A series of tests of a full-scale river icebreaker was conducted to investigate the characteristics of ice-induced hull vibration.The test was conducted when the river icebreaker was operating in an ice-covered river ...A series of tests of a full-scale river icebreaker was conducted to investigate the characteristics of ice-induced hull vibration.The test was conducted when the river icebreaker was operating in an ice-covered river at temperatures of-4 to 0°C with ice thicknesses of 300 to 400 mm.In the tests,the ice condition and icebreaker speed were chosen as the main influence factors.By analyzing the measured test data,we identified some important points regarding ice-induced hull vibration.When the river icebreaker navigates in an area with complete ice coverage,the peak value of the acceleration amplitude spectrum is highest.Also,the vibration response excited by the icebreaking load in an area with complete ice coverage exhibits more frequencies.With an increase in icebreaker speed,the vibration acceleration response gradually increases.However,habitability of the bow region on the main and driving decks is maintained due to the harmless vibration levels.In addition,the icebreaking operation of the river icebreaker causes violent local vibration of the grillage on the main deck.展开更多
BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading lesions.Gross morphology and surface characteristics may help predict ...BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading lesions.Gross morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic evaluation.This is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United States.AIM To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal neoplasia.METHODS This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February 2017.The main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 mo.RESULTS A total of 480 patients with 500 lesions were included in the study.The median age was 68(Inter quantile range:14)with 52%males.The most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most prevalent.Submucosal invasion was present in 23(4.6%)out of 500 lesions.The independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value<0.004)and Paris classification 0-IIc(Odds ratio:18.2;P value<0.01).Out of 500,354 post-endoscopic mucosal resection scars were examined at surveillance colonoscopy.Recurrence was noted in 21.8%(77 cases).CONCLUSION There was overall low prevalence of SMIL in our study.Kudo pit pattern(IIIL+IV and V)and Paris classification 0-IIc were the only factors identified as an independent risk factor for submucosal invasion.The independent risk factor for recurrence was adenoma size(>40 mm).Almost all recurrences(98.8%)were treated endoscopically.展开更多
Background: More and more chronic kidney disease (CKD) patients are accompanied with hyperuricaemia. As is known, hyperuricaemia is an independent hazard of both cardiovascular diseases (CVD) and chronic kidney diseas...Background: More and more chronic kidney disease (CKD) patients are accompanied with hyperuricaemia. As is known, hyperuricaemia is an independent hazard of both cardiovascular diseases (CVD) and chronic kidney diseases. We aim at identifying Single Nucleotide Polymorphism (SNP) difference of hURAT1 (rs7932775) and ABCG2 (rs3825016) on CKD patient with hyperuricemia and/or gout. Methods: All forty-two CKD patients were divided into two groups: hyperuricemia, and control group. 24 hours urine sample and serum were prepared for testing biochemistry parameters. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method is used to analyze hURAT1 and ABCG2 single nucleotide polymorphisms in different groups. Results: 17 patients have CT SNP of hURAT1 (rs7932775) and 13 patients have CT SNP of ABCG2 (rs3825016) in hyperuricemia group, while only 5 persons and 6 persons have the same mutations in control group respectively. 7 patients have CT SNP of both hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group, while only 2 persons have the same mutations in control group. CT mutation rates of hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group were 60.7% (17/28) and 50% (13/28) respectively, higher than that of control group (35.7% (5/14) and 42.8% (6/14)). What is more, Double SNP mutations in both hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group were 25% (7/28), higher than that of control group (14.2%, 2/14). Conclusion: There are higher mutation rates of CT SNP in hURAT1 (rs7932775) and/or ABCG2 (rs3825016) in hyperuricemia group. We can conclude that hyperuricemia is a high risk factor in progress of CKD, which is necessary to take measures of decreasing serum uric acid to delay CKD progress.展开更多
