astigmatic vector values J0 and J4s, and the corneal total higher-order aberration for 3 and 6 mm pupil diameters （HOA3 mm and HOA6mm）. Statistical analysis was performed by SPSS 15.0. Results： A total of 47 eyes of 46 patients met the criteria and were included in this study. The mean follow-up time was （28±7） months. The mean UCVA was 0.45±0.23 （IogMAR） （MAR： minimum angle of resolution） and the mean BSCVA was 0.19±0.15 （IogMAR）, which were all sig- nificantly positively correlated with postoperative TA3 mm and HOA3 turn. The mean S-I corneal thickness differences were （44.62±37.74） IJm, and the mean N-T was （38.57±32.29） pm. S-12 mm was significantly positively correlated with J0 （r=0.31）, J45 （r=0.42）, HOA3 mm （r=0.37）, and HOA6 mm （r=0.48）. S-14 mm and S-Is mm were significantly positively corre- lated with HOA3 mm （t=0.30, t=0.40） and HOA6 mm （r=0.46, r=0.35）. The X-axis distance between corneal pupillary center and corneal apex was significantly positively correlated with J45 （r=0.29）. Conclusions： In patients with ad- vanced keratoconus after FBDALK, the unevenly distributed thickness at corneal pupillary area and the misalignment of corneal apex and pupillary center might cause significant regular and irregular astigmatism, which affected the postoperative visual quality.展开更多
Objective：To report surgical management and favorable outcome in a case with delayed repair of traumatic laser in situ keratomileusis（LASIK）flap dislocation with shrinkage and folds.Methods：A 30-year-old man with ...Objective：To report surgical management and favorable outcome in a case with delayed repair of traumatic laser in situ keratomileusis（LASIK）flap dislocation with shrinkage and folds.Methods：A 30-year-old man with a five-year history of bilateral LASIK experienced blunt trauma to his right eye followed by decreased vision for 5 weeks.The surgical management included initially softening the flap by irrigation with balanced salt solution（BSS）.The shrinkage folds were carefully and gently stretched by scraping with a 26-gauge cannula accompanied by BSS irrigation.All of the epithelial ingrowth on the flap inner surface and on the bed was thoroughly debrided by scraping and irrigation.After the flap was repositioned to match its original margin,a soft bandage contact lens was placed.Results：At his initial visit,slit-lamp microscopy and optical coherence tomography（OCT）showed shrinkage of the LASIK flap with an elevated margin approximately 3 mm above the original position.The flap covered half of the pupil and had multiple horizontal folds.Two months after surgery,the flap remained well positioned with only faint streaks in the anterior stroma.The uncorrected visual acuity of the right eye was 20/20 with a manifest refraction of Plano.Conclusions：For delayed repair of traumatically dislocated LASIK flaps,sufficient softening by BSS,stretching the shrinkage folds,and thorough debridement of ingrowth epithelium enable resetting the flap and provide satisfactory results.展开更多
基金funded by Scientific and Technological Planning Project of Guangzhou City(Grant No.201803010115)Projects of The National Natural Science Foundation of China(Grant No.82173972)+1 种基金2021 Traditional Chinese Medicine(Medicine of South China)Industry Talents Project-Innovation Team of South China Medicine Resources,Guangdong Provincial Basic and Applied Basic Research Fund(Grant No.2023A1515011147)supported by the Key Unit of Chinese Medicine Digitalization Quality Evaluation of State Administration of Traditional Chinese Medicine.
文摘Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac diseases.Nevertheless,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic effects.The objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat model.Methods:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of SZDP.The integration of network pharmacology and metabolomics was conducted to investigate the mechanisms.Molecular docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated targets.Results:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart damage.Metabolomics results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for CMI.Integrating network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl formamidocarboxamide.Conclusion:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.
