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Relationship Between Microcystin in Drinking Water and Colorectal Cancer 被引量:24
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作者 ZhouL yuh 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2002年第2期166-171,共6页
Objective To investigate the association of microcystin (MC) in drinking water with the incidence of colorectal cancer. Methods The study was designed as a retrospective cohort. Eight townships or towns were random... Objective To investigate the association of microcystin (MC) in drinking water with the incidence of colorectal cancer. Methods The study was designed as a retrospective cohort. Eight townships or towns were randomly selected as the study sites in Haining City of Zhejiang Province, China. 408 cases of colon and rectum carcinomas diagnosed from 1977 to 1996 in the study sites were included, and a survey on types of drinking water of these patients was conducted. Samples of different water sources (well, tap, river and pond) were collected separately and microcystin concentrations were determined by indirect competitive ELISA method. Results The incidence rate of colorectal cancer was significantly higher in population who drank river and pond water than those who drank well and tap water. Compared to well water, the relative risk (RR) for colorectal cancer was 1.88 (tap), 7.94 (river) and 7.70 (pond) respectively. The positive rate (>50 pg/mL) of microcystin in samples of well, tap, river and pond water was 0, 0, 36.23% and 17.14% respectively. The concentration of microcystin in river and pond water was significantly higher than that in well and tap water (P<0.01). Spearman rank correlation analysis showed that in the study sites, the microcystin concentration of river and pond water was positively associated with the incidence of colorectal cancer (rs= 0.881, P<0.01). Conclusions The types of drinking water are positively associated with the incidence of colorectal cancer in the study sites, and this may be related to microcystin contamination of drinking water. Further biological study is needed to support the possible causative role of mycrocystin in carcinogenesis of colon and rectum. 展开更多
关键词 Drinking water MICROCYSTIN Colorectal cancer
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用富含CpG的质粒初免并以蛋白及CpG寡核苷酸和Quil A加强免疫可诱导强的抗HCV NS3细胞及体液免疫应答
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作者 yuh BabinkLA +2 位作者 vanDrunenLittel-vandenHurkS 施海晶 胡云章 《国外医学(预防.诊断.治疗用生物制品分册)》 2005年第4期186-186,共1页
丙型肝炎病毒(HCV)中具有丝氨酸蛋白酶活性和解旋酶活性的NS3蛋白是最保守的蛋白之一;另外,与慢性感染病人相比,在感染恢复病人体内更易于检测到较强的NS3特异性免疫应答,使得NS3成为一种受到关注的候选疫苗。
关键词 CPG寡核苷酸 体液免疫应答 抗HCV 加强免疫 丙型肝炎病毒(HCV) 特异性免疫应答 白及 初免 质粒 细胞 NS3蛋白 蛋白酶活性 感染病人 候选疫苗 丝氨酸 人体内
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