Dear Editor,I am Dr. Feng Hu, from the Department of Ophthalmology of Beijing Tongren Hospital, Beijing, China. I write to present a case report of cytomegalovirus retinitis (CMVR) in Good’s syndrome (GS).GS is an ex...Dear Editor,I am Dr. Feng Hu, from the Department of Ophthalmology of Beijing Tongren Hospital, Beijing, China. I write to present a case report of cytomegalovirus retinitis (CMVR) in Good’s syndrome (GS).GS is an extremely rare primary immune-deficiency syndrome,which consists of simultaneous occurrence of展开更多
OBJECTIVE To explore the effects and underlying mechanism of Jieyu Anshen granule(JY) in chronic unpredictable mild stress(CUMS)-treated rats after ischemic stroke.METHODS A rat model of post-stroke depression(PSD) wa...OBJECTIVE To explore the effects and underlying mechanism of Jieyu Anshen granule(JY) in chronic unpredictable mild stress(CUMS)-treated rats after ischemic stroke.METHODS A rat model of post-stroke depression(PSD) was developed by additional CUMS procedures after middle cere.bral artery occlusion(MCAO).Sprague-Dawley rats were given 1 g·kg^(-1) and 3 g·kg^(-1) of JY by gastrogavage for 4 weeks.Escitalopram(10 mg·kg^(-1)) served as a reference drug.Behavioral tests including sucrose preference test,forced swim test and open-field test were performed to evaluate the antidepressant effects.Levels of norepinephrine(NE),dopamine(DA) and 5-hydroxytryptamine(5-HT) in rat brain were assayed.The anti-inflammatory activity was evaluated by measuring TNF-α and IL-1β in brain.Serum adrenocorticotropic hormone(ACTH) and corticosterone(CORT) were estimated as indices of hypothalamic-pituitary-adrenal(HPA) axis activity.Western blot analysis was used to evaluate hippo.campal expression of the 5-HT1 A receptor(5-HT_(1A)R) and brain-derived neurotrophic factor(BDNF).RESULTS PSD rats exhibited decreased sucrose consumption and motor activity,increased immobility time(P<0.01).JY treatment reversed the depressive behaviors in PSD rats(P<0.05,P<0.01).Treat.ment with JY resulted in significantly increased levels of NE,DA and 5-HT in the hippocampus and prefrontal cortex(P<0.05,P<0.01),and increased expression of 5-HT_(1A)R and BDNF in the hippocampus(P<0.01).JY treatment significantly down-regulated the levels of TNF-α and IL-1β in hippocampus and prefrontal cortex(P<0.05).Treatment with JY also resulted in significantly decreased ACTH and CORT in serum which had been increased(P<0.05).CONCLUSION These findings suggest that JY treat.ment could ameliorate PSD,and the effects are likely ascribed to inhibiting HPA axis hyperfunction and inflammatory,up-regulating the levels of neurotransmitters(NE,DA and 5-HT),and the expression of hippocampal 5-HT_(1A)R and BDNF.展开更多
The liver has a complex cellular composition and a remarkable regenerative capacity.The primary cell types in the liver are two parenchymal cell populations,hepatocytes and cholangiocytes,that perform most of the func...The liver has a complex cellular composition and a remarkable regenerative capacity.The primary cell types in the liver are two parenchymal cell populations,hepatocytes and cholangiocytes,that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells,endothelia and various hemopoietic cell populations.The regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydrates,the extracellular matrix,working synergistically with soluble paracrine and systemic signals.In recent years,with the rapid development of genetic sequencing technologies,research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensively explored.Meanwhile breakthroughs in strategies for cell transplantation are enabling a future in which there can be a rescue of patients with end-stage liver diseases,offering potential solutions to the chronic shortage of livers and alternatives to liver transplantation.This review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells to be transplanted to achieve liver regeneration and repair.Recent advances are summarized for promoting the treatment of end-stage liver diseases by forms of cell transplantation that now include grafting strategies.展开更多
The Real-Time Kinematic(RTK)positioning method of the Global Navigation Satellite System(GNSS)has been widely used for landslide monitoring.The stability of its reference station is crucial to obtain accurate and reli...The Real-Time Kinematic(RTK)positioning method of the Global Navigation Satellite System(GNSS)has been widely used for landslide monitoring.The stability of its reference station is crucial to obtain accurate and reliable monitoring results.Unstable reference stations due to the geological environment and human activities are difficult to detect and in practical applications often ignored.As a result,it affects the positioning solutions and subsequently the interpretation and detection of landslide motions,which must be addressed in GNSS landslide monitoring.To solve this problem,we propose using the Precise Point Positioning(PPP)technique to