The structure and operational principle on a new type reversing valve of hydraulic breaker are introduced. The nonlinear mathematic model and simulation model of the new type reversing valve are built. The dynamic sim...The structure and operational principle on a new type reversing valve of hydraulic breaker are introduced. The nonlinear mathematic model and simulation model of the new type reversing valve are built. The dynamic simulation research of the new type reversing valve is conducted. The effects of the system parameters on the working performance are researched systematically and deeply. The regular understanding on the motion of the reversing valve is obtained, which provides theoretical basis for the innovation and manufacturing of a new generation of hydraulic breaker reversing valve.展开更多
Amines are important for new particle formation and subsequent growth in the atmosphere.Consequently,the processes involved are receiving more attention in recent years.Here,we conduct a field observation in order to ...Amines are important for new particle formation and subsequent growth in the atmosphere.Consequently,the processes involved are receiving more attention in recent years.Here,we conduct a field observation in order to investigate the atmospheric particulate amines at a background site in the Yangtze River Delta(YRD)during the summer of 2018.Four amines in PM_(2.5),i.e.,methylamine(MA),dimethylamine(DMA),diethylamine(DEA),and trimethylamine(TMA),were collected,twice daily and analyzed.During the campaign,our measurements found the concentrations of MA,DMA,DEA,and TMA of 15.0±15.0,6.3±6.9,20.4±30.1,and 4.0±5.9 ng m^-(3),respectively,and the four amines correlated well with each other.The concentration of amines appear to be independent of whether they were collected during the day or night.Both MA and DMA exhibited a bimodal size distribution that had peaks at 0.67 and 1.1μm,suggesting amines preferably distribute on submicron particles.Boundary layer height(BLH),relative humidity,and pH of aerosols were found have a negative relationship with amines,while aerosol liquid water content(ALWC)was found to have a positive relationship with amines.The PMF(positive matrix factorization)source apportionment results showed that the main source of amines in Chongming Island was of anthropogenic origin such as industrial and biomass emission,followed by marine sources including sea salt and marine biogenic sources.Given that the YRD region is still suffering from complex atmospheric pollution and that the knowledge on aerosol amines is still limited,more field studies are in urgent need for a better understanding of the pollution characteristics of amines.展开更多
Objective The aim of the study was to evaluate the clinical efficacy of decitabine(DEC)combined with ruxolitinib(RUX)in the treatment of chronic myelomonocytic leukemia(CMML).Methods The clinical characteristics of 12...Objective The aim of the study was to evaluate the clinical efficacy of decitabine(DEC)combined with ruxolitinib(RUX)in the treatment of chronic myelomonocytic leukemia(CMML).Methods The clinical characteristics of 12 patients with CMML were analyzed retrospectively and subsequent target sequencing was performed to investigate the efficacy of the combined treatment with DEC and RUX and the molecular signatures therein.Results Among the 12 cases,clinical improvement was observed in all patients(100%),spleen reduction was observed in six patients(67%),and hematologic improvement was observed in four patients(33%).In the CMML-1 group,the overall response was 50%(3/6),one case achieved complete response,one achieved bone marrow remission,and one achieved hematological improvement.In the CMML-2 group,the overall response was 17%(1/6),one case achieved complete response,four showed disease progression(PD),and one exhibited no response.As expected,ASXL1 mutation was predictive for the outcome of CMML(hazard ratio of 2.97,95%confidence interval of 1.21–7.06;P=0.02).Conclusion The use of DEC combined with RUX in the treatment of CMML effectively improved the clinical response and quality of life,especially for CMML-1 patients.Ongoing clinical trials will further evaluate the safety and efficacy of this novel therapeutic approach.展开更多
Limited by single function,it is difficult for the traditional stirred vessels to meet the requirements of mixing system in biomass wastewater treatment processes.The estimation of biomass wastewater stirring reactor ...Limited by single function,it is difficult for the traditional stirred vessels to meet the requirements of mixing system in biomass wastewater treatment processes.The estimation of biomass wastewater stirring reactor performance by computational fluid dynamics(CFD)during multiphase reactions is important,due to the uncertainty in the numerical results.In this study,a novel double-partition stirred vessel with eccentrically located impellers was developed for the special subject.In addition,many simulations were carried out with the wastewater from biomass ethanol production as the medium to ensure the high reactor performance.The fluid flow was simulated and analyzed using the turbulent RNG k-ε model and multi reference frames.A good agreement is found between the simulation results and the confirmatory experiment.Moreover,the weir crest and interconnected pore were specially designed for the establishment of the circulation of fluid to maintain different technological conditions in the two regions.The distributions of radial velocities and tangential velocities were concentrated near the stirring blade.From the velocity profile,it is deduced that the flow pattern in the stirred vessel is insensitive to Reynolds number.Finally,this simulation study could contribute to the improvement and optimization of the structure,as well as the operation of the novel stirred vessel.展开更多
