AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a ...AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular trauma.METHODS:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham injection.Left eyes were used as normal controls.The intraocular pressure(IOP)was monitored using an iCare tonometer.PVR severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence staining.RESULTS:During the observation period,PVR severity gradually increased.Intense Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR group.Ozurdex significantly alleviated PVR development and Müller cell gliosis.Post-traumatic inflammation fluctuated and was persistent.The interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after injury.The expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1βexpression.Ozurdex suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal limits.CONCLUSION:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over 6wk.Ozurdex treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR severity.This study highlights the important role of IL-1β,and Ozurdex inhibites inflammation presumably via the NF-κB/NLRP3/IL-1βinflammatory axis.In summary,Ozurdex provides a potential therapeutic option for traumatic PVR.展开更多
AIM: To evaluate the efficacy and safety of combined anti-vascular endothelial growth factor(VEGF) agents, oral glucocorticoid, and laser photocoagulation therapy for macular edema(ME) secondary to retinal vein occlus...AIM: To evaluate the efficacy and safety of combined anti-vascular endothelial growth factor(VEGF) agents, oral glucocorticoid, and laser photocoagulation therapy for macular edema(ME) secondary to retinal vein occlusion(RVO).METHODS: This study included 16 eyes of 16 patients with RVO-associated ME. Patients were initially treated with oral prednisone and an intravitreal anti-VEGF agent. Two weeks later, patients underwent standard laser photocoagulation. Best-corrected visual acuity(BCVA), central retinal thickness(CRT), and retinal vessel oxygenation were examined over 12 mo.RESULTS: Patients received 1.43±0.81 anti-VEGF injections. Mean baseline and 12-month log MAR BCVA were 0.96±0.51(20/178) and 0.31±0.88(20/40), respectively, in eyes with central retinal vein occlusion(CRVO)(P<0.00), and 1.02±0.45(20/209) and 0.60±0.49(20/80), respectively, in eyes with branch retinal vein occlusion(BRVO)(P<0.00). At 12 mo, CRT had significantly decreased in eyes with CRVO(P<0.00) and BRVO(P<0.00). Venous oxygen saturation had significantly increased in eyes with CRVO(P<0.00) and BRVO(P<0.00). No examined parameters were significantly different between the 2 RVO groups. No serious adverse effects occurred.CONCLUSION: Anti-VEGF, glucocorticoid, and photocoagulation combination therapy improves visual outcome, prolongs therapeutic effect, and reduces the number of intravitreal injections in eyes with RVOassociated ME.展开更多
The needling sensation of Deqi during acupuncture is a key factor of influencing acupuncture outcome.Recent studies have mainly focused on the brain function effects of Deqi in a physiological state.Functional magneti...The needling sensation of Deqi during acupuncture is a key factor of influencing acupuncture outcome.Recent studies have mainly focused on the brain function effects of Deqi in a physiological state.Functional magnetic resonance imaging(f MRI)on the effects of acupuncture at Waiguan(SJ5)in pathological and physiological states is controversial.In this study,12 patients with ischemic stroke received acupuncture at Waiguan(SJ5)and simultaneously underwent f MRI scanning of the brain,with imaging data of the activated areas obtained.Based on the patient’s sensation,imaging data were allocated to either the Deqi group or non-Deqi group.In the Deqi group,the activated/deactivated areas were the left superior temporal gyrus(BA39)/right anterior lobe of the cerebellum and left thalamus.In the non-Deqi group,the activated areas included the medial frontal gyrus of the right frontal lobe(BA11),right limbic lobe(BA30,35),and left frontal lobe(BA47),while the only deactivated area was the right parietal lobe(BA40).Compared with the non-Deqi group,the Deqi group exhibited marked activation of the right anterior lobe of the cerebellum and right limbic lobe(BA30).These findings confirm that the clinical effect of Deqi during acupuncture is based on brain functional changes.Cerebellar activation may be one of the central mechanisms of acupuncture in the treatment of ischemic stroke.展开更多
