Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can b...Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression.However,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information representation.Here,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any attenuation.Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.展开更多
Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage devices.However,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their a...Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage devices.However,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their applications.Herein,single nickel(Ni)atoms on two-dimensional(2D)nitrogen(N)-doped carbon with Ni-N_(4)-O overcoordinated structure(SANi-N_(4)-O/NC)are prepared and firstly used as a sulfur host of Li-S batteries.Due to the efficient polysulfides traps and highly LiPSs conversion effect of SANi-N_(4)-O/NC,the electrochemical performance of Li-S batteries obviously improved.The batteries can well operate even under high sulfur loading(5.8 mg cm^(-2))and lean electrolyte(6.1μL mg^(-1))condition.Meanwhile,density functional theory(DFT)calculations demonstrate that Ni single atom’s active sites decrease the energy barriers of conversion reactions from Li_(2)S_(8)to Li2S due to the strong interaction between SANi-N_(4)-O/NC and LiPSs.Thus,the kinetic conversion of LiPSs was accelerated and the shuttle effect is suppressed on SANi-N_(4)-O/NC host.This study provides a new design strategy for a 2D structure with single-atom overcoordinated active sites to facilitate the fast kinetic conversion of LiPSs for Li-S cathode.展开更多
Hybrid supercapacitors have shown great potentials to fulfill the demand of future diverse applications such as electric vehicles and portable/wearable electronics.In particular,aqueous zinc-ion hybrid supercapacitors...Hybrid supercapacitors have shown great potentials to fulfill the demand of future diverse applications such as electric vehicles and portable/wearable electronics.In particular,aqueous zinc-ion hybrid supercapacitors(ZHSCs)have gained much attention due to their low-cost,high energy density,and environmental friendliness.Nevertheless,typical ZHSCs use Zn metal anode and normal liquid electrolyte,causing the dendrite issue,restricted working temperature,and inferior device flexibility.Herein,a novel flexible Zn-ion hybrid supercapacitor(FZHSC)is developed by using activated carbon(AC)anode,δ-MnO_(2) cathode,and innovative PVA-based gel electrolyte.In this design,heavy Zn anode and its dendrite issue are avoided and layered cathode with large interlayer spacing is employed.In addition,flexible electrodes are prepared and integrated with an anti-freezing,stretchable,and compressible hydrogel electrolyte,which is attained by simultaneously using glycerol additive and freezing/thawing technique to regulate the hydrogen bond and microstructure.The resulting FZHSC exhibits good rate capability,high energy density(47.86 Wh kg^(−1);3.94 mWh cm^(−3)),high power density(5.81 kW kg^(−1);480 mW cm^(−3)),and excellent cycling stability(~91%capacity retention after 30000 cycles).Furthermore,our FZHSC demonstrates outstanding flexibility with capacitance almost unchanged even after various continuous shape deformations.The hydrogel electrolyte still maintains high ionic conductivity at ultralow temperatures(≤−30℃),enabling the FZHSC cycled well,and powering electronic timer robustly within an all-climate temperature range of−30~80℃.This work highlights that the promising Zn metal-free aqueous ZHSCs can be designed with great multifunctionality for more practical application scenarios.展开更多
Reclaimed water irrigation has become an effective mean to alleviate the contradiction between water availability and its consumption worldwide.In this study,three types of irrigation water sources(rural sewage’s pri...Reclaimed water irrigation has become an effective mean to alleviate the contradiction between water availability and its consumption worldwide.In this study,three types of irrigation water sources(rural sewage’s primary treated water R1 and secondary treated water R2,and river water R3)meeting the requirements of water quality for farmland irrigation were selected,and three types of irrigation water levels(low water levelW1 of 0–80 mm,medium water level W2 of 0–100 mm,and high water level W3 of 0–150 mm)were adopted to carry out research on the influence mechanismS of different irrigation water sources and water levels on water and nitrogen use and crop growth in paddy field.The water quantity indicators(irrigation times and irrigation volume),soil ammonium nitrogen(NH4+-N)and nitrate nitrogen(NO3−-N),rice yield indicators(thousand-grain weight,the number of grains per spike,and the number of effective spikes),and quality indicators(the amount of protein,amylose,vitamin C,nitrate and nitrite content)of rice were measured.The results showed that,the average irrigation volume under W3 was 2.4 and 1.9 times of that under W1 and W2,respectively.Compared with R3,the peak consumption of rice was lagged behind under R1 and R2,and the nitrogen form in 0–40 cm soil layers under rural sewage irrigation was mainly NH4+-N.The changes of NO3−-N and NH4+-N in the 0–40 cm soil layer showed the trend of declining and then increasing.The water level control only had a significant effect on the change of NO3−-N in the 60–80 cm soil layer.Both irrigation water use efficiency and crop water use efficiency were gradually reduced with the increase of field water level control.The nitrogen utilization efficiency under rural sewage irrigation was significantly higher than that under R3.Compared with the R3,rural sewage irrigation could significantly increase the yield of rice,and as the field water level rose,the effect of yield promotion was more obvious.It was noteworthy that the grain of rice under R1 monitored the low nitrate and nitrite content,but no nitrate and nitrite was discovered under R2 and R3.Therefore,reasonable rural sewage irrigation(R2)and medium water level(W2)were beneficial to improve nitrogen utilization efficiency,crop yield and crop quality promotion.展开更多
Spectrally uncorrelated biphotons are the essential resources for achieving various quantum information processing protocols.We theoretically investigate the generation of spectrally uncorrelated biphotons emitted by ...Spectrally uncorrelated biphotons are the essential resources for achieving various quantum information processing protocols.We theoretically investigate the generation of spectrally uncorrelated biphotons emitted by spontaneous fourwave mixing from a fiber nonlinear interferometer which consists of an N-stage nonlinear gain fiber and an(N-1)-stage dispersion modulation fiber.The output biphoton states of nonlinear interference are the coherent superposition of various biphoton states born in each nonlinear fiber,and thus the interference fringe will reshape the biphoton joint spectra.As a result,resorting to Taylor expansion to first order for phase mismatching,we theoretically verify that the orientation of phase matching contours will rotate in a specific way with only varying the length of dispersion modulation fiber.The rotation in orientation of phase matching contours may result in spectrally uncorrelated biphotons and even arbitrary correlation biphotons.Further,we choose micro/nanofiber as the nonlinear gain fiber and single-mode communication fiber as dispersion modulation fiber to numerically simulate the generation of spectrally uncorrelated biphotons from spontaneous fourwave mixing.Here,due to significant frequency detuning(hundreds of THz),Raman background noise can be considerably suppressed,even at room temperature,and photons with largely tunable wavelengths can be achieved,indicating a practicability in many quantum fields.A photon mode purity of 97.2%will be theoretically attained without weakening the heralding nature of biphoton sources.We think that this fiber nonlinear interference with the flexibly engineered quantum state can be an excellent practical source for quantum information processing.展开更多
