Since it was first reported in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has spread rapidly around the world to cause the ongoing pandemic.Although the clinical manifestations ...Since it was first reported in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has spread rapidly around the world to cause the ongoing pandemic.Although the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system,liver enzyme abnormalities exist in around half of the cases,which indicate liver injury,and raise clinical concern.At present,there is no consensus whether the liver injury is directly caused by viral replication in the liver tissue or indirectly by the systemic inflammatory response.This review aims to summarize the clinical manifestations and to explore the underlying mechanisms of liver dysfunction in patients with SARSCoV-2 infection.展开更多
AIM To investigate the distribution and function of interstitialcells of Cajal(ICCs) and platelet-derived growth factor receptor-α positive(PDGFRα+) cells in the proximal and distal colon.METHODS The comparison of c...AIM To investigate the distribution and function of interstitialcells of Cajal(ICCs) and platelet-derived growth factor receptor-α positive(PDGFRα+) cells in the proximal and distal colon.METHODS The comparison of colonic transit in the proximal and distal ends was performed by colonic migrating motor complexes(CMMCs). The tension of the colonic smooth muscle was examined by smooth muscle spontaneous contractile experiments with both ends of the smooth muscle strip tied with a silk thread. Intracellular recordings were used to assess electrical field stimulation(EFS)-induced inhibitory junction potentials(IJP) on the colonic smooth muscle. Western blot analysis was used to examine the expression levels of ICCs and PDGFRα in the colonic smooth muscle.RESULTS Treatment with NG-nitro-L-arginine methyl ester hydrochloride(L-NAME) significantly increased the CMMC frequency and spontaneous contractions, especially in the proximal colon, while treatment with MRS2500 increased only distal CMMC activity and smooth muscle contractions. Both CMMCs and spontaneous contractions were markedly inhibited by NPPB, especially in the proximal colon. Accordingly, CyPPA sharply inhibited the distal contraction of both CMMCs and spontaneous contractions. Additionally, the amplitude of stimulationinduced nitric oxide(NO)/ICC-dependent slow IJPs(sIJPs) by intracellular recordings from the smooth muscles in the proximal colon was larger than that in the distal colon, while the amplitude of electric field stimulationinduced purinergic/PDGFRα-dependent fast IJPs(fIJPs) in the distal colon was larger than that in the proximal colon. Consistently, protein expression levels of c-Kit and anoctamin-1(ANO1) in the proximal colon were much higher, while protein expression levels of PDGFRα and small conductance calcium-activated potassium channel 3(SK3) in the distal colon were much higher.CONCLUSION The ICCs are mainly distributed in the proximal colon and there are more PDGFRα+ cells are in the distal colon, which generates a pressure gradient between the two ends of the colon to propel the feces to the anus.展开更多
The impact of the variations of threshold voltage(V_(th))and hold voltage(V_(hold))of threshold switching(TS)selector in1 S1 R crossbar array is investigated.Based on ON/OFF state I–V curves measurements from a large...The impact of the variations of threshold voltage(V_(th))and hold voltage(V_(hold))of threshold switching(TS)selector in1 S1 R crossbar array is investigated.Based on ON/OFF state I–V curves measurements from a large number of Ag-filament TS selectors,V_(th)and V_(hold)are extracted and their variations distribution expressions are obtained,which are then employed to evaluate the impact on read process and write process in 32×321 S1 R crossbar array under different bias schemes.The results indicate that V_(th)and V_(hold)variations of TS selector can lead to degradation of 1 S1 R array performance parameters,such as minimum read/write voltage,bit error rate(BER),and power consumption.For the read process,a small V_(hold)variation not only results in the minimum read voltage increasing but it also leads to serious degradation of BER.As the standard deviation of V_(hold)and V_(th)increases,the BER and the power consumption of 1 S1 R crossbar array under 1/2 bias,1/3 bias,and floating scheme degrade,and the case under 1/2 bias tends to be more serious compared with other two schemes.For the write process,the minimum write voltage also increases with the variation of V_(hold)from small to large value.A slight increase of V_(th)standard deviation not only decreases write power efficiency markedly but also increases write power consumption.These results have reference significance to understand the voltage variation impacts and design of selector properly.展开更多
BACKGROUND Lateral facial clefts are atypical with a low incidence in the facial cleft spectrum.With the development of ultrasonography(US)prenatal screening,such facial malformations can be detected and diagnosed pre...BACKGROUND Lateral facial clefts are atypical with a low incidence in the facial cleft spectrum.With the development of ultrasonography(US)prenatal screening,such facial malformations can be detected and diagnosed prenatally rather than at birth.Although three-dimensional US(3DUS)can render the fetus'face via 3D reconstruction,the 3D images are displayed on two-dimensional screens without field depth,which impedes the understanding of untrained individuals.In contrast,a 3D-printed model of the fetus'face helps both parents and doctors develop a more comprehensive understanding of the facial malformation by creating more interactive aspects.Herein,we present an isolated lateral facial cleft case that was diagnosed via US combined with a 3D-printed model.CASE SUMMARY A 31-year-old