BACKGROUND Miller fisher syndrome(MFS)is a variant of Guillain-Barrésyndrome,an acute immune-mediated peripheral neuropathy that is often secondary to viral infections.Anti-ganglioside antibodies play crucial rol...BACKGROUND Miller fisher syndrome(MFS)is a variant of Guillain-Barrésyndrome,an acute immune-mediated peripheral neuropathy that is often secondary to viral infections.Anti-ganglioside antibodies play crucial roles in the development of MFS.The positive rate of ganglioside antibodies is exceptionally high in MFS patients,particularly for anti-GQ1b antibodies.However,the presence of other ganglioside antibodies does not exclude MFS.CASE SUMMARY We present a 56-year-old female patient who suddenly developed right blepharoptosis and progressively worsening vision in both eyes.There were flu symptoms prior to onset,and a coronavirus disease 2019 test was positive.On physical examination,the patient exhibited bilateral extraocular muscle paralysis,weakened reflexes in both limbs,and impaired coordination.The cerebrospinal fluid examination results showed no obvious abnormalities.Bilateral peroneal nerve F-waves were not extracted.Serum anti-GD1b IgG and anti-GT1a IgG antibodies were positive.The patient received intravenous methylprednisolone(1000 mg/day),with the dosage gradually decreased.Additionally,intravenous high-dose immunoglobulin treatment was administered for 5 days(0.4 g/kg/day)from day 2 to day 6 of hospitalization.The patient’s symptoms improved after treatment with immunoglobulins and hormones.CONCLUSION Positive ganglioside antibodies may be used as supporting evidence for the diagnosis;however,the diagnosis of MFS is more reliant on clinical symptoms.展开更多
The internal behaviors of carriers in InGaAsP single-junction solar cell are investigated by using electroluminescence(EL) measurements. Two emission peaks can be observed in current-dependent electroluminescence spec...The internal behaviors of carriers in InGaAsP single-junction solar cell are investigated by using electroluminescence(EL) measurements. Two emission peaks can be observed in current-dependent electroluminescence spectra at low temperatures, and carrier localization exists for both peaks under low excitation. The trends of power index α extracted from excitation-dependent EL spectra at different temperatures imply that there exists a competition between Shockley–Read–Hall recombination and Auger recombination. Auger recombination becomes dominant at high temperatures, which is probably responsible for the lower current density of InGaAsP solar cell. Besides, the anomalous “S-shape” tendency with the temperature of band-edge peak position can be attributed to potential fluctuation and carrier redistribution, demonstrating delocalization, transfer, and redistribution of carriers in the continuum band-edge. Furthermore, the strong reduction of activation energy at high excitations indicates that electrons and holes escaped independently, and the faster-escaping carriers are holes.展开更多
Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of ST...Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of STAT3 in epithelial/tumor cells in inflammation-associated colorectal cancer(CRC)is associated with sphingosine-1-phosphate(S1P)receptor signaling.In inflammatory response whereby interleukin(IL)-6 production is abundant,STAT3-mediated pathways were found to promote the activation of sphingosine kinases(SphK1and SphK2)leading to the production of S1P.Reciprocally,S1P encourages the activation of STAT3 through a positive autocrine-loop signaling.The crosstalk between IL-6,STAT3 and sphingolipid regulated pathways may play an essential role in tumorigenesis and tumor progression in inflamed intestines.Therapeutics targeting both STAT3 and sphingolipid are therefore likely to contribute novel and more effective therapeutic strategies against inflammation-associated CRC.展开更多
In this paper, the problem of the global exponential stability analysis is investigated for a class of recurrent neural networks （RNNs） with time-varying discrete and distributed delays. Due to a novel technique whe...In this paper, the problem of the global exponential stability analysis is investigated for a class of recurrent neural networks （RNNs） with time-varying discrete and distributed delays. Due to a novel technique when estimating the upper bound of the derivative of Lyapunov functional, we establish new exponential stability criteria in terms of LMIs. It is shown that the obtained criteria can provide less conservative results than some existing ones. Numerical examples are given to show the effectiveness of the proposed results.展开更多
Placenta accreta spectrum disorder (PASD) and placenta previa (PP) are two of the mosthideous obstetric complications which are usually associated with a history of cesarean section(CS). Moreover, women with PASD, PP ...Placenta accreta spectrum disorder (PASD) and placenta previa (PP) are two of the mosthideous obstetric complications which are usually associated with a history of cesarean section(CS). Moreover, women with PASD, PP and/or a cesarean scarred uterus are more likely to haveadverse pregnancy outcomes, including blood transfusion, hysterectomy, pelvic organs damage,postpartum hemorhage, disseminated intravascular coagulation, multi-organ dysfunction syndromeand even maternal or fetal death. This study aimed to investigate the efficacy of precesareaninternal iliac artery balloon catheterization (BC) for managing severe hemorhage caused by PASDand PP with a history of CS. This participant-assigned interventional study was conducted inTongji Hospital. We recruited 128 women with suspected PASD, PP and a history of CS. Womenin the BC group accepted precesarean BC of bilateral internal iliac arteries before the scheduledcesarean delivery. Women in the control group underwent a conventional cesarean delivery.Intraoperative hemorrhage, transfusion volume, radiation dose, exposure