The structure of the oxide film on FGH96 alloy powders significantly influences the mechanical properties of superalloys.In this study,FGH96 alloy powders with various oxygen contents were investigated using high-reso...The structure of the oxide film on FGH96 alloy powders significantly influences the mechanical properties of superalloys.In this study,FGH96 alloy powders with various oxygen contents were investigated using high-resolution transmission electron microscopy and atomic probe technology to elucidate the structure evolution of the oxide film.Energy dispersive spectrometer analysis revealed the presence of two distinct components in the oxide film of the alloy powders:amorphous oxide layer covering the γ matrix and amorphous oxide particles above the carbide.The alloying elements within the oxide layer showed a laminated distribution,with Ni,Co,Cr,and Al/Ti,which was attributed to the decreasing oxygen equilibrium pressure as oxygen diffused from the surface into the γ matrix.On the other hand,Ti enrichment was observed in the oxide particles caused by the oxidation and decomposition of the carbide phase.Comparative analysis of the oxide film with oxygen contents of 140,280,and 340 ppm showed similar element distributions,while the thickness of the oxide film varies approximately at 9,14,and 30 nm,respectively.These findings provide valuable insights into the structural analysis of the oxide film on FGH96 alloy powders.展开更多
An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of th...An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of the fragments formed.This study investigated the fragmentation performance of a new high-carbon silicon-manganese(HCSiMn)steel cylindrical shell through fragment recovery experiments.Compared with the conventional 45Cr steel shell,the number of small mass fragments produced by the HCSi Mn steel shell was significantly increased with a scale parameter of 0.57 g fitted by the Weibull distribution model.The fragmentation process of the HCSi Mn shell exhibited more brittle tensile fracture characteristics,with the microcrack damage zone on the outer surface being the direct cause of its high fragmentation.On the one hand,the doping of alloy elements resulted in grain refinement by forming metallographic structure of tempered sorbite,so that microscopic intergranular fracture reduces the characteristic mass of the fragments;on the other hand,the distribution of alloy carbides can exert a"pinning"effect on the substrate grains,causing more initial cracks to form and propagate along the brittle carbides,further improving the shell fragmentation.Although the killing power radius for light armored vehicles was slightly reduced by about 6%,the dense killing radius of HCSiMn steel projectile against personnel can be significantly increased by about 26%based on theoretical assessment.These results provided an experimental basis for high fragmentation warhead design,and to some extent,revealed the correlation mechanism between metallographic structure and shell fragmentation.展开更多
Increasing photosynthesis and light capture offers possibilities for improving crop yield and provides a sustainable way to meet the increasing global demand for food.However,the poor light transmittance of transparen...Increasing photosynthesis and light capture offers possibilities for improving crop yield and provides a sustainable way to meet the increasing global demand for food.However,the poor light transmittance of transparent plastic films and shade avoidance at high planting density seriously reduce photosynthesis and alter fruit quality in vegetable crops,and therefore it is important to investigate the mechanisms of light signaling regulation of photosynthesis and metabolism in tomato(Solanum lycopersicum).Here,a combination of red,blue,and white(R1W1B0.5)light promoted the accumulation of chlorophyll,carotenoid,and anthocyanin,and enhanced photosynthesis and electron transport rates by increasing the density of active reaction centers and the expression of the genes LIGHT-HARVESTING COMPLEX B(SlLHCB)and A(SlLHCA),resulting in increased plant biomass.In addition,R1W1B0.5 light induced carotenoid accumulation and fruit ripening by decreasing the expression of LYCOPENEβ-CYCLASE(SlCYCB).Disruption of SlCYCB largely induced fruit lycopene accumulation,and reduced chlorophyll content and photosynthesis in leaves under red,blue,and white light.Molecular studies showed that ELONGATED HYPOCOTYL 5(SlHY5)directly activated SlCYCB,SlLHCB,and SlLHCA expression to enhance chlorophyll accumulation and photosynthesis.Furthermore,R1W1B0.5 light-induced chlorophyll accumulation,photosynthesis,and SlHY5 expression were largely decreased in the slphyb1cry1 mutant.Collectively,R1W1B0.5 light noticeably promoted photosynthesis,biomass,and fruit quality through the photoreceptor(SlPHYB1 and SlCRY1)-SlHY5-SlLHCA/B/SlCYCB module in tomato.Thus,the manipulation of light environments in protected agriculture is a crucial tool to regulate the two vital agronomic traits related to crop production efficiency and fruit nutritional quality in tomato.展开更多
Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei- mer＇s disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Al...Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei- mer＇s disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer＇s disease. Lipid rafts are glycolipid-rich liquid domains of the plasma membrane, where certain types of protein tend to aggregate and intercalate. Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides. In this paper, we review the mechanism by which lipid rafts disturb the aberrant deg- radative autophagic-lysosomal pathway of amyloid-beta, which plays an important role in the pathological process of Alzheimer＇s disease. Moreover, we describe this mechanism from the view of the Two-system Theory of fasciology and thus, suggest that lipid rafts may be a new target of Alzheimer＇s disease treatment.展开更多
In this study,the effects of geometrical and physical factors on light particles dispersion in stirred tank were investigated by agitation characteristic curve.The experiments and CFD simulations with discrete phase m...In this study,the effects of geometrical and physical factors on light particles dispersion in stirred tank were investigated by agitation characteristic curve.The experiments and CFD simulations with discrete phase model(DPM)and volume of fluid model(VOF)were conducted in this paper.Five factors,which include four geometrical factors(submergence,impeller-to-tank ratio,number of impeller blades and baffling mode)and a physical factor(liquid viscosity)were considered.For each factor,the power consumption curve and agitation characteristic curve were drawn to compare the power consumption and mixing results in the stirred tank.Characteristics of the agitation characteristic curves were compared with the previous published literatures and theories.It is found that the agitation characteristic curves reflect the tendency of power consumption and particles distribution well in stirred tank.The good agreement indicates the applicability of the agitation characteristic curves for the study of light particles distribution in stirred tank.展开更多
[ Objective] This study aimed to screen yeast strains suitable for high temperature processing of formulated biological feed. [ Method ] High temperature resistance and culture conditions of six yeast strains were inv...[ Objective] This study aimed to screen yeast strains suitable for high temperature processing of formulated biological feed. [ Method ] High temperature resistance and culture conditions of six yeast strains were investigated. [Result] Two yeast strains resistant to high temperature （45 ℃ ） with high viable cell number （10^8 cells/ml） were screened, including DQFC2117-1 and DQFC2122-2. [ Conclusion] Strains DQFC2117-1 and DQFC2122-2 could be used as high temperature resistant yeast strains for processing of formulated biological feed.展开更多
[Objective] The study aims at analyzing a regional rainstorm in Yulin City of northern Shaanxi. [Method] Based on conventional meteorological data, satellite cloud pictures and ncep 1 ° ×1 ° reanalysis ...[Objective] The study aims at analyzing a regional rainstorm in Yulin City of northern Shaanxi. [Method] Based on conventional meteorological data, satellite cloud pictures and ncep 1 ° ×1 ° reanalysis products, a regional rainstorm occurring during July 1 -3, 2011 in Yulin City of northern Shaanxi was discussed from the aspects of circulation pattem, mesoscale system, water vapor and dynamical conditions.[Result] There was a small closed high-pressure center near Fujian, around which southwest air flow existed constantly, providing water vapor for rainstorm areas for a long time; plateau trough moved eastwards, which provided dynamical field for rainstorm areas; the convergence between northeast cold air and low-level jet flow triggered this rainstorm; rainstorm areas were closely related to mesoscale low-pressure, and the storm appeared in the lowlevel jet flow in front of mesoscale low pressure; upper-trough cloud system and low-level jet cloud system combined, increased and generated rainstorm cloud cluster, while brightness temperature on the top of clouds was below -90 ℃ [ Conclusion] The research could provide theoretical foundation for forecast of rainstorms in future.展开更多
[Objectives]To explore the proper intercropping pattern between chewing cane and peanut.[Methods]A field experiment was carried out to investigate the yield and economic benefit of chewing cane and peanut,as well as t...[Objectives]To explore the proper intercropping pattern between chewing cane and peanut.[Methods]A field experiment was carried out to investigate the yield and economic benefit of chewing cane and peanut,as well as the changes in soil properties under different chewing cane/peanut intercropping patterns.Three chewing cane/peanut intercropping patterns were designed,in which with every row of chewing cane intercropping one row of peanut(CP_(1)),intercropping two rows of peanut(CP_(2))and chewing cane mono-cropping(MC).