Infection of plum bark necrosis stem pitting associated virus(PBNSPaV)has been reported in many Prunus species in several countries,causing significant economic losses.The very small proteins encoded by plant viruses ...Infection of plum bark necrosis stem pitting associated virus(PBNSPaV)has been reported in many Prunus species in several countries,causing significant economic losses.The very small proteins encoded by plant viruses are often overlooked due to their short sequences and uncertain significance.However,numerous studies have indicated that they might play important roles in the pathogenesis of virus infection.The role of small hydrophobic protein P6,encoded by the open reading frame 2 of PBNSPaV,has not been well explored.In this study,we amplified the P6 fragment from a PBNSPaV isolate by RT-PCR using specific primers and found that it is 174 bp long and encodes a protein of approximately 6.3 kD with a transmembrane domain.Subcellular localization analysis of P6 proteins in tobacco leaves showed that P6 localizes to the cytomembrane and nuclear membrane.To further clarify the pathogenicity of P6 proteins,we constructed a PVX-P6 expression vector by inserting the p6 fragment into a potato virus X(PVX)-based vector and transformed it into Agrobacterium tumefaciens GV3101.Infiltration of Nicotiana benthamiana(N.benthamiana)with the PVX vector-transformed A.tumefaciens led to slight mosaic symptoms at 14 days of post-inoculation.Meanwhile,infiltration with the PVX-P6 vector-transformed A.tumefaciens resulted in no significant symptoms.These results demonstrated that heterologous expression of P6 in N.benthamiana could not enhance the pathogenicity of PVX.Our study indicates that P6 may not be a potential pathogenic factor associate with the causing of symptoms,and the mode of action of PBNSPaV-P6 protein remains to be further studied.展开更多
Objective: The “six-step teaching method” is a teaching method, which is summarized based on practical experience. This study aimed to explore the effect of “six-step teaching method” in clinical teaching of ...Objective: The “six-step teaching method” is a teaching method, which is summarized based on practical experience. This study aimed to explore the effect of “six-step teaching method” in clinical teaching of obstetrics. Methods: A quasi-experimental study design was used, 30 nursing students who entered obstetrics practice from March 2022 to July 2022 were selected as the control group according to the order of time, and traditional teaching methods were adopted. From August to December 2022, 30 interns were selected as the experimental group, and the “six-step teaching method” was adopted. After 8 weeks of clinical practice, the assessment results and teaching effect satisfaction of the two groups were compared. Results: The scores of obstetrical specialty in the experimental group were higher than those in the control group, and the difference was statistically significant (P < 0.05);The evaluation of teaching methods, teaching quality, classroom atmosphere and individual observation ability, clinical thinking ability and nurse-patient communication ability of the experimental group were higher than those of the control group, and the differences were statistically significant (P Conclusion: “six-step teaching method” can effectively master the professional knowledge of obstetrics, stimulate the clinical thinking ability of interns, and improve the teaching effect and satisfaction. .展开更多
Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and...Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and is not fully understood.Intracellular calcium dynamics have been implicated in temporal lobe epilepsy.However,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving mice.In this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy process.We found that calcium signals varied according to the grade of temporal lobe epilepsy episodes.In particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor seizures.Chemogenetic inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠepisodes.In addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly reduced.Intriguingly,it was possible to rescue the altered intracellular calcium dynamics.Via simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were improved.Our results indicate that the calcium dynamic between CA1 and M1 may reflect specific epileptic behaviors corresponding to different grades.Furthermore,the selective regulation of abnormal calcium signals in CA1 pyramidal neurons appears to effectively alleviate temporal lobe epilepsy,thereby providing a potential molecular mechanism for a new temporal lobe epilepsy diagnosis and treatment strategy.展开更多
Objective:To investigate the effects of maternal body mass index(BMI)and gestational weight gain on maternal and neonatal outcomes in twin pregnancies.Methods:Five hundred cases of twin pregnancies were divided into a...Objective:To investigate the effects of maternal body mass index(BMI)and gestational weight gain on maternal and neonatal outcomes in twin pregnancies.Methods:Five hundred cases of twin pregnancies were divided into a low body weight group(68 cases),a normal weight group(355 cases),an overweight group(65 cases),and an obesity group(12 cases)according to the World Health Organization(WHO)Body Mass Index(BMI)classification guidelines Results:Comparison of weight gain during different pregnancies revealed that pregnant women were mainly of low weight and average weight.The higher the BMI before pregnancy,the higher the incidence of excessive weight gain during pregnancy.The incidences of gestational diabetes mellitus(GDM)and premature rupture of membranes in women with low weight gain were significantly higher than those in women with average weight gain and high weight gain(P<0.05).The incidences of gestational hypertension,preeclampsia,and anemia in women with high weight gain were significantly higher than those in women with low weight gain and average weight gain(P<0.05).The incidence of neonatal birth weight,fetal distress,and macrosomia in the high weight gain group was significantly higher than those in the low weight gain and average weight gain groups(P<0.05).The birth weight of newborns in low-weight gain mothers was significantly lower than that of normal-weight gain mothers(P<0.05).Conclusion:Poor maternal and infant outcomes were common in women with insufficient or excessive weight gain during pregnancy.Therefore,for women with twin pregnancies,weight management is crucial to ensure maternal and infant health.展开更多