time, complicationsand neonatal outcomes were discussed. There were significant differences in calculated bloodloss (CBL) between BC group and control group (1015.0±144.9 vs. 1467.0±171.0 mL, P=0.04).Precesarean BC could reduce intraoperative red blood cell (RBC) transfusion as compared withcontrol group (799.5±136.1 vs. 1286.0±161.6 mL, P=0.02) and lessen the rate of using bloodproducts (57.1% vs. 76.4%, P=0.02). The incidence of hysterectomy was also lower in BC groupthan in control group. Postpartum outcomes showed no significant differences between the twogroups, except that postoperation hospitalization was longer in BC group than in control group(6.7±0.4 vs. 5.8±0.2 days, P=0.03). Precesarean BC of internal iliac artery is an effective methodfor managing severe hemorrhage caused by PASD and PP with a cesarean scarred uterus, as it couldreduce intraoperative blood loss, lessen intraoperative RBC transfusions and potentially decreasehysterectomies.展开更多
This paper is concerned with the stability analysis for static recurrent neural networks （RNNs） with time-varying delay. By Lyapunov functional method and linear matrix inequality technique, some new delay-dependent...This paper is concerned with the stability analysis for static recurrent neural networks （RNNs） with time-varying delay. By Lyapunov functional method and linear matrix inequality technique, some new delay-dependent conditions are established to ensure the asymptotic stability of the neural network. Expressed in linear matrix inequalities （LMIs）, the proposed delay-dependent stability conditions can be checked using the recently developed algorithms. A numerical example is given to show that the obtained conditions can provide less conservative results than some existing ones.展开更多
Superfine green tea powder is a new kind of tea product that can be eaten directly.It provided most of the benefits of whole green tea leaves,with all of the bioactive ingredients.This paper highlighted the characteri...Superfine green tea powder is a new kind of tea product that can be eaten directly.It provided most of the benefits of whole green tea leaves,with all of the bioactive ingredients.This paper highlighted the characteristics and health benefits of superfine green tea powder,and its applications in food industry.展开更多
Purpose:To develop a multicultural nursing competence instrument for use in assessing undergraduate student nurses(SNs).Methods:This study enrolled 322 student nurses(SNs)employed at five hospitals in Hunan Province.T...Purpose:To develop a multicultural nursing competence instrument for use in assessing undergraduate student nurses(SNs).Methods:This study enrolled 322 student nurses(SNs)employed at five hospitals in Hunan Province.The nurses were identified by the cluster sampling method.The items on the competence instrument were retained or deleted after analyzing their coefficient of variation,coefficient of correlation with the total score,t-test results.Reliability tests and correlation analysis were used to examine internal consistency,while exploratory factor analysis was used to determine construct validity.Results:After analyzing items,the final multicultural nursing competence instrument comprised a total of 49 items that evaluated five dimensions.The instrument showed good overall reliability(0.958),and the internal consistency of the five dimensions ranged from 0.884 to 0.952.Furthermore,the correlations among the five dimensions were statistically significant(P<0.01).An exploratory factor analysis of the five dimensions showed that five items incorporated aspects of cultural cognition(factor loading range,0.824-0.888),five items incorporated aspects of cultural attitude(factor loading range,0.629-0.815),twentytwo items involved cultural knowledge(factor loading range,0.587-0.792),seven items incorporated aspects of cultural skills(factor loading range,0.743-0.860),and 10 items involved cultural encounters(factor loading range,0.522-0.909).Conclusion:The multicultural nursing competence instrument for SNs demonstrated good reliability and validity,and can be utilized in nursing education programs and research.展开更多
Objective:To study the anti-HCV activity and mechanism of Hehuan Yin aqueous extract.Methods:Huh7.5.1 cells were used to establish the HCV2a virus infection model.Cell survival rate(%)and Renilla Luciferase Assay Kit(...Objective:To study the anti-HCV activity and mechanism of Hehuan Yin aqueous extract.Methods:Huh7.5.1 cells were used to establish the HCV2a virus infection model.Cell survival rate(%)and Renilla Luciferase Assay Kit(%)were calculated by Celltiter-GLO Assay for evaluating CC50,EC50 and SI values.To observe the drug resistance of the virus to different concentrations of Hehuan Yin within 72 hours by detecting luciferase activity,western-blot was used to detect the protein expression levels of NS5A,NS3 and NS5B.Results:the CC50,EC50 and SI of Hehuan Yin against HCV2a were 132.50g/ml,1.90g/ml and 67.90 respectively.The EC50 after 24h,48h and 72h administration were 18g/ml,5.8g/ml and 2.3g/ml respectively.Within the range of drug concentration,the aqueous extract Hehuan Yin had inhibitory effect on the expression of NS5A and NS5B proteins in a dose-effect relationship,but had no obvious effect on the expression of NS3 protein.Conclusion:The aqueous extract of Hehuan Yin may inhibit the replication of HCV2a virus by changing the protein expression levels of NS5A and NS5B,and the virus has no tolerance to the aqueous extract of Hehuan Yin.展开更多
With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of di...With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.展开更多