[Results]It had no significant effect on the agronomic characters of chewing cane and peanut in CP_(1)and CP_(2),compared with MC.The soil properties before the planting(BP)and after the harvest(AH)indicated that the chewing cane/peanut intercropping patterns significantly increased soil organic matter and soil available nitrogen contents,but decreased soil available potassium contents,and CP_(2)had better effect on soil structure than CP_(1).The total production value and economic benefit were increased significantly on the CP_(1)and CP_(2),comparing the MC,and the benefit of CP_(2)was higher significantly than that of CP_(1).The land equivalent ratios(LER)for CP_(1)and CP_(2)were 1.94 and 1.72,respectively,which was significantly higher than that of MC(0.83).Although planting cost was increased in chewing cane/peanut intercropping patterns partly,the production value and the profits were enhanced significantly.[Conclusions]CP_(2)could be significantly advantageous for the yield and benefits of chewing cane and peanut and soil properties.The favorable intercropping pattern for economic return would be one row of 120 cm width for chewing cane with two rows of peanut.展开更多
CsPbBr3 nanocrystal is used as the saturable absorber(SA) for mode-locking Tm-doped fiber laser in a ring fiber cavity.The modulation depth, saturable intensity, and non-saturable loss of the fabricated SA are 14.1%, ...CsPbBr3 nanocrystal is used as the saturable absorber(SA) for mode-locking Tm-doped fiber laser in a ring fiber cavity.The modulation depth, saturable intensity, and non-saturable loss of the fabricated SA are 14.1%, 2.5 MW/cm^2,and 5.9%, respectively.In the mode-locking operation, the mode-locked pulse train has a repetition rate of 16.6 MHz with pulse width of 24.2 ps.The laser wavelength is centered at 1992.9 nm with 3-dB spectrum width of 2.5 nm.The maximum output power is 110 mW with slope efficiency of 7.1%.Our experiment shows that CsPbBr3 nanocrystal can be used as an efficient SA in the 2-μm wavelength region.展开更多
Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats （1 day old） underwent paravertebral fascial massage （15 co...Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats （1 day old） underwent paravertebral fascial massage （15 consecutive days）, followed by subcutaneous injection of insulin-like growth factor 1 receptor antagonist, JB1 （9 consecutive days）. Paravertebral fascial massage significantly increased insulin-like growth factor 1 expression and cell proliferation in the subventricular zone of the lateral ventricle and dentate gyrus of the hippocampus. However, JB1 inhibited this increase. Results suggest that paravertebral fascial massage can promote brain development of neonatal rats via the insulin-like growth factor I pathway.展开更多
A Scalable Multi-Hash( SMH) name lookup method is proposed,which is based on hierarchical name decomposition to aggregate names sharing common prefixes and multiple scalable hash tables to minimize collisions among pr...A Scalable Multi-Hash( SMH) name lookup method is proposed,which is based on hierarchical name decomposition to aggregate names sharing common prefixes and multiple scalable hash tables to minimize collisions among prefixes. We take the component instead of the entire name as a key in the hash functions. The SMH method achieves lookup speeds of 21. 45 and 20. 87 Mbps on prefix table with 2 million and 3. 6 million names,respectively. The proposed method is the fastest of the four methods considered and requires 61.63 and 89.17 Mb of memory on the prefix tables with 2 million and 3. 6 million names,respectively. The required memory is slightly larger than the best method. The scalability of SMH outperforms that of the other two methods.展开更多
Intuitionistic fuzzy starshaped sets (i.f.s.) is a generalized model of fuzzy starshaped set. By the definition of i.f.s., the intuitionistic fuzzy general starshaped sets (i.f.g.s.), intuitionistic fuzzy quasi-starsh...Intuitionistic fuzzy starshaped sets (i.f.s.) is a generalized model of fuzzy starshaped set. By the definition of i.f.s., the intuitionistic fuzzy general starshaped sets (i.f.g.s.), intuitionistic fuzzy quasi-starshaped sets (i.f.q-s.) and intuitionistic fuzzy pseudo-starshaped sets (i.f.p-s.) are proposed and the relationships among them are studied. The equivalent discrimination conditions of i.f.q-s. and i.f.p-s. are presented on the basis of their properties which are meaningful for the research of the generalized fuzzy starshaped sets. Moreover, the invariance of the two given fuzzy sets under the translation transformation and linear reversible transformation are discussed.展开更多