文摘Several studies have reported a relationship between the length of the CAG-repeat in the polymerase y （POLG） gene and male infertility. However, other studies have not reproduced this result. In our study, the POLG-CAG-repeat length was analyzed in 535 healthy individuals from six Chinese Han populations living in different provinces. The frequencies of IO-CAG alleles and genotypes were high （97.38 and 94.13%, respectively）, with no significant difference among the six Chinese Han populations. Furthermore, we determined the distribution of the POLG-CAG-repeat in 150 infertile men and 126 fertile men. Our study suggested that the distributions of POLG-CAG-repeat alleles and genotypes were not significantly different between infertile （95.67 and 92.67%, respectively） and fertile men （97.22 and 94.44%, respectively）. In a subsequent meta-analysis, combining our data with data from previous studies, a comparison of the CAG-repeat alleles in fertile versus infertile men showed no obvious risk for male infertility associated with any particular allele （pooled odds ratio （0R）=0.94; 95% confidence interval （CI）： 0.60-1.48）. The significance level was not attained with any of the following genetic models： homozygote comparison （not lO/not 10 versus 10110： OR= 1.34; 95% Ch 0.66-2.72）, heterozygote comparison （lO/not 10 versus 10/10： OR= 1.04; 95% Ch 0.78-1.38）, dominant model comparison （not lO/not 10＋ 101 not 10 versus 10110. OR= 1.08; 95% Ch 0.79-1.47） and recessive genetic comparison （not lO/not 10 versus lO/not 10＋ 10/10- OR= 1.31; 95% Ch 0.68-2.55）. In conclusion, there is no significant difference of the frequencies of POLG-CAG-repeat variants among six Chinese Han populations, and this polymorphism may not be associated with Chinese male infertility. On the basis of a meta-analysis, there is no obvious association between CAG-repeat variants of the POLG gene and male infertility.
基金supported by the Health Commission of Zhejiang Province(WKJ-ZJ-1905 and 2018ZD007)the Key Research and Development Projects of Zhejiang Province(2018C03082)the National Natural Science Foundation of China(61625107)。
文摘Infectious keratitis is the most common condition of corneal diseases in which a pathogen grows in the cornea leading to inflammation and destruction of the corneal tissues.Infectious keratitis is a medical emergency for which a rapid and accurate diagnosis is needed to ensure prompt and precise treatment to halt the disease progression and to limit the extent of corneal damage;otherwise,it may develop a sight-threatening and even eye-globe-threatening condition.In this paper,we propose a sequentiallevel deep model to effectively discriminate infectious corneal disease via the classification of clinical images.In this approach,we devise an appropriate mechanism to preserve the spatial structures of clinical images and disentangle the informative features for clinical image classification of infectious keratitis.In a comparison,the performance of the proposed sequential-level deep model achieved 80%diagnostic accuracy,far better than the 49.27%±11.5%diagnostic accuracy achieved by 421 ophthalmologists over 120 test images.
基金Financial supported by the National Natural Science Foundation of China (Grant No.81673872and 81460659)Department of Education Guangdong of Province (Grant No. YQ2013043)Department of Science and Technology of Tibet autonomous region (Grant No.2016ZR-ZY-01).
文摘Objective: To explore the main chemical compounds in Xiaoer Qixing Cha Formulae (XQCF), and investigate its mechanisms for the treatment of infantile functional dyspepsia (IFD). Methods: The chemical components were identified by UPLC-QTOF/MS analytic technique. Targets of the compounds were screened from TCMSP and SWISS database, and disease targets were screened from OMIM and TTD online database. Candidate targets of compounds were mapped to the disease targets as predict therapeutic targets for XQCF. Several networks were constructed and analyzed by Cytoscape ver. 3.2.1. Meanwhile, prescription compatibility in XQCF was interpreted from the network perspective based on distribution of the number of targets. Furthermore, Gene Ontology (GO) enrichment analysis and KEGG pathway analysis were operated via Clue Go to illustrate complex relationships between the potential targets and pharmacological mechanisms. Results: A total of fifty-three compounds were recognized or tentatively characterized belonging to XQCF based on MS data and online chemical database. Sixty-three therapeutic targets were screened. AKT1, FOS, SLC6A4, COMT and 5-HT receptors were focused as therapeutic targets of XQCF. Pathways including carbohydrate digestion and absorption, serotonergic synapse, calcium signaling pathway and cAMP signaling pathway were predicted as significant regulatory pathways. The results indicated that the predicted targets and pathways related in brain-gut axis to a great extent, which could be potential pharmacological mechanism of XQCF for the treatment of IFD. Conclusions: The findings in this study provided the experimental and theoretical basis for further research for XQCF. Those also illustrated a reasonable method worth intensive study on pharmacodynamic mechanisms of TCM Formulae.