To summarize the clinical experience of professor Luo Zhijuan in the treatment of premature ovarian insufficiency(POI).It is believed that the main pathogenesis of POI is kidney deficiency.On the basis of"tonifyi...To summarize the clinical experience of professor Luo Zhijuan in the treatment of premature ovarian insufficiency(POI).It is believed that the main pathogenesis of POI is kidney deficiency.On the basis of"tonifying the kidney".We advocate the"Rule of Thirds Theory"which is to treat POI according to different stages,menstrual cycles and syndromes,the prescription can be flexibly added or decreased.And make good use of cream prescription,to ping for a period of time,the curative effect is obvious.展开更多
Objective:To study the correlation of serum C-type natriuretic peptide (CNP) and insulin-like growth factor-Ⅱ (IGF-Ⅱ) contents with brain injury and inflammatory response in patients with craniocerebral trauma.Metho...Objective:To study the correlation of serum C-type natriuretic peptide (CNP) and insulin-like growth factor-Ⅱ (IGF-Ⅱ) contents with brain injury and inflammatory response in patients with craniocerebral trauma.Methods: Patients with craniocerebral trauma who were treated in the First Affiliated Hospital of Xi'an Jiaotong University between March 2015 and July 2017 were included in the case group of the study, and the healthy volunteers who received physical examination during the same period were included in the control group. The contents of CNP, IGF-Ⅱ, nerve markers and pro-inflammatory cytokines in serum as well as the expression of inflammatory signaling molecules in peripheral blood were measured.Results: CNP and IGF-Ⅱ contents in serum of case group were significantly lower than those of control group whereas UCH-L1, GFAP, S100B, Tau, MIP-1α, IL-1β, IL-6, IL-8 and TNF-α contents in serum as well as JAK2, STAT3, MEK and ERK1/2 mRNA expression in peripheral blood were significantly higher than those of control group;CNP and IGF-Ⅱ contents in serum of case group were negatively correlated with UCH-L1, GFAP, S100B, Tau, MIP-1α, IL-1β, IL-6, IL-8 and TNF-α contents in serum as well as JAK2, STAT3, MEK and ERK1/2 mRNA expression in peripheral blood.Conclusion: The decrease of serum CNP and IGF-Ⅱ in patients with craniocerebral trauma is closely related to the aggravation of brain injury and the over-activation of inflammatory response.展开更多
To brew tea correctly is very important to absorb the tea nutrition for people.The dynamic changes of the main compositions in brewing Pu'erh tea processing with different conditions were studied.Three different t...To brew tea correctly is very important to absorb the tea nutrition for people.The dynamic changes of the main compositions in brewing Pu'erh tea processing with different conditions were studied.Three different temperatures and eight times were designed to study the effects on the tea infusion quality.The index t0.5min(50%concentration of compounds in tea infusion) was used to evaluate the extract speed of compound in this experiment.The results showed that caffeine solubility speed at 80℃ was the highest to compare with tea polyphenols,amino acid,caffeine,soluble sugar,theaflavins and theabrownine,t0.5min of caffeine was 4.8 min,amino acid 10.3min was the second,the third one was tea polyphenols,soluble sugar was the lowest.We also found in different infusion temperature the t0.5min of compounds was distinguishing.With increasing the temperature all t0.5min of six compounds were shorter.However,the change regulations of t0.5min for all compounds in 90℃ and 100℃ were similar to in 80℃.Total quality score(TQS) were applied to evaluate the quality of tea infusion.The results found the TQS score of infusion was higher with the temperature rising,and the temperature to brew best quality infusion was 100℃ for 4-5min.According to the multiple regression analysis between sensory assessments and chemical components of Pu'erh tea we suggested the TQS was mainly affected by theaflavins,amino acid,soluble sugar and theabrowine four factors in 100℃.展开更多
Major depression disorder(MDD),which can affect individuals of any age,is one of the most common diseases,affecting an estimated 350 million people worldwide and placing a significant burden on individuals and society...Major depression disorder(MDD),which can affect individuals of any age,is one of the most common diseases,affecting an estimated 350 million people worldwide and placing a significant burden on individuals and society.MDD is heterogeneous.The conventional antidepressants are only partially effective and only 44%of patients are in remission during treatment.Therefore,improving the efficacy of MDD therapy has become a key research focus.An increasing number of studies have shown that the microbiota-gut-brain axis is closely related to the physiological and pathological processes of depression,suggesting that the gut microbiota may have protective or pathogenic effects on the development of MDD.Gut microbiota-oriented treatment is one of the most promising approaches.Fecal microbiota transplantation(FMT)has great potential to improve MDD more directly and effectively,although few research results in this area has been conducted.To assess the gut microbiota's connection with MDD,the efficiency of the nodes and the prospects of FMT therapy for MDD have been reviewed in this paper.展开更多
Since the discovery of ferromagnetic morphotropic phase boundary(MPB)in 2010,the connotation and extension of MPB have been becoming more and more abundant.Over the last dozen years,much experimental work has been don...Since the discovery of ferromagnetic morphotropic phase boundary(MPB)in 2010,the connotation and extension of MPB have been becoming more and more abundant.Over the last dozen years,much experimental work has been done to design magnetostrictive materials based on the MPB principle.However,due to the difficulty in direct experimental observations and the complexity of theoretical treatments,the insight into the microstructure property relationships and underlying mechanisms near the ferromagnetic MPB has not been fully revealed.Here,we have reviewed our recent computer simulation work about the super-magnetoelastic behavior near the critical region of several typical materials.Phase-field modeling and simulation are employed to explore the domain configuration and engineering in single crystals as well as the grain size effect in polycrystals.Besides,a general nano-embryonic mechanism for superelasticity is also introduced.Finally,some future perspectives and challenges are presented to stimulate a deeper consideration of the research paradigm between multiscale modeling and material development.展开更多