G2P1 patient presented for routine prenatal screening at the 22nd wk of gestation.The coronal nostril-lip section of two-dimensional US(2DUS)demonstrated that the fetus'bilateral oral commissures were asymmetrical,and left oral commissure was abnormally wide.The left oblique-coronal section showed a cleft at the left oral commissure which extended to the left cheek.The results of 3DUS confirmed the cleft.Furthermore,we created a model of the fetal face using 3D printing technology,which clearly presented facial malformations.The fetus was diagnosed with a left lateral facial cleft,which was categorized as a No.7 facial cleft according to the Tessier facial cleft classification.The parents terminated the pregnancy at the 24th wk of gestation after parental counseling.CONCLUSION In the diagnostic course of the current case,in addition to the traditional application of 2D and 3DUS,we created a 3D-printed model of the fetus,which enhanced diagnostic evidence,benefited the education of junior doctors,improved parental counseling,and had the potential to guide surgical planning.展开更多
World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Cupping,developed under the leadership of Tianjin University of Traditional Chinese Medicine,was approved b...World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Cupping,developed under the leadership of Tianjin University of Traditional Chinese Medicine,was approved by WFAS.This technical benchmark was issued on October 9,2023,and implemented on December 31,2023.The main contents include the scope,normative references,terms and definitions,procedures and rules,and safety.This article focuses on the above contents,an outlook on the application,popularization,and update plan of this technical benchmark is proposed.展开更多
Hepatitis C virus (HCV) infection is a major global health problem.There is no effective vaccine and the current treatment regimen with pegylated interferon α and ribavirin is associated with significant adverse even...Hepatitis C virus (HCV) infection is a major global health problem.There is no effective vaccine and the current treatment regimen with pegylated interferon α and ribavirin is associated with significant adverse events.Therefore,there is an urgent need to identify new antiviral targets for HCV therapy.In recent years,a grow,ing number of microRNAs (miRNAs) have been reported to be able to regulate HCV replication and infection by interacting with the HCV genome directly or by regulating host innate immunity to build a nonspecific antiviral state within cells.In this review,we discuss HCV virology and standard of care followed by miRNA in general,and then give a brief overview of miRNAs involved in HCV infection and discuss their potential application as a therapeutic option for the treatment of HCV infection.展开更多
基金Supported by Sino-German Center for Research Promotion,National Natural Science Foundation of China,No.C-0029Health Commission of Chengdu,No.2020179.
文摘Since it was first reported in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has spread rapidly around the world to cause the ongoing pandemic.Although the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system,liver enzyme abnormalities exist in around half of the cases,which indicate liver injury,and raise clinical concern.At present,there is no consensus whether the liver injury is directly caused by viral replication in the liver tissue or indirectly by the systemic inflammatory response.This review aims to summarize the clinical manifestations and to explore the underlying mechanisms of liver dysfunction in patients with SARSCoV-2 infection.
基金Supported by The National Natural Science Foundation of China,No.31671192 and No.31571180Foundation of Xin Hua Hospital,No.JZPI201708
文摘AIM To investigate the distribution and function of interstitialcells of Cajal(ICCs) and platelet-derived growth factor receptor-α positive(PDGFRα+) cells in the proximal and distal colon.METHODS The comparison of colonic transit in the proximal and distal ends was performed by colonic migrating motor complexes(CMMCs). The tension of the colonic smooth muscle was examined by smooth muscle spontaneous contractile experiments with both ends of the smooth muscle strip tied with a silk thread. Intracellular recordings were used to assess electrical field stimulation(EFS)-induced inhibitory junction potentials(IJP) on the colonic smooth muscle. Western blot analysis was used to examine the expression levels of ICCs and PDGFRα in the colonic smooth muscle.RESULTS Treatment with NG-nitro-L-arginine methyl ester hydrochloride(L-NAME) significantly increased the CMMC frequency and spontaneous contractions, especially in the proximal colon, while treatment with MRS2500 increased only distal CMMC activity and smooth muscle contractions. Both CMMCs and spontaneous contractions were markedly inhibited by NPPB, especially in the proximal colon. Accordingly, CyPPA sharply inhibited the distal contraction of both CMMCs and spontaneous contractions. Additionally, the amplitude of stimulationinduced nitric oxide(NO)/ICC-dependent slow IJPs(sIJPs) by intracellular recordings from the smooth muscles in the proximal colon was larger than that in the distal colon, while the amplitude of electric field stimulationinduced purinergic/PDGFRα-dependent fast IJPs(fIJPs) in the distal colon was larger than that in the proximal colon. Consistently, protein expression levels of c-Kit and anoctamin-1(ANO1) in the proximal colon were much higher, while protein expression levels of PDGFRα and small conductance calcium-activated potassium channel 3(SK3) in the distal colon were much higher.CONCLUSION The ICCs are mainly distributed in the proximal colon and there are more PDGFRα+ cells are in the distal colon, which generates a pressure gradient between the two ends of the colon to propel the feces to the anus.