High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS...High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS4-polyethylene oxide is synthesized by the solution-phase reaction method with an improved ionic conductivity up to 9.4 × 10-5 S/cm at room temperature. Moreover, polyethylene oxide polymer layer is wrapped homogeneously on the surface of Na3PS4 particles, which could effectively avoid the direct contact between Na3PS4 electrolyte and sodium metal, thus alleviate their side reactions. We demonstrate that all-solid-state battery SnS2/Na with the composite solid electrolyte Na3PS4-polyethylene oxide delivers an enhanced electrochemical performance with 230 m Ah/g after 40 cycles.展开更多
In this study, we developed a novel artificial nerve graft termed self-assembling peptide nanofiber scaffold(SAPNS)-containing poly(lactic-co-glycolic acid)(PLGA) conduit(SPC) and used it to bridge a 10-mm-long sciati...In this study, we developed a novel artificial nerve graft termed self-assembling peptide nanofiber scaffold(SAPNS)-containing poly(lactic-co-glycolic acid)(PLGA) conduit(SPC) and used it to bridge a 10-mm-long sciatic nerve defect in the rat. Retrograde tracing, behavioral testing and histomorphometric analyses showed that compared with the empty PLGA conduit implantation group, the SPC implantation group had a larger number of growing and extending axons, a markedly increased diameter of regenerated axons and a greater thickness of the myelin sheath in the conduit. Furthermore, there was an increase in the size of the neuromuscular junction and myofiber diameter in the target muscle. These findings suggest that the novel artificial SPC nerve graft can promote axonal regeneration and remyelination in the transected peripheral nerve and can be used for repairing peripheral nerve injury.展开更多
Lithium-sulfur(Li-S)batteries have become a promising candidate for advanced energy storage system owing to low cost and high theoretical specific energy.In the last decade,in pursuit of Li-S batteries with enhanced s...Lithium-sulfur(Li-S)batteries have become a promising candidate for advanced energy storage system owing to low cost and high theoretical specific energy.In the last decade,in pursuit of Li-S batteries with enhanced safety and energy density,the investigation on the electrolytes has leaped form liquid organic electrolytes to solid polymer ones.However,such solid-state Li-S battery system is greatly limited by unfavorable ionic conductivity,poor interfacial contact and narrow electrochemical windows on account of the absence of any liquid components.To address these issues,gel polymer electrolytes(GPEs),the incorporation of liquid electrolytes into solid polymer matrixes,have been newly developed.Although the excellent ionic transport and low interfacial resistance provided by GPEs have prompted numerous researchers to make certain progress on high-performance Li-S coins,a comprehensive review on GPEs for Li-S batteries remains vacant.Herein,this review focuses on recent development and progress on GPEs in view of their physical and chemical properties for the applications in Li-S batteries.Studies on the components including solid hosts,liquid solutions and fillers of GPEs are systematically summarized with particular emphasis on the relationship between components and performance.Finally,current challenges and directional outlook for fabricating GPEs-based Li-S batteries with outstanding performance are outlined.展开更多
A series of environmental and energy issues,such as global warming,water pollution,acid rain,and energy shortage,have to be settled urgently.Metal-organic frameworks(MOFs)are compounds consisting of metal ions or clus...A series of environmental and energy issues,such as global warming,water pollution,acid rain,and energy shortage,have to be settled urgently.Metal-organic frameworks(MOFs)are compounds consisting of metal ions or clusters coordinated to organic ligands,which show great promise for alleviating or mitigating these challenges owing to their outstanding physical and chemical properties.In this review,we summarize the recent advances of MOFs in the fields of green applications,including carbon capture,harmful gas removal,sewage treatment,and green energy storage.In addition,the challenges and prospects of the large-scale commercialized use of MOFs in handling environmental issues are also discussed.展开更多
Vanadium-based cathodes have attracted great interest in aqueous zinc ion batteries(AZIBs)due to their large capacities,good rate performance and facile synthesis in large scale.However,their practical application is ...Vanadium-based cathodes have attracted great interest in aqueous zinc ion batteries(AZIBs)due to their large capacities,good rate performance and facile synthesis in large scale.However,their practical application is greatly hampered by vanadium dissolution issue in conventional dilute electrolytes.Herein,taking a new potassium vanadate K0.486V2O5(KVO)cathode with large interlayer spacing(~0.95 nm)and high capacity as an example,we propose that the cycle life of vanadates can be greatly upgraded in AZIBs by regulating the concentration of ZnCl2 electrolyte,but with no need to approach“water-in-salt”threshold.With the optimized moderate concentration of 15 m ZnCl2 electrolyte,the KVO exhibits the best cycling stability with ~95.02% capacity retention after 1400 cycles.We further design a novel sodium carboxymethyl cellulose(CMC)-moderate concentration ZnCl2 gel electrolyte with high ionic conductivity of 10.08 mS cm^-1 for the first time and assemble a quasi-solid-state AZIB.This device is bendable with remarkable energy density(268.2 Wh kg^−1),excellent stability(97.35% after 2800 cycles),low self-discharge rate,and good environmental(temperature,pressure)suitability,and is capable of powering small electronics.The device also exhibits good electrochemical performance with high KVO mass loading(5 and 10 mg cm^-2).Our work sheds light on the feasibility of using moderately concentrated electrolyte to address the stability issue of aqueous soluble electrode materials.展开更多
Background and objective Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase(RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cas...Background and objective Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase(RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cases of rare complication of anlotinib-bronchial fistula(BF) during the treatment of lung cancer patients and summarize the possible causes.Methods We collected three patients who developed BF due to anlotinib treatment, and conducted a search of Medline and Pub Med for medical literature published between 2018 and 2020 using the following search terms: "anlotinib," "lung cancer," and "fistula."Results Our literature search produced two case reports(three patients) which, in addition to our three patients. We collated the patients’ clinical characteristics including demographic information, cancer type, imaging features, treatment received, risk factors for anlotinib related BF, and treatment-related outcomes. The six patients shared some common characteristics: advanced age, male, concurrent infection symptoms, diabetes mellitus(DM), advanced squamous cell and small cell lung cancers, centrally located tumors, tumor measuring ≥5 cm in longest diameter, and newly formed tumor cavitation after multi-line treatment especially after receiving radiotherapy. Fistula types included broncho-pericardial fistula, broncho-pleural fistula, and esophagotracheobronchial fistula. Six patients all died within 6 months.Conclusion Although anlotinib is relatively safe, it is still necessary to pay attention to the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients.展开更多
Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related biomarkers.Methods:Seventy-one sub...Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related biomarkers.Methods:Seventy-one subjects were enrolled in the study.We assessed blood glucose,blood lipids,body mass index(BMI),and phlegm-dampness pattern,which was confirmed by a traditional Chinese medicine clinician.Of the participants,we included healthy participants with normal weight(NW,n=23),overweight/obese participants with normal metabolism(ONM,n=19),overweight/obese participants with pre-diabetes(OPD,n=12),and overweight/obese participants with marginally-elevated blood lipids(OML,n=17).Among them,the ONM,OPD,and OML groups were diagnosed with phlegmdampness pattern.The data-independent acquisition(DIA)method was first used to analyze the plasma protein expression of each group,and the relevant differential proteins of each group were screened.The co-expressed proteins were evaluated by Venn analysis.The pathway analyses of the differential proteins were analyzed using Ingenuity Pathway Analysis(IPA)software.Parallel reaction monitoring(PRM)was used to verify the differential and common proteins in each group.Results:After comparing ONM,OPD,and OML groups with NW group,we identified the differentially expressed proteins(DEPs).Next,we determined the DEPs among OPD,OML,and ONM groups.Using Venn analysis of the DEPs in each group,24 co-expressed proteins were screened.Two co-expressed proteins were verified by PRM.IPA analysis showed that pathways including LXR/RXR activation,acute phase response signaling,and FXR/RXR activation were common to all three groups of phlegmdamp overweight/obesity participants.However,the activation or inhibition of these pathways was different among the three groups.Conclusion:Participants with overweight/obesity have similar proteomic characteristics,though each type shows specific proteomic characteristics.Two co-expressed proteins,VTN and ORM1,are potential biomarkers for glucose and lipid metabolism diseases with overweight/obesity caused by phlegmdampness retention.展开更多
A new crosslinked polymer,called P65,with appropriate photo-electrochemical,opto-electronic,and thermal properties,has been designed and synthesized as an efficient,dopant-free,hole-transport material(HTM)for n-i-p ty...A new crosslinked polymer,called P65,with appropriate photo-electrochemical,opto-electronic,and thermal properties,has been designed and synthesized as an efficient,dopant-free,hole-transport material(HTM)for n-i-p type planar perovskite solar cells(PSCs).P65 is obtained from a low-cost and easily synthesized spiro[fluorene-9,90-xanthene]-30,60-diol(SFX-OH)-based monomer X65 through a freeradical polymerization reaction.The combination of a three-dimensional(3 D)SFX core unit,holetransport methoxydiphenylamine group,and crosslinked polyvinyl network provides P65 with good solubility and excellent film-forming properties.By employing P65 as a dopant-free hole-transport layer in conventional n-i-p type PSCs,a power conversion efficiency(PCE)of up to 17.7%is achieved.To the best of our knowledge,this is the first time a 3 D,crosslinked,polymeric dopant-free HTM has been reported for use in conventional n-i-p type PSCs.This study provides a new strategy for the future development of a 3 D crosslinked polymeric dopant-free HTM with a simple synthetic route and low-cost for commercial,large-scale applications in future PSCs.展开更多
Aqueous flow batteries(AFBs) are among the most promising electrochemical energy storage solutions for the massive-scale adoption of renewable electricity because of decoupled energy and power, design flexibility, imp...Aqueous flow batteries(AFBs) are among the most promising electrochemical energy storage solutions for the massive-scale adoption of renewable electricity because of decoupled energy and power, design flexibility, improved safety and low cost. The development of high-voltage AFB is, however, limited by the lack of stable anolytes that have low redox potential. Here we report Eu-based anolytes for high-voltage p H-neutral AFB applications. Eu^(3+) has a reduction potential of -0.39 V vs. SHE, which can be dramatically lowered when forming stable complex with inexpensive organic chelates. A typical complex, Eu DTPA,features a low redox potential of -1.09 V vs. SHE, fast redox kinetics, and a high water solubility of 1.5 M. When paired with ferrocyanide, the battery had an open-circuit voltage of 1.56 V and demonstrated stable cell cycling performance, including a capacity retention rate of 99.997% per cycle over500 cycles at 40 m A cm^(-2), a current efficiency of >99.9%, and an energy efficiency of >83.3%. A high concentration anolyte at 1.5 M exhibited a volumetric capacity of 40.2 Ah L^(-1), which is one of the highest known for p H-neutral AFBs, promising a potent solution for the grid-scale storage of renewable electricity.展开更多
As an innovative maintenance technology of asphalt pavement,encapsulated rejuvenator used to improve its self-healing performance has been widely investigated by researchers in recent years.In this work,the selfhealin...As an innovative maintenance technology of asphalt pavement,encapsulated rejuvenator used to improve its self-healing performance has been widely investigated by researchers in recent years.In this work,the selfhealing properties of asphalt mixture with and without encapsulations were comparatively studied considering these parameters:Healing time,healing cycles and microwave heating.Three-point bending strength recovery test and fatigue loading cycles recovery test were conducted for two kinds of encapsulations containing the healing agents present inside the asphalt mixture,namely compartmented Ca-alginate/SiO_(2) fiber and compartmented Ca-alginate/graphene oxide fiber.The results showed that the optimum healing time was three days.After the 30 s of microwave heating,the recovery of fatigue loading cycles of asphalt mixture with compartmented Ca-alginate/graphene oxide fiber was four times larger than that of control asphalt mixture.Compared with the single effect related to the encapsulated healing agent or temperature,the synergistic effect of temperature and encapsulation could further significantly improve the self-healing properties of asphalt mixture.The compartmented Ca-alginate/graphene oxide fiber not only could soften asphalt through the encapsulated healing agent to improve self-healing properties of asphalt,but also could repeatedly and quickly heal cracks thanks to microwave action.The synthesis of the fiber breaks the current boundary between the two technologies(capsules healing method and induction healing method)and opens up a new horizon for the asphalt self-healing technology.展开更多
基金the Natural Science Foundation of Beijing Municipality(2222075)National Natural Science Foundation of China(22279010,21671020,51673026)Analysis&Testing Center,Beijing Institute of Technology.
文摘Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression.However,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information representation.Here,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any attenuation.Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.
