Objective:To study the effect of cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy on esophageal cancer cell proliferation and invasion.Methods:A total of 62 patients with esophageal cancer who w...Objective:To study the effect of cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy on esophageal cancer cell proliferation and invasion.Methods:A total of 62 patients with esophageal cancer who were treated in the hospital between January 2015 and December 2016 were collected and divided into control group and observation group according to random number table, with 31 cases in each group. Control group of patients received paclitaxel + cisplatin neoadjuvant chemotherapy + surgery, and observation group of patients accepted cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy + surgery. The differences in proliferation and invasion gene expression in the tumor tissue were compared between two groups of patients before and after chemotherapy.Results:Before chemotherapy, differences in proliferation and invasion gene expression in tumor tissue were not statistically significant between two groups of patients. After chemotherapy, pro-proliferation genes FOXA1, ABCE1, USP39 and Nestin mRNA expression in tumor tissue of observation group were significantly lower than those of control group;anti-proliferation genes PETN, KLF4, TSLC1 and AnnexinA2 mRNA expression were significantly higher than those of control group;pro-invasion genesγ-synuclein, CXCR4 and Snail mRNA expression were significantly lower than those of control group;anti-invasion genes CIAPIN1, Fez and Lrig1 mRNA expression were significantly higher than that of control group.Conclusions:Cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy can effectively inhibit the malignant degree of esophageal cancer cells and inhibit its proliferation and invasion.展开更多
Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China....Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.展开更多
Inclusions have a great infuence on the quality of FeSiB amorphous ribbon.The evolution behavior of inclusions was analyzed.The results show that the spherical and elliptical inclusions,consisting of Al2O3 and SiO2,ma...Inclusions have a great infuence on the quality of FeSiB amorphous ribbon.The evolution behavior of inclusions was analyzed.The results show that the spherical and elliptical inclusions,consisting of Al2O3 and SiO2,mainly come from industrial pure iron.Ellipsoidal inclusions of 20-30μm in pure iron were removed by foatation during the smelting process,and spherical inclusions of 1-3μm combined with deoxidized products in FeSiB melt form Al2O3·SiO2 and CaO·Al2O3·SiO2 inclusions.Some inclusions accumulated on the inner wall of the nozzle during the spraying process,and others fowed out of the nozzle and remained in FeSiB amorphous ribbon.By controlling the total oxygen content in industrial pure iron to 31×10^-6,clogging on the inner wall of the nozzle can be reduced and the free surface smoothness of the amorphous ribbon can be improved.展开更多
文摘Objective:To study the effect of cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy on esophageal cancer cell proliferation and invasion.Methods:A total of 62 patients with esophageal cancer who were treated in the hospital between January 2015 and December 2016 were collected and divided into control group and observation group according to random number table, with 31 cases in each group. Control group of patients received paclitaxel + cisplatin neoadjuvant chemotherapy + surgery, and observation group of patients accepted cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy + surgery. The differences in proliferation and invasion gene expression in the tumor tissue were compared between two groups of patients before and after chemotherapy.Results:Before chemotherapy, differences in proliferation and invasion gene expression in tumor tissue were not statistically significant between two groups of patients. After chemotherapy, pro-proliferation genes FOXA1, ABCE1, USP39 and Nestin mRNA expression in tumor tissue of observation group were significantly lower than those of control group;anti-proliferation genes PETN, KLF4, TSLC1 and AnnexinA2 mRNA expression were significantly higher than those of control group;pro-invasion genesγ-synuclein, CXCR4 and Snail mRNA expression were significantly lower than those of control group;anti-invasion genes CIAPIN1, Fez and Lrig1 mRNA expression were significantly higher than that of control group.Conclusions:Cetuximab combined with paclitaxel + cisplatin neoadjuvant chemotherapy can effectively inhibit the malignant degree of esophageal cancer cells and inhibit its proliferation and invasion.
基金National High Level Hospital Clinical Research Funding,Grant/Award Number:2022-NHLHCRF-YGJE-02Natural Science Foundation of Beijing Municipality,Grant/Award Number:7212090。
文摘Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.Methods:This study was conducted by 45 tertiary Grade-A hospitals in China.Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,2023.The collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory disorders.Results:Complete questionnaires were obtained from 35,566 subjects.The overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction.Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction.Before infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey.The median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 days.The overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying symptoms.Conclusions:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China.Incidence and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.
基金This work was financially supported by the National Natural Science Foundation of China(No.51774098).
文摘Inclusions have a great infuence on the quality of FeSiB amorphous ribbon.The evolution behavior of inclusions was analyzed.The results show that the spherical and elliptical inclusions,consisting of Al2O3 and SiO2,mainly come from industrial pure iron.Ellipsoidal inclusions of 20-30μm in pure iron were removed by foatation during the smelting process,and spherical inclusions of 1-3μm combined with deoxidized products in FeSiB melt form Al2O3·SiO2 and CaO·Al2O3·SiO2 inclusions.Some inclusions accumulated on the inner wall of the nozzle during the spraying process,and others fowed out of the nozzle and remained in FeSiB amorphous ribbon.By controlling the total oxygen content in industrial pure iron to 31×10^-6,clogging on the inner wall of the nozzle can be reduced and the free surface smoothness of the amorphous ribbon can be improved.