analyze the stability of the reference station by verifying its position.The deformations of the monitoring stations are then compensated.First,the reference station coordinates are obtained by the PPP technique and tectonic motion is considered in data processing.The change or breakout of the reference station position is then determined using a cumulative sum control chart method.Finally,each monitoring station’s displacements are compensated according to the displacements of the reference station.According to the results of the Tengqing landslide experiment,the PPP technique can be used in GNSS landslide monitoring to analyze the stability of reference stations.With PPP,millimeter-level accuracy for the coordinates of reference stations is achieved.Compared to the traditional deformation series,the compensated displacement series more reliably reflects the landslide motions.This study will increase the reliability of monitoring results and contribute to implementing GNSS in monitoring landslides.展开更多
To the Editor： Benign prostatic hyperplasia （BPH） is a prevalent chronic disease that predominately affects males aged over 40 years, characterized by benign unregulated hyperplasia that arises from stromal and epi...To the Editor： Benign prostatic hyperplasia （BPH） is a prevalent chronic disease that predominately affects males aged over 40 years, characterized by benign unregulated hyperplasia that arises from stromal and epithelial prostate cells. Although the association between altered microRNA （miRNA） expressions and the incidence of prostate cancer has been widely investigated, there still remains a poor understanding of the mechanism underlying miRNA expressions in BPH of the prostatic stroma. More recently, emerging evidence has highlighted the role ofantitumor miRNA-340 （miR-340） in the event of prostate cancer progression and metastasis.展开更多
基金This study was funded by the National keyResearch and Development program (2016YFC0303406)FundamentalResearch Funds for the Central University (HEUCFD1515,HEUCFM170113)+2 种基金High Technology Ship Funds of Ministry ofIndustry and Information of China, Assembly Advanced Research Fundof China (No. 6140210020105)China Postdoctoral Science Foundation(No. 2014M552661)Major innovation projects of High TechnologyShip Funds of Ministry of Industry and Information of China, Navalpre-research project, National Natural Science Foundation of China(Nos. 51209052 and 51 709 063).
文摘A series of tests of a full-scale river icebreaker was conducted to investigate the characteristics of ice-induced hull vibration.The test was conducted when the river icebreaker was operating in an ice-covered river at temperatures of-4 to 0°C with ice thicknesses of 300 to 400 mm.In the tests,the ice condition and icebreaker speed were chosen as the main influence factors.By analyzing the measured test data,we identified some important points regarding ice-induced hull vibration.When the river icebreaker navigates in an area with complete ice coverage,the peak value of the acceleration amplitude spectrum is highest.Also,the vibration response excited by the icebreaking load in an area with complete ice coverage exhibits more frequencies.With an increase in icebreaker speed,the vibration acceleration response gradually increases.However,habitability of the bow region on the main and driving decks is maintained due to the harmless vibration levels.In addition,the icebreaking operation of the river icebreaker causes violent local vibration of the grillage on the main deck.
文摘BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading lesions.Gross morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic evaluation.This is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United States.AIM To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal neoplasia.METHODS This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February 2017.The main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 mo.RESULTS A total of 480 patients with 500 lesions were included in the study.The median age was 68(Inter quantile range:14)with 52%males.The most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most prevalent.Submucosal invasion was present in 23(4.6%)out of 500 lesions.The independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value<0.004)and Paris classification 0-IIc(Odds ratio:18.2;P value<0.01).Out of 500,354 post-endoscopic mucosal resection scars were examined at surveillance colonoscopy.Recurrence was noted in 21.8%(77 cases).CONCLUSION There was overall low prevalence of SMIL in our study.Kudo pit pattern(IIIL+IV and V)and Paris classification 0-IIc were the only factors identified as an independent risk factor for submucosal invasion.The independent risk factor for recurrence was adenoma size(>40 mm).Almost all recurrences(98.8%)were treated endoscopically.