基金financial support from the National Natural Science Foundation of China(21878270,21878267,21922811,21978258 and 21961160742)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01006)+3 种基金the Zhejiang Provincial Natural Science Foundation of China(LR19B060002)the Fundamental Research Funds for the Central Universities(2020XZZX002-09)the Startup Foundation for Hundred-Talent Program of Zhejiang Universitythe Zhejiang Key Laboratory of Marine Materials and Protective Technologies(2020K10)。
文摘Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage devices.However,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their applications.Herein,single nickel(Ni)atoms on two-dimensional(2D)nitrogen(N)-doped carbon with Ni-N_(4)-O overcoordinated structure(SANi-N_(4)-O/NC)are prepared and firstly used as a sulfur host of Li-S batteries.Due to the efficient polysulfides traps and highly LiPSs conversion effect of SANi-N_(4)-O/NC,the electrochemical performance of Li-S batteries obviously improved.The batteries can well operate even under high sulfur loading(5.8 mg cm^(-2))and lean electrolyte(6.1μL mg^(-1))condition.Meanwhile,density functional theory(DFT)calculations demonstrate that Ni single atom’s active sites decrease the energy barriers of conversion reactions from Li_(2)S_(8)to Li2S due to the strong interaction between SANi-N_(4)-O/NC and LiPSs.Thus,the kinetic conversion of LiPSs was accelerated and the shuttle effect is suppressed on SANi-N_(4)-O/NC host.This study provides a new design strategy for a 2D structure with single-atom overcoordinated active sites to facilitate the fast kinetic conversion of LiPSs for Li-S cathode.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.52072136,51972257,51872104,and 52172229)the Ningxia Key R&D Program(2019BFG02018)the Fundamental Research Funds for the Central Universities(WUT:2021IVA115,2021IVA071).
文摘Hybrid supercapacitors have shown great potentials to fulfill the demand of future diverse applications such as electric vehicles and portable/wearable electronics.In particular,aqueous zinc-ion hybrid supercapacitors(ZHSCs)have gained much attention due to their low-cost,high energy density,and environmental friendliness.Nevertheless,typical ZHSCs use Zn metal anode and normal liquid electrolyte,causing the dendrite issue,restricted working temperature,and inferior device flexibility.Herein,a novel flexible Zn-ion hybrid supercapacitor(FZHSC)is developed by using activated carbon(AC)anode,δ-MnO_(2) cathode,and innovative PVA-based gel electrolyte.In this design,heavy Zn anode and its dendrite issue are avoided and layered cathode with large interlayer spacing is employed.In addition,flexible electrodes are prepared and integrated with an anti-freezing,stretchable,and compressible hydrogel electrolyte,which is attained by simultaneously using glycerol additive and freezing/thawing technique to regulate the hydrogen bond and microstructure.The resulting FZHSC exhibits good rate capability,high energy density(47.86 Wh kg^(−1);3.94 mWh cm^(−3)),high power density(5.81 kW kg^(−1);480 mW cm^(−3)),and excellent cycling stability(~91%capacity retention after 30000 cycles).Furthermore,our FZHSC demonstrates outstanding flexibility with capacitance almost unchanged even after various continuous shape deformations.The hydrogel electrolyte still maintains high ionic conductivity at ultralow temperatures(≤−30℃),enabling the FZHSC cycled well,and powering electronic timer robustly within an all-climate temperature range of−30~80℃.This work highlights that the promising Zn metal-free aqueous ZHSCs can be designed with great multifunctionality for more practical application scenarios.
基金financially supported by National Key Research and Development Program(2019YFC0408803)Basic Public Welfare Research Project of Zhejiang Province(LGN20E090001)+2 种基金Major Scientific and Technological Projects of Zhejiang Provincial Department of Water Resources(RA1913)Water Conservancy Science and Technology in Zhejiang Province(RC1918,RC2029)National Natural Science Foundation of China(52009044).
文摘Reclaimed water irrigation has become an effective mean to alleviate the contradiction between water availability and its consumption worldwide.In this study,three types of irrigation water sources(rural sewage’s primary treated water R1 and secondary treated water R2,and river water R3)meeting the requirements of water quality for farmland irrigation were selected,and three types of irrigation water levels(low water levelW1 of 0–80 mm,medium water level W2 of 0–100 mm,and high water level W3 of 0–150 mm)were adopted to carry out research on the influence mechanismS of different irrigation water sources and water levels on water and nitrogen use and crop growth in paddy field.The water quantity indicators(irrigation times and irrigation volume),soil ammonium nitrogen(NH4+-N)and nitrate nitrogen(NO3−-N),rice yield indicators(thousand-grain weight,the number of grains per spike,and the number of effective spikes),and quality indicators(the amount of protein,amylose,vitamin C,nitrate and nitrite content)of rice were measured.The results showed that,the average irrigation volume under W3 was 2.4 and 1.9 times of that under W1 and W2,respectively.Compared with R3,the peak consumption of rice was lagged behind under R1 and R2,and the nitrogen form in 0–40 cm soil layers under rural sewage irrigation was mainly NH4+-N.The changes of NO3−-N and NH4+-N in the 0–40 cm soil layer showed the trend of declining and then increasing.The water level control only had a significant effect on the change of NO3−-N in the 60–80 cm soil layer.Both irrigation water use efficiency and crop water use efficiency were gradually reduced with the increase of field water level control.The nitrogen utilization efficiency under rural sewage irrigation was significantly higher than that under R3.Compared with the R3,rural sewage irrigation could significantly increase the yield of rice,and as the field water level rose,the effect of yield promotion was more obvious.It was noteworthy that the grain of rice under R1 monitored the low nitrate and nitrite content,but no nitrate and nitrite was discovered under R2 and R3.Therefore,reasonable rural sewage irrigation(R2)and medium water level(W2)were beneficial to improve nitrogen utilization efficiency,crop yield and crop quality promotion.
基金Project supported by the Science and Technology Key Project of Henan Province,China(Grant No.182102210577)the National Natural Science Foundation of China(Grant No.61605249)。
文摘Spectrally uncorrelated biphotons are the essential resources for achieving various quantum information processing protocols.We theoretically investigate the generation of spectrally uncorrelated biphotons emitted by spontaneous fourwave mixing from a fiber nonlinear interferometer which consists of an N-stage nonlinear gain fiber and an(N-1)-stage dispersion modulation fiber.The output biphoton states of nonlinear interference are the coherent superposition of various biphoton states born in each nonlinear fiber,and thus the interference fringe will reshape the biphoton joint spectra.As a result,resorting to Taylor expansion to first order for phase mismatching,we theoretically verify that the orientation of phase matching contours will rotate in a specific way with only varying the length of dispersion modulation fiber.The rotation in orientation of phase matching contours may result in spectrally uncorrelated biphotons and even arbitrary correlation biphotons.Further,we choose micro/nanofiber as the nonlinear gain fiber and single-mode communication fiber as dispersion modulation fiber to numerically simulate the generation of spectrally uncorrelated biphotons from spontaneous fourwave mixing.Here,due to significant frequency detuning(hundreds of THz),Raman background noise can be considerably suppressed,even at room temperature,and photons with largely tunable wavelengths can be achieved,indicating a practicability in many quantum fields.A photon mode purity of 97.2%will be theoretically attained without weakening the heralding nature of biphoton sources.We think that this fiber nonlinear interference with the flexibly engineered quantum state can be an excellent practical source for quantum information processing.