基金Supported by the Science and Technology Program for Basic Research in Shenzhen (No.JCYJ20200109140412476)Clinical Research Project of Shenzhen Second People’s Hospital in 2019 (No.20193357009)。
文摘The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjogren’s syndrome(pSS) cannot be completely cured. Human studies have revealed that GM species and diversity are altered in patients with p SS compared with healthy individuals. Animal studies have provided possible mechanisms for the association between pSS and GM. The potential role of GM in pSS is exerted through several mechanisms. GM dysbiosis leads to increased intestinal permeability, which increases the risk of GM antigen exposure and activates specific autoreactive T lymphocytes via “molecular mimicry”. In addition, GM antigen exposure and intestinal immune tolerance loss caused by GM dysbiosis together induce chronic local gut mucosal inflammation, which deteriorates to systemic chronic non-specific inflammation with the circulation of pro-inflammatory lymphocytes and cytokines. These factors eventually activate autoreactive B lymphocytes and lead to pSS. If GM plays a key role in the pathogenesis of pSS, clarifying the underlying mechanisms will be helpful for the development of new therapies targeting GM for dry eye associated with pSS. This review summarizes the latest knowledge about the relationship between GM and p SS,with the aim of contributing to future research and to the development of new clinical applications.
文摘An improved name disambiguation method based on atom cluster. Aiming at the method of character-related properties of similarity based on information extraction depends on the character information, a new name disambiguation method is proposed, and improved k-means algorism for name disambiguation is proposed in this paper. The cluster analysis cluster is introduced to the name disambiguation process. Experiment results show that the proposed method having the high implementation efficiency and can distinguish the different people with the same name.
文摘A name disambiguation method is proposed based on attribute match and link analysis applying in the field of insurance. Aiming at the former name disambiguation methods such as text clustering method needs to be considered in a lot of useless words, a new name disambiguation method is advanced. Firstly, the same attribute matching is applied, merging the identity of a successful match, secondly, the link analysis is used, structural analysis of customers network is analyzed, Finally, the same cooperating information is merged. Experiment results show that the proposed method can realize name disambiguation successfully.
基金Project (No. 2011C13029-2) supported by the Major Program for Science and Technology Research of Zhejiang Province, China
文摘Objective: To compare postoperative outcomes of full-bed deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in treating keratoconus. Methods: Seventy-five eyes of 64 patients who received full-bed DALK and 52 eyes of 51 patients who received PK between June 2000 and August 2010 were included in this retrospective study. Full-bed DALK was performed using Yao's hooking-detaching technique. PK was performed using a standard technique. Intraoperative and postoperative complications, visual acuity, rejection, graft survival, endothelial cell density, corneal sensation recovery, and re-innervation were compared between the two groups. Results: A best correct visual acuity of 0.5 or better was achieved in 90.7% of eyes after full-bed DALK and in 92.3% of eyes after PK (P=0.75). By the fifth postoperative year, graft endothelial cell loss reached 34.6% in the PK group vs. 13.9% in the full-bed DALK group (P<0.001). There were no statistical differences in corneal sensitivity recovery or corneal re-innervation between the groups (P>0.05). Intraoperative microperforation occurred in seven out of 75 (9.3%) eyes with a temporally postoperative double anterior chamber in two eyes in the full-bed DALK group. Postoperative complications in the PK vs. the full-bed DALK groups respectively were: rejection (7.7% vs. 0%, P=0.015), high intraocular pressure (IOP) (46.2% vs. 1.3%, P<0.001), secondary glaucoma (9.6% vs. 0%, P=0.006), complicated cataract (19.2% vs. 0%, P<0.001), and wound dehiscence (9.6% vs. 0%, P=0.006). Conclusions: Both full-bed DALK and PK can offer long-term satisfactory visual outcomes for keratoconus. Graft rejection, secondary glaucoma, complicated cataracts, and constant endothelial cell loss were observed in eyes only after PK.