Based on the Gurson-Tvergaard-Needleman(GTN)model and Hill's quadratic anisotropic yield criterion,a combined experimental-numerical study on fracture initiation in the process of thermal stamping of Mg alloy AZ31...Based on the Gurson-Tvergaard-Needleman(GTN)model and Hill's quadratic anisotropic yield criterion,a combined experimental-numerical study on fracture initiation in the process of thermal stamping of Mg alloy AZ31 sheets was carried out.The aim is to predict the formability of thermal stamping of the Mg alloy sheets at different temperatures.The presented theoretical framework was implemented into a VUMAT subroutine for ABAQUS/EXPLICIT.Internal damage evolution due to void growth and coalescence developed at different temperatures in the Mg alloy sheets was observed by scanning electron microscopy(SEM).Moreover,the thermal effects on the void growth,coalescence,and fracture behavior of the Mg alloy sheets were analyzed by the extended GTN model and forming limit diagrams(FLD).Parameters employed in the GTN model were determined from tensile tests and numerical iterative computation.The distribution of major and minor principal strains in the specimens was determined from the numerical results.Therefore,the corresponding forming limit diagrams at different stress levels and temperatures were drawn.The comparison between the predicted forming limits and the experimental data shows a good agreement.展开更多
Seeking high-performance computing methods to solve the problem of a large amount of calculation,low calculation efficiency,and small simulation scale on the traditional single central processing unit (CPU) platform i...Seeking high-performance computing methods to solve the problem of a large amount of calculation,low calculation efficiency,and small simulation scale on the traditional single central processing unit (CPU) platform is of great value to the simulation study of micro-structure.In this study,based on the three-dimensional multi-phase-field model of KKSO coupling phase-field and solute field,the open computing language (OpenCL) + graphics processing unit (GPU) heterogeneous parallel computing technology is used to simulate the eutectoid growth of Fe-C alloy and the end growth process of pearlite under pure diffusion.The effects of initial supercooling and different diffusion coefficients on the growth morphology of lamellar pearlite were investigated.The results show that ferrite and cementite are perpendicular to the front of the solid-solid interface and are coupled and coordinated to grow,and there is no leading phase under the initial supercooling degree of 20 K.With the continuous increase of the initial supercooling degree (19 K-22 K),the morphology changes of the eutectoid layer are as follows:cementite stops growing → slice amplitude increases → regular symmetric growth → oblique growth → layer merge.With the increase of the diffusion coefficient from 3×10^(-13) m^(2)·s^(-1) to 15×10^(-13) m^(2)·s^(-1),the growth rate of the microstructure of the lamellar pearlite increases linearly,and there is no obvious change in the frontal appearance of the pearlite.展开更多
Background and Aims:The results of basic research implicate the vascular endothelial growth factor(VEGF)family as a potential target of hepatopulmonary syndrome(HPS).However,the negative results of anti-angiogenetic t...Background and Aims:The results of basic research implicate the vascular endothelial growth factor(VEGF)family as a potential target of hepatopulmonary syndrome(HPS).However,the negative results of anti-angiogenetic therapy in clinical studies have highlighted the need for markers for HPS.Therefore,we aimed to determine whether VEGF family members and their receptors can be potential biomarkers for HPS through clinical and experimental studies.Methods:Clinically,patients with chronic liver disease from two medical centers were enrolled and examined for HPS.Patients were divided into HPS,intrapulmonary vascular dilation[positive contrast-enhanced echocardiography(CEE)and normal oxygenation]and CEE-negative groups.Baseline information and perioperative clinical data were compared between HPS and non-HPS patients.Serum levels of VEGF family members and their receptors were measured.In parallel,HPS rats were established by common bile duct ligation.Liver,lung and serum samples were collected for the evaluation of pathophysiologic changes,as well as the expression levels of the above factors.Results:In HPS rats,all VEGF family members and their receptors underwent significant changes;however,only soluble VEGFR1(sFlt-1)and the sFlt-1/placental growth factor(PLGF)ratio were changed in almost the same manner as those in HPS patients.Furthermore,through feature selection and internal and external validation,sFlt-1 and the sFlt-1/PLGF ratio were identified as the most important variables to distinguish HPS from non-HPS patients.Conclusions:Our results from animal and human studies indicate that sFlt-1 and the sFlt-1/PLGF ratio in serum are potential markers for HPS.展开更多