We present the electromagnetically induced transparency(EIT)spectra of cold Rydberg four-level cascade atoms consisting of the 6S_(1/2)→6P_(3/2)→7S_(1/2)→60P_(3/2) scheme.A coupling laser drives the Rydberg transit...We present the electromagnetically induced transparency(EIT)spectra of cold Rydberg four-level cascade atoms consisting of the 6S_(1/2)→6P_(3/2)→7S_(1/2)→60P_(3/2) scheme.A coupling laser drives the Rydberg transition,a dressing laser couples two intermediate levels and a weak probe laser probes the EIT signal.We numerically solve the Bloch equations and investigate the dependence of the probe transmission rate signal on the coupling and dressing lasers.We find that the probe transmission rate can display an EIT or electromagnetically induced absorption(EIA)profile,depending on the Rabi frequencies of the coupling and dressing lasers.When we increase the Rabi frequency of the coupling laser and keep the Rabi frequency of the probe and dressing laser fixed,flipping of the EIA to EIT spectrum occurs at the critical coupling Rabi frequency.When we apply a microwave field coupling the transition 60P_(3/2)→61S_(1/2),the EIT spectrum shows Autler–Townes splitting,which is employed to measure the microwave field.The theoretical measurement sensitivity can be 1.52×10^(−2) nV・cm^(−1)・Hz−^(1/2) at the EIA–EIT flipping point.展开更多
Theaflavins(TFs) are the dimers of a couple of epimerized catechins,which are specially formed during black tea fermentation.To explore the differences among four main TF derivatives(theaflavin(TF 1),theaflavin3-galla...Theaflavins(TFs) are the dimers of a couple of epimerized catechins,which are specially formed during black tea fermentation.To explore the differences among four main TF derivatives(theaflavin(TF 1),theaflavin3-gallate(TF 2 A),theaflavin-3'-gallate(TF 2 B),and theaflavin-3,3'-digallate(TF 3)) in scavenging reactive oxygen species(ROS) in vitro,their properties of inhibiting superoxide,singlet oxygen,hydrogen peroxide,and the hydroxyl radical,and their effects on hydroxyl radical-induced DNA oxidative damage were systematically analyzed in the present study.The results show that,compared with()-epigallocatechin gallate(EGCG),TF derivatives were good antioxidants for scavenging ROS and preventing the hydroxyl radical-induced DNA damage in vitro.TF 3 was the most positive in scavenging hydrogen peroxide and hydroxyl radical,and TF 1 suppressed superoxide.Positive antioxidant capacities of TF 2 B on singlet oxygen,hydrogen peroxide,hydroxyl radical,and the hydroxyl radical-induced DNA damage in vitro were found.The differences between the antioxidant capacities of four main TF derivatives in relation to their chemical structures were also discussed.We suggest that these activity differences among TF derivatives would be beneficial to scavenge different ROS with therapeutic potential.展开更多
As a novel structure, inverse opal, with threedimensional periodic macropore and mesopore and huge specific surface area, has great promising applications. In this paper, tin dioxide (SnO_(2)) inverse opal films were ...As a novel structure, inverse opal, with threedimensional periodic macropore and mesopore and huge specific surface area, has great promising applications. In this paper, tin dioxide (SnO_(2)) inverse opal films were prepared with sol–gel method by cooperative opal template. The surface morphologies of SnO_(2)inverse opal films were examined by scanning electron microscopy (SEM), the inner structure of SnO_(2)inverse opal films was examined by transmission electron microscopy (TEM), the optical properties of SnO_(2)inverse opal films were studied and discussed in detail. Optical reflectance spectra reveal that, for the opal films, the wavelengths of the reflectance peak confirmed by the experimental reflectance spectra are consistent with the theoretical values;for the SnO_(2)inverse opal films, the wavelengths of the reflectance peak confirmed by the experimental reflectance spectra deviate from theoretical values largely.展开更多
文摘BACKGROUND Miller fisher syndrome(MFS)is a variant of Guillain-Barrésyndrome,an acute immune-mediated peripheral neuropathy that is often secondary to viral infections.Anti-ganglioside antibodies play crucial roles in the development of MFS.The positive rate of ganglioside antibodies is exceptionally high in MFS patients,particularly for anti-GQ1b antibodies.However,the presence of other ganglioside antibodies does not exclude MFS.CASE SUMMARY We present a 56-year-old female patient who suddenly developed right blepharoptosis and progressively worsening vision in both eyes.There were flu symptoms prior to onset,and a coronavirus disease 2019 test was positive.On physical examination,the patient exhibited bilateral extraocular muscle paralysis,weakened reflexes in both limbs,and impaired coordination.The cerebrospinal fluid examination results showed no obvious abnormalities.Bilateral peroneal nerve F-waves were not extracted.Serum anti-GD1b IgG and anti-GT1a IgG antibodies were positive.The patient received intravenous methylprednisolone(1000 mg/day),with the dosage gradually decreased.Additionally,intravenous high-dose immunoglobulin treatment was administered for 5 days(0.4 g/kg/day)from day 2 to day 6 of hospitalization.The patient’s symptoms improved after treatment with immunoglobulins and hormones.CONCLUSION Positive ganglioside antibodies may be used as supporting evidence for the diagnosis;however,the diagnosis of MFS is more reliant on clinical symptoms.