文摘Background: More and more chronic kidney disease (CKD) patients are accompanied with hyperuricaemia. As is known, hyperuricaemia is an independent hazard of both cardiovascular diseases (CVD) and chronic kidney diseases. We aim at identifying Single Nucleotide Polymorphism (SNP) difference of hURAT1 (rs7932775) and ABCG2 (rs3825016) on CKD patient with hyperuricemia and/or gout. Methods: All forty-two CKD patients were divided into two groups: hyperuricemia, and control group. 24 hours urine sample and serum were prepared for testing biochemistry parameters. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method is used to analyze hURAT1 and ABCG2 single nucleotide polymorphisms in different groups. Results: 17 patients have CT SNP of hURAT1 (rs7932775) and 13 patients have CT SNP of ABCG2 (rs3825016) in hyperuricemia group, while only 5 persons and 6 persons have the same mutations in control group respectively. 7 patients have CT SNP of both hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group, while only 2 persons have the same mutations in control group. CT mutation rates of hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group were 60.7% (17/28) and 50% (13/28) respectively, higher than that of control group (35.7% (5/14) and 42.8% (6/14)). What is more, Double SNP mutations in both hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group were 25% (7/28), higher than that of control group (14.2%, 2/14). Conclusion: There are higher mutation rates of CT SNP in hURAT1 (rs7932775) and/or ABCG2 (rs3825016) in hyperuricemia group. We can conclude that hyperuricemia is a high risk factor in progress of CKD, which is necessary to take measures of decreasing serum uric acid to delay CKD progress.
基金Supported by the Capital Health Research and Development of Special(No.SF-2018-2-1081)
文摘Dear Editor,I am Dr. Feng Hu, from the Department of Ophthalmology of Beijing Tongren Hospital, Beijing, China. I write to present a case report of cytomegalovirus retinitis (CMVR) in Good’s syndrome (GS).GS is an extremely rare primary immune-deficiency syndrome,which consists of simultaneous occurrence of
基金supported by National Natural Science Foundation of China(8157369)
文摘OBJECTIVE To explore the effects and underlying mechanism of Jieyu Anshen granule(JY) in chronic unpredictable mild stress(CUMS)-treated rats after ischemic stroke.METHODS A rat model of post-stroke depression(PSD) was developed by additional CUMS procedures after middle cere.bral artery occlusion(MCAO).Sprague-Dawley rats were given 1 g·kg^(-1) and 3 g·kg^(-1) of JY by gastrogavage for 4 weeks.Escitalopram(10 mg·kg^(-1)) served as a reference drug.Behavioral tests including sucrose preference test,forced swim test and open-field test were performed to evaluate the antidepressant effects.Levels of norepinephrine(NE),dopamine(DA) and 5-hydroxytryptamine(5-HT) in rat brain were assayed.The anti-inflammatory activity was evaluated by measuring TNF-α and IL-1β in brain.Serum adrenocorticotropic hormone(ACTH) and corticosterone(CORT) were estimated as indices of hypothalamic-pituitary-adrenal(HPA) axis activity.Western blot analysis was used to evaluate hippo.campal expression of the 5-HT1 A receptor(5-HT_(1A)R) and brain-derived neurotrophic factor(BDNF).RESULTS PSD rats exhibited decreased sucrose consumption and motor activity,increased immobility time(P<0.01).JY treatment reversed the depressive behaviors in PSD rats(P<0.05,P<0.01).Treat.ment with JY resulted in significantly increased levels of NE,DA and 5-HT in the hippocampus and prefrontal cortex(P<0.05,P<0.01),and increased expression of 5-HT_(1A)R and BDNF in the hippocampus(P<0.01).JY treatment significantly down-regulated the levels of TNF-α and IL-1β in hippocampus and prefrontal cortex(P<0.05).Treatment with JY also resulted in significantly decreased ACTH and CORT in serum which had been increased(P<0.05).CONCLUSION These findings suggest that JY treat.ment could ameliorate PSD,and the effects are likely ascribed to inhibiting HPA axis hyperfunction and inflammatory,up-regulating the levels of neurotransmitters(NE,DA and 5-HT),and the expression of hippocampal 5-HT_(1A)R and BDNF.