Objective:To investigate the cognition degree of male nursing students to HPV and nine-valent vaccine and the influencing factors of male willingness to receive nine-valent HPV vaccine.Methods:Qualitative research sem...Objective:To investigate the cognition degree of male nursing students to HPV and nine-valent vaccine and the influencing factors of male willingness to receive nine-valent HPV vaccine.Methods:Qualitative research semi-structured interview was conducted on male nursing students,and phenomenological research method was used to record,ran scribe,encode and classify the interview data and extract the topic.The number of interviews was determined according to the information saturation.Results:Seven themes were summarized in this study,which were mainly divided into two aspects.The promotion of vaccination includes two aspects:self-benefit and benefit of others.The prevention of vaccination mainly includes low awareness rate,feminization of vaccine infbnnation,high cost and safety and effectiveness.Conclusion:Male nursing students have low cognition degree and inoculation intention to human papillomavirus and nine-valent vaccine,so it is necessary to further strengthen publicity and carry out college education to improve vaccination.展开更多
Herein,a novel MoS_(2)-stainless steel composite material was first synthetized via a 3D printing method(3DP MoS_(2)-SS)for peroxymonosulfate(PMS)activation and organics degradation.Compared with MoS_(2)-SS powder/PMS...Herein,a novel MoS_(2)-stainless steel composite material was first synthetized via a 3D printing method(3DP MoS_(2)-SS)for peroxymonosulfate(PMS)activation and organics degradation.Compared with MoS_(2)-SS powder/PMS system(0.37 g/(m^(2)/min)),4.3-fold higher k_(FLO)/S_(BET)value was obtained in 3DP MoS_(2)-SS/PMS system(1.60 g/(m^(2)/min),resulting from the superior utilization of active sites.We observed that 3DP MoS_(2)-SS significantly outperformed the 3DP SS due to the enhanced electron transfer rate and increased active sites.Moreover,Mo^(4+)facilitated the Fe^(2+)/Fe^(3+)cycle,resulting in the rapid degradation of florfenicol(FLO).Quenching experiments and electron paramagnetic resonance spectra indicated that·OH,SO_(4)·^(-),O_(2)·^(-)and^(1)O_(2)were involved in the degradation of FLO.The effect of influencing factors on the degradation of FLO were evaluated,and the optimized degradation efficiency of 98.69%was achieved at 1 mM PMS and pH of 3.0.Six degradation products were detected by UPLC/MS analyses and several possible degradation pathways were proposed to be the cleavage of C-N bonds,dechlorination,hydrolysis,defluorination and hydroxylation.In addition,3DP MoS_(2)-SS/PMS system also demonstrated superior degradation performance for 2-chlorophenol,acetaminophen,ibuprofen and carbamazepine.This study provided deep insights into the MoS_(2)-SS catalyst prepared by 3DP technology for PMS activation and FLO-polluted water treatment.展开更多
A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing A H_(4)SiW_(12)O_(40)as th...A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing A H_(4)SiW_(12)O_(40)as the catalyst and dimethyl carbonate(DMC)as the solvent,a diverse range of 2-acylbenzoic acid derivatives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoindolinones with the yield range of 61%-87%.Advantages of this transformation include green catalyst and solvent,available starting materials,broad substrate scope,high efficiency and operational simplicity with water as the sole by-product.The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones,which would provide opportunities for the synthesis of potential biologically active molecules in a green manner.展开更多
Nanozymes based on metal-organic frameworks (MOFs) have been concentrated on due to their naturally high-disperse metal active sites and the adjustable coordination chemistry. In this work, an N-rich melamine (Mel) wa...Nanozymes based on metal-organic frameworks (MOFs) have been concentrated on due to their naturally high-disperse metal active sites and the adjustable coordination chemistry. In this work, an N-rich melamine (Mel) was introduced into the Cu-MOF composed of copper(II) nitrate and 2-aminoterephthalic acid (Cu-NH_(2)-BDC-Mel) to mimic the laccase, which enzyme-like activities were assessed and applied in sensing analyses toward several phenols and amines. Compared to unmodified Cu-NH_(2)-BDC, the resulting Cu-NH_(2)-BDC-Mel exhibits enhanced laccase-like activity, superior stability and catalytic kinetics. It is demonstrated that melamine-doping has increased nitrogen content as well as the surface area, as a result, exhibits a lower Michaelis–Menten constant (K m) (0.1877 mM) and higher maximum reaction rate (V max) (1.7933 × 10^(−3) mM·min^(−1)) in comparison with that of natural laccase. Based on that, an efficient colorimetric sensing strategy for several phenols and amines was built up with excellent selectivity and anti-interference by using the laccase-like Cu-NH_(2)-BDC-Mel, the detection limits are 3.51 µM of adrenaline and 4.41 µM of dopamine. The work broadens the prospect development of bio-colorimetric sensing based on the ligand-modified Cu-MOFs nanozymes catalysis.展开更多
基金financially supported by the National Key R&D Program of China(No.2021YFB3704000)the National Natural Science Foundation of China(Nos.52074032,51974029,52071013,and 52130407)+3 种基金the Beijing Natural Science Foundation(No.2232084)the Guangdong Basic and Applied Basic Research Foundation(No.2021B1515120033)the 111 Project(No.B170003)the Basic and Applied Basic Research Fund of Guangdong Province,China(No.BK20BE015).