基金Project supported by the National Key Research and Development Program,China (Grant No.2018YFB2003305)the National Natural Science Foundation of China (Grant Nos.61774165 and 61827823)the Key Laboratory Fund in Suzhou Institute of Suzhou Nano-Tech and NanoBionis (SINANO),Chinese Academy of Sciences (Grant No.Y4JAQ21005)。
文摘The internal behaviors of carriers in InGaAsP single-junction solar cell are investigated by using electroluminescence(EL) measurements. Two emission peaks can be observed in current-dependent electroluminescence spectra at low temperatures, and carrier localization exists for both peaks under low excitation. The trends of power index α extracted from excitation-dependent EL spectra at different temperatures imply that there exists a competition between Shockley–Read–Hall recombination and Auger recombination. Auger recombination becomes dominant at high temperatures, which is probably responsible for the lower current density of InGaAsP solar cell. Besides, the anomalous “S-shape” tendency with the temperature of band-edge peak position can be attributed to potential fluctuation and carrier redistribution, demonstrating delocalization, transfer, and redistribution of carriers in the continuum band-edge. Furthermore, the strong reduction of activation energy at high excitations indicates that electrons and holes escaped independently, and the faster-escaping carriers are holes.
文摘Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of STAT3 in epithelial/tumor cells in inflammation-associated colorectal cancer(CRC)is associated with sphingosine-1-phosphate(S1P)receptor signaling.In inflammatory response whereby interleukin(IL)-6 production is abundant,STAT3-mediated pathways were found to promote the activation of sphingosine kinases(SphK1and SphK2)leading to the production of S1P.Reciprocally,S1P encourages the activation of STAT3 through a positive autocrine-loop signaling.The crosstalk between IL-6,STAT3 and sphingolipid regulated pathways may play an essential role in tumorigenesis and tumor progression in inflamed intestines.Therapeutics targeting both STAT3 and sphingolipid are therefore likely to contribute novel and more effective therapeutic strategies against inflammation-associated CRC.
基金supported by National Natural Science Foundation of China (No.60674027,No.60974127)Key Project of Education Ministry of China (No.208074)
文摘In this paper, the problem of the global exponential stability analysis is investigated for a class of recurrent neural networks （RNNs） with time-varying discrete and distributed delays. Due to a novel technique when estimating the upper bound of the derivative of Lyapunov functional, we establish new exponential stability criteria in terms of LMIs. It is shown that the obtained criteria can provide less conservative results than some existing ones. Numerical examples are given to show the effectiveness of the proposed results.
基金supported by grants from the NationalScience & Technology Pillar Program of China duringthe Twelfth Five-year Plan Period (No. 2014BAI05B05)the National Natural Science Foundation of China (No.81873843)the Foundation at Research Funds forthe Central Universities (No. 2017kfyXJJ102 and No.2019kfyXKJC053).
