Developing organic field-effect transistor(OFET)biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical diagnosis.In ...Developing organic field-effect transistor(OFET)biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical diagnosis.In this work,design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio(SNR)to the device-performance parameters.Steep subthreshold swing(SS),proper threshold voltage(Vth),good-enough bias-stress stability,and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency(gm/ID)for large SNR.Combining a low trap-density channel and a high-k/low-k gate dielectric layer,low-temperature(<100℃)solution-processed flexible OFETs can meet the performance requirements to maximize the gm/ID.An extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21,achieving a detection limit below 10 pM with high selectivity at a low operation voltage(<1 V).展开更多
A series of novel organic conjugated molecules （5a--5d） comprising 2,3-benzopyridiazine as electron-with- drawing core and thiophene derivatives as electron-donating arms have been synthesized successfully in good y...A series of novel organic conjugated molecules （5a--5d） comprising 2,3-benzopyridiazine as electron-with- drawing core and thiophene derivatives as electron-donating arms have been synthesized successfully in good yields. The ultraviolet-visible （UV-Vis） absorption spectra and fluorescence spectra of 5a--5d revealed that the optical properties are strongly influenced by the interactions between nitrogen and sulfur atoms in the conjugated backbone, as well as the position of the alkyl chains in the thiophene rings. The experimental results and theoretical calculation data clearly indicated that the band gap and the energy levels of LUMO and HOMO could be fine-tuned by the po- sition of alkyl chains in the thiophene rings. Thus, the structure-property correlation of this class of conjugated molecules can be well established.展开更多
基金supported by the National Natural Science Foundation of China under Grant (61334008,61804094,and 61974091)National Science Fund for Excellent Young Scholars under Grant 61922057the Research Grants Council (RGC)of Hong Kong,China (Project No.C5015-15G).
文摘Developing organic field-effect transistor(OFET)biosensors for customizable detection of biomarkers for many diseases would provide a low-cost and convenient tool for both biological studies and clinical diagnosis.In this work,design principles of the OFET transducer for biosensors were derived to relate the signal-to-noise ratio(SNR)to the device-performance parameters.Steep subthreshold swing(SS),proper threshold voltage(Vth),good-enough bias-stress stability,and mechanical durability are shown to be the key prerequisites for realizing OFET bio-sensors of high transconductance efficiency(gm/ID)for large SNR.Combining a low trap-density channel and a high-k/low-k gate dielectric layer,low-temperature(<100℃)solution-processed flexible OFETs can meet the performance requirements to maximize the gm/ID.An extended gate-structure OFET biosensor was further implemented for label-free detection of miR-21,achieving a detection limit below 10 pM with high selectivity at a low operation voltage(<1 V).
基金We acknowledge funding support from Natural Science Foundation of China，the Shanghai Committee of Science and Technology，Shanghai Pujiang Program，Shanghai Jiao Tong University
文摘A series of novel organic conjugated molecules （5a--5d） comprising 2,3-benzopyridiazine as electron-with- drawing core and thiophene derivatives as electron-donating arms have been synthesized successfully in good yields. The ultraviolet-visible （UV-Vis） absorption spectra and fluorescence spectra of 5a--5d revealed that the optical properties are strongly influenced by the interactions between nitrogen and sulfur atoms in the conjugated backbone, as well as the position of the alkyl chains in the thiophene rings. The experimental results and theoretical calculation data clearly indicated that the band gap and the energy levels of LUMO and HOMO could be fine-tuned by the po- sition of alkyl chains in the thiophene rings. Thus, the structure-property correlation of this class of conjugated molecules can be well established.