文摘The structure of the oxide film on FGH96 alloy powders significantly influences the mechanical properties of superalloys.In this study,FGH96 alloy powders with various oxygen contents were investigated using high-resolution transmission electron microscopy and atomic probe technology to elucidate the structure evolution of the oxide film.Energy dispersive spectrometer analysis revealed the presence of two distinct components in the oxide film of the alloy powders:amorphous oxide layer covering the γ matrix and amorphous oxide particles above the carbide.The alloying elements within the oxide layer showed a laminated distribution,with Ni,Co,Cr,and Al/Ti,which was attributed to the decreasing oxygen equilibrium pressure as oxygen diffused from the surface into the γ matrix.On the other hand,Ti enrichment was observed in the oxide particles caused by the oxidation and decomposition of the carbide phase.Comparative analysis of the oxide film with oxygen contents of 140,280,and 340 ppm showed similar element distributions,while the thickness of the oxide film varies approximately at 9,14,and 30 nm,respectively.These findings provide valuable insights into the structural analysis of the oxide film on FGH96 alloy powders.
基金funded by the National Natural Science Foundation of China (Grant Nos.12302444 and 12202349)。
文摘An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of the fragments formed.This study investigated the fragmentation performance of a new high-carbon silicon-manganese(HCSiMn)steel cylindrical shell through fragment recovery experiments.Compared with the conventional 45Cr steel shell,the number of small mass fragments produced by the HCSi Mn steel shell was significantly increased with a scale parameter of 0.57 g fitted by the Weibull distribution model.The fragmentation process of the HCSi Mn shell exhibited more brittle tensile fracture characteristics,with the microcrack damage zone on the outer surface being the direct cause of its high fragmentation.On the one hand,the doping of alloy elements resulted in grain refinement by forming metallographic structure of tempered sorbite,so that microscopic intergranular fracture reduces the characteristic mass of the fragments;on the other hand,the distribution of alloy carbides can exert a"pinning"effect on the substrate grains,causing more initial cracks to form and propagate along the brittle carbides,further improving the shell fragmentation.Although the killing power radius for light armored vehicles was slightly reduced by about 6%,the dense killing radius of HCSiMn steel projectile against personnel can be significantly increased by about 26%based on theoretical assessment.These results provided an experimental basis for high fragmentation warhead design,and to some extent,revealed the correlation mechanism between metallographic structure and shell fragmentation.
基金We thank the Tomato Genetics Resource Center(http://tgrc.ucdavis.edu)for offering slphyb1cry1 mutant,‘Moneymaker’,and‘Ailsa Craig’seeds.This work was funded by the National Natural Science Foundation of China(32122081,32272698)the National Key Research and Development Program of China(2023YFF1002000)+7 种基金the Natural Science Foundation of Liaoning Province for Excellent Youth(2022-YQ-18)the National Key Research and Development Program of China(2019YFD1000300)the China Agriculture Research System(CARS-23)the National Natural Science Foundation of China(31801904,31991184)the Liao Ning Revitalization Talents Program(XLYC1807020)the Young and Middle-aged Science and Technology Innovation Talent Support Program in Shenyang(RC200449)the Ministry of Science and Technology of the People’s Republic of China(DL2022026004L)the Innovative Research Team(Science and Technology)in University of Henan Province(23IRTSTHN024).
文摘Increasing photosynthesis and light capture offers possibilities for improving crop yield and provides a sustainable way to meet the increasing global demand for food.However,the poor light transmittance of transparent plastic films and shade avoidance at high planting density seriously reduce photosynthesis and alter fruit quality in vegetable crops,and therefore it is important to investigate the mechanisms of light signaling regulation of photosynthesis and metabolism in tomato(Solanum lycopersicum).Here,a combination of red,blue,and white(R1W1B0.5)light promoted the accumulation of chlorophyll,carotenoid,and anthocyanin,and enhanced photosynthesis and electron transport rates by increasing the density of active reaction centers and the expression of the genes LIGHT-HARVESTING COMPLEX B(SlLHCB)and A(SlLHCA),resulting in increased plant biomass.In addition,R1W1B0.5 light induced carotenoid accumulation and fruit ripening by decreasing the expression of LYCOPENEβ-CYCLASE(SlCYCB).Disruption of SlCYCB largely induced fruit lycopene accumulation,and reduced chlorophyll content and photosynthesis in leaves under red,blue,and white light.Molecular studies showed that ELONGATED HYPOCOTYL 5(SlHY5)directly activated SlCYCB,SlLHCB,and SlLHCA expression to enhance chlorophyll accumulation and photosynthesis.Furthermore,R1W1B0.5 light-induced chlorophyll accumulation,photosynthesis,and SlHY5 expression were largely decreased in the slphyb1cry1 mutant.Collectively,R1W1B0.5 light noticeably promoted photosynthesis,biomass,and fruit quality through the photoreceptor(SlPHYB1 and SlCRY1)-SlHY5-SlLHCA/B/SlCYCB module in tomato.Thus,the manipulation of light environments in protected agriculture is a crucial tool to regulate the two vital agronomic traits related to crop production efficiency and fruit nutritional quality in tomato.