A new species of the genus Micropeplus Latreille is described under the name of M. songi sp. nov. Color photos of habitus, head, pronotum, elytra, wing, metasternum, the 3rd to 7th tergites of abdomen, the 8th sternit...A new species of the genus Micropeplus Latreille is described under the name of M. songi sp. nov. Color photos of habitus, head, pronotum, elytra, wing, metasternum, the 3rd to 7th tergites of abdomen, the 8th sternite, and aedeagus are provided. This species was found on fungi from Mt. Wahui in Jiulong County, Sichuan, China.展开更多
The peptide-receptor kinase-based intercellular signaling becomes an important molecular base for various aspects of plant life activities[1],particularly exemplified in the extensive molecular interactions in the jou...The peptide-receptor kinase-based intercellular signaling becomes an important molecular base for various aspects of plant life activities[1],particularly exemplified in the extensive molecular interactions in the journey of pollen tube growth in pistil of flowering plants[2].Researches in the past two decades demonstrated that peptide-receptor kinase signaling complexes mediat epollen tube promotion,guidance and reception,as well as selfincompatibility and gamete fusion.A recent exciting discovery published on Science by Zhong et al.expands the biological functions of peptide-receptor kinase signaling to facilitating formation of a new plant species[3].展开更多
A nanoporous N-doped reduced graphene oxide(p-N-rGO) was prepared through carbothermal reaction between graphene oxide and ammonium-containing oxometalates as sulfur host for Li-S batteries.The p-N-rGO sheets have abu...A nanoporous N-doped reduced graphene oxide(p-N-rGO) was prepared through carbothermal reaction between graphene oxide and ammonium-containing oxometalates as sulfur host for Li-S batteries.The p-N-rGO sheets have abundant nanopores with diameters of 10-40 nm and the nitrogen content is 2.65 at%.When used as sulfur cathode,the obtained p-N-rGO/S composite has a high reversible capacity of 1110mAhg^1 at 1C rate and stable cycling performance with 781.8 mAhg^1 retained after 110 cycles,much better than those of the rGO/S composite.The enhanced electrochemical performance is ascribed to the rational combination of nanopores and N-doping,which provide efficient contact and wetting with the electrolyte,accommodate volume expansion and immobilize polysulfides during cycling.展开更多
Progress in humanity has intensified the demand for efficient and renewable energy storage,which warrants the development of advanced rechargeable batteries such as lithium-ion batteries(LIBs),sodium-ion batteries(SIB...Progress in humanity has intensified the demand for efficient and renewable energy storage,which warrants the development of advanced rechargeable batteries such as lithium-ion batteries(LIBs),sodium-ion batteries(SIBs),zinc-ion batteries(ZIBs),and lithium-sulfur batteries(Li-S batteries).Nevertheless,these batteries still suffer from certain limitations,such as the insufficient capacity and inferior stability in their electrode materials.Therefore,developing a feasible electrode material for Li/Na/Zn ion storage represents a critical challenge.Recently,polyoxovanadates(POVs)materials,particularly decavanadate anion(V_(10)O_(28))^(6-)clusters,have attracted considerate attention as promising battery electrodes,due to their rich multi-electron redox process,high structural stability,simple preparation process,and abundant ligand environment.In this review,we provide an overview of the research progress of(V_(10)O_(28))^(6-)-based materials in various metal-ion battery systems,including LIBs,SIBs,ZIBs,and Li-S batteries.We also discuss the underlying challenges associated with this type of materials,and we provide alternative strategies to overcome these issues.This review aims to facilitate the research and development of the nextgeneration(V_(10)O_(28))^(6-)-based battery materials.展开更多