基金Project supported by the MOST of China(Grant No.2016YFA0201801)the Beijing Advanced Innovation Center for Future Chip(ICFC)+2 种基金Beijing Municipal Science and Technology Project(Grant No.D161100001716002)the National Natural Science Foundation of China(Grant Nos.61674089,61674087,61674092,61076115,and 61774012)the Research Fund from Beijing Innovation Center for Future Chip(Grant No.KYJJ2016008)
文摘The impact of the variations of threshold voltage(V_(th))and hold voltage(V_(hold))of threshold switching(TS)selector in1 S1 R crossbar array is investigated.Based on ON/OFF state I–V curves measurements from a large number of Ag-filament TS selectors,V_(th)and V_(hold)are extracted and their variations distribution expressions are obtained,which are then employed to evaluate the impact on read process and write process in 32×321 S1 R crossbar array under different bias schemes.The results indicate that V_(th)and V_(hold)variations of TS selector can lead to degradation of 1 S1 R array performance parameters,such as minimum read/write voltage,bit error rate(BER),and power consumption.For the read process,a small V_(hold)variation not only results in the minimum read voltage increasing but it also leads to serious degradation of BER.As the standard deviation of V_(hold)and V_(th)increases,the BER and the power consumption of 1 S1 R crossbar array under 1/2 bias,1/3 bias,and floating scheme degrade,and the case under 1/2 bias tends to be more serious compared with other two schemes.For the write process,the minimum write voltage also increases with the variation of V_(hold)from small to large value.A slight increase of V_(th)standard deviation not only decreases write power efficiency markedly but also increases write power consumption.These results have reference significance to understand the voltage variation impacts and design of selector properly.
文摘BACKGROUND Lateral facial clefts are atypical with a low incidence in the facial cleft spectrum.With the development of ultrasonography(US)prenatal screening,such facial malformations can be detected and diagnosed prenatally rather than at birth.Although three-dimensional US(3DUS)can render the fetus'face via 3D reconstruction,the 3D images are displayed on two-dimensional screens without field depth,which impedes the understanding of untrained individuals.In contrast,a 3D-printed model of the fetus'face helps both parents and doctors develop a more comprehensive understanding of the facial malformation by creating more interactive aspects.Herein,we present an isolated lateral facial cleft case that was diagnosed via US combined with a 3D-printed model.CASE SUMMARY A 31-year-old G2P1 patient presented for routine prenatal screening at the 22nd wk of gestation.The coronal nostril-lip section of two-dimensional US(2DUS)demonstrated that the fetus'bilateral oral commissures were asymmetrical,and left oral commissure was abnormally wide.The left oblique-coronal section showed a cleft at the left oral commissure which extended to the left cheek.The results of 3DUS confirmed the cleft.Furthermore,we created a model of the fetal face using 3D printing technology,which clearly presented facial malformations.The fetus was diagnosed with a left lateral facial cleft,which was categorized as a No.7 facial cleft according to the Tessier facial cleft classification.The parents terminated the pregnancy at the 24th wk of gestation after parental counseling.CONCLUSION In the diagnostic course of the current case,in addition to the traditional application of 2D and 3DUS,we created a 3D-printed model of the fetus,which enhanced diagnostic evidence,benefited the education of junior doctors,improved parental counseling,and had the potential to guide surgical planning.
基金Supported by National Key R&D Program of China:2019YFC1712200-2019YFC1712204。
文摘World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Cupping,developed under the leadership of Tianjin University of Traditional Chinese Medicine,was approved by WFAS.This technical benchmark was issued on October 9,2023,and implemented on December 31,2023.The main contents include the scope,normative references,terms and definitions,procedures and rules,and safety.This article focuses on the above contents,an outlook on the application,popularization,and update plan of this technical benchmark is proposed.
文摘Hepatitis C virus (HCV) infection is a major global health problem.There is no effective vaccine and the current treatment regimen with pegylated interferon α and ribavirin is associated with significant adverse events.Therefore,there is an urgent need to identify new antiviral targets for HCV therapy.In recent years,a grow,ing number of microRNAs (miRNAs) have been reported to be able to regulate HCV replication and infection by interacting with the HCV genome directly or by regulating host innate immunity to build a nonspecific antiviral state within cells.In this review,we discuss HCV virology and standard of care followed by miRNA in general,and then give a brief overview of miRNAs involved in HCV infection and discuss their potential application as a therapeutic option for the treatment of HCV infection.