基金supported by a grant from Projects of High-tech Industrialization of Guangdong Province of China,No.2011B010500004a grant from National Financial Major Project of China
文摘Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei- mer＇s disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer＇s disease. Lipid rafts are glycolipid-rich liquid domains of the plasma membrane, where certain types of protein tend to aggregate and intercalate. Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides. In this paper, we review the mechanism by which lipid rafts disturb the aberrant deg- radative autophagic-lysosomal pathway of amyloid-beta, which plays an important role in the pathological process of Alzheimer＇s disease. Moreover, we describe this mechanism from the view of the Two-system Theory of fasciology and thus, suggest that lipid rafts may be a new target of Alzheimer＇s disease treatment.
基金Supported by the National Natural Science Foundation of China(51474109,51609090,51679097).
文摘In this study,the effects of geometrical and physical factors on light particles dispersion in stirred tank were investigated by agitation characteristic curve.The experiments and CFD simulations with discrete phase model(DPM)and volume of fluid model(VOF)were conducted in this paper.Five factors,which include four geometrical factors(submergence,impeller-to-tank ratio,number of impeller blades and baffling mode)and a physical factor(liquid viscosity)were considered.For each factor,the power consumption curve and agitation characteristic curve were drawn to compare the power consumption and mixing results in the stirred tank.Characteristics of the agitation characteristic curves were compared with the previous published literatures and theories.It is found that the agitation characteristic curves reflect the tendency of power consumption and particles distribution well in stirred tank.The good agreement indicates the applicability of the agitation characteristic curves for the study of light particles distribution in stirred tank.
基金Supported by Special Fund for Basic and Applied Research from the Finance Department of Heilongjiang Province
文摘[ Objective] This study aimed to screen yeast strains suitable for high temperature processing of formulated biological feed. [ Method ] High temperature resistance and culture conditions of six yeast strains were investigated. [Result] Two yeast strains resistant to high temperature （45 ℃ ） with high viable cell number （10^8 cells/ml） were screened, including DQFC2117-1 and DQFC2122-2. [ Conclusion] Strains DQFC2117-1 and DQFC2122-2 could be used as high temperature resistant yeast strains for processing of formulated biological feed.
文摘[Objective] The study aims at analyzing a regional rainstorm in Yulin City of northern Shaanxi. [Method] Based on conventional meteorological data, satellite cloud pictures and ncep 1 ° ×1 ° reanalysis products, a regional rainstorm occurring during July 1 -3, 2011 in Yulin City of northern Shaanxi was discussed from the aspects of circulation pattem, mesoscale system, water vapor and dynamical conditions.[Result] There was a small closed high-pressure center near Fujian, around which southwest air flow existed constantly, providing water vapor for rainstorm areas for a long time; plateau trough moved eastwards, which provided dynamical field for rainstorm areas; the convergence between northeast cold air and low-level jet flow triggered this rainstorm; rainstorm areas were closely related to mesoscale low-pressure, and the storm appeared in the lowlevel jet flow in front of mesoscale low pressure; upper-trough cloud system and low-level jet cloud system combined, increased and generated rainstorm cloud cluster, while brightness temperature on the top of clouds was below -90 ℃ [ Conclusion] The research could provide theoretical foundation for forecast of rainstorms in future.
基金Supported by Natural Science Foundation of Guangxi(2021GXNSFAA-075039)Scientific Base and Talents Foundation of Guangxi(AD20297103).
文摘[Objectives]To explore the proper intercropping pattern between chewing cane and peanut.[Methods]A field experiment was carried out to investigate the yield and economic benefit of chewing cane and peanut,as well as the changes in soil properties under different chewing cane/peanut intercropping patterns.Three chewing cane/peanut intercropping patterns were designed,in which with every row of chewing cane intercropping one row of peanut(CP_(1)),intercropping two rows of peanut(CP_(2))and chewing cane mono-cropping(MC).[Results]It had no significant effect on the agronomic characters of chewing cane and peanut in CP_(1)and CP_(2),compared with MC.The soil properties before the planting(BP)and after the harvest(AH)indicated that the chewing cane/peanut intercropping patterns significantly increased soil organic matter and soil available nitrogen contents,but decreased soil available potassium contents,and CP_(2)had better effect on soil structure than CP_(1).The total production value and economic benefit were increased significantly on the CP_(1)and CP_(2),comparing the MC,and the benefit of CP_(2)was higher significantly than that of CP_(1).The land equivalent ratios(LER)for CP_(1)and CP_(2)were 1.94 and 1.72,respectively,which was significantly higher than that of MC(0.83).Although planting cost was increased in chewing cane/peanut intercropping patterns partly,the production value and the profits were enhanced significantly.[Conclusions]CP_(2)could be significantly advantageous for the yield and benefits of chewing cane and peanut and soil properties.The favorable intercropping pattern for economic return would be one row of 120 cm width for chewing cane with two rows of peanut.