Background and Aims:Screening for hepatopulmonary syndrome in cirrhotic patients is limited due to the need to perform contrast enhanced echocardiography(CEE)and arterial blood gas(ABG)analysis.We aimed to develop a s...Background and Aims:Screening for hepatopulmonary syndrome in cirrhotic patients is limited due to the need to perform contrast enhanced echocardiography(CEE)and arterial blood gas(ABG)analysis.We aimed to develop a simple and quick method to screen for the presence of intrapulmonary vascular dilation(IPVD)using noninvasive and easily available variables with machine learning(ML)algorithms.Methods:Cirrhotic patients were enrolled from our hospital.All eligible patients underwent CEE,ABG analysis and physical examination.We developed a twostep model based on three ML algorithms,namely,adaptive boosting(termed AdaBoost),gradient boosting decision tree(termed GBDT)and eXtreme gradient boosting(termed Xgboost).Noninvasive variables were input in the first step(the NI model),and for the second step(the NIBG model),a combination of noninvasive variables and ABG results were used.Model performance was determined by the area under the curve of receiver operating characteristics(AUCROCs),precision,recall,F1-score and accuracy.Results:A total of 193 cirrhotic patients were ultimately analyzed.The AUCROCs of the NI and NIBG models were 0.850(0.738–0.962)and 0.867(0.760–0.973),respectively,and both had an accuracy of 87.2%.For both negative and positive cases,the recall values of the NI and NIBG models were both 0.867(0.760–0.973)and 0.875(0.771–0.979),respectively,and the precisions were 0.813(0.690–0.935)and 0.913(0.825–1.000),respectively.Conclusions:We developed a two-step model based on ML using noninvasive variables and ABG results to screen for the presence of IPVD in cirrhotic patients.This model may partly solve the problem of limited access to CEE and ABG by a large numbers of cirrhotic patients.展开更多
基金Supported by National Natural Science Foundation of China(No.81974135,No.81900851)。
文摘AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular trauma.METHODS:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham injection.Left eyes were used as normal controls.The intraocular pressure(IOP)was monitored using an iCare tonometer.PVR severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence staining.RESULTS:During the observation period,PVR severity gradually increased.Intense Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR group.Ozurdex significantly alleviated PVR development and Müller cell gliosis.Post-traumatic inflammation fluctuated and was persistent.The interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after injury.The expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1βexpression.Ozurdex suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal limits.CONCLUSION:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over 6wk.Ozurdex treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR severity.This study highlights the important role of IL-1β,and Ozurdex inhibites inflammation presumably via the NF-κB/NLRP3/IL-1βinflammatory axis.In summary,Ozurdex provides a potential therapeutic option for traumatic PVR.
基金Supported by Technology Planning Project of Guangdong Province,China(No.2015B020211004)
文摘AIM: To evaluate the efficacy and safety of combined anti-vascular endothelial growth factor(VEGF) agents, oral glucocorticoid, and laser photocoagulation therapy for macular edema(ME) secondary to retinal vein occlusion(RVO).METHODS: This study included 16 eyes of 16 patients with RVO-associated ME. Patients were initially treated with oral prednisone and an intravitreal anti-VEGF agent. Two weeks later, patients underwent standard laser photocoagulation. Best-corrected visual acuity(BCVA), central retinal thickness(CRT), and retinal vessel oxygenation were examined over 12 mo.RESULTS: Patients received 1.43±0.81 anti-VEGF injections. Mean baseline and 12-month log MAR BCVA were 0.96±0.51(20/178) and 0.31±0.88(20/40), respectively, in eyes with central retinal vein occlusion(CRVO)(P<0.00), and 1.02±0.45(20/209) and 0.60±0.49(20/80), respectively, in eyes with branch retinal vein occlusion(BRVO)(P<0.00). At 12 mo, CRT had significantly decreased in eyes with CRVO(P<0.00) and BRVO(P<0.00). Venous oxygen saturation had significantly increased in eyes with CRVO(P<0.00) and BRVO(P<0.00). No examined parameters were significantly different between the 2 RVO groups. No serious adverse effects occurred.CONCLUSION: Anti-VEGF, glucocorticoid, and photocoagulation combination therapy improves visual outcome, prolongs therapeutic effect, and reduces the number of intravitreal injections in eyes with RVOassociated ME.
