期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
Paradoxical roles of inhibitory autapse and excitatory synapse in formation of counterintuitive anticipated synchronization
1
作者 丁学利 古华光 +1 位作者 李玉叶 贾雁兵 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第8期499-509,共11页
Different from the common delayed synchronization(DS)in which response appears after stimulation,anticipated synchronization(AS)in unidirectionally coupled neurons denotes a counterintuitive phenomenon in which respon... Different from the common delayed synchronization(DS)in which response appears after stimulation,anticipated synchronization(AS)in unidirectionally coupled neurons denotes a counterintuitive phenomenon in which response of the receiver neuron appears before stimulation of the sender neuron,showing an interesting function of brain to anticipate the future.The dynamical mechanism for the AS remains unclear due to complex dynamics of inhibitory and excitatory modulations.In this article,the paradoxical roles of excitatory synapse and inhibitory autapse in the formation of AS are acquired.Firstly,in addition to the common roles such that inhibitory modulation delays and excitatory modulation advances spike,paradoxical roles of excitatory stimulation to delay spike via type-II phase response and of inhibitory autapse to advance spike are obtained in suitable parameter regions,extending the dynamics and functions of the excitatory and inhibitory modulations.Secondly,AS is related to the paradoxical roles of the excitatory and inhibitory modulations,presenting deep understandings to the AS.Inhibitory autapse induces spike of the receiver neuron advanced to appear before that of the sender neuron at first,and then excitatory synapse plays a delay role to prevent the spike further advanced,resulting in the AS as the advance and delay effects realize a dynamic balance.Lastly,inhibitory autapse with strong advance,middle advance,and weak advance and delay effects induce phase drift(spike of the receiver neuron advances continuously),AS,and DS,respectively,presenting comprehensive relationships between AS and other behaviors.The results present potential measures to modulate AS related to brain function. 展开更多
关键词 anticipated synchronization inhibitory autapse excitatory synapse paradoxical firing
原文传递
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
2
作者 Suiyi Tan Wenjuan li +18 位作者 Chan Yang Qingping Zhan Kunyu Lu Jun liu Yong-Mei Jin Jin-Song Bai lin Wang Jinqing li Zhaofeng li Fei Yu yu-ye li Yue-Xun Duan Lu Lu Tong Zhang Jiaqi Wei lin li Yong-Tang Zheng Shibo Jiang Shuwen liu 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2024年第5期479-494,共16页
Apart from mediating viral entry,the function of the free HIV-1 envelope protein(gp120)has yet to be elucidated.Our group previously showed that EP2 derived from oneβ-strand in gp120 can form amyloid fibrils that inc... Apart from mediating viral entry,the function of the free HIV-1 envelope protein(gp120)has yet to be elucidated.Our group previously showed that EP2 derived from oneβ-strand in gp120 can form amyloid fibrils that increase HIV-1 infectivity.Importantly,gp120 contains~30β-strands.We examined whether gp120 might serve as a precursor protein for the proteolytic release of amyloidogenic fragments that form amyloid fibrils,thereby promoting viral infection.Peptide array scanning,enzyme degradation assays,and viral infection experiments in vitro confirmed that manyβ-stranded peptides derived from gp120 can indeed form amyloid fibrils that increase HIV-1 infectivity.These gp120-derived amyloidogenic peptides,or GAPs,which were confirmed to form amyloid fibrils,were termed gp120-derived enhancers of viral infection(GEVIs).GEVIs specifically capture HIV-1 virions and promote their attachment to target cells,thereby increasing HIV-1 infectivity.Different GAPs can cross-interact to form heterogeneous fibrils that retain the ability to increase HIV-1 infectivity.GEVIs even suppressed the antiviral activity of a panel of antiretroviral agents.Notably,endogenous GAPs and GEVIs were found in the lymphatic fluid,lymph nodes,and cerebrospinal fluid(CSF)of AIDS patients in vivo.Overall,gp120-derived amyloid fibrils might play a crucial role in the process of HIV-1 infectivity and thus represent novel targets for anti-HIV therapeutics. 展开更多
关键词 HIV-1 GP120 Amyloid fibril Enhancement of viral infectivity
原文传递
2019 Chinese expert consensus statement on diagnosis and treatment of syphilis 被引量:2
3
作者 Qian-Qiu Wang +18 位作者 Rui-li Zhang Yue-Ping Yin Quan-Zhong liu Shu-Zhen Qi Dong-Mei Xu yu-ye li Xiao-Fang li Xiao-Hong Su Min-Zhi Wu Xian-Biao Zou li-Gang Yang Xiang-Sheng Chen Ping-Yu Zhou Jin-Hua Xu Xiang-Dong Gong Guo-Jun liang Juan Jiang Hao Cheng Feng-Qin Ge 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第19期2335-2337,共3页
Syphilis,caused by Treponema pallidum subsp pallidum(T.pallidum),is a chronic,systemic human disease transmitted through sexual contact.The incidence and prevalence of syphilis is still high in China.[1]To guide the p... Syphilis,caused by Treponema pallidum subsp pallidum(T.pallidum),is a chronic,systemic human disease transmitted through sexual contact.The incidence and prevalence of syphilis is still high in China.[1]To guide the prevention measures and management of this disease,we renew the guidelines on diagnosis and treatment of syphilis[Supplementary file,http://links.lww.com/CM9/A292].Manifestations and diagnosis of all stages of syphilis are presented in Table 1,and management in Table 2. 展开更多
关键词 DIAGNOSIS PREVENTION TREATMENT
原文传递
National Guidelines on Diagnosis and Treatment of Gonorrhea in China (2020) 被引量:2
4
作者 Qian-Qiu Wang Rui-li Zhang +20 位作者 Quan-Zhong liu Jin-Hua Xu Xiao-Hong Su Yue-Ping Yin Shu-Zhen Qi Dong-Mei Xu Ping-Yu Zhou yu-ye li Xiao-Fang li Min-Zhi Wu Xian-Biao Zou li-Gang Yang Xiang-Sheng Chen Xiang-Dong Gong Guo-Jun liang Juan Jiang Hao Cheng Feng-Qin Ge National Center for STD Control,Chinese Centers for Disease Control and Prevention Committee of STD,Branch of Dermatovenereology,Chinese Medical Association Committee of STD,Chinese Dermatologist Association 《International Journal of Dermatology and Venereology》 2020年第3期129-134,共6页
Gonorrhea is one of the main sexually transmitted diseases in China.It mainly affects the genitourinary tract,and its clinical manifestations vary from asymptomatic to complicated types.The diagnosis of gonorrhea shou... Gonorrhea is one of the main sexually transmitted diseases in China.It mainly affects the genitourinary tract,and its clinical manifestations vary from asymptomatic to complicated types.The diagnosis of gonorrhea should be based on the patient's epidemiologicai history,clinical manifestations,and laboratory examination results.Treatment should be prompt and standardized and should involve the recommended treatment regimens.Patients should be appropriately followed up after treatment.The antimicrobial resistance of gonococcal isolates has become a severe problem of clinical concern.In order to provide technical guidance of the diagnosis and treatment of gonorrhea for health care workers,the authors developed the guidelines based on the version of 2014,which will be of important in the standardizing medical care of gonorrhea,and further facilitating control and prevention of the disease. 展开更多
关键词 GONORRHEA DIAGNOSIS TREATMENT GUIDELINES
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部