基金funded by the National Natural Science Foundation of China(32102143)Shandong Province Natural Sciences Foundation of China(ZR2019PC011 and ZR2020QC122)+1 种基金Scientific Research Foundation for Ph.D.Programs of Zaozhuang University(2018BS040 and 2018BS042)Science and Technology Program of Zaozhuang(2019NS03).
文摘Infection of plum bark necrosis stem pitting associated virus(PBNSPaV)has been reported in many Prunus species in several countries,causing significant economic losses.The very small proteins encoded by plant viruses are often overlooked due to their short sequences and uncertain significance.However,numerous studies have indicated that they might play important roles in the pathogenesis of virus infection.The role of small hydrophobic protein P6,encoded by the open reading frame 2 of PBNSPaV,has not been well explored.In this study,we amplified the P6 fragment from a PBNSPaV isolate by RT-PCR using specific primers and found that it is 174 bp long and encodes a protein of approximately 6.3 kD with a transmembrane domain.Subcellular localization analysis of P6 proteins in tobacco leaves showed that P6 localizes to the cytomembrane and nuclear membrane.To further clarify the pathogenicity of P6 proteins,we constructed a PVX-P6 expression vector by inserting the p6 fragment into a potato virus X(PVX)-based vector and transformed it into Agrobacterium tumefaciens GV3101.Infiltration of Nicotiana benthamiana(N.benthamiana)with the PVX vector-transformed A.tumefaciens led to slight mosaic symptoms at 14 days of post-inoculation.Meanwhile,infiltration with the PVX-P6 vector-transformed A.tumefaciens resulted in no significant symptoms.These results demonstrated that heterologous expression of P6 in N.benthamiana could not enhance the pathogenicity of PVX.Our study indicates that P6 may not be a potential pathogenic factor associate with the causing of symptoms,and the mode of action of PBNSPaV-P6 protein remains to be further studied.
文摘Objective: The “six-step teaching method” is a teaching method, which is summarized based on practical experience. This study aimed to explore the effect of “six-step teaching method” in clinical teaching of obstetrics. Methods: A quasi-experimental study design was used, 30 nursing students who entered obstetrics practice from March 2022 to July 2022 were selected as the control group according to the order of time, and traditional teaching methods were adopted. From August to December 2022, 30 interns were selected as the experimental group, and the “six-step teaching method” was adopted. After 8 weeks of clinical practice, the assessment results and teaching effect satisfaction of the two groups were compared. Results: The scores of obstetrical specialty in the experimental group were higher than those in the control group, and the difference was statistically significant (P < 0.05);The evaluation of teaching methods, teaching quality, classroom atmosphere and individual observation ability, clinical thinking ability and nurse-patient communication ability of the experimental group were higher than those of the control group, and the differences were statistically significant (P Conclusion: “six-step teaching method” can effectively master the professional knowledge of obstetrics, stimulate the clinical thinking ability of interns, and improve the teaching effect and satisfaction. .
基金supported by the National Natural Science Foundation of China,Nos.62027812(to HS),81771470(to HS),and 82101608(to YL)Tianjin Postgraduate Research and Innovation Project,No.2020YJSS122(to XD)。
文摘Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence rate.The pathogenesis of temporal lobe epilepsy is complex and is not fully understood.Intracellular calcium dynamics have been implicated in temporal lobe epilepsy.However,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving mice.In this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy process.We found that calcium signals varied according to the grade of temporal lobe epilepsy episodes.In particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor seizures.Chemogenetic inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠepisodes.In addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly reduced.Intriguingly,it was possible to rescue the altered intracellular calcium dynamics.Via simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were improved.Our results indicate that the calcium dynamic between CA1 and M1 may reflect specific epileptic behaviors corresponding to different grades.Furthermore,the selective regulation of abnormal calcium signals in CA1 pyramidal neurons appears to effectively alleviate temporal lobe epilepsy,thereby providing a potential molecular mechanism for a new temporal lobe epilepsy diagnosis and treatment strategy.
文摘Objective:To investigate the effects of maternal body mass index(BMI)and gestational weight gain on maternal and neonatal outcomes in twin pregnancies.Methods:Five hundred cases of twin pregnancies were divided into a low body weight group(68 cases),a normal weight group(355 cases),an overweight group(65 cases),and an obesity group(12 cases)according to the World Health Organization(WHO)Body Mass Index(BMI)classification guidelines Results:Comparison of weight gain during different pregnancies revealed that pregnant women were mainly of low weight and average weight.The higher the BMI before pregnancy,the higher the incidence of excessive weight gain during pregnancy.The incidences of gestational diabetes mellitus(GDM)and premature rupture of membranes in women with low weight gain were significantly higher than those in women with average weight gain and high weight gain(P<0.05).The incidences of gestational hypertension,preeclampsia,and anemia in women with high weight gain were significantly higher than those in women with low weight gain and average weight gain(P<0.05).The incidence of neonatal birth weight,fetal distress,and macrosomia in the high weight gain group was significantly higher than those in the low weight gain and average weight gain groups(P<0.05).The birth weight of newborns in low-weight gain mothers was significantly lower than that of normal-weight gain mothers(P<0.05).Conclusion:Poor maternal and infant outcomes were common in women with insufficient or excessive weight gain during pregnancy.Therefore,for women with twin pregnancies,weight management is crucial to ensure maternal and infant health.