基金Project supported by the National Key R&D Program of China(Grant No.2018YFB0504500)the National Natural Science Foundation of China(Grant Nos.51472162,51672177,and 61475171)the Talent Introduction Research Project of Shanghai Institute of Technology,China(Grant No.YJ 2018-8)
文摘CsPbBr3 nanocrystal is used as the saturable absorber(SA) for mode-locking Tm-doped fiber laser in a ring fiber cavity.The modulation depth, saturable intensity, and non-saturable loss of the fabricated SA are 14.1%, 2.5 MW/cm^2,and 5.9%, respectively.In the mode-locking operation, the mode-locked pulse train has a repetition rate of 16.6 MHz with pulse width of 24.2 ps.The laser wavelength is centered at 1992.9 nm with 3-dB spectrum width of 2.5 nm.The maximum output power is 110 mW with slope efficiency of 7.1%.Our experiment shows that CsPbBr3 nanocrystal can be used as an efficient SA in the 2-μm wavelength region.
基金supported by the National Basic Research Program of China (973 Program), No. 2007CB512705the General Program for Youths of the National Nature science Foundation of China, No. 30801464
文摘Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats （1 day old） underwent paravertebral fascial massage （15 consecutive days）, followed by subcutaneous injection of insulin-like growth factor 1 receptor antagonist, JB1 （9 consecutive days）. Paravertebral fascial massage significantly increased insulin-like growth factor 1 expression and cell proliferation in the subventricular zone of the lateral ventricle and dentate gyrus of the hippocampus. However, JB1 inhibited this increase. Results suggest that paravertebral fascial massage can promote brain development of neonatal rats via the insulin-like growth factor I pathway.
基金sponsored by the National Basic Research Program of China(973 Program)(Grant No.2011CB302605)the National High Technology Research and Development Program of China(863 Program)(Grants No.2011AA010705+5 种基金2012AA0125022012AA012506)the National Key Technology R&D Program of China(Grant No.2012BAH37B01)the National Science Foundation of China(Grant No.6120245761402149)the CNNIC(Grant No.K201211043)
文摘A Scalable Multi-Hash( SMH) name lookup method is proposed,which is based on hierarchical name decomposition to aggregate names sharing common prefixes and multiple scalable hash tables to minimize collisions among prefixes. We take the component instead of the entire name as a key in the hash functions. The SMH method achieves lookup speeds of 21. 45 and 20. 87 Mbps on prefix table with 2 million and 3. 6 million names,respectively. The proposed method is the fastest of the four methods considered and requires 61.63 and 89.17 Mb of memory on the prefix tables with 2 million and 3. 6 million names,respectively. The required memory is slightly larger than the best method. The scalability of SMH outperforms that of the other two methods.
文摘Intuitionistic fuzzy starshaped sets (i.f.s.) is a generalized model of fuzzy starshaped set. By the definition of i.f.s., the intuitionistic fuzzy general starshaped sets (i.f.g.s.), intuitionistic fuzzy quasi-starshaped sets (i.f.q-s.) and intuitionistic fuzzy pseudo-starshaped sets (i.f.p-s.) are proposed and the relationships among them are studied. The equivalent discrimination conditions of i.f.q-s. and i.f.p-s. are presented on the basis of their properties which are meaningful for the research of the generalized fuzzy starshaped sets. Moreover, the invariance of the two given fuzzy sets under the translation transformation and linear reversible transformation are discussed.
文摘Objective:To investigate the cognition degree of male nursing students to HPV and nine-valent vaccine and the influencing factors of male willingness to receive nine-valent HPV vaccine.Methods:Qualitative research semi-structured interview was conducted on male nursing students,and phenomenological research method was used to record,ran scribe,encode and classify the interview data and extract the topic.The number of interviews was determined according to the information saturation.Results:Seven themes were summarized in this study,which were mainly divided into two aspects.The promotion of vaccination includes two aspects:self-benefit and benefit of others.The prevention of vaccination mainly includes low awareness rate,feminization of vaccine infbnnation,high cost and safety and effectiveness.Conclusion:Male nursing students have low cognition degree and inoculation intention to human papillomavirus and nine-valent vaccine,so it is necessary to further strengthen publicity and carry out college education to improve vaccination.