The preparation of green and economical bio-aviation fuel is a priority for the sustainable development industry.In this study,Jatropha oil was used as a raw material to catalyze the conversion of raw material to avia...The preparation of green and economical bio-aviation fuel is a priority for the sustainable development industry.In this study,Jatropha oil was used as a raw material to catalyze the conversion of raw material to aviation kerosene fraction by photothermal coupling under the conditions of light and low temperature.The correlations among conversion rate,target alkane selectivity,composition distribution,and catalyst microstructure were investigated by X-ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM),nitrogen(N2)adsorption and desorption,X-ray fluorescence(XRF),ammoniatemperature programmed desorption(NH3-TPD),ultraviolet-visible spectrophotometry(UV-Vis),and other characterization.The correlation between conversion and target alkane selectivity and composition distribution and catalyst microstructure was investigated,and different modification methods and different molecular sieve materials were selected.The results showed that the molecular sieves modified with the solid dispersion method could retain the structural stability of titanium dioxide(TiO2)and molecular sieves to a great extent while slightly enhancing the pore capacity and pore size of the catalyst to make it easier to adsorb reactants;the introduction of active metal platinum(Pt)could reduce the forbidden bandwidth of the catalyst,increase the weak acid amount of the catalyst,improve the adsorption capacity of hydrogen(H2),and thus improve the catalytic ability,resulting in a suitable catalyst for this study:P-21.The photothermal catalytic reaction of Jatropha oil using P-21 catalyst obtained 97.21%conversion and 74.99%selectivity of the target alkanes under the optimal process parameters.The results of this study provide effective catalyst parameters for research in the field of clean energy.展开更多
文摘The structure and operational principle on a new type reversing valve of hydraulic breaker are introduced. The nonlinear mathematic model and simulation model of the new type reversing valve are built. The dynamic simulation research of the new type reversing valve is conducted. The effects of the system parameters on the working performance are researched systematically and deeply. The regular understanding on the motion of the reversing valve is obtained, which provides theoretical basis for the innovation and manufacturing of a new generation of hydraulic breaker reversing valve.
基金This work was financially supported by National Key R&D Plan,Ministry of Science and Technology of China—“Mechanism and chemical process characterization of atmospheric particulate matter multi-isotope fractionation”(Grant No.2017YFC0212703)the program from National Natural Science Foundation of China(Grant No.41773117)the program of Happiness Flower Plan of East China Normal University of China.
文摘Amines are important for new particle formation and subsequent growth in the atmosphere.Consequently,the processes involved are receiving more attention in recent years.Here,we conduct a field observation in order to investigate the atmospheric particulate amines at a background site in the Yangtze River Delta(YRD)during the summer of 2018.Four amines in PM_(2.5),i.e.,methylamine(MA),dimethylamine(DMA),diethylamine(DEA),and trimethylamine(TMA),were collected,twice daily and analyzed.During the campaign,our measurements found the concentrations of MA,DMA,DEA,and TMA of 15.0±15.0,6.3±6.9,20.4±30.1,and 4.0±5.9 ng m^-(3),respectively,and the four amines correlated well with each other.The concentration of amines appear to be independent of whether they were collected during the day or night.Both MA and DMA exhibited a bimodal size distribution that had peaks at 0.67 and 1.1μm,suggesting amines preferably distribute on submicron particles.Boundary layer height(BLH),relative humidity,and pH of aerosols were found have a negative relationship with amines,while aerosol liquid water content(ALWC)was found to have a positive relationship with amines.The PMF(positive matrix factorization)source apportionment results showed that the main source of amines in Chongming Island was of anthropogenic origin such as industrial and biomass emission,followed by marine sources including sea salt and marine biogenic sources.Given that the YRD region is still suffering from complex atmospheric pollution and that the knowledge on aerosol amines is still limited,more field studies are in urgent need for a better understanding of the pollution characteristics of amines.
基金Supported by a grant from the Fund of Ruijin Hospital North affiliated to Shanghai Jiao Tong University School of Medicine(No:2018ZY03)
文摘Objective The aim of the study was to evaluate the clinical efficacy of decitabine(DEC)combined with ruxolitinib(RUX)in the treatment of chronic myelomonocytic leukemia(CMML).Methods The clinical characteristics of 12 patients with CMML were analyzed retrospectively and subsequent target sequencing was performed to investigate the efficacy of the combined treatment with DEC and RUX and the molecular signatures therein.Results Among the 12 cases,clinical improvement was observed in all patients(100%),spleen reduction was observed in six patients(67%),and hematologic improvement was observed in four patients(33%).In the CMML-1 group,the overall response was 50%(3/6),one case achieved complete response,one achieved bone marrow remission,and one achieved hematological improvement.In the CMML-2 group,the overall response was 17%(1/6),one case achieved complete response,four showed disease progression(PD),and one exhibited no response.As expected,ASXL1 mutation was predictive for the outcome of CMML(hazard ratio of 2.97,95%confidence interval of 1.21–7.06;P=0.02).Conclusion The use of DEC combined with RUX in the treatment of CMML effectively improved the clinical response and quality of life,especially for CMML-1 patients.Ongoing clinical trials will further evaluate the safety and efficacy of this novel therapeutic approach.