基金Project supported by the Key Research&Development Projects of Zhejiang Province(No.2018C03082)the Health Commission of Zhejiang Province(Nos.WKJ-ZJ-1905 and 2018ZD007),China
文摘Objective: To evaluate the safety and effectiveness of eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye. Methods: This was a prospective, randomized, open-label, investigator-masked, and self-controlled study. We randomly assigned one eye of patients with meibomian gland dysfunction-associated dry eye to the treatment group, and the other eye to the control group. Both groups received artificial tears and lid warming;the treatment group received an additional one-time in-office eyelid margin cleaning using Deep Cleaning Device. Non-invasive tear break-up time(NITBUT) and tear meniscus height(TMH) of each eye, and Standard Patient Evaluation for Eye Dryness II(SPEED II) score of each patient were evaluated before and at one week after treatment. Results: Thirty eyes of 15 patients were enrolled. No adverse effects occurred during the treatment. Compared with the baseline values, the SPEED score decreased significantly at one week after treatment(mean±95% confidence interval, 11.00±0.99 vs. 5.67±1.67, P<0.0001), the NITBUT-first in the treatment group increased significantly at one week after treatment((4.74±1.27) s vs.(7.49±2.22) s, P=0.01). The NITBUT-first was significantly longer in the treatment group((7.49±2.22) s) than in the control group((5.17±0.91) s) at one week after treatment(P=0.042). No significant differences were found in other tear film parameters between the two groups. Conclusions: Eyelid margin cleaning using the novel Deep Cleaning Device is a convenient, effective, and safe treatment for patients with meibomian gland dysfunction-associated dry eye.
基金Project supported by the National Natural Science Foundation of China(Nos.51875518 and 51475419)the Key Research and Development Projects of Zhejiang Province(Nos.2017C01054 and2018C03062)the Fundamental Research Funds for the Central Universities(No.2019FZA4002),China
文摘Background:The shortage of donor corneas is a severe global issue,and hence the development of corneal alternatives is imperative and urgent.Although attempts to produce artificial cornea substitutes by tissue engineering have made some positive progress,many problems remain that hamper their clinical application worldwide.For example,the curvature of tissue-engineered cornea substitutes cannot be designed to fit the bulbus oculi of patients.Objective:To overcome these limitations,in this paper,we present a novel integrated three-dimensional(3 D) bioprintingbased cornea substitute fabrication strategy to realize design,customized fabrication,and evaluation of multi-layer hollow structures with complicated surfaces.Methods:The key rationale for this method is to combine digital light processing(DLP) and extrusion bioprinting into an integrated 3 D cornea bioprinting system.A designable and personalized corneal substitute was designed based on mathematical modelling and a computer tomography scan of a natural cornea.The printed corneal substitute was evaluated based on biomechanical analysis,weight,structural integrity,and fit.Results:The results revealed that the fabrication of high water content and highly transparent curved films with geometric features designed according to the natural human cornea can be achieved using a rapid,simple,and low-cost manufacturing process with a high repetition rate and quality.Conclusions:This study demonstrated the feasibility of customized design,analysis,and fabrication of a corneal substitute.The programmability of this method opens up the possibility of producing substitutes for other cornea-like shell structures with different scale and geometry features,such as the glomerulus,atrium,and oophoron.