基金funding support from the Major new drug creation project (2017ZX09101002-002-008)National Natural Science Foundation of China (81403171)Autonomous Program of China Academy of Chinese Medical Sciences (QZPT001 and 2014065)
基金supported by the National Key Basic Research and Development Plan of China(973 Program),No.2006CB504505,2012CB518504the"University Students Innovation Experiment Project"in Guangdong Province of China,No.1212112038
文摘The needling sensation of Deqi during acupuncture is a key factor of influencing acupuncture outcome.Recent studies have mainly focused on the brain function effects of Deqi in a physiological state.Functional magnetic resonance imaging(f MRI)on the effects of acupuncture at Waiguan(SJ5)in pathological and physiological states is controversial.In this study,12 patients with ischemic stroke received acupuncture at Waiguan(SJ5)and simultaneously underwent f MRI scanning of the brain,with imaging data of the activated areas obtained.Based on the patient’s sensation,imaging data were allocated to either the Deqi group or non-Deqi group.In the Deqi group,the activated/deactivated areas were the left superior temporal gyrus(BA39)/right anterior lobe of the cerebellum and left thalamus.In the non-Deqi group,the activated areas included the medial frontal gyrus of the right frontal lobe(BA11),right limbic lobe(BA30,35),and left frontal lobe(BA47),while the only deactivated area was the right parietal lobe(BA40).Compared with the non-Deqi group,the Deqi group exhibited marked activation of the right anterior lobe of the cerebellum and right limbic lobe(BA30).These findings confirm that the clinical effect of Deqi during acupuncture is based on brain functional changes.Cerebellar activation may be one of the central mechanisms of acupuncture in the treatment of ischemic stroke.
基金financially supported by the National Natural Science Foundation of China (No.51222106)the research grant from University of Science and Technology Beijing (No.32001023)
文摘Based on the Gurson-Tvergaard-Needleman(GTN)model and Hill's quadratic anisotropic yield criterion,a combined experimental-numerical study on fracture initiation in the process of thermal stamping of Mg alloy AZ31 sheets was carried out.The aim is to predict the formability of thermal stamping of the Mg alloy sheets at different temperatures.The presented theoretical framework was implemented into a VUMAT subroutine for ABAQUS/EXPLICIT.Internal damage evolution due to void growth and coalescence developed at different temperatures in the Mg alloy sheets was observed by scanning electron microscopy(SEM).Moreover,the thermal effects on the void growth,coalescence,and fracture behavior of the Mg alloy sheets were analyzed by the extended GTN model and forming limit diagrams(FLD).Parameters employed in the GTN model were determined from tensile tests and numerical iterative computation.The distribution of major and minor principal strains in the specimens was determined from the numerical results.Therefore,the corresponding forming limit diagrams at different stress levels and temperatures were drawn.The comparison between the predicted forming limits and the experimental data shows a good agreement.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51661020,11504149 and 11364024)the Postdoctoral Science Foundation of China(Grant No.2014M560371)the Funds for Distinguished Young Scientists of Lanzhou University of Technology(Grant No.J201304)。
文摘Seeking high-performance computing methods to solve the problem of a large amount of calculation,low calculation efficiency,and small simulation scale on the traditional single central processing unit (CPU) platform is of great value to the simulation study of micro-structure.In this study,based on the three-dimensional multi-phase-field model of KKSO coupling phase-field and solute field,the open computing language (OpenCL) + graphics processing unit (GPU) heterogeneous parallel computing technology is used to simulate the eutectoid growth of Fe-C alloy and the end growth process of pearlite under pure diffusion.The effects of initial supercooling and different diffusion coefficients on the growth morphology of lamellar pearlite were investigated.The results show that ferrite and cementite are perpendicular to the front of the solid-solid interface and are coupled and coordinated to grow,and there is no leading phase under the initial supercooling degree of 20 K.With the continuous increase of the initial supercooling degree (19 K-22 K),the morphology changes of the eutectoid layer are as follows:cementite stops growing → slice amplitude increases → regular symmetric growth → oblique growth → layer merge.With the increase of the diffusion coefficient from 3×10^(-13) m^(2)·s^(-1) to 15×10^(-13) m^(2)·s^(-1),the growth rate of the microstructure of the lamellar pearlite increases linearly,and there is no obvious change in the frontal appearance of the pearlite.