基金funding support from 1000 Talent Plan program(NO.31370086963030)research projects from Shandong Province(2018JMRH0211,2017CXGC1010 and 2016GGX104001)+2 种基金Taishan Scholar Program(11370085961006)the National Science Foundation of Shandong Province(ZR2017MEM002)the Fundamental Research Funds of Shandong University(201810422046,2017JC010,2017JC042,and 2016JC005)。
文摘High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS4-polyethylene oxide is synthesized by the solution-phase reaction method with an improved ionic conductivity up to 9.4 × 10-5 S/cm at room temperature. Moreover, polyethylene oxide polymer layer is wrapped homogeneously on the surface of Na3PS4 particles, which could effectively avoid the direct contact between Na3PS4 electrolyte and sodium metal, thus alleviate their side reactions. We demonstrate that all-solid-state battery SnS2/Na with the composite solid electrolyte Na3PS4-polyethylene oxide delivers an enhanced electrochemical performance with 230 m Ah/g after 40 cycles.
基金supported by a grant from the National Key Basic Research Program of China,No.2014CB542202 and 2014CB542205the National Natural Science Foundation of China,No.30973095&81371354+2 种基金a grant from Science and Technology Project of Guangzhou,in China,No.12C32121609the Natural Science Foundation of Guangdong Province of China,No.S2013010014697 to Guo JSHong Kong SCI Fund to Wu WT
文摘In this study, we developed a novel artificial nerve graft termed self-assembling peptide nanofiber scaffold(SAPNS)-containing poly(lactic-co-glycolic acid)(PLGA) conduit(SPC) and used it to bridge a 10-mm-long sciatic nerve defect in the rat. Retrograde tracing, behavioral testing and histomorphometric analyses showed that compared with the empty PLGA conduit implantation group, the SPC implantation group had a larger number of growing and extending axons, a markedly increased diameter of regenerated axons and a greater thickness of the myelin sheath in the conduit. Furthermore, there was an increase in the size of the neuromuscular junction and myofiber diameter in the target muscle. These findings suggest that the novel artificial SPC nerve graft can promote axonal regeneration and remyelination in the transected peripheral nerve and can be used for repairing peripheral nerve injury.
基金supported by the National Natural Science Foundation of China(Nos.21978258,21776249 and 21676248)。
文摘Lithium-sulfur(Li-S)batteries have become a promising candidate for advanced energy storage system owing to low cost and high theoretical specific energy.In the last decade,in pursuit of Li-S batteries with enhanced safety and energy density,the investigation on the electrolytes has leaped form liquid organic electrolytes to solid polymer ones.However,such solid-state Li-S battery system is greatly limited by unfavorable ionic conductivity,poor interfacial contact and narrow electrochemical windows on account of the absence of any liquid components.To address these issues,gel polymer electrolytes(GPEs),the incorporation of liquid electrolytes into solid polymer matrixes,have been newly developed.Although the excellent ionic transport and low interfacial resistance provided by GPEs have prompted numerous researchers to make certain progress on high-performance Li-S coins,a comprehensive review on GPEs for Li-S batteries remains vacant.Herein,this review focuses on recent development and progress on GPEs in view of their physical and chemical properties for the applications in Li-S batteries.Studies on the components including solid hosts,liquid solutions and fillers of GPEs are systematically summarized with particular emphasis on the relationship between components and performance.Finally,current challenges and directional outlook for fabricating GPEs-based Li-S batteries with outstanding performance are outlined.
基金from the National Natural Science Foundation of China(21776097,21802103,and 22008032)the Guangdong Natural Science Foundation(2017A030313052)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(2019A1515110706)the Guangdong Natural Science Foundation(2017A030313052)。
文摘A series of environmental and energy issues,such as global warming,water pollution,acid rain,and energy shortage,have to be settled urgently.Metal-organic frameworks(MOFs)are compounds consisting of metal ions or clusters coordinated to organic ligands,which show great promise for alleviating or mitigating these challenges owing to their outstanding physical and chemical properties.In this review,we summarize the recent advances of MOFs in the fields of green applications,including carbon capture,harmful gas removal,sewage treatment,and green energy storage.In addition,the challenges and prospects of the large-scale commercialized use of MOFs in handling environmental issues are also discussed.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.51872104,51972257 and 51672205)the National Key R&D Program of China(Grant No.2016YFA0202602)the Natural Science Foundation of Hubei Province(2018CFB581).
文摘Vanadium-based cathodes have attracted great interest in aqueous zinc ion batteries(AZIBs)due to their large capacities,good rate performance and facile synthesis in large scale.However,their practical application is greatly hampered by vanadium dissolution issue in conventional dilute electrolytes.Herein,taking a new potassium vanadate K0.486V2O5(KVO)cathode with large interlayer spacing(~0.95 nm)and high capacity as an example,we propose that the cycle life of vanadates can be greatly upgraded in AZIBs by regulating the concentration of ZnCl2 electrolyte,but with no need to approach“water-in-salt”threshold.With the optimized moderate concentration of 15 m ZnCl2 electrolyte,the KVO exhibits the best cycling stability with ~95.02% capacity retention after 1400 cycles.We further design a novel sodium carboxymethyl cellulose(CMC)-moderate concentration ZnCl2 gel electrolyte with high ionic conductivity of 10.08 mS cm^-1 for the first time and assemble a quasi-solid-state AZIB.This device is bendable with remarkable energy density(268.2 Wh kg^−1),excellent stability(97.35% after 2800 cycles),low self-discharge rate,and good environmental(temperature,pressure)suitability,and is capable of powering small electronics.The device also exhibits good electrochemical performance with high KVO mass loading(5 and 10 mg cm^-2).Our work sheds light on the feasibility of using moderately concentrated electrolyte to address the stability issue of aqueous soluble electrode materials.
文摘Background and objective Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase(RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cases of rare complication of anlotinib-bronchial fistula(BF) during the treatment of lung cancer patients and summarize the possible causes.Methods We collected three patients who developed BF due to anlotinib treatment, and conducted a search of Medline and Pub Med for medical literature published between 2018 and 2020 using the following search terms: "anlotinib," "lung cancer," and "fistula."Results Our literature search produced two case reports(three patients) which, in addition to our three patients. We collated the patients’ clinical characteristics including demographic information, cancer type, imaging features, treatment received, risk factors for anlotinib related BF, and treatment-related outcomes. The six patients shared some common characteristics: advanced age, male, concurrent infection symptoms, diabetes mellitus(DM), advanced squamous cell and small cell lung cancers, centrally located tumors, tumor measuring ≥5 cm in longest diameter, and newly formed tumor cavitation after multi-line treatment especially after receiving radiotherapy. Fistula types included broncho-pericardial fistula, broncho-pleural fistula, and esophagotracheobronchial fistula. Six patients all died within 6 months.Conclusion Although anlotinib is relatively safe, it is still necessary to pay attention to the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients.