基金Project (No. 2012KYA107) supported by the Health Bureau of Zhejiang Province,China
文摘Objective:To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber angle.Methods:Among the general physical check-up population,subjects with shallow anterior chambers,as judged by van Herick technique,were recruited for further investigation.Ultrasound biomicroscope(UBM) was used to detect and measure the cysts located in the iris and/or ciliary body,the anterior chamber depth(ACD),the angle opening distance at 500 μm(AOD500),and the trabecular-iris angle(TIA).A-scan ultrasonography was used to measure the ocular biometry,including lens thickness,axial length,lens/axial length factor(LAF),and relative lens position(RLP).The effect of the cyst on narrowing the corresponding anterior chamber angle and the entire angle was evaluated by the UBM images,ocular biometry,and gonioscopic grading.The eye with unilateral cyst was compared with the eye without the cyst for further analysis.Results:Among the 727 subjects with shallow anterior chamber,primary iris and ciliary body cysts were detected in 250(34.4%) patients;among them 96(38.4%) patients showed unilateral single cyst,21(8.4%) patients had unilateral double cysts,and 42(16.8%) patients manifested unilateral multiple and multi-quadrants cysts.Plateau iris configuration was found in 140 of 361(38.8%) eyes with cysts.The mean size of total cysts was(0.6547±0.2319) mm.In evaluation of the effect of the cyst size and location on narrowing the corresponding angle to their position,the proportion of the cysts causing corresponding angle narrowing or closure among the cysts larger than 0.8 mm(113/121,93.4%) was found to be significantly higher than that of the cysts smaller than 0.8 mm(373/801,46.6%),and a significant higher proportion was also found in the cysts located at iridociliary sulcus(354/437,81.0%) than in that at the pars plicata(131/484,27.1%).In evaluating the effect of the cyst on the entire anterior chamber angle,the eyes with multiple and multi-quadrants cysts manifested significant narrowing of the entire anterior chamber angle as compared with the eyes without cysts,based on the data analysis in comparison of TIA,AOD500,and gonioscopic grading evaluation.The unilateral single or double cysts in the eyes had no significant effect on narrowing of anterior chamber angle as compared with eyes without cysts.The iris and/or ciliary body cysts did not seem to affect the axial length,ACD,lens thickness,RLP,LAF.Conclusions:The prevalence of primary iris and ciliary body cyst was 34.4% in the subjects with shallow anterior chamber.The cysts larger than 0.8 mm,locating at iridociliary sulcus,or multiple and extensive cysts were inclined to cause the angle narrowing or closure.
基金Project supported by the Yunnan Provincial Science and Technology Department (No.2008CC021)the National Natural Science Foundation of China (No.30900798)the CAMS-JSPS China-Japan Medical Exchange Program
文摘A study of the human leukocyte antigen （HLA） genetic characteristics in the Zhuang, the largest ethnic population in China, would provide insight into Zhuang history and give a useful tool for disease associations, transplantation, and anthropology. In the present study, we report the comprehensive HLA-A, HLA-B, HLA-C, and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time. A total of 13 HLA-A, 24 HLA-B, 22 HLA-C, and 18 HLA-DRB1 were identified in 104 Zhuang individuals. The frequencies of HLA-A＊11：01, A^＊02：07, A^＊24：02, A^＊02：03, and A^＊33：03 on A loci, B^＊15：02, B^＊58：01, B^＊46：01, and B^＊13：01 on B loci, C^＊03：04, C^＊08：01, C^＊01：02, C^＊03：02, and C^＊07：02 on C loci, and DRBl＊15：01, DRBl^＊16：02, DRB1^＊14：01, DRBl^＊15：02, and DRBI^＊03：01 on the DRB1 loci were 〉10%. The A^＊33：03-C^＊03：02-B^＊58：01-DRBl^＊03：01 and A^＊02：07-C^＊01：02- B^＊46：01-DRB1^＊14：01 haplotypes were predominant in the Zhuang. The phylogenetic tree, as well as the analysis of haplotypes, suggested that the Zhuang are genetically similar to southern Chinese populations, especially the Zhuang-Dong language-speaking populations, such as the Bouyei, Dai, and Maonan. Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes, the Zhuang has maintained its unique genetic characteristics.