文摘Placenta accreta spectrum disorder (PASD) and placenta previa (PP) are two of the mosthideous obstetric complications which are usually associated with a history of cesarean section(CS). Moreover, women with PASD, PP and/or a cesarean scarred uterus are more likely to haveadverse pregnancy outcomes, including blood transfusion, hysterectomy, pelvic organs damage,postpartum hemorhage, disseminated intravascular coagulation, multi-organ dysfunction syndromeand even maternal or fetal death. This study aimed to investigate the efficacy of precesareaninternal iliac artery balloon catheterization (BC) for managing severe hemorhage caused by PASDand PP with a history of CS. This participant-assigned interventional study was conducted inTongji Hospital. We recruited 128 women with suspected PASD, PP and a history of CS. Womenin the BC group accepted precesarean BC of bilateral internal iliac arteries before the scheduledcesarean delivery. Women in the control group underwent a conventional cesarean delivery.Intraoperative hemorrhage, transfusion volume, radiation dose, exposure time, complicationsand neonatal outcomes were discussed. There were significant differences in calculated bloodloss (CBL) between BC group and control group (1015.0±144.9 vs. 1467.0±171.0 mL, P=0.04).Precesarean BC could reduce intraoperative red blood cell (RBC) transfusion as compared withcontrol group (799.5±136.1 vs. 1286.0±161.6 mL, P=0.02) and lessen the rate of using bloodproducts (57.1% vs. 76.4%, P=0.02). The incidence of hysterectomy was also lower in BC groupthan in control group. Postpartum outcomes showed no significant differences between the twogroups, except that postoperation hospitalization was longer in BC group than in control group(6.7±0.4 vs. 5.8±0.2 days, P=0.03). Precesarean BC of internal iliac artery is an effective methodfor managing severe hemorrhage caused by PASD and PP with a cesarean scarred uterus, as it couldreduce intraoperative blood loss, lessen intraoperative RBC transfusions and potentially decreasehysterectomies.
基金supported by National Natural Science Foundation of China (No. 60674027)
文摘This paper is concerned with the stability analysis for static recurrent neural networks （RNNs） with time-varying delay. By Lyapunov functional method and linear matrix inequality technique, some new delay-dependent conditions are established to ensure the asymptotic stability of the neural network. Expressed in linear matrix inequalities （LMIs）, the proposed delay-dependent stability conditions can be checked using the recently developed algorithms. A numerical example is given to show that the obtained conditions can provide less conservative results than some existing ones.
基金supported by Zhejiang Provincial Natural Science Foundation of China (LQ12C20007)Scientific Research Fund of Zhejiang Provincial Education department (Y201226032)Zhejiang Provincial key program for Tea Innovation and Technology group (No.2011R50024)
文摘Superfine green tea powder is a new kind of tea product that can be eaten directly.It provided most of the benefits of whole green tea leaves,with all of the bioactive ingredients.This paper highlighted the characteristics and health benefits of superfine green tea powder,and its applications in food industry.
基金This research was partially funded by the Social Science Fund of Hengyang city(Project number:2014D132)the Education Science“Twelfth Five-year”plan of Hunan province(Project number:XJK014BGD069).
文摘Purpose:To develop a multicultural nursing competence instrument for use in assessing undergraduate student nurses(SNs).Methods:This study enrolled 322 student nurses(SNs)employed at five hospitals in Hunan Province.The nurses were identified by the cluster sampling method.The items on the competence instrument were retained or deleted after analyzing their coefficient of variation,coefficient of correlation with the total score,t-test results.Reliability tests and correlation analysis were used to examine internal consistency,while exploratory factor analysis was used to determine construct validity.Results:After analyzing items,the final multicultural nursing competence instrument comprised a total of 49 items that evaluated five dimensions.The instrument showed good overall reliability(0.958),and the internal consistency of the five dimensions ranged from 0.884 to 0.952.Furthermore,the correlations among the five dimensions were statistically significant(P<0.01).An exploratory factor analysis of the five dimensions showed that five items incorporated aspects of cultural cognition(factor loading range,0.824-0.888),five items incorporated aspects of cultural attitude(factor loading range,0.629-0.815),twentytwo items involved cultural knowledge(factor loading range,0.587-0.792),seven items incorporated aspects of cultural skills(factor loading range,0.743-0.860),and 10 items involved cultural encounters(factor loading range,0.522-0.909).Conclusion:The multicultural nursing competence instrument for SNs demonstrated good reliability and validity,and can be utilized in nursing education programs and research.
基金Natural Foundation of Guangdong Province(No.2018A030313308)。
文摘Objective:To study the anti-HCV activity and mechanism of Hehuan Yin aqueous extract.Methods:Huh7.5.1 cells were used to establish the HCV2a virus infection model.Cell survival rate(%)and Renilla Luciferase Assay Kit(%)were calculated by Celltiter-GLO Assay for evaluating CC50,EC50 and SI values.To observe the drug resistance of the virus to different concentrations of Hehuan Yin within 72 hours by detecting luciferase activity,western-blot was used to detect the protein expression levels of NS5A,NS3 and NS5B.Results:the CC50,EC50 and SI of Hehuan Yin against HCV2a were 132.50g/ml,1.90g/ml and 67.90 respectively.The EC50 after 24h,48h and 72h administration were 18g/ml,5.8g/ml and 2.3g/ml respectively.Within the range of drug concentration,the aqueous extract Hehuan Yin had inhibitory effect on the expression of NS5A and NS5B proteins in a dose-effect relationship,but had no obvious effect on the expression of NS3 protein.Conclusion:The aqueous extract of Hehuan Yin may inhibit the replication of HCV2a virus by changing the protein expression levels of NS5A and NS5B,and the virus has no tolerance to the aqueous extract of Hehuan Yin.