基金supported by the General Program of National Natural Science Foundation of China(81673836)。
文摘Objective:To investigate the proteomic characteristics of overweight/obesity and related abnormal glucose and lipid metabolism caused by phlegm-dampness retention to identify related biomarkers.Methods:Seventy-one subjects were enrolled in the study.We assessed blood glucose,blood lipids,body mass index(BMI),and phlegm-dampness pattern,which was confirmed by a traditional Chinese medicine clinician.Of the participants,we included healthy participants with normal weight(NW,n=23),overweight/obese participants with normal metabolism(ONM,n=19),overweight/obese participants with pre-diabetes(OPD,n=12),and overweight/obese participants with marginally-elevated blood lipids(OML,n=17).Among them,the ONM,OPD,and OML groups were diagnosed with phlegmdampness pattern.The data-independent acquisition(DIA)method was first used to analyze the plasma protein expression of each group,and the relevant differential proteins of each group were screened.The co-expressed proteins were evaluated by Venn analysis.The pathway analyses of the differential proteins were analyzed using Ingenuity Pathway Analysis(IPA)software.Parallel reaction monitoring(PRM)was used to verify the differential and common proteins in each group.Results:After comparing ONM,OPD,and OML groups with NW group,we identified the differentially expressed proteins(DEPs).Next,we determined the DEPs among OPD,OML,and ONM groups.Using Venn analysis of the DEPs in each group,24 co-expressed proteins were screened.Two co-expressed proteins were verified by PRM.IPA analysis showed that pathways including LXR/RXR activation,acute phase response signaling,and FXR/RXR activation were common to all three groups of phlegmdamp overweight/obesity participants.However,the activation or inhibition of these pathways was different among the three groups.Conclusion:Participants with overweight/obesity have similar proteomic characteristics,though each type shows specific proteomic characteristics.Two co-expressed proteins,VTN and ORM1,are potential biomarkers for glucose and lipid metabolism diseases with overweight/obesity caused by phlegmdampness retention.
基金the support of the Swedish Energy Agency and Swedish Foundation for Strategic Research(SSF)for their financial supportthe China Scholarship Council(CSC)for its financial support。
文摘A new crosslinked polymer,called P65,with appropriate photo-electrochemical,opto-electronic,and thermal properties,has been designed and synthesized as an efficient,dopant-free,hole-transport material(HTM)for n-i-p type planar perovskite solar cells(PSCs).P65 is obtained from a low-cost and easily synthesized spiro[fluorene-9,90-xanthene]-30,60-diol(SFX-OH)-based monomer X65 through a freeradical polymerization reaction.The combination of a three-dimensional(3 D)SFX core unit,holetransport methoxydiphenylamine group,and crosslinked polyvinyl network provides P65 with good solubility and excellent film-forming properties.By employing P65 as a dopant-free hole-transport layer in conventional n-i-p type PSCs,a power conversion efficiency(PCE)of up to 17.7%is achieved.To the best of our knowledge,this is the first time a 3 D,crosslinked,polymeric dopant-free HTM has been reported for use in conventional n-i-p type PSCs.This study provides a new strategy for the future development of a 3 D crosslinked polymeric dopant-free HTM with a simple synthetic route and low-cost for commercial,large-scale applications in future PSCs.
基金project has been supported by the National Natural Science Foundation of China (Nos. 21878281, 21922510 and 21720102003)the DNL Cooperation Fund, CAS (DNL201910)。
文摘Aqueous flow batteries(AFBs) are among the most promising electrochemical energy storage solutions for the massive-scale adoption of renewable electricity because of decoupled energy and power, design flexibility, improved safety and low cost. The development of high-voltage AFB is, however, limited by the lack of stable anolytes that have low redox potential. Here we report Eu-based anolytes for high-voltage p H-neutral AFB applications. Eu^(3+) has a reduction potential of -0.39 V vs. SHE, which can be dramatically lowered when forming stable complex with inexpensive organic chelates. A typical complex, Eu DTPA,features a low redox potential of -1.09 V vs. SHE, fast redox kinetics, and a high water solubility of 1.5 M. When paired with ferrocyanide, the battery had an open-circuit voltage of 1.56 V and demonstrated stable cell cycling performance, including a capacity retention rate of 99.997% per cycle over500 cycles at 40 m A cm^(-2), a current efficiency of >99.9%, and an energy efficiency of >83.3%. A high concentration anolyte at 1.5 M exhibited a volumetric capacity of 40.2 Ah L^(-1), which is one of the highest known for p H-neutral AFBs, promising a potent solution for the grid-scale storage of renewable electricity.
基金funded by Foshan Self-Finance Science and Technology Project(No.2020001005441)the National Key R&D Program of China(No.2018YFB1600200)the National Natural Science Foundation of China(No.51978547).
文摘As an innovative maintenance technology of asphalt pavement,encapsulated rejuvenator used to improve its self-healing performance has been widely investigated by researchers in recent years.In this work,the selfhealing properties of asphalt mixture with and without encapsulations were comparatively studied considering these parameters:Healing time,healing cycles and microwave heating.Three-point bending strength recovery test and fatigue loading cycles recovery test were conducted for two kinds of encapsulations containing the healing agents present inside the asphalt mixture,namely compartmented Ca-alginate/SiO_(2) fiber and compartmented Ca-alginate/graphene oxide fiber.The results showed that the optimum healing time was three days.After the 30 s of microwave heating,the recovery of fatigue loading cycles of asphalt mixture with compartmented Ca-alginate/graphene oxide fiber was four times larger than that of control asphalt mixture.Compared with the single effect related to the encapsulated healing agent or temperature,the synergistic effect of temperature and encapsulation could further significantly improve the self-healing properties of asphalt mixture.The compartmented Ca-alginate/graphene oxide fiber not only could soften asphalt through the encapsulated healing agent to improve self-healing properties of asphalt,but also could repeatedly and quickly heal cracks thanks to microwave action.The synthesis of the fiber breaks the current boundary between the two technologies(capsules healing method and induction healing method)and opens up a new horizon for the asphalt self-healing technology.