基金Project supported by the Major Program for Science and Technology Research of Zhejiang Province(No.2011C13029-2)the Medical Scientific Research Foundation of Zhejiang Province(Nos2012ZDA026 and 2013ZDA012),China
文摘Objective： To evaluate the clinical efficacy of peripheral deep anterior lamellar keratoplasty （DALK） using a cryopreserved donor cornea for Terrien＇s marginal degeneration （TMD）. Methods： Thirty-one eyes of 27 patients with TMD underwent peripheral DALK using cryopreserved donor corneas, According to the distance between the inner edge of the lesion and the limbus, a ring-shaped or D-shaped DALK was performed. All grafts were stored at -20 ℃. Cryopreserved comeoscleral rims were prepared for ring-shaped grafts and cryopreserved whole eyeballs were prepared for D-shaped grafts. The general conditions, intraoperative performance, postoperative corneal reconstruc- tion, astigmatism, best corrected visual acuity （BCVA）, and various complications were analyzed. Results： Ring-shaped DALK was performed in 28 eyes and D-shaped DALK was performed in 3 eyes. Postoperative follow-up time was （28.4±24.8） months. There was evidence of inflammation before surgery in 12 eyes （38.7%） and intraoper- ative perforation occurred in 13 eyes （41.9%）. The corneal structures of all eyes were reconstructed. Postoperative astigmatism and BCVA showed improvement （both P=0.00） except for cases that underwent D-shaped DALK. Ten eyes （32.2%） developed transient ocular hypertension and one eye （3.2%） developed secondary glaucoma. No pri- mary disease recurrence or corneal allograft rejection was observed. Conclusions： Peripheral DALK for TMD using cryopreserved donor tissue is an effective technique that eliminates rejection and extends the use of donor eyes. Inflammatory history or intraoperative perforation has no adverse effect on graft recovery. However, D-shaped DALK did not achieve good visual outcomes.
文摘Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮（g） = {（x,y） ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie algebras of P. Levy [J. Algebra, 2002, 250： 473-484], we show that the variety ∮（g） is reducible, and not equidimensional. Irreducible components of ∮（g） and their dimensions are precisely given. As a consequence, the variety ∮（g） is not normal.
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LQ16H120002)
文摘Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography（HD-OCT）. Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results： Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye（P=0.024）. For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures（R=-0.579, P=0.008）, and was significantly positively correlated with time following surgery（R=0.636, P=0.003）. In the fellow eye, a significant positive correlation was found between age and CCET（R=0.551, P=0.012）, and a significant negative correlation between age and CTFT（R=-0.491, P=0.028）. LTMH was found to be significantly correlated between operated and fellow eyes（R=0.554, P=0.011）. There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures（all possible correlations, P0.05）. Conclusions： Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual＇s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.
文摘Objective:To investigate gene mutations associated with three different types of corneal dystrophies(CDs),and to establish a phenotype-genotype correlation.Methods:Two patients with Avellino corneal dystrophy(ACD),four patients with lattice corneal dystrophy type I(LCD I) from one family,and three patients with macular corneal dystrophy type I(MCD I) were subjected to both clinical and genetic examinations.Slit lamp examination was performed for all the subjects to assess their corneal phenotypes.Genomic DNA was extracted from peripheral blood leukocytes.The coding regions of the human transforming growth factor β-induced(TGFBI) gene and carbohydrate sulfotransferase 6(CHST6) gene were amplified by polymerase chain reaction(PCR) and subjected to direct sequencing.DNA samples from 50 healthy volunteers were used as controls.Results:Clinical examination showed three different phenotypes of CDs.Genetic examination identified that two ACD subjects were associated with homozygous R124H mutation of TGFBI,and four LCD I subjects were all associated with R124C heterozygous mutation.One MCD I subject was associated with a novel S51X homozygous mutation in CHST6,while the other two MCD I subjects harbored a previously reported W232X homozygous mutation.Conclusions:Our study highlights the prevalence of codon 124 mutations in the TGFBI gene among the Chinese ACD and LCD I patients.Moreover,we found a novel mutation among MCD I patients.
基金supported by the National Natural Science Foundation of China(Nos.11771279,11671138)the Natural Science Foundation of Shanghai(No.16ZR1415000).
文摘Let F be an algebraically closed field of prime characteristic, and W(m, n, 1) be the simple restricted Lie superalgebra of Witt type over F, which is the Lie superalgebra of superderivations of the superalgebra ■(m;1) ■∧(n), where ■(m;1) is the truncated polynomial algebra with m indeterminants and ∧(n) is the Grassmann algebra with n indeterminants. In this paper, the author determines the character formulas for a class of simple restricted modules of W(m, n, 1) with atypical weights of type Ⅰ.