基金Youth fund project of guangxi first-class discipline construction and opening subject(No.2019XK175)University-level innovation project for general postgraduate students of guangxi university of traditional Chinese medicine(No.YCSY201900112)
文摘With the national second child policy, old-age fertility problem increasingly prominent, female fertility decline by the increase of age, so the incidence of infertility also will increase from the understanding of disease dialectical trichotomy therapy to summarize professor LUO Zhi-juan clinical experience infertility think the disease occurs mainly in kidney empty as this, liver and spleen viscera dysfunction to heart, wet phlegm and blood stasis as the main pathological product of common cause kidney - menstruation - ran ren - cell palace reproductive axis dysfunction and infertility.
基金Guangxi first-class subject construction open subject youth fund project(No.2019XK175)
文摘To summarize the clinical experience of professor Luo Zhijuan in the treatment of premature ovarian insufficiency(POI).It is believed that the main pathogenesis of POI is kidney deficiency.On the basis of"tonifying the kidney".We advocate the"Rule of Thirds Theory"which is to treat POI according to different stages,menstrual cycles and syndromes,the prescription can be flexibly added or decreased.And make good use of cream prescription,to ping for a period of time,the curative effect is obvious.
文摘Objective:To study the correlation of serum C-type natriuretic peptide (CNP) and insulin-like growth factor-Ⅱ (IGF-Ⅱ) contents with brain injury and inflammatory response in patients with craniocerebral trauma.Methods: Patients with craniocerebral trauma who were treated in the First Affiliated Hospital of Xi'an Jiaotong University between March 2015 and July 2017 were included in the case group of the study, and the healthy volunteers who received physical examination during the same period were included in the control group. The contents of CNP, IGF-Ⅱ, nerve markers and pro-inflammatory cytokines in serum as well as the expression of inflammatory signaling molecules in peripheral blood were measured.Results: CNP and IGF-Ⅱ contents in serum of case group were significantly lower than those of control group whereas UCH-L1, GFAP, S100B, Tau, MIP-1α, IL-1β, IL-6, IL-8 and TNF-α contents in serum as well as JAK2, STAT3, MEK and ERK1/2 mRNA expression in peripheral blood were significantly higher than those of control group;CNP and IGF-Ⅱ contents in serum of case group were negatively correlated with UCH-L1, GFAP, S100B, Tau, MIP-1α, IL-1β, IL-6, IL-8 and TNF-α contents in serum as well as JAK2, STAT3, MEK and ERK1/2 mRNA expression in peripheral blood.Conclusion: The decrease of serum CNP and IGF-Ⅱ in patients with craniocerebral trauma is closely related to the aggravation of brain injury and the over-activation of inflammatory response.
基金supported by a research grant of Philips "Brain-Bridge Plan"
文摘To brew tea correctly is very important to absorb the tea nutrition for people.The dynamic changes of the main compositions in brewing Pu'erh tea processing with different conditions were studied.Three different temperatures and eight times were designed to study the effects on the tea infusion quality.The index t0.5min(50%concentration of compounds in tea infusion) was used to evaluate the extract speed of compound in this experiment.The results showed that caffeine solubility speed at 80℃ was the highest to compare with tea polyphenols,amino acid,caffeine,soluble sugar,theaflavins and theabrownine,t0.5min of caffeine was 4.8 min,amino acid 10.3min was the second,the third one was tea polyphenols,soluble sugar was the lowest.We also found in different infusion temperature the t0.5min of compounds was distinguishing.With increasing the temperature all t0.5min of six compounds were shorter.However,the change regulations of t0.5min for all compounds in 90℃ and 100℃ were similar to in 80℃.Total quality score(TQS) were applied to evaluate the quality of tea infusion.The results found the TQS score of infusion was higher with the temperature rising,and the temperature to brew best quality infusion was 100℃ for 4-5min.According to the multiple regression analysis between sensory assessments and chemical components of Pu'erh tea we suggested the TQS was mainly affected by theaflavins,amino acid,soluble sugar and theabrowine four factors in 100℃.
文摘Major depression disorder(MDD),which can affect individuals of any age,is one of the most common diseases,affecting an estimated 350 million people worldwide and placing a significant burden on individuals and society.MDD is heterogeneous.The conventional antidepressants are only partially effective and only 44%of patients are in remission during treatment.Therefore,improving the efficacy of MDD therapy has become a key research focus.An increasing number of studies have shown that the microbiota-gut-brain axis is closely related to the physiological and pathological processes of depression,suggesting that the gut microbiota may have protective or pathogenic effects on the development of MDD.Gut microbiota-oriented treatment is one of the most promising approaches.Fecal microbiota transplantation(FMT)has great potential to improve MDD more directly and effectively,although few research results in this area has been conducted.To assess the gut microbiota's connection with MDD,the efficiency of the nodes and the prospects of FMT therapy for MDD have been reviewed in this paper.
