Background:Colorectal cancer(CRC)is a leading cause of cancer mortality globally.This study aims to develop a prognostic model based on disulfidptosis-related genes to assess survival outcomes in CRC,highlighting the ...Background:Colorectal cancer(CRC)is a leading cause of cancer mortality globally.This study aims to develop a prognostic model based on disulfidptosis-related genes to assess survival outcomes in CRC,highlighting the tumor microenvironment’s role.Methods:The thought of traditional Chinese medicine syndrome differentiation and treatment runs through the whole study.We analyzed CRC tissue data from The Cancer Genome Atlas and the Gene Expression Omnibus using single-sample gene set enrichment and weighted gene correlation network analyses to identify prognostic markers and evaluate immune infiltration.We also investigated predictive drug sensitivities.Results:We identified seven disulfidptosis-related markers–complement C1q A chain(C1QA),solute carrier family 11 member 1(SLC11A1),cluster of differentiation 36(CD36),cluster of differentiation 6(CD6),interleukin 1 receptor associated kinase 3(IRAK3),S100 calcium binding protein A8(S100A8),and CD8 subunit alpha(CD8A)–that significantly influence prognosis.Patients classified in the low-risk group demonstrated improved overall survival compared to those in the high-risk group across training(P=0.0026)and validation cohorts(P=0.032).Differential gene expression was significant in the high-risk group(P<0.001),and prevalent mutations included APC regulator of WNT signaling pathway(APC),tumor protein P53(TP53),Titin(TTN),and Kirsten rat sarcoma viral oncogene(KRAS).The risk score correlated linearly with tumor microenvironment attributes.The results of drug analysis showed that some traditional drugs may have anticancer effects through the vertical action of disulfidptosis.Conclusion:Our prognostic model,integrating seven disulfidptosis-related genes,categorizes CRC patients by survival probability and underscores these genes as potential biomarkers linked to the tumor microenvironment.These findings support their use in refining therapeutic strategies for CRC.展开更多
GW Ori is a young hierarchical triple system located in λ Orionis, consisting of a binary(GW Ori A and B), a tertiary star(GW Ori C) and a rare circumtriple disk. Due to the limited data with poor accuracy, several s...GW Ori is a young hierarchical triple system located in λ Orionis, consisting of a binary(GW Ori A and B), a tertiary star(GW Ori C) and a rare circumtriple disk. Due to the limited data with poor accuracy, several short-period signals were detected in this system, but the values from diferent studies are not fully consistent. As one of the most successful transiting surveys, the transiting exoplanet survey satellite(TESS) provides an unprecedented opportunity to make a comprehensive periodic analysis of GW Ori. In this work we discover two significant modulation signals by analyzing the light curves of GW Ori's four observations from TESS, i.e.,(3.02 ± 0.15) and(1.92 ± 0.06) d, which are very likely to be the rotational periods caused by starspot modulation on the primary and secondary components, respectively. We calculate the inclinations of GW Ori A and B according to the two rotational periods. The results suggest that the rotational plane of GW Ori A and B and the orbital plane of the binary are almost coplanar. We also discuss the aperiodic features in the light curves;these may be related to unstable accretion. The light curves of GW Ori also include a third(possible) modulation signal with a period of(2.51±0.09) d, but the third is neither quite stable nor statistically significant.展开更多
文摘Background:Colorectal cancer(CRC)is a leading cause of cancer mortality globally.This study aims to develop a prognostic model based on disulfidptosis-related genes to assess survival outcomes in CRC,highlighting the tumor microenvironment’s role.Methods:The thought of traditional Chinese medicine syndrome differentiation and treatment runs through the whole study.We analyzed CRC tissue data from The Cancer Genome Atlas and the Gene Expression Omnibus using single-sample gene set enrichment and weighted gene correlation network analyses to identify prognostic markers and evaluate immune infiltration.We also investigated predictive drug sensitivities.Results:We identified seven disulfidptosis-related markers–complement C1q A chain(C1QA),solute carrier family 11 member 1(SLC11A1),cluster of differentiation 36(CD36),cluster of differentiation 6(CD6),interleukin 1 receptor associated kinase 3(IRAK3),S100 calcium binding protein A8(S100A8),and CD8 subunit alpha(CD8A)–that significantly influence prognosis.Patients classified in the low-risk group demonstrated improved overall survival compared to those in the high-risk group across training(P=0.0026)and validation cohorts(P=0.032).Differential gene expression was significant in the high-risk group(P<0.001),and prevalent mutations included APC regulator of WNT signaling pathway(APC),tumor protein P53(TP53),Titin(TTN),and Kirsten rat sarcoma viral oncogene(KRAS).The risk score correlated linearly with tumor microenvironment attributes.The results of drug analysis showed that some traditional drugs may have anticancer effects through the vertical action of disulfidptosis.Conclusion:Our prognostic model,integrating seven disulfidptosis-related genes,categorizes CRC patients by survival probability and underscores these genes as potential biomarkers linked to the tumor microenvironment.These findings support their use in refining therapeutic strategies for CRC.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11873034, U2031202, and 12203029)the Department of Science and Technology of Hubei Province for the Outstanding Youth Fund (Grant No. 2019CFA087)+2 种基金the Cultivation Project for LAMOST Scientific Payoff and Research Achievement of CAMS-CAS, and the science research grants from the China Manned Space Project (Grant No. CMSCSST-2021-A08)CSST Milky Way and Nearby Galaxies Survey on Dust and Extinction Project (Grant No. CMS-CSST-2021-A09)Funding for the TESS mission is provided by NASA’s Science Mission directorate。
文摘GW Ori is a young hierarchical triple system located in λ Orionis, consisting of a binary(GW Ori A and B), a tertiary star(GW Ori C) and a rare circumtriple disk. Due to the limited data with poor accuracy, several short-period signals were detected in this system, but the values from diferent studies are not fully consistent. As one of the most successful transiting surveys, the transiting exoplanet survey satellite(TESS) provides an unprecedented opportunity to make a comprehensive periodic analysis of GW Ori. In this work we discover two significant modulation signals by analyzing the light curves of GW Ori's four observations from TESS, i.e.,(3.02 ± 0.15) and(1.92 ± 0.06) d, which are very likely to be the rotational periods caused by starspot modulation on the primary and secondary components, respectively. We calculate the inclinations of GW Ori A and B according to the two rotational periods. The results suggest that the rotational plane of GW Ori A and B and the orbital plane of the binary are almost coplanar. We also discuss the aperiodic features in the light curves;these may be related to unstable accretion. The light curves of GW Ori also include a third(possible) modulation signal with a period of(2.51±0.09) d, but the third is neither quite stable nor statistically significant.