基金supported by National Science Foundation of China(No.82070630 from Bin Yi,82100658 from Yu-jie Li and 82170634 from Peng Li)National Key R&D Program of China(No.2018YFC0116702 from Bin Yi)+2 种基金Special support for Chongqing postdoctoral research project in 2020 from Yujie Li,Sichuan science and technology department research projects(2019YFS0221 from Peng Li)Chongqing Science and health joint medical research project(2020FYYX076,from Bin Yi)special support project for improving scientific and technological innovation ability of undergraduate(2021XBK19 from Xian-feng Wu).
文摘Background and Aims:The results of basic research implicate the vascular endothelial growth factor(VEGF)family as a potential target of hepatopulmonary syndrome(HPS).However,the negative results of anti-angiogenetic therapy in clinical studies have highlighted the need for markers for HPS.Therefore,we aimed to determine whether VEGF family members and their receptors can be potential biomarkers for HPS through clinical and experimental studies.Methods:Clinically,patients with chronic liver disease from two medical centers were enrolled and examined for HPS.Patients were divided into HPS,intrapulmonary vascular dilation[positive contrast-enhanced echocardiography(CEE)and normal oxygenation]and CEE-negative groups.Baseline information and perioperative clinical data were compared between HPS and non-HPS patients.Serum levels of VEGF family members and their receptors were measured.In parallel,HPS rats were established by common bile duct ligation.Liver,lung and serum samples were collected for the evaluation of pathophysiologic changes,as well as the expression levels of the above factors.Results:In HPS rats,all VEGF family members and their receptors underwent significant changes;however,only soluble VEGFR1(sFlt-1)and the sFlt-1/placental growth factor(PLGF)ratio were changed in almost the same manner as those in HPS patients.Furthermore,through feature selection and internal and external validation,sFlt-1 and the sFlt-1/PLGF ratio were identified as the most important variables to distinguish HPS from non-HPS patients.Conclusions:Our results from animal and human studies indicate that sFlt-1 and the sFlt-1/PLGF ratio in serum are potential markers for HPS.
文摘A new species of the genus Micropeplus Latreille is described under the name of M. songi sp. nov. Color photos of habitus, head, pronotum, elytra, wing, metasternum, the 3rd to 7th tergites of abdomen, the 8th sternite, and aedeagus are provided. This species was found on fungi from Mt. Wahui in Jiulong County, Sichuan, China.
基金supported by the National Natural Science Foundation of China(31570318)
文摘The peptide-receptor kinase-based intercellular signaling becomes an important molecular base for various aspects of plant life activities[1],particularly exemplified in the extensive molecular interactions in the journey of pollen tube growth in pistil of flowering plants[2].Researches in the past two decades demonstrated that peptide-receptor kinase signaling complexes mediat epollen tube promotion,guidance and reception,as well as selfincompatibility and gamete fusion.A recent exciting discovery published on Science by Zhong et al.expands the biological functions of peptide-receptor kinase signaling to facilitating formation of a new plant species[3].
基金Financial support from the Research Project of National University of Defense Technology (No. ZDYYjc Yj20140701)
文摘A nanoporous N-doped reduced graphene oxide(p-N-rGO) was prepared through carbothermal reaction between graphene oxide and ammonium-containing oxometalates as sulfur host for Li-S batteries.The p-N-rGO sheets have abundant nanopores with diameters of 10-40 nm and the nitrogen content is 2.65 at%.When used as sulfur cathode,the obtained p-N-rGO/S composite has a high reversible capacity of 1110mAhg^1 at 1C rate and stable cycling performance with 781.8 mAhg^1 retained after 110 cycles,much better than those of the rGO/S composite.The enhanced electrochemical performance is ascribed to the rational combination of nanopores and N-doping,which provide efficient contact and wetting with the electrolyte,accommodate volume expansion and immobilize polysulfides during cycling.