基金supported by the Natural Science Foundation of China(Nos.51701091,12174210 and 52174346)Shandong Provincial Natural Science Foundation,China(Nos.ZR2020QE028 and ZR2022ME030)+2 种基金the Innovation Team of Higher Educational Science and Technology Program in Shandong Province(No.2019KJA025)the Research Foundation of Liaocheng University(No.318012119)the Science and Technology Innovation Foundation of Liaocheng University(No.CXCY2021139)。
文摘Since the discovery of ferromagnetic morphotropic phase boundary(MPB)in 2010,the connotation and extension of MPB have been becoming more and more abundant.Over the last dozen years,much experimental work has been done to design magnetostrictive materials based on the MPB principle.However,due to the difficulty in direct experimental observations and the complexity of theoretical treatments,the insight into the microstructure property relationships and underlying mechanisms near the ferromagnetic MPB has not been fully revealed.Here,we have reviewed our recent computer simulation work about the super-magnetoelastic behavior near the critical region of several typical materials.Phase-field modeling and simulation are employed to explore the domain configuration and engineering in single crystals as well as the grain size effect in polycrystals.Besides,a general nano-embryonic mechanism for superelasticity is also introduced.Finally,some future perspectives and challenges are presented to stimulate a deeper consideration of the research paradigm between multiscale modeling and material development.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.U2341211,62175136,12241408,and 12120101004)the Innovation Program for Quantum Science and Technology(Grant No.2023ZD0300902)+1 种基金the Fundamental Research Program of Shanxi Province(Grant No.202303021224007)the 1331 Project of Shanxi Province.
文摘We present the electromagnetically induced transparency(EIT)spectra of cold Rydberg four-level cascade atoms consisting of the 6S_(1/2)→6P_(3/2)→7S_(1/2)→60P_(3/2) scheme.A coupling laser drives the Rydberg transition,a dressing laser couples two intermediate levels and a weak probe laser probes the EIT signal.We numerically solve the Bloch equations and investigate the dependence of the probe transmission rate signal on the coupling and dressing lasers.We find that the probe transmission rate can display an EIT or electromagnetically induced absorption(EIA)profile,depending on the Rabi frequencies of the coupling and dressing lasers.When we increase the Rabi frequency of the coupling laser and keep the Rabi frequency of the probe and dressing laser fixed,flipping of the EIA to EIT spectrum occurs at the critical coupling Rabi frequency.When we apply a microwave field coupling the transition 60P_(3/2)→61S_(1/2),the EIT spectrum shows Autler–Townes splitting,which is employed to measure the microwave field.The theoretical measurement sensitivity can be 1.52×10^(−2) nV・cm^(−1)・Hz−^(1/2) at the EIA–EIT flipping point.
基金Project supported by the National Natural Science Foundation of China (No. 30901002)the Fundamental Research Funds for the Central Universitiesthe China Postdoctoral Science Foundation Funded Project (No. 20070421210)
文摘Theaflavins(TFs) are the dimers of a couple of epimerized catechins,which are specially formed during black tea fermentation.To explore the differences among four main TF derivatives(theaflavin(TF 1),theaflavin3-gallate(TF 2 A),theaflavin-3'-gallate(TF 2 B),and theaflavin-3,3'-digallate(TF 3)) in scavenging reactive oxygen species(ROS) in vitro,their properties of inhibiting superoxide,singlet oxygen,hydrogen peroxide,and the hydroxyl radical,and their effects on hydroxyl radical-induced DNA oxidative damage were systematically analyzed in the present study.The results show that,compared with()-epigallocatechin gallate(EGCG),TF derivatives were good antioxidants for scavenging ROS and preventing the hydroxyl radical-induced DNA damage in vitro.TF 3 was the most positive in scavenging hydrogen peroxide and hydroxyl radical,and TF 1 suppressed superoxide.Positive antioxidant capacities of TF 2 B on singlet oxygen,hydrogen peroxide,hydroxyl radical,and the hydroxyl radical-induced DNA damage in vitro were found.The differences between the antioxidant capacities of four main TF derivatives in relation to their chemical structures were also discussed.We suggest that these activity differences among TF derivatives would be beneficial to scavenge different ROS with therapeutic potential.
基金financially supported by the National Natural Science Foundation of China (No. 51072177)Jiangsu Province Environmental Material Key Laboratory Project (No. 017375003)Jiangsu Ordinary University Graduate Students Scientific Research Innovation Project (No. CXZZ12_0896)。
文摘As a novel structure, inverse opal, with threedimensional periodic macropore and mesopore and huge specific surface area, has great promising applications. In this paper, tin dioxide (SnO_(2)) inverse opal films were prepared with sol–gel method by cooperative opal template. The surface morphologies of SnO_(2)inverse opal films were examined by scanning electron microscopy (SEM), the inner structure of SnO_(2)inverse opal films was examined by transmission electron microscopy (TEM), the optical properties of SnO_(2)inverse opal films were studied and discussed in detail. Optical reflectance spectra reveal that, for the opal films, the wavelengths of the reflectance peak confirmed by the experimental reflectance spectra are consistent with the theoretical values;for the SnO_(2)inverse opal films, the wavelengths of the reflectance peak confirmed by the experimental reflectance spectra deviate from theoretical values largely.