基金supported by the Guangdong Province Enterprise Science and Technology Commissioner Project (No.GDKTP2021048000)the National Natural Science Foundation of China (No.41907292)+2 种基金the Guangdong Basic and Applied Basic Research Foundation (No.2019A1515110497)the Key-Area Research and Development Program of Guangdong Province (No.2020B090923002)the Guangdong Basic and Applied Basic Research Foundation (No.2019B1515130005)。
文摘Herein,a novel MoS_(2)-stainless steel composite material was first synthetized via a 3D printing method(3DP MoS_(2)-SS)for peroxymonosulfate(PMS)activation and organics degradation.Compared with MoS_(2)-SS powder/PMS system(0.37 g/(m^(2)/min)),4.3-fold higher k_(FLO)/S_(BET)value was obtained in 3DP MoS_(2)-SS/PMS system(1.60 g/(m^(2)/min),resulting from the superior utilization of active sites.We observed that 3DP MoS_(2)-SS significantly outperformed the 3DP SS due to the enhanced electron transfer rate and increased active sites.Moreover,Mo^(4+)facilitated the Fe^(2+)/Fe^(3+)cycle,resulting in the rapid degradation of florfenicol(FLO).Quenching experiments and electron paramagnetic resonance spectra indicated that·OH,SO_(4)·^(-),O_(2)·^(-)and^(1)O_(2)were involved in the degradation of FLO.The effect of influencing factors on the degradation of FLO were evaluated,and the optimized degradation efficiency of 98.69%was achieved at 1 mM PMS and pH of 3.0.Six degradation products were detected by UPLC/MS analyses and several possible degradation pathways were proposed to be the cleavage of C-N bonds,dechlorination,hydrolysis,defluorination and hydroxylation.In addition,3DP MoS_(2)-SS/PMS system also demonstrated superior degradation performance for 2-chlorophenol,acetaminophen,ibuprofen and carbamazepine.This study provided deep insights into the MoS_(2)-SS catalyst prepared by 3DP technology for PMS activation and FLO-polluted water treatment.
基金the National Natural Science Foundation of China(No.22001034)Jiangxi Provincial Natural Science Foundation(No.20212BAB213001).
文摘A H_(4)SiW_(12)O_(40)-catalyzed three-component tandem reaction of 2-acylbenzoic acids,primary amines and phosphine oxides to form 3,3-disubstituted isoindolinones was developed.By employing A H_(4)SiW_(12)O_(40)as the catalyst and dimethyl carbonate(DMC)as the solvent,a diverse range of 2-acylbenzoic acid derivatives and primary amines worked well to give the C3-phosphinoyl-functionalized 3,3-disubstituted isoindolinones with the yield range of 61%-87%.Advantages of this transformation include green catalyst and solvent,available starting materials,broad substrate scope,high efficiency and operational simplicity with water as the sole by-product.The strategy achieved an efficient and green molecular fragment assembly to access isoindolinones,which would provide opportunities for the synthesis of potential biologically active molecules in a green manner.
基金financial support of Liaoning Science and Technology Development Foundation Guided by Central Government(No.2021JH6/10500141)Fundamental Research Funds for the Central Universities(No.N232410019).
文摘Nanozymes based on metal-organic frameworks (MOFs) have been concentrated on due to their naturally high-disperse metal active sites and the adjustable coordination chemistry. In this work, an N-rich melamine (Mel) was introduced into the Cu-MOF composed of copper(II) nitrate and 2-aminoterephthalic acid (Cu-NH_(2)-BDC-Mel) to mimic the laccase, which enzyme-like activities were assessed and applied in sensing analyses toward several phenols and amines. Compared to unmodified Cu-NH_(2)-BDC, the resulting Cu-NH_(2)-BDC-Mel exhibits enhanced laccase-like activity, superior stability and catalytic kinetics. It is demonstrated that melamine-doping has increased nitrogen content as well as the surface area, as a result, exhibits a lower Michaelis–Menten constant (K m) (0.1877 mM) and higher maximum reaction rate (V max) (1.7933 × 10^(−3) mM·min^(−1)) in comparison with that of natural laccase. Based on that, an efficient colorimetric sensing strategy for several phenols and amines was built up with excellent selectivity and anti-interference by using the laccase-like Cu-NH_(2)-BDC-Mel, the detection limits are 3.51 µM of adrenaline and 4.41 µM of dopamine. The work broadens the prospect development of bio-colorimetric sensing based on the ligand-modified Cu-MOFs nanozymes catalysis.