基金financially supported by the National Natural Science Foundation of China(Nos.52071132,U21A20284,U1904216)Zhongyuan Thousand People Plan-The Zhongyuan Youth Talent Support Program(in Science and Technology),China(No.ZYQR201810139)+2 种基金the Innovative Funds Plan of Henan University of Technology,China(No.2020ZKCJ04)the Natural Science Foundation of Henan,China(No.222300420138)the support from the NSF Center for the Advancement of Wearable Technologies(No.1849243)。
文摘Progress in humanity has intensified the demand for efficient and renewable energy storage,which warrants the development of advanced rechargeable batteries such as lithium-ion batteries(LIBs),sodium-ion batteries(SIBs),zinc-ion batteries(ZIBs),and lithium-sulfur batteries(Li-S batteries).Nevertheless,these batteries still suffer from certain limitations,such as the insufficient capacity and inferior stability in their electrode materials.Therefore,developing a feasible electrode material for Li/Na/Zn ion storage represents a critical challenge.Recently,polyoxovanadates(POVs)materials,particularly decavanadate anion(V_(10)O_(28))^(6-)clusters,have attracted considerate attention as promising battery electrodes,due to their rich multi-electron redox process,high structural stability,simple preparation process,and abundant ligand environment.In this review,we provide an overview of the research progress of(V_(10)O_(28))^(6-)-based materials in various metal-ion battery systems,including LIBs,SIBs,ZIBs,and Li-S batteries.We also discuss the underlying challenges associated with this type of materials,and we provide alternative strategies to overcome these issues.This review aims to facilitate the research and development of the nextgeneration(V_(10)O_(28))^(6-)-based battery materials.
基金The project was supported by the National Key R&D Program of China(No.2018YFC0116702 to BY)National Natural Science Foundation of China(No.82070630 to BY and No.81600035 to YC)+1 种基金Medical Innovation Capacity Improvement Program for Medical Staff of the First Affiliated Hospital of the Third Military Medical University(No.SWH2018QNKJ-27 to YJL)Technology Innovation and Application Research and Development Project of Chongqing City(cstc2019jscx-msxmX0237 to BY).
文摘Background and Aims:Screening for hepatopulmonary syndrome in cirrhotic patients is limited due to the need to perform contrast enhanced echocardiography(CEE)and arterial blood gas(ABG)analysis.We aimed to develop a simple and quick method to screen for the presence of intrapulmonary vascular dilation(IPVD)using noninvasive and easily available variables with machine learning(ML)algorithms.Methods:Cirrhotic patients were enrolled from our hospital.All eligible patients underwent CEE,ABG analysis and physical examination.We developed a twostep model based on three ML algorithms,namely,adaptive boosting(termed AdaBoost),gradient boosting decision tree(termed GBDT)and eXtreme gradient boosting(termed Xgboost).Noninvasive variables were input in the first step(the NI model),and for the second step(the NIBG model),a combination of noninvasive variables and ABG results were used.Model performance was determined by the area under the curve of receiver operating characteristics(AUCROCs),precision,recall,F1-score and accuracy.Results:A total of 193 cirrhotic patients were ultimately analyzed.The AUCROCs of the NI and NIBG models were 0.850(0.738–0.962)and 0.867(0.760–0.973),respectively,and both had an accuracy of 87.2%.For both negative and positive cases,the recall values of the NI and NIBG models were both 0.867(0.760–0.973)and 0.875(0.771–0.979),respectively,and the precisions were 0.813(0.690–0.935)and 0.913(0.825–1.000),respectively.Conclusions:We developed a two-step model based on ML using noninvasive variables and ABG results to screen for the presence of IPVD in cirrhotic patients.This model may partly solve the problem of limited access to CEE and ABG by a large numbers of cirrhotic patients.