基金funded by Major Program of National Key Research and Development Project(Nos.2020YFA0112600 and 2019YFA0801502)National Natural Science Foundation of China(Nos.82173019,82270638,and 82203741)+8 种基金Shanghai Pujiang Program(No.21PJD059)the Project of Shanghai Science and Technology Commission(Nos.22ZR1451100,19140902900,and 22Y11908500),Program of Shanghai Academic/Technology Research Leader(No.20XD1434000)Peak Disciplines(Type Ⅳ)of Institutions of Higher Learning in Shanghai,Jiangxi Provincial Natural Science Foundation(No.20212ACB206033)Shanghai Engineering Research Center of Stem Cells Translational Medicine(No.20DZ2255100)funded by Vesta Therapeutics(Bethesda,MD),an NIH grant(HL051587)awarded to J.Piedrahita(NCSU,Raleigh,NC)funding from the UNC School of Medicine,the Fibrolamellar Carcinoma Foundation(Greenwich,CT)by multiple NIH Core and Center grants(5P41EB002025)Center for Gastrointestinal and Biliary Disease Biology(NIDDK Grant:P30 DK034987)the Lineberger Cancer Center grant(NCI grant#CA016086).
文摘The liver has a complex cellular composition and a remarkable regenerative capacity.The primary cell types in the liver are two parenchymal cell populations,hepatocytes and cholangiocytes,that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells,endothelia and various hemopoietic cell populations.The regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydrates,the extracellular matrix,working synergistically with soluble paracrine and systemic signals.In recent years,with the rapid development of genetic sequencing technologies,research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensively explored.Meanwhile breakthroughs in strategies for cell transplantation are enabling a future in which there can be a rescue of patients with end-stage liver diseases,offering potential solutions to the chronic shortage of livers and alternatives to liver transplantation.This review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells to be transplanted to achieve liver regeneration and repair.Recent advances are summarized for promoting the treatment of end-stage liver diseases by forms of cell transplantation that now include grafting strategies.
基金This work was funded by the National Natural Science Foundation of China(41941019,42090053,and 42127802)the Key R&D Program of Shaanxi Province(2022ZDLSF07-12)the Fundamental Research Funds for the Central Universities of CHD(300102263401).
文摘The Real-Time Kinematic(RTK)positioning method of the Global Navigation Satellite System(GNSS)has been widely used for landslide monitoring.The stability of its reference station is crucial to obtain accurate and reliable monitoring results.Unstable reference stations due to the geological environment and human activities are difficult to detect and in practical applications often ignored.As a result,it affects the positioning solutions and subsequently the interpretation and detection of landslide motions,which must be addressed in GNSS landslide monitoring.To solve this problem,we propose using the Precise Point Positioning(PPP)technique to analyze the stability of the reference station by verifying its position.The deformations of the monitoring stations are then compensated.First,the reference station coordinates are obtained by the PPP technique and tectonic motion is considered in data processing.The change or breakout of the reference station position is then determined using a cumulative sum control chart method.Finally,each monitoring station’s displacements are compensated according to the displacements of the reference station.According to the results of the Tengqing landslide experiment,the PPP technique can be used in GNSS landslide monitoring to analyze the stability of reference stations.With PPP,millimeter-level accuracy for the coordinates of reference stations is achieved.Compared to the traditional deformation series,the compensated displacement series more reliably reflects the landslide motions.This study will increase the reliability of monitoring results and contribute to implementing GNSS in monitoring landslides.
文摘To the Editor： Benign prostatic hyperplasia （BPH） is a prevalent chronic disease that predominately affects males aged over 40 years, characterized by benign unregulated hyperplasia that arises from stromal and epithelial prostate cells. Although the association between altered microRNA （miRNA） expressions and the incidence of prostate cancer has been widely investigated, there still remains a poor understanding of the mechanism underlying miRNA expressions in BPH of the prostatic stroma. More recently, emerging evidence has highlighted the role ofantitumor miRNA-340 （miR-340） in the event of prostate cancer progression and metastasis.