基金supported by the National Natural Science Foundation of China(Grant No.21868014)Low-carbon Development Guidance Project of Yunnan Province in 2021(No.135)+5 种基金Key Sci-Tech Project of China Tobacco Yunnan Industrial Co.,Ltd.,(Grant No.2022GY03)Key Project of Yunnan Fundamental Research Program(Grant No.2019FA004)Yunnan Academician and Expert Workstation(Grant No.202205 AF150024)Kunming International Sci-Tech Cooperation Base,China(Grant No.GHJD-2020026)Yunnan Sci-Tech Talents and Platform Program(Grant No.202105AC160058)Scientific research project of Yunnan Environmental Science Society,China(No.XHKYKT006).
文摘Limited by single function,it is difficult for the traditional stirred vessels to meet the requirements of mixing system in biomass wastewater treatment processes.The estimation of biomass wastewater stirring reactor performance by computational fluid dynamics(CFD)during multiphase reactions is important,due to the uncertainty in the numerical results.In this study,a novel double-partition stirred vessel with eccentrically located impellers was developed for the special subject.In addition,many simulations were carried out with the wastewater from biomass ethanol production as the medium to ensure the high reactor performance.The fluid flow was simulated and analyzed using the turbulent RNG k-ε model and multi reference frames.A good agreement is found between the simulation results and the confirmatory experiment.Moreover,the weir crest and interconnected pore were specially designed for the establishment of the circulation of fluid to maintain different technological conditions in the two regions.The distributions of radial velocities and tangential velocities were concentrated near the stirring blade.From the velocity profile,it is deduced that the flow pattern in the stirred vessel is insensitive to Reynolds number.Finally,this simulation study could contribute to the improvement and optimization of the structure,as well as the operation of the novel stirred vessel.
基金supported by the National Natural Science Foundation of China(Grant No.21868014)a Key Project of the Yunnan Fundamental Research Program(Study on Design of Novel Catalyst and Catalytic Process for Preparation of Bioaviation Kerosene from Vegetable Oils Based on Photo-thermal Catalytic Technology),2021 Low-carbon Development Guide Project of Yunnan Province,China(No.135),Key S&T Project of China Tobacco Yunnan Industrial Co.,Ltd.,(Grant No.2022GY03)+4 种基金Yunnan Academician and Expert Workstation(Grant No.202205AF150024)Yunnan International S&T Cooperation Program,China(Grant No.202003AF140001)Yunnan S&T Talents and Platform Program(Grant No.202105AC160058)Kunming International S&T Cooperation Base,China(Grant No.GHJD-2020026)Scientific research project of Yunnan Environmental Science Society,China(Grant No.XHKYKT006).
文摘The preparation of green and economical bio-aviation fuel is a priority for the sustainable development industry.In this study,Jatropha oil was used as a raw material to catalyze the conversion of raw material to aviation kerosene fraction by photothermal coupling under the conditions of light and low temperature.The correlations among conversion rate,target alkane selectivity,composition distribution,and catalyst microstructure were investigated by X-ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM),nitrogen(N2)adsorption and desorption,X-ray fluorescence(XRF),ammoniatemperature programmed desorption(NH3-TPD),ultraviolet-visible spectrophotometry(UV-Vis),and other characterization.The correlation between conversion and target alkane selectivity and composition distribution and catalyst microstructure was investigated,and different modification methods and different molecular sieve materials were selected.The results showed that the molecular sieves modified with the solid dispersion method could retain the structural stability of titanium dioxide(TiO2)and molecular sieves to a great extent while slightly enhancing the pore capacity and pore size of the catalyst to make it easier to adsorb reactants;the introduction of active metal platinum(Pt)could reduce the forbidden bandwidth of the catalyst,increase the weak acid amount of the catalyst,improve the adsorption capacity of hydrogen(H2),and thus improve the catalytic ability,resulting in a suitable catalyst for this study:P-21.The photothermal catalytic reaction of Jatropha oil using P-21 catalyst obtained 97.21%conversion and 74.99%selectivity of the target alkanes under the optimal process parameters.The results of this study provide effective catalyst parameters for research in the field of clean energy.