基金Project supported by the Medical Scientific Research Foundation of Zhejiang Province(No.2018ZD007),China
文摘Objective： To investigate the effects of corneal thickness distribution and apex position on postoperative refractive status after full-bed deep anterior lamellar keratoplasty （FBDALK）. Methods： This is a retrospective analysis of patients who were diagnosed with advanced keratoconus between 2011 and 2014 in our hospital. The base of the cone in all patients did not exceed the central cornea at a 6-mm range. The FBDALK was performed by a same surgeon. All patients had a complete corneal suture removal and the follow-up records were intact. Patients who had graft-bed misalignment or who were complicated with a cataract or glaucoma were excluded. Uncorrected visual acuity （UCVA）, best spectacle corrected visual acuity （BSCVA）, and Pentacam examination data were recorded at two years postoperatively. The recorded data included the superior-inferior （S-I） and nasal-temporal （N-T） corneal thickness differences in 2, 4, 6, and 8 mm diameter concentric circles with the corneal apex as the center （S-I2 mm, S-14 mm, S-I6mm,, S-I8mm, N-T2mm, N-T4 mm, N-T6 mm, and N-T8 mm）, the linear, X-axis, and Y-axis distance between the corneal pupillary center and the cornea apex, total corneal astigmatism at a zone of 3 mm diameter from the corneal apex （TA3 mm）, the astigmatic vector values J0 and J4s, and the corneal total higher-order aberration for 3 and 6 mm pupil diameters （HOA3 mm and HOA6mm）. Statistical analysis was performed by SPSS 15.0. Results： A total of 47 eyes of 46 patients met the criteria and were included in this study. The mean follow-up time was （28±7） months. The mean UCVA was 0.45±0.23 （IogMAR） （MAR： minimum angle of resolution） and the mean BSCVA was 0.19±0.15 （IogMAR）, which were all sig- nificantly positively correlated with postoperative TA3 mm and HOA3 turn. The mean S-I corneal thickness differences were （44.62±37.74） IJm, and the mean N-T was （38.57±32.29） pm. S-12 mm was significantly positively correlated with J0 （r=0.31）, J45 （r=0.42）, HOA3 mm （r=0.37）, and HOA6 mm （r=0.48）. S-14 mm and S-Is mm were significantly positively corre- lated with HOA3 mm （t=0.30, t=0.40） and HOA6 mm （r=0.46, r=0.35）. The X-axis distance between corneal pupillary center and corneal apex was significantly positively correlated with J45 （r=0.29）. Conclusions： In patients with ad- vanced keratoconus after FBDALK, the unevenly distributed thickness at corneal pupillary area and the misalignment of corneal apex and pupillary center might cause significant regular and irregular astigmatism, which affected the postoperative visual quality.
基金supported by the Zhejiang Provincial Department of Education(No.Y201533941),China
文摘Objective：To report surgical management and favorable outcome in a case with delayed repair of traumatic laser in situ keratomileusis（LASIK）flap dislocation with shrinkage and folds.Methods：A 30-year-old man with a five-year history of bilateral LASIK experienced blunt trauma to his right eye followed by decreased vision for 5 weeks.The surgical management included initially softening the flap by irrigation with balanced salt solution（BSS）.The shrinkage folds were carefully and gently stretched by scraping with a 26-gauge cannula accompanied by BSS irrigation.All of the epithelial ingrowth on the flap inner surface and on the bed was thoroughly debrided by scraping and irrigation.After the flap was repositioned to match its original margin,a soft bandage contact lens was placed.Results：At his initial visit,slit-lamp microscopy and optical coherence tomography（OCT）showed shrinkage of the LASIK flap with an elevated margin approximately 3 mm above the original position.The flap covered half of the pupil and had multiple horizontal folds.Two months after surgery,the flap remained well positioned with only faint streaks in the anterior stroma.The uncorrected visual acuity of the right eye was 20/20 with a manifest refraction of Plano.Conclusions：For delayed repair of traumatically dislocated LASIK flaps,sufficient softening by BSS,stretching the shrinkage folds,and thorough debridement of ingrowth epithelium enable resetting the flap and provide satisfactory results.
